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This study, which examines the factors affecting reading comprehension from various perspectives, is a literature review. Accordingly, research and review articles on reading comprehension skill, factors affecting reading comprehension, reading comprehension barriers in Google Academic, ULAKBİM, YÖK Academic, Web of Science, ERIC, Proquest database were scanned and the variables affecting reading comprehension skills were scanned. Determined and the effects of these variables on the reading comprehension process are explained. According to the results of the literature review; Six factors affecting reading comprehension, namely reading comprehension strategies, vocabulary knowledge, fluent reading, text type and text type awareness, affective qualities of reading, metacognitive reading strategies, were determined and these factors were explained with various dimensions. One of the results obtained from the research is that the main difference that distinguishes competent readers from weak readers is their ability to use these six factors consciously, to organize the reading process accordingly, and to use these factors in a timely and effective manner in the reading process. In addition, it has been concluded that the six factors determined have a direct effect on the reading comprehension skill, are related to each other, and have features that can be taught and gained to students.