Yıl 2020, Cilt 21 , Sayı 1, Sayfalar 70 - 75 2020-03-20

Meme Kanseri Hastalarında Dinamik Tiyol, Disülfit Dengesi ile CA-15-3 Seviyeleri Arasındaki İlişki
The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer

Ayşe ÖZDEMİR [1] , Uttku DÖNEM DİLLİ [2] , Dalyan ÖZDEMİR [3] , Salim NEŞELİOĞLU [4] , Özcan EREL [5]


Tiyol/disülfit dengesi birçok hastalıkda önemli bir oksidatif belirteçtir. Kanserli olgularda  biyo-belirteç olması yönünde çalışmalar yapılmaktadır. Bu çalışmanın amacı meme kanserli hastalarda oksidatif stres belirteci [tiyol-disülfid homeostazis] ile CA 15-3 (kanser antijeni 15-3) ve CEA [karsinoembriyojenik antijen], IMA[iskemik modifiye albümin], albümin arasındaki ilişkiyi araştırmak ve literatürde ilk kez yapılan sağlıklı kontrollerle karşılaştırmaktır. Çalışmaya 39 kanserli hasta ve 41 sağlıklı toplamda 80 hasta dahil edildi. Deneye katılan hastaların CEA, CA 15-3 düzeyleri ve IMA, Albumin, Dinamik tiyol [-SH], Disülfit [-S-S] ve Total tiyol [TT] düzeyleri incelendi. Hastalar kemoterapi altında çalışmaya katıldılar. Çalışma prospektif bir çalışmadır. Kontrol -Meme CA grupları arasında IMA, albumin ve CA-15-3 açısından istatiksel olarak anlamlı fark olduğu belirlendi (p<0,05). CA 15-3 in yüksek olduğu grupta SH/TT değerlerinde azalma, SS/TT değerlerinde artış görülmesine rağmen tiyol ve disülfid miktarlarında anlamlı bir değişiklik olmadı. Tiyol-disülfid parametreleri ile Meme Ca grubunda tümör biyo-belirteç değerleri arasında ilişki görülmedi. Tiyol-disülfid homeostazisindeki değişikliklerin CA 15-3 ile etkileşmediği söylenebilir. 

Thiol/disulphide homeostasis is important in cancer. Studies are carried out to be biomarkers in cancer patients. The aim of this study is to investigate the relationship between oxidative stress biomarker [thiol-disulphide homeostasis] and CEA [carcinoembryonic antigen], IMA [ischemic modified albumin], albumin, CA 15-3 (cancer antigen 15-3) in patients with breast cancer and compare it with healthy controls, which is conducted for the first time in the literature.A total of 80 participants including 39 patients with breast cancer and 41 healthy individuals were included in the study. CEA, CA15-3, native thiol, total thiol, and disulphide as well as disulphide/native thiol and disulphide/total thiol ratios were compared between the groups. Native thiol[-SH], disulfide [-S-S] and total thiol [TT] concentrations were measured with a novel automated method. Patients participated in the study under chemotherapy. The study is a prospective study. In breast cancer group, IMA, albümin and CA-15-3  were obtained sitatiscally significant difference compared to the controlegroup (p<0.05).  Although in high CA-15-3 group decreased SH/TT and increased SS/TT ratios, there wasn’t a significant change in the amount of thiol and disulfide. There was not any relationship between thiol-disulphide parameters and tumor markers in the the breast cancer group. Itcould be said that changes in the thiol-disulphide homeostasis may notbe interact with CA 15-3 values.

  • 1. Özdemir A, Erel O. Thıol-Dısulphıde Balance: Could be a new marker for Thyroid Cancer? Journal of Cancer Therapy [JCT]. 2018; 9: 8.
  • 2. Kamińska M,Ciszewski T, Łopacka-Szatan C, Miotła P, Starosławska E. Breast cancer risk factors. Prz Menopauzalny 2015; 14: 196–202.
  • 3. Robert G. Allen. Oxidative stress and superoxide dismutase in development, aging and gene regulation , Age [Omaha], 1998; 21[2].
  • 4. Yalçın, GT. Flavonoidlerin kanser hücrelerine etkisi. Effect of Flavonoids on the Cancer Cells. phD Thesis, Institute Of Health Sciences, Selcuk University. Konya; 2013.
  • 5. Chianeh YR. Prabhu,K. Protein Thiols as an Indicator of Oxidative Stress, Archives Medical Review Journal.2014; 23[39]: 443-456.
  • 6. Cerutti PA. Prooxidant states and tumor promotion. Science. 1985; 227:375-81.
  • 7. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical Biochemistry.2014; 47[18]: 326-332.
  • 8. Hjerkind KV,Ellingjord-Dale M, Johansson AL. et al. Breast cancer risk factors and volumetric breast density in a national breast cancer screening program. Cancer Research. 2018; 78-13.
  • 9. Papadimitriou JP, Burchell JM, Plunkett, T, Graham R., Correa I, Miles D, Smith M. MUC1 and the Immunobiology of Cancer . Journal of Mammary Gland Biology and Neoplasia. 2002;7[2]: 209–221.
  • 10. Mohebtash M, Tsang KY, Madan RA.et al. A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer. Clin Cancer Res; 2011;17[22]; 1–10.
  • 11. Gürdöl F, Ademoglu, E.[Editors]. Biyokimya. 2. Baskı. Nobel Tıp Kitapevleri, 2010: 669.
  • 12. Gupta, RK, Patel AK, Shah N, et al. Oxidative Stress and Antioxidants in Disease and Cancer: A Review. Asian Pacific Journal of Cancer Prevention, 2014; l -15: 4405-4409.
  • 13. Ates I, Kaplan M, Yuksel M, et al. Determination of thiol/ disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxidation. Endocrine 2016; 51:47-51.
  • 14. Kundi H, Ates I, Kızıltunc E, et al.A novel oxidative stress marker in acute myocardial infarction: thiol/disulphide homeostasis.Am J Emerg Med 2015; 33:1567-71.
  • 15. Özdemir A. Investıgatıon Of The Effects Of Mentha Spıcata Lamıaceae Mentha Extracts Prepared In Dıfferent Solvents Gıven To Rats Wıth Dry Powder On Blood, Β- Carotene, A,C Vıtamıns, Catalase, Glutathıone Peroxıdase, Glutathıone Reductase, Malondıaldehyde, Superoxıde Dısmutase Enzymes And Total Antı- Oxıdant Capacıty. phD Thesis,No:2010-003. Afyon Kocatepe University, Institute of Health Sciences.Departement of Biochemistery.Afyon;2010.
  • 16. Özdemir A, Sözbilir NB. The Effect of Mentha Spicata L. Dry Powder and its Different Typses Extracts on Certain Biochemical Parameters and Total Anti-oxidant Capacity. Afyon Kocatepe University Kocatepe Veterinary Journal, 2016; 9[1]:12-18.
  • 17. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-Biological Interactions. 2006; 160 -1:40.
  • 18. Koçak S, Çelik L,Özbaş S, Dizbay Sak S, Tükün A, Yalçın B. Rısk Factors In Breast Cancer, Rısk Assessment And Preventıon:2010 Istanbul Consensus Meeetıng Report. The Journal of Breast Health 2011; 7: 2.
  • 19. Chianeh YR., Prabhu K. 2014, Protein Thiols as an Indicator of Oxidative Stress Oksidatif, Archives Medical Review Journal. 2014; 23[3] :443-456.
  • 20. Winther JR, Thorpe C. Quantification of thiols and disulfides.,Biochim Biophys Acta. 2014 Feb;1840[2]:838-46.
  • 21. Erel Ö. A new automated colorimetric method for measuring total oxidant status,Clinical Biochemistry. 2005; 38[12]: 1103–1111.
  • 22. Bektaş H, Vural G, Gümüşyayla Ş,Deniz O, Alışık M, Erel Ö. Akut İskemik İnmeli Hastalarda Tiyol-disülfid Dengesinin Araştırılması,Türk Beyin Damar Hast Dergisi.2015; 22 [1] :5.
  • 23. Dirican N, Dirican A, Şen O, Aynalı A, Atalay Ş, Bircan HA, Öztürk Ö, Erdoğan S, Çakır M, Akkaya A. Thiol/disulfide homeostasis: A prognostic biomarker for patients with advanced non-small cell lung cancer? Redox Rep. 2016;21[5]:197-203.
  • 24. Özkan S, Büyükdoğan M. Meme kanserinde prognostik faktörler: vakalarımızın retrospektif analizi, Tıp Araştırmaları Dergisi 8 [1] :9-14.
  • 25. Ergin M, Cendek BD, Neselioglu S, Avsar AF and Erel Ö. Dynamic thiol-disulfide homeostasis in Hyperemesis gravidarum. Journal of Perinatology [2015], 1–5.
  • 26. Kilinc F,Sener S, Akbas A, Neselioglu S, Erel Ö. and Aktas A. Investigation of Dynamic Thiol-Disulfide Homeostasis in Alopecia Areata Patients. British Journal of Medicine & Medical Research [2017], 21[6]: 1-7.
  • 27. Hazini A, Cemek M, Isıldak I, et al. Investigation of ischemia modified albumin, oxidant and antioxidant markers in acute myocardial infarction. Postepy Kardiol Interwencyjnej. 2015;11: 298–303.
  • 28. Eom JE, Lee E, Jeon KH, Sim J, Suh M, Jhon GJ, et al. Development of an albumin copper binding (ACuB) assay to detect ischemia modified albumin. Anal Sci 2014; 30:985-90.
  • 29. Beetham R, Monk C, Keating L, et al. Effects of storage at 20 degrees C on ischaemia-modified albumin results. Ann Clin Biochem. 2006;43:500–502.
  • 30. Yeh C-C, Hou MF, Tsai S-M et al. Superoxide anion radical, lipid peroxides and antioxidant status in the blood of patients with breast cancer. Clinica Chimica Acta, 2005;361(1–2): 104-111.
  • 31. Rajneesh C P, Manimaran A, Sasikala K R, Adaikappan P. Lipid peroxidation and antioxidant status in patients with breast cancer. Singapore Med J 2008; 49(8) : 640.
Birincil Dil en
Konular Tıp
Yayımlanma Tarihi MART 2020
Bölüm Makaleler-Araştırma Yazıları
Yazarlar

Orcid: 0000-0003-2639-7344
Yazar: Ayşe ÖZDEMİR (Sorumlu Yazar)
Kurum: USAK UNIVERSITY
Ülke: Turkey


Orcid: 0000-0001-5620-8466
Yazar: Uttku DÖNEM DİLLİ
Kurum: USAK UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-9524-4352
Yazar: Dalyan ÖZDEMİR
Kurum: Uşak Medikal Park Hastanesi
Ülke: Turkey


Orcid: 0000-0002-0974-5717
Yazar: Salim NEŞELİOĞLU
Kurum: YILDIRIM BEYAZIT UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-2996-3236
Yazar: Özcan EREL
Kurum: YILDIRIM BEYAZIT UNIVERSITY
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 20 Mart 2020

Bibtex @araştırma makalesi { kocatepetip560366, journal = {Kocatepe Tıp Dergisi}, issn = {1302-4612}, eissn = {2149-7869}, address = {}, publisher = {Afyonkarahisar Sağlık Bilimleri Üniversitesi}, year = {2020}, volume = {21}, pages = {70 - 75}, doi = {10.18229/kocatepetip.560366}, title = {The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer}, key = {cite}, author = {ÖZDEMİR, Ayşe and DÖNEM DİLLİ, Uttku and ÖZDEMİR, Dalyan and NEŞELİOĞLU, Salim and EREL, Özcan} }
APA ÖZDEMİR, A , DÖNEM DİLLİ, U , ÖZDEMİR, D , NEŞELİOĞLU, S , EREL, Ö . (2020). The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer. Kocatepe Tıp Dergisi , 21 (1) , 70-75 . DOI: 10.18229/kocatepetip.560366
MLA ÖZDEMİR, A , DÖNEM DİLLİ, U , ÖZDEMİR, D , NEŞELİOĞLU, S , EREL, Ö . "The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer". Kocatepe Tıp Dergisi 21 (2020 ): 70-75 <https://dergipark.org.tr/tr/pub/kocatepetip/issue/53095/560366>
Chicago ÖZDEMİR, A , DÖNEM DİLLİ, U , ÖZDEMİR, D , NEŞELİOĞLU, S , EREL, Ö . "The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer". Kocatepe Tıp Dergisi 21 (2020 ): 70-75
RIS TY - JOUR T1 - The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer AU - Ayşe ÖZDEMİR , Uttku DÖNEM DİLLİ , Dalyan ÖZDEMİR , Salim NEŞELİOĞLU , Özcan EREL Y1 - 2020 PY - 2020 N1 - doi: 10.18229/kocatepetip.560366 DO - 10.18229/kocatepetip.560366 T2 - Kocatepe Tıp Dergisi JF - Journal JO - JOR SP - 70 EP - 75 VL - 21 IS - 1 SN - 1302-4612-2149-7869 M3 - doi: 10.18229/kocatepetip.560366 UR - https://doi.org/10.18229/kocatepetip.560366 Y2 - 2019 ER -
EndNote %0 Kocatepe Tıp Dergisi The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer %A Ayşe ÖZDEMİR , Uttku DÖNEM DİLLİ , Dalyan ÖZDEMİR , Salim NEŞELİOĞLU , Özcan EREL %T The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer %D 2020 %J Kocatepe Tıp Dergisi %P 1302-4612-2149-7869 %V 21 %N 1 %R doi: 10.18229/kocatepetip.560366 %U 10.18229/kocatepetip.560366
ISNAD ÖZDEMİR, Ayşe , DÖNEM DİLLİ, Uttku , ÖZDEMİR, Dalyan , NEŞELİOĞLU, Salim , EREL, Özcan . "The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer". Kocatepe Tıp Dergisi 21 / 1 (Mart 2020): 70-75 . https://doi.org/10.18229/kocatepetip.560366
AMA ÖZDEMİR A , DÖNEM DİLLİ U , ÖZDEMİR D , NEŞELİOĞLU S , EREL Ö . The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer. KTD. 2020; 21(1): 70-75.
Vancouver ÖZDEMİR A , DÖNEM DİLLİ U , ÖZDEMİR D , NEŞELİOĞLU S , EREL Ö . The Association between Thiol-Disulphide Balance and CA-15-3 Levels in Patients with Breast Cancer. Kocatepe Tıp Dergisi. 2020; 21(1): 75-70.