Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü

Yıl 2025, Cilt: 6 Sayı: 2, 384 - 394, 29.11.2025

Müzeyyen Aybüke Yayla , Çağlar Adıgüzel

https://doi.org/10.63716/guffd.1759695

Öz

Nikel oksit (NiO) endüstride sıklıkla kulanılan bir geçiş metalidir. Yaygın kullanımına bağlı olarak halk sağlığı ve çevre sorunları meydana gelmiştir. Resveratrol (RES) antioksidan aktiviteleri güçlü olan bir fenolik bileşikdir. Şu anki çalışma NiO’nun ratların akciğer dokusundaki yarattığı oksidatif ve histopatolojik hasara karşı RES’in koruyucu rolünü araştırmıştır. Çalışmada 4 grup (her grupta 6 hayvan) oluşturulmuştur. Kontrol grubu, RES grubu (10 mg/kg v.a.), NiO grubu (10 mg/kg v.a.) ve RES+NiO grubu. 28 günlük oral gavaj uygulaması sonrası NiO uygulanan ratların akciğer dokularındaki, nikel birikimi ve MDA miktarı konrol grubuna göre anlamlı bir yükselme göstermiştir (p<0,05). SOD, CAT, GPx ve GST gibi antioksidanlarda ise anlamlı bir azalma meydana gelmiştir (p<0,05). Ayrıca NiO uygulanan gruptaki ratların akciğer dokularında ciddi histopatolojik değişiklikler gözlenmiştir. RES ve NiO’nun beraber uygulandığı grupta nikel birikiminde ve MDA düzeyinde anlamlı bir azalma, antioksidan aktivitelerde ise anlamlı bir artma meydana gelmiştir. Aynı zamanda histopatolojik incelemede iyileşmeler gözlenmiştir. Bu sonuçlar RES’in önemli bir takviye gıda olduğunu göstermektedir.

Anahtar Kelimeler

Nikel oksit , Resveratrol , Akciğer , Oksidatif stres , Histopatoloji

Etik Beyan

Hayvan deneyleri ile ilgili tüm süreçler Gazi Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu tarafından onaylanmıştır (Etik Kurul No: G.U.ET-24.135).

Teşekkür

Çalışmamızın hayvan deneyleri kısmını FYL-2024-9656 no’lu pojeden destekleyen Gazi Üniversitesi Bilimsel Araştırma Projeleri birimine teşekkür ederiz. Bu çalışma, Gazi Üniversitesi Fen Bilimleri Enstitüsü Biyoloji Anabilim Dalında, “Nikel Oksit'in Rat Akciğer Dokusu Üzerine Toksik Etkisi ve Resveratrol'ün Koruyucu Etkisi” isimli yüksek lisans tezinden türetilmiştir.

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