Melatonin and Melatonin-Rich Foods

Öz

Vegetables and fruits are found in the most popular diets. And they are considered as rich sources of vitamins and minerals. Vitamin and mineral deficiency are one of the major causes of various diseases that are common nowadays. Especially vitamins which are known to affect directly on various hormones in our body. Melatonin (N-acetyl-5-methoxytryptamine), one of these hormones, is synthesized in various peripheral organs and tissues, especially the pineal gland and retina. Endogenous melatonin secretion rhythm is regulated by the suprachiasmatic nucleus and maintained with a bright dark cycle. Melatonin hormone is responsible for many activities in the human body. In addition to, especially is found in various foods (milk and milk product, nuts, olive oil, and various fruits). In this review, the recent studies that focused on the biosynthesis and metabolism of melatonin in addition to those investigated food content of melatonin and their effects on physiological and biological human health.

Anahtar Kelimeler

• : Melatonin
• Melatonin hormone
• Vegetables
• fruits

Kaynakça

1. Atasoy N, 2019. Melatonin ve antioksidan etkileri. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 9(3): 196-201.
2. Beyer CE, Steketee JD, Saphier D, 1998. Antioxidant properties of melatonin an emerging mystery. Biochemical Pharmacology, 56 (10): 1265-1272.
3. Binici Hİ, Şat İG, Aoudeh E, 2021. Nutritional Composition and Health Benefits of Walnut and its Products. Ataturk University Journal of Agricultural Faculty, 52 (2): 224-230.
4. Cam A, Erdogan MF, 2003. Melatonin. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 56: 103-112.
5. Claustrat B, Brun J, Chazot G, 2005. The basic physiology and pathophisology of melatonin. Sleep Medicine Reviews, 9(1): 11-24.
6. Claustrat B, Brun J, Geoffriau M, Chazot G, 1998. Melatonin: from the hormone to the drug? Restorative Neurology and Neuroscience, 12(2, 3): 151-157.
7. de la Puerta C, Carrascosa-Salmoral MP, García-Luna PP, Lardone PJ, Herrera JL, Fernández-Montesinos R, Pozo D, 2007. Melatonin is a phytochemical in olive oil. Food Chemistry, 104(2): 609-612.
8. Guardiola-Lemaitre B, 2007. Melatoninergic receptor agonists and antagonists: therapeutic perspectives. Journal de la Societe de Biologie, 201(1): 105-113.

9. Hattori A, Migitaka H, Iigo M, Itoh M, Yamamoto K, Ohtani-Kaneko R, Reiter RJ, 1995. Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates. Biochemistry and Molecular Biology İnternational, 35(3): 627-634.
10. Huang X, Mazza G, 2011. Application of LC and LC-MS to the analysis of melatonin and serotonin in edible plants. Critical Reviews in Food Science and Nutrition, 51(4): 269-284.
11. Johns NP, Johns J, Porasuphatana S, Plaimee P, Sae-Teaw M, 2013. Dietary intake of melatonin from tropical fruit altered urinary excretion of 6-sulfatoxymelatonin in healthy volunteers. Journal of Agricultural and Food Chemistry, 61(4): 913-919.
12. Kocadağlı T, Yılmaz C, Gökmen V, 2014. Determination of melatonin and its isomer in foods by liquid chromatography tandem mass spectrometry. Food Chemistry, 153: 151-156.
13. Lee YM, Chen HR, Hsiao G, Sheu JR, Wang JJ, Yen MH, 2002. Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. Journal of Pineal Research, 33(2): 72-80.
14. Liebmann PM, Wölfler A, Felsner P, Hofer D, Schauenstein K, 1997. Melatonin and the immune system. International Archives of Allergy and İmmunology, 112(3): 203-211.
15. Manchester LC, Tan DX, Reiter RJ, Park W, Monis K, Qi W, 2000. High levels of melatonin in the seeds of edible plants: possible function in germ tissue protection. Life Sciences, 67(25): 3023-3029.
16. Mercolini L, Addolorata Saracino M, Bugamelli F, Ferranti A, Malaguti M, Hrelia S, Raggi MA, 2008. HPLC‐F analysis of melatonin and resveratrol isomers in wine using an SPE procedure. Journal of Separation Science, 31(6‐7): 1007-1014.
17. Mercolini L, Mandrioli R, Raggi MA, 2012. Content of melatonin and other antioxidants in grape‐related foodstuffs: measurement using a MEPS‐HPLC‐F method. Journal of Pineal Research, 53(1): 21-28.
18. Millet B, Touitou Y, Poirier MF, Bourdel MC, Amado I, Hantouche EG, Olié JP, 1999. Obsessive-compulsive disorder: evaluation of clinical and biological circadian parameters during fluoxetine treatment. Psychopharmacology, 146(3): 268-274.
19. Mollaoglu H, Ozguner MF, 2005. Yaslanma surecinde melatoninin rolu. Suleyman Demirel Üniversitesi Tıp Fakultesi Dergisi, 12: 52-56.
20. Ostrowska Z, Kos-Kudla B, Marek B, Kajdaniuk D, Staszewicz P, Szapska B, Strzelczyk J, 2002. The influence of pinealectomy and melatonin administration on the dynamic pattern of biochemical markers of bone metabolism in experimental osteoporosis in the rat. Neuroendocrinology Letters, 23(1): 104-110.
21. Ozcelik F, Erdem M, Bolu A, Gülsün M, 2013. Melatonin: Genel özellikleri ve psikiyatrik bozukluklardaki rolü. Psikiyatride Güncel Yaklaşımlar, 5(2): 179-203.
22. Paredes SD, Korkmaz A, Manchester LC, Tan DX, Reiter RJ, 2009. Phytomelatonin: a review. Journal of Experimental Botany, 60(1): 57-69.
23. Reiter RJ, 1991. Neuroendocrine effects of light. International Journal of Biometeorology, 35(3): 169-175.
24. Reiter RJ, 2002. Potential biological consequences of excessive light exposure: melatonin suppression, DNA damage, cancer and neurodegenerative diseases. Neuroendocrinology Letters, 23: 9-13.
25. Reiter RJ, Manchester LC, Tan DX, 2005. Melatonin in walnuts: influence on levels of melatonin and total antioxidant capacity of blood. Nutrition, 21(9): 920-924.
26. Reiter RJ, Tan DX, 2003. Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovascular Research, 58(1): 10-19.
27. Reiter RJ, Tan DX, Erren TC, Fuentes-Broto L, Paredes SD, 2009. Light-mediated perturbations of circadian timing and cancer risk: a mechanistic analysis. Integrative Cancer Therapies, 8(4): 354-360.
28. Sangsopha J, Johns NP, Johns J, Moongngarm A, 2020. Dietary sources of melatonin and benefits from production of high melatonin pasteurized milk. Journal of food science and technology, 1-12.
29. Sener G, Goren FO, Ulusoy NB, Ersoy Y, Arbak S, Dólger GA, 2005. Protective effect of melatonin and omeprazole against alendronat-induced gastric damage. Digestive Diseases and Dciences, 50(8): 1506-1512.
30. Stürtz M, Cerezo AB, Cantos-Villar E, Garcia-Parrilla MC, 2011. Determination of the melatonin content of different varieties of tomatoes (Lycopersicon esculentum) and strawberries (Fragaria ananassa). Food Chemistry, 127(3): 1329-1334.
31. Suzuki N, Somei M, Seki, A, Reiter RJ, Hattori A, 2008. Novel bromomelatonin derivatives as potentially effective drugs to treat bone diseases. Journal of Pineal Research, 45(3): 229-234.
32. Şener G, 2010. Karanlığın hormonu: Melatonin. Marmara Eczacılık Dergisi. 14: 112-120.
33. Tan DX, Manchester LC, Reiter RJ, Qi W, Kim SJ, El‐Sokkary GH, 1998. Ischemia/reperfusion‐induced arrhythmias in the isolated rat heart: prevention by melatonin. Journal of Pineal Research, 25(3): 184-191.
34. Yıldız M, Akdemir O, 2009. Assessment of the effects of physiological release of melatonin on arterial distensibility and blood pressure. Cardiology in the Young, 19(2): 198-203.