A New Biomarker in The Distinction Between Stable Coronary Artery Disease and Acute Coronary Syndrome:Thiols

Öz

Backraund; Thiols are important elements for oxidation reactions and under oxidative stress. The aim of this study was to determine thiole levels, an antioxidative marker in CAD patients with stable and acute coronary syndrome. Methods; 210 of the patients included in the study were diagnosed with acute coronary syndrome (ACS), 205 consisted of patients with stable angina pectoris (SAP). Thiol groups levels and thiol/disulphide homeostasis was measured by spectrophotometrically. Results: Native thiol and total thiol levels, disulfide/natural thiol and disulfide/total thiol ratios were decreased in the ACS groups compared to the SAP groups Conclusions: Thiol levels and thiol / disulfide ratios can be used as markers to evaluate acute coronary syndrome.

Anahtar Kelimeler

• Thiol
• acute coronary sendrom
• stable angina pectoris

Stabil Koroner Arter Hastalığı ile Akut Koroner Sendrom Arasındaki Ayrımda Yeni Bir Biyobelirteç: Tiyoller

Öz

Amaç: Tiyoller, oksidasyon reaksiyonları ve oksidatif stres durumlarında önemli elementlerdendir. Bu çalışmanın amacı, stabil koroner arter hastalığı hastalarında ve akut koroner sendromlu (AKS) hastalarda bir antioksidan belirteç olan tiyol düzeylerini belirlemektir.

Gereç ve Yöntem: Çalışmaya 210'u AKS, 205'i ise stabil angina pektoris (SAP) tanısı alan hasta dahil edildi. Tiyol gruplarının seviyeleri ve tiyol/disülfid homeostazı spektrofotometrik olarak ölçüldü.

Bulgular: SAP gruplarına kıyasla AKS gruplarında nativ tiyol düzeyleri (332,03±59,84’ e karşı 404,71±67,64, p<0001, toplam tiyol düzeyleri (367,07±64,62’ e karşı 454,28±78,49, p<0001), disulfid (17,52±8,56’ e karşı 24,79±11,17, p<0001, nativ tiyol/ disulfid (5,3±2,6’ e karşı 6,1±2,5, p<005) ve toplam tiyol/disulfid (4,77±2,08’ e karşı 5,36±2, p<003) oranları azalmış olarak tespit edildi.

Sonuç: Tiyol düzeyleri ve tiyol/disülfid oranları AKS’ yi değerlendirmede belirteç olarak kullanılabilir.

Anahtar Kelimeler

• Akut koroner sendrom
• tiyol
• stabil angina pectoris

Kaynakça

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