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Inflammation Markers Associated with Metabolic Syndrome

Yıl 2022, Cilt 1, Sayı 2, 24 - 49, 01.10.2022

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Metabolik Sendromla İlişkili Enflamasyon Belirteçleri

Yıl 2022, Cilt 1, Sayı 2, 24 - 49, 01.10.2022

Öz

Metabolik sendrom, insülin direnci, merkezi ve abdominal obezite, hipertansiyon ve aterojenik dislipidemiyi içeren bir dizi biyokimyasal, metabolic ve klinik anormallikler bütünü olup kronik böbrek hastalığı, aterosklerotik kardiyovasküler hastalık, gut ve obstrüktif uyku apnesi ile güçlü bir ilişkiye sahiptir. Metabolik sendrom, küresel acil sağlık sorunlarının ilk sıralarında yerini korumaktadır. Metabolik sendromun patogenezinde kronik düşük dereceli enflamasyonun ve bağışıklık sisteminin aktivasyonunun rol oynadığı kabul edilmektedir. Obezite varlığında, yağ dokusu, karaciğer, kas ve pankreas başlıca enflamasyon bölgeleridir. Bağışıklık hücreleri, sitokinler ve adipokinler metabolik sendromla ilişkili hayati komplikasyonları tetiklemektedir. Obezite sırasında yükselen sitokinler ve adipokinler insülin direncine neden olarak metabolik sendromun ilerlemesine katkıda bulunmaktadır. Metabolik sendromun tanısında ve prognozunda enflamatuar biyobelirteçlerin dolaşım düzeyleri önem arz etmektedir. Enflamasyonun kontrolü, metabolik sendromla ilgili birçok patolojinin yönetimine destek olmaktadır. Metabolik sendromla ilişkili enflamasyon belirteçleri olan C-reaktif protein, seruloplazmin, fibrinojen, albumin, ferritin, interlökin (IL)-1 alfa, IL-1 beta, IL-6, IL-8, IL-10, IL-12, tümör nekroz faktör-alfa, plazminojen aktivatör inhibitörü-1, omentin, resistin, visfatin, apelin, kemerin, ghrelin, leptin ve adiponektine odaklanan bu derlemede literatür irdelenerek güncel bilgi sunulmuştur.

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Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Derlemeler
Yazarlar

Emine İncilay TORUNOĞLU>
Ondokuz Mayıs Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Samsun
0000-0003-4641-0067
Türkiye


Gül Fatma YARIM> (Sorumlu Yazar)
Ondokuz Mayıs Üniversitesi Veteriner Fakültesi Biyokimya Anabilim Dalı Atakum Samsun
0000-0003-4050-429X
Türkiye

Yayımlanma Tarihi 1 Ekim 2022
Yayınlandığı Sayı Yıl 2022, Cilt 1, Sayı 2

Kaynak Göster

APA Torunoğlu, E. İ. & Yarım, G. F. (2022). Metabolik Sendromla İlişkili Enflamasyon Belirteçleri . Doğu Karadeniz Sağlık Bilimleri Dergisi , 1 (2) , 24-49 . Retrieved from https://dergipark.org.tr/tr/pub/ebshealth/issue/72764/1144674

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