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Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat

Yıl 2020, Cilt: 47 Sayı: 3, 638 - 644, 25.09.2020
https://doi.org/10.5798/dicletip.800025

Öz

Objective: Blind mole rats (Nannospalax xanthodon Nehring, 1898) are subterranean mammals that are well-known for their high tolerance to hypoxia and resistance to cancer. Due to their unusual habitat, these animals have developed several adaptations during their evolution. Therefore, this study aimed to identify possible structural differences in Nannospalax visual system in comparison to other mammals that might have arisen as a result of adaptation to underground life.
Method: Six blind mole rats were used in the study. No procedure was performed on the rats. After the animals were anesthetized with ether, their eyes and optic nerves were removed. For this purpose, pseudo-eyes and optic nerves were harvested and fixed in 10% formaldehyde for a week. Tissues were embedded into paraffin and blocked via routine histological procedures. Five micrometer sections in thickness were taken and stained with Hematoxylin & Eosin (H&E) and Cresyl Violet.
Results: Histopathological analysis of the eye revealed the presence of cornea, retina, sclera, iris, zonula adherens, lacrimal gland and ducts, fatty tissue, muscle layer and the vascular structures. No pathology was observed of optic nerve.
Conclusions: We found that the visual system of N. xanthodon share some similarities with other blind mole rat species from Israel, while some histological properties were defined by our study for the first time in the literature.

Kaynakça

  • 1.Nevo E, Filippucci MG, Redi C, et al.Chromosomalspeciationandadaptiveradiation ofmolerats inAsiaMinorcorrelatedwithincreasedecologicalstress.ProcNatlAcadSci U S A.1994; 91: 8160-4.
  • 2.Nevo E, Filippucci MG, Redi C, etal.Karyotypeandgeneticevolution in speciation ofsubterraneanmolerats of thegenusSpalax in Turkey.BiologicalJournal of theLinneanSociety. 1995; 54:203-29.
  • 3.Savic IR andNevo E. TheSpalacidae:evolutionaryhistory, speciation,andpopulationbiology. In: Nevo, E. ve Reig, O.A.(eds). Evolution of SubterraneanMammals attheOrganismalandMolecularLevels. Wiley-Liss, NewYork,1990, pp. 129-54.

Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat

Yıl 2020, Cilt: 47 Sayı: 3, 638 - 644, 25.09.2020
https://doi.org/10.5798/dicletip.800025

Öz

Kaynakça

  • 1.Nevo E, Filippucci MG, Redi C, et al.Chromosomalspeciationandadaptiveradiation ofmolerats inAsiaMinorcorrelatedwithincreasedecologicalstress.ProcNatlAcadSci U S A.1994; 91: 8160-4.
  • 2.Nevo E, Filippucci MG, Redi C, etal.Karyotypeandgeneticevolution in speciation ofsubterraneanmolerats of thegenusSpalax in Turkey.BiologicalJournal of theLinneanSociety. 1995; 54:203-29.
  • 3.Savic IR andNevo E. TheSpalacidae:evolutionaryhistory, speciation,andpopulationbiology. In: Nevo, E. ve Reig, O.A.(eds). Evolution of SubterraneanMammals attheOrganismalandMolecularLevels. Wiley-Liss, NewYork,1990, pp. 129-54.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Original Articles
Yazarlar

Ayşe İKİNCİ KELEŞ Bu kişi benim

Burcu BİTERGE SÜT

Teoman KANKILIÇ Bu kişi benim

Yayımlanma Tarihi 25 Eylül 2020
Gönderilme Tarihi 3 Ocak 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 47 Sayı: 3

Kaynak Göster

APA İKİNCİ KELEŞ, A., BİTERGE SÜT, B., & KANKILIÇ, T. (2020). Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat. Dicle Tıp Dergisi, 47(3), 638-644. https://doi.org/10.5798/dicletip.800025
AMA İKİNCİ KELEŞ A, BİTERGE SÜT B, KANKILIÇ T. Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat. diclemedj. Eylül 2020;47(3):638-644. doi:10.5798/dicletip.800025
Chicago İKİNCİ KELEŞ, Ayşe, Burcu BİTERGE SÜT, ve Teoman KANKILIÇ. “Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat”. Dicle Tıp Dergisi 47, sy. 3 (Eylül 2020): 638-44. https://doi.org/10.5798/dicletip.800025.
EndNote İKİNCİ KELEŞ A, BİTERGE SÜT B, KANKILIÇ T (01 Eylül 2020) Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat. Dicle Tıp Dergisi 47 3 638–644.
IEEE A. İKİNCİ KELEŞ, B. BİTERGE SÜT, ve T. KANKILIÇ, “Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat”, diclemedj, c. 47, sy. 3, ss. 638–644, 2020, doi: 10.5798/dicletip.800025.
ISNAD İKİNCİ KELEŞ, Ayşe vd. “Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat”. Dicle Tıp Dergisi 47/3 (Eylül 2020), 638-644. https://doi.org/10.5798/dicletip.800025.
JAMA İKİNCİ KELEŞ A, BİTERGE SÜT B, KANKILIÇ T. Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat. diclemedj. 2020;47:638–644.
MLA İKİNCİ KELEŞ, Ayşe vd. “Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat”. Dicle Tıp Dergisi, c. 47, sy. 3, 2020, ss. 638-44, doi:10.5798/dicletip.800025.
Vancouver İKİNCİ KELEŞ A, BİTERGE SÜT B, KANKILIÇ T. Histopathological Analysis of The Eye And Optic Nerve Structure In The Blind Mole Rat. diclemedj. 2020;47(3):638-44.