Coronavirus and Influenza Viruses: An Overview of Their Differences and Similarities

Yıl 2020, Cilt: 9 Sayı: 4, 427 - 432, 02.01.2021

Lale Türkmen Aydın Kıvanç

https://doi.org/10.37989/gumussagbil.817120

Öz

SARS-CoV-2 is a new virus that is the cause of the current COVID-19 pandemic. We currently do not have a cure and immunity against this pathogen. Influenza viruses, on the other hand, are constantly evolving and undergo various levels of antigenic drift and shift that will become less recognizable by our immune system. This makes it difficult to develop a widespread effective influenza vaccine and also poses a risk of pandemics by leading to the emergence of new strains of zoonotic Influenza. Both Coronaviruses and Influenza viruses are enveloped RNA viruses and one of the primary pathogens affecting human respiration. COVID-19 and Influenza infections have similar transmission routes and symptoms. The reviewed literature indicates that there are important structural differences between COVID-19 and Influenza. These include differences in genome structures, surface proteins, number of strain and subtypes. In addition, incubation times, risk groups, asymptomatic transmission and transmission rate are important difference between the two viruses. However, unlike Influenza, the lack of vaccines and treatments for COVID-19 poses serious difficulties in controlling the spread of the disease. As a result, Coronavirus is spreading rapidly and due to the risk of possible co-infection with Influenza virus, it is extremely important to evaluate COVID-19 and Influenza infection together and developing public health measures accordingly.

Anahtar Kelimeler

Coronavirus, COVID-19, Flu, Influenza virus

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Coronavirus ve Influenza Viruslar: Farklılıklarına ve Benzerliklerine Genel Bir Bakış

Öz

Mevcut COVID-19 pandemisi’nin nedeni olan SARS-CoV-2 yeni bir virüstür. Bu patojene karşı mevcut tedavi ve bağışıklığımız bulunmamaktadır. Influenza virüsleri ise sürekli olarak evrimleşmekte ve bağışıklık sistemimiz tarafından daha az tanınabilir hale gelecek çeşitli düzeylerde antijenik sürüklenme ve kayma geçirmektedir. Bu, geniş ölçüde etkili bir grip aşısının geliştirilmesini zorlaştırmakta ve aynı zamanda yeni zoonotik influenza suşlarının ortaya çıkması pandemi riski oluşturmaktadır. Hem Coronavirüsler hem de Influenza virüsleri, zarflı RNA virüsleridir ve insan solunumunu etkileyen birincil patojenlerden biridir. COVID-19 ve Influenza enfeksiyonları benzer bulaşma yollarına ve semptomlarına sahiptir. İncelenen literatürler, COVID-19 ve Influenza arasında önemli yapısal farklılıklar olduğunu bildirmektedir. Bunlar, genom yapıları, yüzey proteinleri, suş sayısı ve alt tipleri içerir. Bunlara ek olarak, inkübasyon süreleri, risk grupları, asemptomatik bulaşma ve bulaşma hızı iki virüs arasındaki önemli farklılıklardır. Bununla birlikte, gripten farklı olarak. COVID-19 için aşı ve tedavilerin olmaması, hastalığın yayılmasını kontrol etmede ciddi zorluklar ortaya çıkarmaktadır. Sonuç olarak Coronavirüs hızla yayılıyor ve influenza virüsü ile olası ko-enfeksiyon riski nedeniyle COVID-19 ile birlikte grip enfeksiyonunun değerlendirilmesi ve buna göre halk sağlığı önlemlerinin geliştirilmesi son derece önemlidir.

Anahtar Kelimeler

Coronavirus, COVID-19, Grip, Influenza virus

Proje Numarası

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Kaynakça

• World Health Organization. (2020). “Q&A: Influenza and COVID-19-Similarities and Differences.” Available from :https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/q-a-similarities-and-differences-covid-19-and influenza?gclid=EAIaIQobChMIv6Cc2tvJ7AIVEu7tCh0rIgdGEAAYASAAEgI_s_D_BwE (Accessed September 5, 2020).
• Centers for Disease Control and Prevention. (2020). “Similarities and Differences between Flu and COVID-19.” Available from: https://www.cdc.gov/flu/symptoms/flu-vs-covid19.htm (Accessed October 10, 2020).
• World Health Organization. (2020). “WHO COVID-19 Preparedness and Response Progress Report.” Available from: file:///C:/Users/hp/Downloads/srp-covid-19-6month.pdf(Accessed October 10, 2020).
• World Health Organization. (2020). “Archived: WHO Timeline-COVID-19.” Available from: https://www.who.int/news/item/27-04-2020-who-timeline---covid-19 (Accessed September 5, 2020).
• World Health Organization. (2020). “Coronavirus Disease (COVID-19) Dashboard.” 17 Available from: https://covid19.who.int/ (Accessed October 17, 2020).
• Kisa S, Kisa A. (2020). “Under‐reporting of COVID‐19 Cases in Turkey.” Int J Health Plann Mgmt, 35 (5), 1009-1013.
• Republic of Turkey Ministry of Health Corona Table. (2020). Available from: https://www.saglik.gov.tr/ (Accessed October 17, 2020).
• Morens DM., Breman JG, Calisher CH., Doherty PC., Hahn B H., Keusch GT et al. (2020). “The Origin of COVID-19 and Why It Matters.” The American Journal of Tropical Medicine and Hygiene, 103 (3), 955–959.
• Cui J, Li F, Shi Z. (2019). “Origin and Evolution of Pathogenic Coronaviruses.” Nat Rev Microbiol, 17(3):181-192.
• Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. “The Proximal Origin of SARS-CoV-2.” Nat Med. 2020 Apr;26(4):450-452.
• World Health Organization. (2017). “Limiting the Spread of Pandemic, Zoonotic, and Seasonal Epidemic Influenza”. Available:from:https://www.who.int/influenza/resources/research/research_agenda_influenza_stream_2_limiting_spread.pdf WHO public health research agenda for influenza: 2017 update. (Accessed September 5, 2020).
• Centers for Disease Control and Prevention. (2019). “Types of Influenza Viruses.” Available from: https://www.cdc.gov/flu/about/viruses/types.htm (Accessed September 5, 2020).
• Taubenberger JK. (2006). “The Origin and Virulence of the 1918 "Spanish" Influenza Virus.” Proceedings of the American Philosophical Society, 150 (1), 86–112.
• World Health Organization. (2018). “Influenza (Avian and other zoonotic.” Available from: https://www.who.int/news-room/fact-sheets/detail/influenza-(avian-and-other-zoonotic) (Accessed September 10, 2020).
• World Health Organization. (2018). “Influenza (Seasonal) https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal).” Available from: https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal) (Accessed September 5, 2020).
• American Society for Microbiology. (2020). “COVID -19 and the Flu.” Available from: https://asm.org/Articles/2020/July/COVID-19-and-the-Flu (Accessed October 10, 2020).
• Islam MR., Hoque M., Rahman MS., Alam A, Akther M., Puspo JA.et al. (2020). “Genome-wide Analysis of SARS-CoV-2 Virus Strains Circulating Worldwide Implicates Heterogeneity.” Scientific reports, 10 (1), 14004.
• Bouvier NM., Palese P. (2008). “The Biology of Influenza Viruses.” Vaccine, 26 (Suppl 4), 49–53.
• Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong JC, Turner AJ et al. “Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2.” Circ Res, 8, 126 (10), 1456-1474.
• Centers for Disease Control and Prevention. (2015). “Transmission of Avian Influenza A Viruses Between Animals and People.” Available from: https://www.cdc.gov/flu/avianflu/virus-transmission.htm (Accessed September 5, 2020).
• Baron S, Fons M, Albrecht T. “Viral Pathogenesis. (1996).” In: Baron S, editor. Medical Microbiology. 4th edition. Chapter 45. Galveston (TX): University of Texas Medical Branch at Galveston.
• World Health Organization (2020). “Transmission of SARS-CoV-2: implications for infection prevention precautions”. Available:from:https://www.who.int/newsroom/commentaries/detail/transmission-of-sars-cov-2-implications-for-infection-prevention-precautions (Accessed September 5, 2020).
• World Health Organization. (2020). “Coronavirus disease 2019 (COVID-19) Situation Report – 73.” Available from: https://apps.who.int/iris/bitstream/handle/10665/331686/nCoVsitrep02Apr2020eng.pdf?sequence=1&isAllowed=y (Accessed September 10, 2020).
• Patrozou E, Mermel, LA. (2009). “Does Influenza Transmission Occur from Asymptomatic Infection or Prior to Symptom Onset ?. Public Health Reports ,124 (2), 193–196.
• Killingley B, Nguyen-Van-Tam J. (2013). “Routes of Influenza Transmission. Influenza and Other Respiratory Viruses.” 2(Suppl 2), 42–51.
• World Health Organization. (2020). “COVID-19 Virtual Press conference.” Available from: https://www.who.int/docs/default-source/coronaviruse/covid-19-virtual-press-conference---10-august-at-12-pm-cest.pdf?sfvrsn=46fd5bbd_0 (Accessed September 10, 2020).
• World Health Organization. (2018).“Influenza (Seasonal).” Available from: https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal) (Accessed September 5, 2020).
• World Health Organization. (2020). “Covıd 19 strategy update”. Available from: https://www.who.int/docs/default-source/coronaviruse/covid-strategy-update 14april2020.pdf?sfvrsn=29da3ba0_19 (Accessed September 10, 2020).
• Food and Drug Administration (2020). “Influenza (Flu) Antiviral Drugs and Related Information.” Available from: https://www.fda.gov/drugs/information-drug-class/influenza-flu-antiviral-drugs-and-related-information (Accessed October 10, 2020).
• Menni C, Sudre CH, Steves CJ, Ourselin S, Spector TD. (2020). “Quantifying Additional COVID-19 Symptoms will Save Lives”. Lancet. 20, (395), 107-108.
• McAloon C, Collins Á, Hunt K, Barber A, Byrne AW, Butler F, et al. (2020). “Incubation Period of COVID-19: A Rapid Systematic Review and Meta-analysis of Observational Research.” BMJ Open, 16, 10 (8), 1-9.
• Centers for Disease Control and Prevention. (2020). “How Flu Spreads.” Available from: https://www.cdc.gov/flu/about/disease/spread.html (Accessed October 10, 2020).
• Centers for Disease Control and Prevention. (2020). “Coronavirus Disease 2019 (COVID-19): People with Certain Medical Conditions.” Available from: https://www.cdc.gov/coronavirus/2019-ncov/need-extra precautions/people-with-medical-conditions.html (Accessed October 19, 2020).
• Clarck A, Jit M, Warren-Gash C, Guthrie B, Wang HHX, Mercer SW (2020). “Global, regional, and national estimates of the population at increased risk of severe COVID-19 Due to Underlying Health Conditions in 2020: A Modelling Study.” The Lancet Global Health, 8 (8), 1003-1017.
• Wang X, et al..(2020). “Global Burden of Respiratory Infections Associated with Seasonal Influenza in Children Under 5 Years in 2018: A Systematic Review and Modelling Study”. Lancet Glob Health, 8 (4), 497-510.
• Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J.et al (2020). “SARS-CoV-2 Infection in Children.” N Engl J Med, 23, (17), 1663-1665.
• Do LAH, Anderson J, Sutton P, Pellicci DG, Mulholland K, Licciardi PV. (2020). “Understanding COVID-19 in Children may Povide Clues to Protect at-risk Populations.” BMJ Paediatr Open, 14, 4 (1), 1-2.
• Nair H, Brooks WA, Katz M, Roca A, Berkley JA, Madhi SA. et al. (2011). “Global Burden of Respiratory Infections due to Seasonal Influenza in Young Children: A Systematic Review and Meta-Analysis.” Lancet, 3, (378), 1917-1930.
• Trushakova S, Kisteneva L, Guglieri-López B, Mukasheva E, Kruzhkova I, Mira-Iglesias A et al. “Epidemiology of Influenza in Pregnant Women Hospitalized with Respiratory Illness in Moscow, 2012/2013-2015/2016: A Hospital-based Active Surveillance Study.” BMC Pregnancy Childbirth, 15, 19 (1), 1-14.
• Marim, F, Karadogan, D., Eyuboglu TS., Emiralioglu N, Gurkan CG, Toreyin ZN.et al. (2020). “Lessons Learned so Far from the Pandemic: A Review on Pregnants and Neonates with COVID-19”. The Eurasian Journal of Medicine, 52 (2), 202–210.