Some Biological Activities of Phenolic Compounds Cinnamic Acid, Caffeic Acid and p-Coumaric Acid

Yıl 2021, Cilt: 11 Sayı: 4, 2587 - 2598, 15.12.2021

Kadriye Aslıhan Onat , Merve Sezer Bekir Çöl

https://doi.org/10.21597/jist.885898

Cited By: 3

Öz

Phenolic compounds are a group of secondary metabolites synthesized by plants. It is formed by adding the hydroxyl group (-OH) or groups to a benzene ring. Phenolic acids are derivatives of phenolic compounds. They are divided into hydroxybenzoic acids containing 7 carbon atoms (C6-C1) and hydroxycinnamic acids containing 9 carbon atoms (C6-C3). Hydroxycinnamic acids have been shown to have anti-bacterial, anti-fungal, anti-viral, anti-oxidant, anti-cancer, anti-inflammatory, anti-diabetic, anti-melanogenic activities. These compounds are widely available, natural, and have many biological activities, which provide advantages in terms of studying. In addition to all these, the broad-spectrum antioxidant activity of trans cinnamic acid, caffeic acid and p-coumaric acid increases their potential for use in pharmaceutical, cosmetic, cleaning and food industries. These advantages and potentials make phenolic compounds attractive to study. In this review, some studies on anti-bacterial, anti-biofilm, anti-oxidant and anti-cancer activities of trans-cinnamic acid, caffeic acid and p-coumaric acid are mentioned.

Anahtar Kelimeler

Trans-cinnamic acid, Caffeic acid, p-coumaric acid, Anti-bacterial activity, Anti-oxidant activity, Anti-cancer activity

Fenolik Bileşiklerden Sinnamik Asit, Kafeik Asit ve p-kumarik Asit’in Bazı Biyolojik Aktiviteleri

Öz

Fenolik bileşikler, bitkiler tarafından sentezlenen sekonder metabolitlerin bir grubudur. Bir benzen halkasına hidroksil grubu (-OH) veya grupları eklenmesi ile oluşur. Fenolik asitler, fenolik bileşiklerin bir türevidir. 7 karbon atomu (C6-C1) içeren hidroksibenzoik asitler ve 9 karbon atomu (C6-C3) içeren hidroksisinnamik asitler olmak üzere ikiye ayrılırlar. Hidroksisinnamik asitlerin, yapılan birçok çalışma ile antibakteriyel, anti-fungal, anti-viral, anti-oksidan, anti-kanser, anti-enflamatuar, anti-diyabetik, anti-melanojenik gibi aktiviteleri olduğu gösterilmiştir. Bu bileşiklerin bitkilerde yaygın olarak bulunması, doğal olması, birçok biyolojik aktivitelerinin bulunması çalışılması açısından avantaj sağlamaktadır. Tüm bunların yanı sıra, trans sinnamik asit, kafeik asit ve p-kumarik asitin geniş spektrumlu antioksidan aktivitesi, ilaç, kozmetik, temizlik, gıda sektörlerinde kullanılabilme potansiyelini arttırmaktadır. Bu avantajları ve potansiyelleri fenolik bileşikleri çalışılması için cezbedici hale getirmektedir. Bu derleme çalışmasında, trans-sinnamik asit, kafeik asit ve pkumarik asitin anti-bakteriyel, anti-biyofilm, anti-oksidan, anti-kanser gibi aktiviteleri üzerine yapılan bazı araştırmalardan bahsedilmiştir.

Anahtar Kelimeler

Trans-sinnamik asit, Kafeik asit, p-kumarik asit, Anti-bakteriyel aktivite, Anti-oksidan aktivite, Anti-oksidan aktivite

Kaynakça

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