Some bioactive properties and antimicrobial activity of some Hypericum species growing wild in Black Sea Region of Turkey

Latife Betül Gül; Nilgün Özdemir; Osman Gül; Cüneyt Çırak; Ahmet Hilmi Çon

EN

Some bioactive properties and antimicrobial activity of some Hypericum species growing wild in Black Sea Region of Turkey

Abstract

The present study was conducted to evaluate the biological activity of four Hypericum species, including H. perfoliatum L., H. aviculariifolium Jaup. and Spach subsp. depilatum (Freyn and Bornm.) Robson var. depilatum, H. origanifolium Wild. and H. linarioides Bosse, growing wild in Black Sea Region of Turkey. Ethanolic extractions of both flowers and leaves of Hypericum species were performed by maceration method. Total phenolic contents were ranged from 83.89 to 148.04 mg GAE/g for flower and 202.83 to 48.03 mg GAE/g for leaf extracts. Antioxidant activities of the extracts were determined between 8.63 – 39.35 mg trolox equivalent/g and the highest antioxidant activity was observed in H. linarioides extracts probably due to high phenolic content. Antimicrobial activities of the extracts were evaluated by minimal inhibitory concentrations (MIC) against seven Gram-positive and two Gram-negative bacteria. MIC results show that the flower extracts generally exhibited higher antimicrobial activity than the leaf extracts. The most prominent antibacterial activity was displayed by flower extract of H. perfoliatum (MIC between 4 – 512 µg/mL) and Escherichia coli was the most resistant organisms to all Hypericum species.

Keywords

Hypericum spp., total phenolic content, antioxidant activity, antimicrobial activity

References

Anusha, K. S., Ganashree, N. K., Kruthika, G. N., Poojashree, R., Sushmitha, K. K., & Kekuda, P. T. R. (2015). Antimicrobial and antioxidant activity of leaf and flower of Hypericum mysorense. Journal of Chemical and Pharmaceutical Research, 7(5), 981-987.
Barış, D., Kızıl, M., Aytekin, Ç., Kızıl, G., Yavuz, M., Çeken, B., & Ertekin, A. S. (2011). In Vitro Antimicrobial and Antioxidant Activity of Ethanol Extract of ThreeHypericumand ThreeAchilleaSpecies From Turkey. International Journal of Food Properties, 14(2), 339-355. doi:10.1080/10942910903189256
Brand-Williams, W., Cuvelier, M. E., & Berset, C. (1995). Use of a Free Radical Method to Evaluate Antioxidant Activity. LWT-Food science and Technology, 28, 25-30.
Camas, N., Radusiene, J., Ivanauskas, L., Jakstas, V., & Cirak, C. (2013). Altitudinal changes in the content of bioactive substances in Hypericum orientale and Hypericum pallens. Acta Physiologiae Plantarum, 36(3), 675-686. doi:10.1007/s11738-013-1446-z
Cirak, C., Radusiene, J., Jakstas, V., Ivanauskas, L., Seyis, F., & Yayla, F. (2016). Secondary metabolites of seven Hypericum species growing in Turkey. Pharm Biol, 54(10), 2244-2253. doi:10.3109/13880209.2016.1152277
Cirak, C., Radušienė, J., Kurtarc, E. S., Marksa, M., & Ivanauskas, L. (2020). In vitro plant regeneration and jasmonic acid induced bioactive chemical accumulations in two Hypericum species from Turkey. South African Journal of Botany, 128, 312-318. doi:10.1016/j.sajb.2019.11.028
Del Monte, D., De Martino, L., Marandino, A., Fratianni, F., Nazzaro, F., & De Feo, V. (2015). Phenolic content, antimicrobial and antioxidant activities of Hypericum perfoliatum L. Industrial Crops and Products, 74, 342-347. doi:10.1016/j.indcrop.2015.04.036
Eroglu Ozkan, E., Yilmaz Ozden, T., Ozsoy, N., & Mat, A. (2018). Evaluation of chemical composition, antioxidant and anti-acetylcholinesterase activities of Hypericum neurocalycinum and Hypericum malatyanum. South African Journal of Botany, 114, 104-110. doi:10.1016/j.sajb.2017.10.022
Ersoy, E., Eroglu Ozkan, E., Boga, M., & Mat, A. (2020). Evaluation of in vitro biological activities of three Hypericum species (H. calycinum, H. confertum, and H. perforatum) from Turkey. South African Journal of Botany, 130, 141-147. doi:10.1016/j.sajb.2019.12.017
Gioti, E. M., Fiamegos, Y. C., Skalkos, D. C., & Stalikas, C. D. (2009). Antioxidant activity and bioactive components of the aerial parts of Hypericum perforatum L. from Epirus, Greece. Food Chemistry, 117(3), 398-404. doi:10.1016/j.foodchem.2009.04.016

Guner, A., Aslan, S., Ekim, T., Vural, M., & Babac, M. T. (2012). List of turkish ¸ flora (Vascular plants). Publication of Nezahat Gokyiğit Botanical Garden and Flora Research Fondation, Istanbul. Available online at http://www.bizimbitkiler.org.tr/v2/hiyerarsi.php?c=Hypericum.
Güzey, G., Ibadova, S., Öztürk, Y., Öztürk, N., Maggi, F., Sagratini, G., . . . Vittori, S. (2011). Antiproliferative and Antioxidant Effects of Three Hypericum Species of Turkish Origin H. perforatum, H. montbretii and H. origanifolium. Medicinal and Aromatic Plant Science and Biotechnology, 5(1), 91-99.
Inouye, S., Takizawa, T., & Yamaguchi, H. (2001). Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact. Journal of antimicrobial chemotherapy, 47(5), 565-573.
Kahkonen, M. J., Hopia, A. I., Vuorela, H. J., Rauha, J., Pihlaja, K., Kujala, T. S., & Heinonen, M. (1999). Antioxidant activity of plant extracts containing phenolic compounds. Journal of Agricultural and Food Chemistry, 47, 3954-3962.
Kamila, P. K., Ray, A., Jena, S., Mohapatra, P. K., & Panda, P. C. (2018). Chemical composition and antioxidant activities of the essential oil of Hypericum gaitii Haines - an endemic species of Eastern India. Nat Prod Res, 32(6), 739-742. doi:10.1080/14786419.2017.1338283
Maltas, E., Uysal, A., Yildiztugay, E., Aladag, M. O., Yildiz, S., & Kucukoduk, M. (2013). Investigation of antioxidant and antibacterial activities of some Hypericum species. Fresenius Environmental Bulletin, 22(3), 862-869.
Maskovic, P., Mladenovic, J., Cvijovic, M., Acamovic-Djokovic, G., Solujic, S., & Radojkovic, M. (2011). Phenolic content, antioxidant and antifungal activities of acetonic, ethanolic and petroleum ether extracts of Hypericum perforatum L. Hemijska industrija, 65(2), 159-164. doi:10.2298/hemind100819004m
Mazandarani, M., Yassaghi, S., Rezaei, M. B., Mansourian, A. R., & Ghaemi, E. O. (2007). Ethnobotany and Antibacterial Activities of Two Endemic Species of Hypericum in North-East of Iran. Asian Journal of Plant Sciences., 6(2), 354-358.
Mohammed, F. S., Şabik, A. E., Dogan, M., Selamoglu, Z., & Sevindik, M. (2020). Antioxidant Potential of Hypericum spectabile JAUB. ET SPACH. Bulletin of Biotechnology, 1(2), 43-45.
Napoli, E., Siracusa, L., Ruberto, G., Carrubba, A., Lazzara, S., Speciale, A., . . . Cristani, M. (2018). Phytochemical profiles, phototoxic and antioxidant properties of eleven Hypericum species - A comparative study. Phytochemistry, 152, 162-173. doi:10.1016/j.phytochem.2018.05.003
Nogueira, T., Medeiros, M. A., Marcelo-Curto, M. J., García-Pérez, B. E., Luna-Herrera, J., & Costa, M. C. (2013). Profile of antimicrobial potential of fifteen Hypericum species from Portugal. Industrial Crops and Products, 47, 126-131. doi:10.1016/j.indcrop.2013.03.005
Özdemir, N., Uzun, F., Gül, L. B., Gül, O., & Çon, A. H. (2020). Assessment of Phenolic Content, Antioxidant Properties and Antimicrobial Activity of Flower and Leaf Extracts from Some Hypericum Species Affected by Wild Habitat Altitude. Alınteri Zirai Bilimler Dergisi, 35(1), 62-68. doi:10.28955/alinterizbd.739372
Öztürk, N., Tunçel, M., & Potoğlu-Erkara, İ. (2009). Phenolic compounds and antioxidant activities of some Hypericum species: A comparative study with H. perforatum. Pharmaceutical Biology, 47(2), 120-127. doi:10.1080/13880200802437073
Radulović, N., Stankov-Jovanović, V., Stojanović, G., Šmelcerović, A., Spiteller, M., & Asakawa, Y. (2007). Screening of in vitro antimicrobial and antioxidant activity of nine Hypericum species from the Balkans. Food Chemistry, 103(1), 15-21. doi:10.1016/j.foodchem.2006.05.062
Saddiqe, Z., Naeem, I., Hellio, C., Patel, A. V., & Abbas, G. (2020). Phytochemical profile, antioxidant and antibacterial activity of four Hypericum species from the UK. South African Journal of Botany, 133, 45-53. doi:10.1016/j.sajb.2020.05.018
Sekeroglu, N., Urlu, E., Kulak, M., Gezici, S., & Dang, R. (2017). Variation in Total Polyphenolic Contents, DNA Protective Potential and Antioxidant Capacity from Aqueous and Ethanol Extracts in Different Plant Parts of Hypericum perforatum L. Indian Journal of Pharmaceutical Education and Research, 51(2s), s1-s7. doi:10.5530/ijper.51.2s.43
Seyrekoğlu, F., & Temiz, H. (2020). Effect of Extraction Conditions on the Phenolic Content and DPPH Radical Scavenging Activity of Hypericum perforatum L. Turkish Journal of Agriculture - Food Science and Technology, 8(1). doi:10.24925/turjaf.v8i1.226-229.3013
Shahidi, F., Janitha, P. K., & Wanasundara, P. D. (1992). Phenolic antioxidants. Critical Reviews in Food science & Nutrition, 32(1), 67-103. Singleton, V. L., & Rossi, J. A. (1965). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture, 16(3), 144-148.
Şerbetçi, T., Özsoy, N., Demirci, B., Can, A., Kültür, Ş., & Başer, K. H. C. (2012). Chemical composition of the essential oil and antioxidant activity of methanolic extracts from fruits and flowers of Hypericum lydium Boiss. Industrial Crops and Products, 36(1), 599-606. doi:10.1016/j.indcrop.2011.11.002
Tian, F., Li, B., Ji, B., Yang, J., Zhang, G., Chen, Y., & Luo, Y. (2009). Antioxidant and antimicrobial activities of consecutive extracts from Galla chinensis:The polarity affects the bioactivities. Food Chemistry, 113(1), 173-179. doi:10.1016/j.foodchem.2008.07.062
Tocci, N., Weil, T., Perenzoni, D., Narduzzi, L., Madriñán, S., Crockett, S., . . . Mattivi, F. (2018). Phenolic profile, chemical relationship and antifungal activity of Andean Hypericum species. Industrial Crops and Products, 112, 32-37. doi:10.1016/j.indcrop.2017.10.030
Tusevski, O., Vinterhalter, B., Krstić Milošević, D., Soković, M., Ćirić, A., Vinterhalter, D., . . . Gadzovska Simic, S. (2016). Production of phenolic compounds, antioxidant and antimicrobial activities in hairy root and shoot cultures of Hypericum perforatum L. Plant Cell, Tissue and Organ Culture (PCTOC), 128(3), 589-605. doi:10.1007/s11240-016-1136-9
Veličković, D., Stankov-Jovanović, V., Mitić, V., Kostić, D., & Palić, R. (2013). Antimicrobial and antioxidant activities of essential oil and crude extracts of Hypericum tetrapterum Fries (Hypericaceae). . Journal of Medicinal Plants Research, 4(14), 1441-1445. doi:10.5897/JMPR10.116

Details

Primary Language

English

Subjects

Food Engineering

Journal Section

Research Article

Authors

Latife Betül Gül ^*
0000-0002-4732-7727
Türkiye

Nilgün Özdemir
0000-0002-4517-9214
Türkiye

Osman Gül
0000-0003-1620-4246
Türkiye

Cüneyt Çırak
0000-0002-6920-1199
Türkiye

Ahmet Hilmi Çon
0000-0002-1225-0133
Türkiye

Publication Date

March 31, 2021

Submission Date

January 16, 2021

Acceptance Date

February 15, 2021

Published in Issue

Year 2021 Volume: 2 Number: 1

IZ

https://izlik.org/JA68HP42AT

APA

Gül, L. B., Özdemir, N., Gül, O., Çırak, C., & Çon, A. H. (2021). Some bioactive properties and antimicrobial activity of some Hypericum species growing wild in Black Sea Region of Turkey. European Food Science and Engineering, 2(1), 1-6. https://izlik.org/JA68HP42AT

AMA

1.Gül LB, Özdemir N, Gül O, Çırak C, Çon AH. Some bioactive properties and antimicrobial activity of some Hypericum species growing wild in Black Sea Region of Turkey. Eur. Food. Sci. Eng. 2021;2(1):1-6. https://izlik.org/JA68HP42AT

Chicago

Gül, Latife Betül, Nilgün Özdemir, Osman Gül, Cüneyt Çırak, and Ahmet Hilmi Çon. 2021. “Some Bioactive Properties and Antimicrobial Activity of Some Hypericum Species Growing Wild in Black Sea Region of Turkey”. European Food Science and Engineering 2 (1): 1-6. https://izlik.org/JA68HP42AT.

EndNote

Gül LB, Özdemir N, Gül O, Çırak C, Çon AH (March 1, 2021) Some bioactive properties and antimicrobial activity of some Hypericum species growing wild in Black Sea Region of Turkey. European Food Science and Engineering 2 1 1–6.

IEEE

[1]L. B. Gül, N. Özdemir, O. Gül, C. Çırak, and A. H. Çon, “Some bioactive properties and antimicrobial activity of some Hypericum species growing wild in Black Sea Region of Turkey”, Eur. Food. Sci. Eng., vol. 2, no. 1, pp. 1–6, Mar. 2021, [Online]. Available: https://izlik.org/JA68HP42AT

ISNAD

Gül, Latife Betül - Özdemir, Nilgün - Gül, Osman - Çırak, Cüneyt - Çon, Ahmet Hilmi. “Some Bioactive Properties and Antimicrobial Activity of Some Hypericum Species Growing Wild in Black Sea Region of Turkey”. European Food Science and Engineering 2/1 (March 1, 2021): 1-6. https://izlik.org/JA68HP42AT.

JAMA

1.Gül LB, Özdemir N, Gül O, Çırak C, Çon AH. Some bioactive properties and antimicrobial activity of some Hypericum species growing wild in Black Sea Region of Turkey. Eur. Food. Sci. Eng. 2021;2:1–6.

MLA

Gül, Latife Betül, et al. “Some Bioactive Properties and Antimicrobial Activity of Some Hypericum Species Growing Wild in Black Sea Region of Turkey”. European Food Science and Engineering, vol. 2, no. 1, Mar. 2021, pp. 1-6, https://izlik.org/JA68HP42AT.

Vancouver

1.Latife Betül Gül, Nilgün Özdemir, Osman Gül, Cüneyt Çırak, Ahmet Hilmi Çon. Some bioactive properties and antimicrobial activity of some Hypericum species growing wild in Black Sea Region of Turkey. Eur. Food. Sci. Eng. [Internet]. 2021 Mar. 1;2(1):1-6. Available from: https://izlik.org/JA68HP42AT

Abstract

Some bioactive properties and antimicrobial activity of some Hypericum species growing wild in Black Sea Region of Turkey

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

Cite