Yıl 2019, Cilt 16 , Sayı 2, Sayfalar 169 - 173 2019-08-29

Effectiveness of light emitting diode phototherapy for direct coombs positive newborns
Direkt coombs pozitif yenidoğanlarda light emitting diode fototerapinin etkinliği

Nilüfer OKUR [1] , Mehmet BÜYÜKTİRYAKİ [2] , Nurdan URAS [3] , Mehmet Yekta ÖNCEL [4] , Ömer ERTEKİN [5] , Fuat Emre CANPOLAT [6] , Şerife Suna OĞUZ [7]


Background: Phototherapy is the most frequently used treatment when serum bilirubin levels exceed physiological limits. The direct antiglobulin titer (DAT) test is regarded as the cornerstone of diagnosis of immune hemolytic disease of the newborn.

Methods: Patients with hyperbilirubinemia who were born in our hospital and whose gestational age was over 35 weeks were enrolled. DAT positive and DAT negative patients were compared in terms of light emitting diode (LED) phototherapy efficacy.

Results: Seventy-seven cases were DAT-negative and 72 were DAT-positive. No statistically significant differences were found for the duration of phototherapy and hospitalization between the DAT-positive and negative groups. In the DAT-positive group, the phototherapy needs of the patients were determined to occur at an earlier stage (postnatal age 1.4 day, p<0.05), and the rate of patients requiring exchange transfusion, blood transfusion and intravenous immunoglobulin was found to be statistically significant higher in DAT-positive infants.

Conclusions: Although LED phototherapy is effective in DAT-positive patients, the need for  exchange transfusion and intravenöz immunoglobulin  (IVIG) shows that there is still a need for more effective phototherapy in these patients.

Amaç: Fototerapi, serum bilirubin düzeyleri fizyolojik sınırları aştığında en sık kullanılan tedavi yöntemidir. Direkt antiglobulin titresi (DAT) testi yenidoğanın immün hemolitik hastalığı tanısının temel taşı olarak kabul edilir.

Materyal ve Metot: Hastanemizde doğan ve gebelik yaşı 35 haftadan fazla olan hiperbilirubinemili hastalar çalışmaya alındı. DAT pozitif ve DAT negatif hastalar light emitting diode (LED) fototerapi etkinliği açısından karşılaştırıldı.

Bulgular: Yetmiş yedi olgu DAT negatif, 72 olgu DAT pozitif idi. DAT pozitif ve negatif gruplar arasında fototerapi ve hastanede yatış süresi açısından istatistiksel olarak anlamlı bir fark bulunmadı. DAT pozitif grupta hastaların fototerapi gereksinimlerinin daha erken bir aşamada (doğum sonrası yaş 1.4 gün, p <0.05) olduğu tespit edildi, exchange transfüzyon ve intravenöz immunoglobulin (IVIG) gerektiren hastaların oranı DAT pozitif bebeklerde istatistiksel olarak anlamlı derecede yüksekti.

Sonuç: LED fototerapi DAT pozitif hastalarda etkilidir ancak kan değişimi ihtiyacı ve IVIG bu hastalarda hala daha etkili fototerapiye ihtiyaç olduğunu göstermektedir.

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Birincil Dil en
Konular Tıp
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-0027-0532
Yazar: Nilüfer OKUR (Sorumlu Yazar)
Kurum: ANKARA DR. ZEKAİ TAHİR BURAK HEALTH RESEARCH CENTER FOR WOMEN'S HEALTH
Ülke: Turkey


Orcid: 0000-0001-8937-4671
Yazar: Mehmet BÜYÜKTİRYAKİ
Kurum: ANKARA DR. ZEKAİ TAHİR BURAK HEALTH RESEARCH CENTER FOR WOMEN'S HEALTH
Ülke: Turkey


Orcid: 0000-0003-3382-7226
Yazar: Nurdan URAS
Kurum: ANKARA DR. ZEKAİ TAHİR BURAK HEALTH RESEARCH CENTER FOR WOMEN'S HEALTH
Ülke: Turkey


Orcid: 0000-0003-0760-0773
Yazar: Mehmet Yekta ÖNCEL
Kurum: ANKARA DR. ZEKAİ TAHİR BURAK HEALTH RESEARCH CENTER FOR WOMEN'S HEALTH
Ülke: Turkey


Orcid: 0000-0002-7846-7634
Yazar: Ömer ERTEKİN
Kurum: ANKARA DR. ZEKAİ TAHİR BURAK HEALTH RESEARCH CENTER FOR WOMEN'S HEALTH
Ülke: Turkey


Orcid: 0000-0001-9307-3003
Yazar: Fuat Emre CANPOLAT
Kurum: ANKARA DR. ZEKAİ TAHİR BURAK HEALTH RESEARCH CENTER FOR WOMEN'S HEALTH
Ülke: Turkey


Orcid: 0000-0002-1870-0983
Yazar: Şerife Suna OĞUZ
Kurum: ANKARA DR. ZEKAİ TAHİR BURAK HEALTH RESEARCH CENTER FOR WOMEN'S HEALTH
Ülke: Turkey


Tarihler

Başvuru Tarihi : 11 Şubat 2019
Kabul Tarihi : 14 Haziran 2019
Yayımlanma Tarihi : 29 Ağustos 2019

Bibtex @araştırma makalesi { hutfd525717, journal = {Harran Üniversitesi Tıp Fakültesi Dergisi}, issn = {1304-9623}, eissn = {1309-4025}, address = {tipdergisi@harran.edu.tr}, publisher = {Harran Üniversitesi}, year = {2019}, volume = {16}, pages = {169 - 173}, doi = {10.35440/hutfd.525717}, title = {Effectiveness of light emitting diode phototherapy for direct coombs positive newborns}, key = {cite}, author = {OKUR, Nilüfer and BÜYÜKTİRYAKİ, Mehmet and URAS, Nurdan and ÖNCEL, Mehmet Yekta and ERTEKİN, Ömer and CANPOLAT, Fuat Emre and OĞUZ, Şerife Suna} }
APA OKUR, N , BÜYÜKTİRYAKİ, M , URAS, N , ÖNCEL, M , ERTEKİN, Ö , CANPOLAT, F , OĞUZ, Ş . (2019). Effectiveness of light emitting diode phototherapy for direct coombs positive newborns. Harran Üniversitesi Tıp Fakültesi Dergisi , 16 (2) , 169-173 . DOI: 10.35440/hutfd.525717
MLA OKUR, N , BÜYÜKTİRYAKİ, M , URAS, N , ÖNCEL, M , ERTEKİN, Ö , CANPOLAT, F , OĞUZ, Ş . "Effectiveness of light emitting diode phototherapy for direct coombs positive newborns". Harran Üniversitesi Tıp Fakültesi Dergisi 16 (2019 ): 169-173 <https://dergipark.org.tr/tr/pub/hutfd/issue/47757/525717>
Chicago OKUR, N , BÜYÜKTİRYAKİ, M , URAS, N , ÖNCEL, M , ERTEKİN, Ö , CANPOLAT, F , OĞUZ, Ş . "Effectiveness of light emitting diode phototherapy for direct coombs positive newborns". Harran Üniversitesi Tıp Fakültesi Dergisi 16 (2019 ): 169-173
RIS TY - JOUR T1 - Effectiveness of light emitting diode phototherapy for direct coombs positive newborns AU - Nilüfer OKUR , Mehmet BÜYÜKTİRYAKİ , Nurdan URAS , Mehmet Yekta ÖNCEL , Ömer ERTEKİN , Fuat Emre CANPOLAT , Şerife Suna OĞUZ Y1 - 2019 PY - 2019 N1 - doi: 10.35440/hutfd.525717 DO - 10.35440/hutfd.525717 T2 - Harran Üniversitesi Tıp Fakültesi Dergisi JF - Journal JO - JOR SP - 169 EP - 173 VL - 16 IS - 2 SN - 1304-9623-1309-4025 M3 - doi: 10.35440/hutfd.525717 UR - https://doi.org/10.35440/hutfd.525717 Y2 - 2019 ER -
EndNote %0 Harran Üniversitesi Tıp Fakültesi Dergisi Effectiveness of light emitting diode phototherapy for direct coombs positive newborns %A Nilüfer OKUR , Mehmet BÜYÜKTİRYAKİ , Nurdan URAS , Mehmet Yekta ÖNCEL , Ömer ERTEKİN , Fuat Emre CANPOLAT , Şerife Suna OĞUZ %T Effectiveness of light emitting diode phototherapy for direct coombs positive newborns %D 2019 %J Harran Üniversitesi Tıp Fakültesi Dergisi %P 1304-9623-1309-4025 %V 16 %N 2 %R doi: 10.35440/hutfd.525717 %U 10.35440/hutfd.525717
ISNAD OKUR, Nilüfer , BÜYÜKTİRYAKİ, Mehmet , URAS, Nurdan , ÖNCEL, Mehmet Yekta , ERTEKİN, Ömer , CANPOLAT, Fuat Emre , OĞUZ, Şerife Suna . "Effectiveness of light emitting diode phototherapy for direct coombs positive newborns". Harran Üniversitesi Tıp Fakültesi Dergisi 16 / 2 (Ağustos 2019): 169-173 . https://doi.org/10.35440/hutfd.525717
AMA OKUR N , BÜYÜKTİRYAKİ M , URAS N , ÖNCEL M , ERTEKİN Ö , CANPOLAT F , OĞUZ Ş . Effectiveness of light emitting diode phototherapy for direct coombs positive newborns. Harran Üniversitesi Tıp Fakültesi Dergisi. 2019; 16(2): 169-173.
Vancouver OKUR N , BÜYÜKTİRYAKİ M , URAS N , ÖNCEL M , ERTEKİN Ö , CANPOLAT F , OĞUZ Ş . Effectiveness of light emitting diode phototherapy for direct coombs positive newborns. Harran Üniversitesi Tıp Fakültesi Dergisi. 2019; 16(2): 173-169.