The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer

Yıl 2020, , 70 - 75, 20.03.2020

Ayşe Özdemir , Uttku Dönem Dilli Dalyan Özdemir Salim Neşelioğlu Özcan Erel

https://doi.org/10.18229/kocatepetip.560366

Öz

Thiol/disulphide homeostasis
is important in cancer. Studies are carried out to be biomarkers in cancer
patients. The aim of this study is to investigate the relationship between
oxidative stress biomarker [thiol-disulphide homeostasis] and CEA [carcinoembryonic
antigen], IMA [ischemic modified albumin], albumin, CA
15-3 (cancer antigen 15-3) in patients with breast cancer and compare it with
healthy controls, which is conducted for the first time in the literature.A total of 80 participants including 39
patients with breast cancer and 41 healthy individuals were included in the
study. CEA, CA15-3, native thiol, total thiol, and disulphide as well as
disulphide/native thiol and disulphide/total thiol ratios were compared between
the groups. Native thiol[-SH], disulfide [-S-S] and total thiol [TT]
concentrations were measured with a novel automated method. Patients participated in the study under
chemotherapy. The study is a prospective study. In breast cancer group, IMA, albümin and CA-15-3  were obtained sitatiscally significant
difference compared to the controlegroup (p<0.05).  Although in high CA-15-3 group decreased
SH/TT and increased SS/TT ratios, there wasn’t a significant change in the
amount of thiol and disulfide. There was not any
relationship between thiol-disulphide parameters and tumor markers in the the
breast cancer group. Itcould be said that changes in the thiol-disulphide homeostasis
may notbe interact with CA 15-3 values.

Anahtar Kelimeler

Disulphide, thiol, tumor marker

Meme Kanseri Hastalarında Dinamik Tiyol, Disülfit Dengesi ile CA-15-3 Seviyeleri Arasındaki İlişki

Öz

Tiyol/disülfit dengesi birçok hastalıkda
önemli bir oksidatif belirteçtir. Kanserli olgularda  biyo-belirteç olması yönünde çalışmalar
yapılmaktadır. Bu çalışmanın amacı meme kanserli hastalarda oksidatif stres
belirteci [tiyol-disülfid homeostazis] ile CA 15-3 (kanser antijeni 15-3) ve
CEA [karsinoembriyojenik antijen], IMA[iskemik modifiye albümin], albümin
arasındaki ilişkiyi araştırmak ve literatürde ilk kez yapılan sağlıklı
kontrollerle karşılaştırmaktır. Çalışmaya 39 kanserli hasta ve 41 sağlıklı
toplamda 80 hasta dahil edildi. Deneye katılan hastaların CEA, CA 15-3
düzeyleri ve IMA, Albumin, Dinamik tiyol [-SH], Disülfit [-S-S] ve Total tiyol
[TT] düzeyleri incelendi. Hastalar kemoterapi altında çalışmaya katıldılar.
Çalışma prospektif bir çalışmadır. Kontrol -Meme CA grupları arasında IMA,
albumin ve CA-15-3 açısından istatiksel olarak anlamlı fark olduğu belirlendi
(p<0,05). CA 15-3 in yüksek olduğu grupta SH/TT değerlerinde azalma, SS/TT
değerlerinde artış görülmesine rağmen tiyol ve disülfid miktarlarında anlamlı
bir değişiklik olmadı. Tiyol-disülfid parametreleri ile Meme Ca grubunda tümör
biyo-belirteç değerleri arasında ilişki görülmedi. Tiyol-disülfid
homeostazisindeki değişikliklerin CA 15-3 ile etkileşmediği söylenebilir. 

Anahtar Kelimeler

Disülfid, tiyol, tümör biyobelirteç

Kaynakça

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