Gıda ve Genom İnteraksiyonu: Beslenme Genomiği

Öz

Beslenme ile sağlıklı yaşam arasındaki ilişki çok uzun zamandır bilinmektedir. Bu ilişkinin temelini oluşturan beslenme genomiği alanı son yıllarda oldukça fazla dikkat çekmektedir. Genomik, proteomik, transkriptomik, metabolomik, epigenomik gibi “omik” teknolojileri ile yakından ilişkili olan beslenme genomiği, gıda bileşenlerinin gen ekspresyonunda oluşturabilecekleri değişiklikleri ve insan vücudunun bu gıda bileşenlerine verebileceği yanıtları incelemektedir. Gıdalar, özellikle DNA metilasyonu, histon modifikasyonları ve kodlamayan RNA gibi mekanizmalarla doğrudan genomun işleyişini etkilemektedirler. Bunların yanında, çölyak, nörodejeneratif rahatsızlıklar, obezite, diyabet, laktoz intolerans, fenilketonüri ve kanser gibi hastalıklar da dolaylı olarak beslenme ile yakından ilişkilidir. Beslenme genomiği alanı gelişim aşamasında olduğundan dolayı, beslenme-sağlık mekanizmasının tam olarak ortaya konulabilmesi için daha fazla çalışmaya ihtiyaç duyulmaktadır.

Anahtar Kelimeler

• Beslenme genomiği
• beslenme
• sağlık

Food and Genome Interaction: Nutritional Genomics

Öz

The relationship between nutrition and health has been known for long time. Nutritional genomics, which forms the basis of this relationship, has received a lot of attention in recent years. Nutritional genomics, which is closely related to "omics" technologies such as genomics, proteomics, transcriptomics, metabolomics, epigenomics, examines the changes that food ingredients can create in gene expression and the responses of the human body to the food components. Foods directly affect the mechanism of the genome, especially through mechanisms such as DNA methylation, histone modifications and non-coding RNA. In addition, diseases such as celiac, neurodegenerative disorders, obesity, diabetes, lactose intolerance, phenylketonuria and cancer are also indirectly related to nutrition. Since the field of nutritional genomics is still developing, more studies are needed to fully reveal the nutrition-health mechanism.

Anahtar Kelimeler

• Nutritional genomics
• nutrition
• health

Kaynakça

1. Afman, L. & Müller, M. (2006). Nutrigenomics: From molecular nutrition to prevention of disease. Journal of the American Dietetic Association, 106(4), 569-576. https://doi.org/10.1016/j.jada.2006.01.001
2. Bal, S. H. & Budak, F. (2013). Genomik, proteomik kavramlarına genel bakış ve uygulama alanları. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 39(1), 65-69.
3. Barnes, S. (2008). Nutritional genomics, polyphenols, diets, and their ımpact on dietetics. Journal of the American Dietetic Association, 108(11), 1888-1895. https://doi.org/10.1016/j.jada.2008.08.014
4. Başaran, E., Aras, S. & Cansaran-Duman, D. (2010). Genomik, proteomik, metabolomik kavramlarına genel bakış ve uygulama alanları. Türk Hijyen ve Deneysel Biyoloji Dergisi, 67(2), 85-96.
5. Bøhn, S. K., Myhrstad, M. C., Thoresen, M., Holden, M., Karlsen, A., Tunheim, S. H., Erlund, I., Svendsen, M., Seljeflot, I., Moskaug, J. O., Duttaroy, A. K., Laake, P., Arnesen, H., Tonstad, S., Collins, A., Drevon, C. A. & Blomhoff, R. (2010). Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers. BMC Medicine, 16, 8-54. https://doi.org/10.1186/1741-7015-8-54
6. Boomgaarden, I., Egert, S., Rimbach, G., Wolffram, S., Müller, M. J. & Döring, F. (2010). Quercetin supplementation and its effect on human monocyte gene expression profiles in vivo. British Journal of Nutrition, 104(3), 336-345. http://doi.org/10.1017/S0007114510000711
7. Bouchard, C. & Ordovas, J. M. (2012). Recent Advances in Nutrigenetics and Nutrigenomics. London-UK: Academic Press. ISBN 978-0-12-398397-8
8. Camargo, A., Ruano, J., Fernandez, J. M., Parnell, L. D., Jimenez, A., Santos-Gonzalez, M., Marin, C., Perez-Martinez, P., Uceda, M., Lopez-Miranda, J. & Perez-Jimenez, F. (2010). Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. BMC Genomics, 11, 253. https://doi.org/10.1186/1471-2164-11-253

9. Chávez, A. & Muñoz de Chávez, M. (2003). Nutrigenomics in public health nutrition: Short-term perspectives. European Journal of Clinical Nutrition, 57, 97-100. https://doi.org/10.1038/sj.ejcn.1601809
10. Chen, L., Yao, H., Hui, J., Ding, S., Fan, Y., Pan, Y., Chen, K., Wan, J. & Jiang, J. (2016). Global transcriptomic study of atherosclerosis development in rats. Gene, 592(1), 43-48. https://doi.org/10.1016/j.gene.2016.07.023.
11. Collins, J., Adamski, M. M., Twohig, C. & Murgia, C. (2018). Opportunities for training for nutritional professionals in nutritional genomics: What is out there? Nutrition & Dietetics, 75, 206-218. https://doi.org/10.1111/1747-0080.12398
12. Cornelis, M. C. & El-Sohemy, A. (2007). Coffee, caffeine, and coronary heart disease. Current Opinion in Lipidology, 18(1), 13–19. https://doi.org/10.1097/MOL.0b013e3280127b04
13. Coşkun, T. (2007). Nütrisyonel genomik. Çocuk Sağlığı ve Hastalıkları Dergisi, 50, 47-66.
14. Cui, J., Zhou, B. Y., Ross, S.A. & Zempleni, J. (2017). Nutrition, microRNAs, and human health. Advances in Nutrition, 8(1), 105–112. https://doi.org/10.3945/an.116.013839
15. Çetinbaş, A. (2017). Mikrobiyota. Eurasian Journal of Family Medicine, 6(2), 51-56.
16. Debusk, R. M., Fogarty, C. P., Ordovas, J. M. & Kornman, K.S. (2005). Nutritional genomics in practice: Where do we begin? Journal of the American Dietetic Association, 105(4), 589-598. https://doi.org/10.1016/j.jada.2005.01.002
17. Demir Karabulut, S., Kasapoğlu, N., Kocak, I. A. A., Külhaş, İ. B. & Andıran, A. N. (2019). İnsan genom projesinin korkulan rüyası; ayrıcalıklı insan yaratma. Türkiye Biyoetik Dergisi, 6(3), 109-115.
18. Demir, A. (2013). Etik açıdan insan genom projesi. İstanbul Ticaret Üniversitesi Sosyal Bilimleri Dergisi, 23, 317-327.
19. Fenech, M. (2008). Genome health nutrigenomics and nutrigenetics–diagnosis and nutritional treatment of genome damage on an individual basis. Food and Chemical Toxicology, 46, 1365-1370. https://doi.org/10.1016/j.fct.2007.06.035
20. Fenech, M., El-Sohemy, A., Cahill, L., Ferguson, L. R., French, T. C., Tai, E. S., Milner, J., Koh, W., Xie, L., Zucker, M., Buckley, M., Cosgrove, L., Lockett, T., Fung, K. Y. C. & Head, R. (2011). Nutrigenetics and nutrigenomics: Viewpoints on the current status and applications in nutrition research and practice. Journal of Nutrigenetics and Nutrigenomics, 4(2), 69-89. https://doi.org/10.1159/000327772
21. Go, V. L. W., Nguyen, C. T. H., Harris, D. M. & Lee, W. P. (2005). Nutrient-gene interaction: metabolic genotype-phenotype relationship. The Journal of Nutrition, 135(12), 3016-3020. https://doi.org/10.1093/jn/135.12.3016S
22. Goodacre, R. (2007). Metabolomics of a superorganism. The Journal of Nutrition, 137(1), 259-266. https://doi.org/10.1093/jn/137.1.259S
23. Guttmacher, A. E. & Collins, F.S. (2002). Genomic medicine: A primer. The New England Journal of Medicine, 347, 1512-1520. https://doi.org/10.1056/NEJMra012240
24. Hatipoğlu, Ö. F., Kaya, E., Yaykaşlı, E. & Yaykaşlı, K. O. (2012). Epigenetik mekanizmalar ve kanser. Düzce Tıp Fakültesi Dergisi, 14(3), 58-68.
25. İsmailoğlu, Ö. & Öngün Yılmaz, H. (2019). Probiyotik kullanımının bağırsak mikrobiyotası üzerine etkisi. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi, 1(1), 38-56.
26. İşleroğlu, H., Yıldırım, Z. & Yıldırım, M. (2005). Fonksiyonel bir gıda olarak keten tohumu. Gaziosmanpaşa Üniversitesi Ziraat Fakültesi Dergisi, 22(2), 23-30.
27. İzmirli, M., Tufan, T. & Alptekin, D. (2012). DNA metilasyonu. Arşiv Kaynak Tarama Dergisi, 21(4), 274-282.
28. Kabir, M., Skurnik, G., Naour, N., Pechtner, V., Meugnier, E., Rome, S., Quignard-Boulangé, A., Vidal, H., Slama, G., Clément, K., Guerre-Millo, M. & Rizkalla, S. W. (2007). Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: A randomized controlled study. The American Journal of Clinical Nutrition, 86, 1670–1679.
29. Kalip, K. & Atak, N. (2018). Bağırsak mikrobiyotası ve sağlık. Turkish Journal of Public Health, 16(1), 58-73.
30. Kaplan, O. & Çelebier, M. (2020). Metabolomik çalışmaların dünü, bugünü ve yarını. Türkiye Klinikleri Tıp Bilimleri Dergisi, 40(3), 366-374. https://doi.org/10.5336/medsci.2020-75489
31. Kaput, J. & Rodriguez, R. L. (2004). Nutritional genomics: The next frontier in the postgenomic era. Physiol Genomics, 16, 166-177. https://doi.org/10.1152/physiolgenomics.00107.2003
32. Kaput, J., Astley, S., Renkema, M., Ordovas, J. & Ommen, B. (2006). Harnessing nutrigenomics: Development of web-based communication, databases, resources, and tools. Genes & Nutrition, 1, 5-12. https://doi.org/10.1007/BF02829931
33. Karaaslan, E., Kartalcı, Ş. & Acar, C. (2022). Epigenetic perspective in schizophrenia: DNA methylation patterns. Archives Medical Review Journal, 31(3), 204-212. https://doi.org/10.17827/aktd.1096901
34. Karatay, E. (2019). Mikrobiyota, probiyotik ve prebiyotikler. Anadolu Güncel Tıp Dergisi, 1(3), 68-71.
35. Koç, G. (2018). Nutrigenomik: Genotipten fenotipe beslenme etkisi. Tıp Fakültesi Klinikleri Dergisi, 1(1), 19-92.
36. Konstantinidou, V., Khymenets, O., Fito, M., De La Torre, R., Anglada, R., Dopazo, A. & Covas, M. I. (2009). Characterization of human gene expression changes after olive oil ıngestion: An exploratory approach. Folia Biologica (Praha), 55, 85-91.
37. Lillycrop, K. A., Hoile, S. P., Grenfell, L. & Burdge, G. C. (2014). DNA methylation, ageing and the influence of early life nutrition. Proceedings of the Nutrition Society, 73(3), 413-421. https://doi.org/10.1017/S0029665114000081
38. Mariman, E. C. M. (2006). Nutrigenomics and nutrigenetics: The ‘omics’ revolution in nutritional science. Biotechnology and Applied Biochemistry, 44, 119-128. https://doi.org/10.1042/BA20050112
39. Mazzatti, D. J., Ouderaa, F. V. D. & Brown, L. (2007). The future of food: Nutrigenomics and nutrigenetics. Agro Food Industry Hi-Tech, 18(2), 63-66.
40. Mullins, V. A., Bresette, W., Johnstone, L., Hallmark, B. & Chilton, F. H. (2020). Genomics in personalized nutrition: Can you “eat for your genes”? Nutrients, 12(10), 3118. https://doi.org/10.3390/nu12103118
41. Ordovas, J. M. & Corella, D. (2004). Nutritional genomics. Review of Genomics and Human Genetics, 5, 71-118. https://doi.org/10.1146/annurev.genom.5.061903.180008
42. Ordovas, J. M. (2004). The quest for cardiovascular health in the genomic era: Nutrigenetics and plasma lipoproteins. Proceedings of the Nutrition Society, 63(1), 145-152. https://doi.org/10.1079/PNS2003313
43. Öksüz, A., Alkan, Ş. B., Taşkın, H. & Ayrancı, M. (2018). Yaşam boyu sağlıklı ve dengeli beslenme için balık tüketiminin önemi. Food and Health, 4(1), 43-62. https://doi.org/10.3153/JFHS18006
44. Peltonen, L. & McKusick, V. A. (2001). Dissecting human disease in the postgenomic era. Science, 291, 1224-1229. https://doi.org/10.1126/science.291.5507.1224
45. Phillips, C. M. (2013). Nutrigenetics and metabolic disease: Current status and implications for personalised nutrition. Nutrients, 5(1), 32-57. https://doi.org/10.3390/nu5010032
46. Prasad, C., Imrhan, V. & Rew, M. (2011). Introducing nutritional genomics teaching in undergraduate dietetic curricula. Journal of Nutrigenetics and Nutrigenomics, 4(3), 165-172. https://doi.org/10.1159/000330237
47. Romero, R., Espinoza, J., Gotsch, F., Kusanovic, J. P., Friel, L. A., Erez, O., Mazaki-Tovi, S., Than, N. G., Hassan, S. & Tromp, G. (2006). The use of high-dimensional biology (genomics, transcriptomics, proteomics, and metabolomics) to understand the preterm parturition syndrome. An International Journal of Obstetrics & Gynaecology, 113, 118-135. https://doi.org/10.1111/j.1471-0528.2006.01150.x
48. Ronteltap, A., van Trijp, J. C. M. & Renes, R. J. (2008). Consumer acceptance of nutrigenomics-based personalised nutrition. British Journal of Nutrition, 101(1), 132-144. http://doi.org/10.1017/S0007114508992552
49. Sales, N. M. R., Pelegrini, P. B. & Goersch, M. C. (2014). Nutrigenomics: Definitions and advances of this new science. Journal of Nutrition and Metabolism, Article ID 202759, https://doi.org/10.1155/2014/202759
50. Scarmeas, N., Stern, Y., Tang, M. X., Mayeux, R. & Luchsinger, J. A. (2006). Mediterranean diet and risk for alzheimer's disease. Annals of Neurology, 59, 912-921. https://doi.org/10.1002/ana.20854
51. Shankar, S., Kumar, D. & Srivastava, R. K. (2013). Epigenetic modifications by dietary phytochemicals: Implications for personalized nutrition. Pharmacology & Therapeutics, 138(1), 1-17. https://doi.org/10.1016/j.pharmthera.2012.11.002
52. Stover, P. J. (2004). Nutritional genomics. Physiological Genomics, 16(2), 161-165. https://doi.org/10.1152/physiolgenomics.00204.2003
53. Sutton, K. H. (2007). Considerations for the successful development and launch of personalised nutrigenomic foods. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 622, 117-121. https://doi.org/10.1016/j.mrfmmm.2007.03.007
54. Şenol, Ş. P. & Tunçtan, B. (2015). Peroksizom proliferatör ile etkinleştirilen reseptörlerin insülin direnci ve septik şok patojenezindeki rolü. Müsbed, 5(4), 247-258. https://doi.org/10.5455/musbed.20150715121617
55. Traka, M., Gasper, A. V., Melchini, A., Bacon, J. R., Needs, P. W., Frost, V., Chantry, A., Jones, A. M. E., Ortori, C. A., Barrett, D. A., Ball, R. Y., Mills, R. D. & Mithen, R. F. (2008). Broccoli consumption ınteracts with gstm1 to perturb oncogenic signalling pathways in the prostate. Plos One, 3(7), e2568. https://doi.org/10.1371/journal.pone.0002568
56. Vakili, S. & Caudill, M. A. (2007). Personalized nutrition: Nutritional genomics ass a potential tool for targeted medical nutrition therapy. Nutrition Reviews, 65(7), 301-315. https://doi.org/10.1111/j.1753-4887.2007.tb00308.x
57. Wang, R. L., Xin, M., Li, Y. J., Zhang, P. Y. & Zhang, M. X. (2016). The functions of histone modification enzymes in cancer. Current Protein & Peptide Science, 17(5), 438-445. https://doi.org/10.2174/1389203717666160122120521
58. Weggemans, R. M., Zock, P. L., Ordovas, J. M., Pedro-Botet, J. & Katan, M. B. (2001). Apoprotein E genotype and the response of serum cholesterol to dietary fat, cholesterol and cafestol. Atherosclerosis, 154(3), 547–555. https://doi.org/10.1016/s0021-9150(00)00720-6
59. Wittwer, J., Rubio-Aliaga, I., Hoeft, B., Bendik, I., Weber, P. & Daniel, H. (2011). Nutrigenomics in human intervention studies: Current status, lessons learned and future perspectives. Molecular Nutrition & Food Research, 55, 341-358. https://doi.org/10.1002/mnfr.201000512
60. Wu, A. H., Yu, M. C., Tseng, C. C., Hankin, J. & Pike, M. C. (2003). Green tea and risk of breast cancer in asian americans. International Journal of Cancer, 106(4), 574-579. https://doi.org/10.1002/ijc.11259
61. Yaktine, A. L. & Pool, R. (2007). Nutrigenomics and beyond: Informing the future. The National Academies of Science, Washington-USA.
62. Zhang, L., Hou, D., Chen, X., Li, D., Zhu, L., Zhang, Y., Li, J., Bian, Z., Liang, X., Cai, X., Yin, Y., Wang, C., Zhang, T., Zhu, D., Zhang, D., Xu, J., Chen, Q., Ba, Y., Liu, J., Wang, Q., Chen, J., Wang, J., Wang, M., Zhang, Q., Zhang, J., Zen, K. & Zhang, C. Y. (2012). Exogenous plant MIR168a specifically targets mammalian LDLRAP1: Evidence of cross-kingdom regulation by microrna. Cell Research, 22, 107–126. https://doi.org/10.1038/cr.2011.158
63. Zimani, A. N., Peterlin, B. & Kovanda, A. (2021). Increasing genomic literacy through national genomic projects. Frontiers in Genetics, 12, 693253. https://doi.org/10.3389/fgene.2021.693253