IN VITRO CYTOTOXICITY ANALYSIS AND SYNTHESIS OF BIOCIDAL ALLICIN/MT/MMA/PEG/POSS NANOCOMPOSITES FOR THE FOOD PACKAGING

Öz

In this study, the new nanocomposites were synthesized using antibacterial and antioxidant curcumin (Cr) and allicin (Ac), the high mechanical strength montmorillonite clay (Mt) and biocompatible methylmethacrylate (MMA), polyethylene glycol (PEG) and polyocta-hedral oligomeric silsesquioxanes (POSS) polymers. Firstly, monomer 1 was synthesized by using Ag+-montmorillonite, the curcumin extract and POSS, then the synthesized monomer 1 was interacted with MMA and PEG polymers, and nanocomposites were synthesized. The synthesized nanocomposites were analyzed by using the methods of Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). After this, the inhibition zones and the surface activity resistances of the nanocomposites were analyzed against the bacteria Escherichia coli (E. coli), Listeria monocytogenes (L. monocytogenes), Salmonella and Staphylococcus aureus (S.aureus) and carried out biocompatibility analysis. According to the analysis results, the nanocomposites have been found to have the strong antibacterial resistance and biocompatibility.

Anahtar Kelimeler

• Surface activity,biocompatibility,the curcumin,biopolimers,the allicin

GIDA AMBALAJI İÇİN BİYOSİDAL ALLİSİN / MT / MMA / PEG / POSS NANOKOMOZİTLERİNİN SENTEZİ VE İN VİTRO SİTOTOKSİSİTE ANALİZİ

Öz

Bu çalışmada, antibakteriyel ve antioksidan kurkumin (Cr) ve allisin (Ac), yüksek mekanik mukavemetli montmorillonit kili (Mt) ve biyouyumlu polimetilmetakrilat (PMMA), polietilen glikol (PEG) ve polioktahedral oligomerik silseskioksan (POSS) polimerleri kullanılarak yeni nanokompozitler sentezlenmiştir. Öncelikle, Ag+-montmorillonit, kurkumin ekstraktı ve POSS kullanılarak monomer 1 sentezlendi, daha sonra sentezlenen monomer 1, MMA ve PEG polimerleri ile etkileştirilmiş, ve nanokompozitler sentezlenmiştir. Sentezlenen yüzey nanokompozitler, Fourier Transform Kızılötesi Spektroskopisi (FTIR), X-ışını kırınımı (XRD) ve taramalı elektron mikroskopisi (SEM) yöntemleri kullanılarak analiz edilmiştir. Daha sonra, nanokompozitlerin inhibisyon bölgesi alanları ve yüzey aktivite dirençleri, Escherichia coli (E.coli), Listeria monocytogenes (L. monocytogenes), Salmonella ve Staphylococcus aureus (S.aureus) bakterilerine karşı analiz edilmiş ve biyouyumluluk testleri yapılmıştır. Analiz sonuçlarına göre, nanokompozitlerin güçlü antibakteriyel dirence ve biyouyumluluğa sahip olduğu bulunmuştur.

Anahtar Kelimeler

• Yüzey aktivitesi,biyouyumluluk,kurkumin,biyopolimerler,allisin

Kaynakça

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