-

Öz

Objective: Arsenic is a metal with a widespread industrial usage and causing oxidative stress. Studies shows serum uric acid and gamma gluthamyl transferase (GGT) levels are increasing in oxidative stress. The aim of this study is to evaluate the effect of arsenic exposure on serum uric acid and GGT levels.Methods: 500 patients who refer to Ankara Occupational Disease Hospital between 2010 to 2014 for periodic examination and urinary arsenic, serum uric acid and serum GGT levels assessed are included in this study. 268 patients with urinary arsenic levels over 35μg/L are defined as exposed and below 35μg/L are controls.Results: Data of 500 patients were analysed. 268 of them had high urine arsenic levels and 232 had normal urine arsenic levels. In the high urine arsenic level group the median serum uric acid level was 5.4 (2.60-7.20) and median serum GGT level was 27 in the other group with normal urine arsenic levels the median serum uric acid level was 4.9 and median serum GGT level was 22 . The difference between two groups was statistically significant (p value: 0.002 and <0.001 respectively)Conclusion: Arsenic exposure may be associated with hyperuricemia and high levels of GGT and with prospective studies the causal relationship between arsenic exposure and hyperuricemia and GGT can be revealed

Anahtar Kelimeler

• Arsenic exposure, hyperuricemia, gamma gluthamyl transferase

Arsenik maruziyeti olan kişilerde serum gama glutamil transferaz ve ürik asit düzeylerinin değerlendirilmesi

Öz

Amaç: Arsenik endüstride oldukça yaygın kullanılan ve oksidatif strese neden olduğu bilinen bir metaldir. Serum ürik asit ve gama glutamil transferaz (GGT) düzeylerinin oksidatif stres durumunda arttığını gösteren çalışmalar bulunmaktadır. Bu çalışmanın amacı arsenik maruziyetinin serum ürik asit ve GGT düzeylerine etkisinin araştırılmasıdır.

Yöntemler: 2010-2014 yılları arasında Ankara Meslek Hastalıkları Hastanesine periyodik muayene amaçlı başvuran idrar arsenik, serum ürik asit ve GGT düzeylerine bakılmış 500 kişi çalışmaya dahil edildi. İdrar arsenik düzeyi 35μg/L’nin üzerinde çıkan 268 kişi arsenik maruz grup, 35μg/L’nin altında çıkan 232 kişi ise kontrol grubu olarak kullanıldı.

Bulgular: Arsenik maruz grubun median serum ürik asit değerleri 5,4 (2,60-7,20) median serum GGT değerleri 27 (10-51) idi. Normal idrar arsenik düzeyleri olan diğer grupta ise median serum ürik asit değerleri 4,9 (2,5-7) median serum GGT değerleri 22 (10-52) idi. İki grup arasındaki fark ürik asit ve GGT için anlamlı idi (p değerleri sırasıyla; 0,002, <0,001).

Sonuç: Arsenik maruziyeti hiperürisemi ve yüksek GGT düzeyleri ile ilişkili olabilir. Prospektif çalışmalarla, arsenik maruziyeti ile hiperürisemi, yüksek GGT düzeyleri ve klinik sonuçlar arasındaki nedensel ilişki ortaya çıkarılmalıdır.

Anahtar kelimeler: Arsenik maruziyeti, hiperürisemi, gama glutamil transferaz.

Anahtar Kelimeler

• Arsenik maruziyeti, hiperürisemi, gama glutamil transferaz

Kaynakça

1. Mandal BK, Suzuki KT. Arsenic round the world: a review.
2. Talanta 2002;58:201-235.
3. Flora SJ. Arsenic-induced oxidative stress and its reversibil
4. ity. Free Radic Biol Med 2011;15:257-281.
5. Bhattacharjee S, Sarkar C, Pal S. Additive beneficial effect
6. of folic acid and vitamin b12 co-administration on arsenic-
7. induced oxidative damage in cardiac tissue in vivo. Asian J
8. Pharm Clin Res 2013;6:64-69.

9. Nan H, Dong Y, Gao W, et al. Diabetes associated with a
10. low serum uric acid level in a general Chinese population.
11. Diabetes Res Clin Pract 2007;76:68–74.
12. Yildirim A, Altinkaynak K, Aksoy H, et al. Plasma xanthine
13. oxidase, superoxide dismutase and glutathione peroxidase
14. activities and uric acid levels in severe and mild pre-eclampsia. Cell Biochem Funct 2004;22:213–217.
15. Akbaş ME, Özçiçek A, Özçiçek F. Metabolik olarak sağlıklı
16. ve sağlıksız obez hastalarda ürik asit seviyeleri. Dicle Tıp
17. Dergisi 2014;41:676-680.
18. Whitfield JB. Gamma glutamyl transferase. Crit Rev Clin
19. Lab Sci 2001;38:263-355.
20. Jones DP, Carlson JL, Mody VC, et al. Redox state of glutathione in human plasma. Free Radic Biol Med 2000;
21. :625-635.
22. Lee DH, Blomhoff R, Jacobs DR Jr. Is serum gamma glutamyltransferase a marker of oxidative stress? Free Radic Res 2004;38:535-539.
23. Abdul-Rasheed OF, Al-Shamma GA, Zillo BH. Serum γ-glutamyltransferase as Oxidative Stress Markerin Pre-and Postmenopausal Iraqi Women. Oman Med J 2010;25:286-288.
24. ACGIH Monograph. TLVs and BEIs, threshold limit values
25. for chemical substances and physical agents and biological
26. exposure indices. Cincinnati, OH: Signature Publications, 2011:122.
27. Casale T, Rosati MV, Ciarrocca M, et al. Assessment of
28. liver function in two groups of outdoor workers exposed to
29. arsenic. Int Arch Occup Environ Health 2014;87:745-752.
30. Kuo CC, Weaver V, Fadrowski JJ, et al. Arsenic exposure, hyperuricemia, and gout in US adults. Environ Int 2015;76:32-34.
31. Robles-Osorio ML, Pérez-Maldonado IN, Martín del Campo D, et al. Urinary arsenic levels and risk of renal injury in a cross-sectional study in open population. Rev Invest Clin 2012;64:609-614.
32. Mershiba SD, Dassprakash MV, Saraswathy SD. Protective
33. effect of naringenin on hepatic and renal dysfunction and
34. oxidative stress in arsenic intoxicated rats. Mol Biol Rep
35. ;40:3681-3691.
36. Yao ML, Zhang AH, Yu C, et al. The establishment of the
37. arsenic poisoning rats model caused by corn flour baked
38. by high-arsenic coal. Zhonghua Yu Fang Yi Xue Za Zhi
39. ;47:799-805.
40. Casale T, Rosati MV, Ciarrocca M, et al. Assessment of
41. liver function in two groups of outdoor workers exposed to
42. arsenic. Int Arch Occup Environ Health 2014;87:745-752.
43. Lee DJ, Choi JS, Kim KM, et al. Combined effect of serum
44. gamma-glutamyl transferase and uric acid on Framingham
45. risk score. Arch Med Res 2014;45:337-342.
46. Kim KM, Kim BT, Lee DJ, et al. Serum gamma-glutamyl transferase as a risk factor for general cardiovascular disease
47. prediction in Koreans. J Investig Med 2012;60:1199-1203.
48. Kong AP, Choi KC, Ho CS, et al. Associations of uric acid
49. and gamma-glutamyltransferase (GGT) with obesity and
50. components of metabolic syndrome in children and adolescents. Pediatr Obes 2013;8:351-357.
51. Long Y, Zeng F, Shi J, et al. Gamma-glutamyltransferase
52. predicts increased risk of mortality: a systematic review
53. and meta-analysis of prospective observational studies.
54. Free Radic Res 2014;48:716-728.