Bioactive Peptides in Dairy Products and Their Functionality (Turkish with English Abstract)

Öz

Milk proteins exert a wide range of nutritional, functional and biological activities. Bioactive peptides derived form hydrolysis of milk proteins and these have been identified within the amino acid sequences of milk proteins. The generation of bioactive peptides is contributed proteolitic enzymes naturally occurring in milk and enzymes from lactic acid bacteria or from exogenous sources. This review discusses formation of bioactive peptides and gives information about their health effects.

Anahtar Kelimeler

• Bioactive peptides, milk proteins, health effects 

Süt Ürünlerinde Bulunan Biyoaktif Peptitler ve Fonksiyonları

Öz

Süt proteinleri besinsel, fonksiyonel ve biyolojik aktiviteye sahiptir. Biyoaktif peptitler süt proteinlerin hidrolize olması ile açığa çıkar ve süt proteinlerinin aminoasit dizilimi içinde yer alır. Biyoaktif peptitlerin oluşumu; sütte doğal olarak bulunan, laktik asit bakterileri tarafından üretilen ya da dışarıdan katılan proteolitik enzimlerle gerçekleşmektedir. Bu makalede biyoaktif peptitlerin oluşum şekilleri ve sağlık üzerine etkileri hakkında bilgi verilmiştir.

Anahtar Kelimeler

• Biyoaktif peptitler, süt proteinleri, sağlık etkisi 

Kaynakça

1. Clare DA Swaisgocd HE. 2000. Bioactive milk peptides: A prospectus. Journal ol Dairy Science. 83: 1187- 1195.
2. Dagdemir E Özdemir C ve Özdemir S. 2003. Süt ürünlerinde bulunan antihipertansif peptitler ve etki mekanizmaları. Süt
3. Tokatlı M. Yıldırım M ve Yıldırım 2. 2005. Kazein türevli biyoaktit peptitler, 4. Gıda Mühendisliği Kongresi, 29 Eylül- 1 Ekim. Ankara.
4. Smacchi E and Gobbetti M. 2000. Bioactive peptides in dairy products: synthesis and interaction with proteolytic enzymes, Food Microbiology, 17: 129- 141.
5. Narva M. 2004. Effects of Lactobacr'fius heiveticus fermented milk and milk-derived bioactive peptides (CPP, IPP and VPP) on calcium and bone metabolism, Doctoral Thesis. Institute of Biomedicine, Pharmacology, University of Helsinki,
6. Helsinki, 83 p. (unpublished) Schanbacher FL, Talhouk RS and Murray FA. 1997. Biology and origin of bioactive peptides in milk. Livestock
7. Production Science, 50: 105- 123. Gobbetti M, Stepaniak L. De Angelis M, Corsetti A and Di Cagno Ft. 2002. Latent bioactive peptides in milk proteins:
8. Proteolytic activation and signiŞcance in dairy processing, Critical Fleviews in Food Science and Nutrition, 42 (3): 223- 239. Kim YE, Yoon S, Yu DY, Lonnerdal B and Chung BH. 1999. Novel angiotensin—I—convening enzyme inhibitory peptides derived from recombinant human casein expressed in E.coli. Journal ot Dairy Research 66: 431- 439.

9. Gauthier SF and Pouliot Y. 2003. Functional and biological properties of peptides obtained by enzymatic hydrolysis of whey proteins. Journal of Dairy Science, 86: (E. Suppl), E78-E87.
10. Pouliot Y, Wijers MC. Gauthier SF and Nadeau L. 1999. Fractionation of whey protein hydrolysates using charged
11. UF/NF membranes, Journal of Membrane Science, 158: 105- 114. Ellegard KH Gammetgard—Larsen C, Sorensen E, and Fedosov S. 1999. Process scale chromatographic isolation, characterization and identification of tryptic bioactive casein phosphopeptides, International Dairy Journal, 9: 639- 652.
12. Fitzgerald RJ and Murray BA 2006. Bioactive peptides and lactic Iermentations, International Journal ot Dairy
13. Haileselassie SS Lee BH and Gibbs BF 1999. Purification and identification of potentially bioactive peptides from
14. Schmidl M and Labuza T. 2000. Essentials of Functional Foods, Apsen Publishers, Inc.. Gaithersburg, Maryland. 395 p.
15. Séverin S and Wenshui X. 2005. Milk biologicaliy active components as nutraceuticals: Review, Critical, Reviews in Food
16. Seppo L, Jauhiainen T, Poussa T and Korpeia Ft. 2003. Atermented milk high in bioactive peptides has a blood pressure
17. Korhonen H, Pihlanto-Leppâlâ A, Hantamâki P and Tupasela T. 1998. Impact of processing on bioactive proteins and Silva SV and Malcata FX. 2005. Caseins as a source of bioactive peptides. International Dairy Journal, 15: 1- 15.
18. Meisel H. 1998. Overview on milk protein-derived peptides, International Dairy Journal, 8: 363- 373.
19. Fiat AM Migliore-Samour D and Jollés P. 1993. Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunomodulating activities. Journal of Dairy Science, 76:.301- 310.
20. Pihlanto-Leppâlâ A. 2001. Bioactive peptides derived from bovine whey proteins: opioid and ace-inhibitory peptides,
21. Tome D and Debabbi H 1998. Physiological effects oi milk protein components. International Dairy Journal, B: 383- 392.
22. Kayser H and Meisel H. 1996. Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from
23. Gauthier SF Paquin P Pouliot Y and Turgeon S. 1993. Sur1ace activity and related functional properties of peptides obtained from whey proteins, Journal of Dairy Science, 76: 321- 328.