Thyroid Functions Of Infants Born To Mothers With Thyroid Disease

Öz

Aim: Thyroid function abnormalities in pregnancy bear various risks for the mother, fetus and newborn. In this study, thyroid function tests of infants born to mothers with thyroid disease were evaluated.Material and Methods: 237 mothers with thyroid disease hospitalized for birth between 2008 and 2010 and 237 newborn were included in this study. Of these cases, medical history, clinical features and laboratory values were retrospectively recorded.Results: In the course of pregnancy, 95 mothers 40.1% received thyroid replacement therapy for hypothyroidism, 5 mothers 2.1% received anti-thyroid agents because of hyperthyroidism and 137 mothers 57.8% were euthyroid, subclinical hypothyroidism or subclinical hyperthyroidism and did not receive any treatment. These 137 mothers were diagnosed with thyroid disorder and were received therapy before pregnancy. Postnatal first thyroid function tests showed TSH>20 μIU/mL 20-30 μIU/mL in 5 cases. In 3 of these 5 cases, the thyroid function tests returned to normal values after the first week and 2 of them 0.8% were diagnosed as congenital hypothyroidism temporary or persistent and received thyroid hormone replacement therapy in the first 2 weeks. In cases of TSH levels between 5-20 μIU/mL in the first week, there was no increase in the second week and neither hyperthyroidism nor hypothyroidism was detected.Conclusion: Thyroid disease is most common in babies of mothers with thyroid disease. Examination of thyroid function in these infants in addition to the neonatal screening in the first week is important. Thus, treatment can be started earlier.

Anahtar Kelimeler

• Thyroid disease,newborn,neonatal screening

Tiroid Hastalıklı Anne Bebeklerinin Tiroid Fonksiyonları

Öz

Amaç: Gebelikte tiroid fonksiyon anormallikleri anne, fetüs ve yenidoğan için çeşitli riskler taşımaktadır. Bu çalışmada tiroid hastalıklı annelerin bebeklerinin tiroid fonksiyonları değerlendirildi.Gereç ve Yöntemler: İki yıllık dönemde doğum için hastaneye başvuran 237 tiroid hastalıklı anne ve onların yeni doğmuş bebekleri n: 237 çalışmaya alındı. Bu olguların tıbbi hikayeleri, klinik özellikleri ve laboratuvar değerleri geriye dönük olarak incelendi.Bulgular: Gebelik süresince 95 annenin %40.1 hipotroidi nedeniyle tiroid replasman tedavisi, 5 annenin %2.1 hipertroidi nedeniyle antitiroid tedavi aldığı, 137 annenin %57.8 ise gebelikte ötiroid, subklinik hipotiroidi veya hipertiroidi oldukları ve tedavi almadıkları tespit edildi. Bu 137 anneye gebelik öncesinde tiroid hastalığı tanısı konmuş ve tedavi verilmişti. Doğum sonrası alınan ilk tiroid fonksiyon testlerinde, 5 olguda TSH>20 μIU/mL 20-30 μIU/mL saptandı. Ancak bu 5 olgunun 3’ünün tiroid fonksiyon testleri bir hafta sonra normale dönerken, ikisine %0.8 konjenital hipotiroidi geçici veya kalıcı tanısıyla tiroid hormon replasman tedavisi başlandı. İlk hafta TSH düzeyleri 5-20 μIU/mL arasında olan hiçbir olguda ikinci hafta TSH düzeylerinde artış olmadı ve bu olgularda hipertiroidi veya hipotiroidi tespit edilmedi.Sonuç: Tiroid hastalıklı anne bebeklerinde tiroid fonksiyon bozukluğu daha yaygındır. Yenidoğan tarama programına ek olarak bu bebeklerde ilk hafta içinde tiroid fonksiyonlarının değerlendirilmesi önemlidir. Böylece tedaviye daha erken başlanabilecektir.

Anahtar Kelimeler

• Tiroid hastalığı,yenidoğan,yenidoğan taraması

Kaynakça

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