Preoperative Approach to Hereditary Angioedema Patients in Two Cases

Öz

Our aim is to draw attention to the importance of prophylactic treatment in preoperative, perioperative and postoperative period for hereditary angioedema patients for whom minor or major surgery is planned. Two patients with a diagnosis of hereditary angioedema were treated with 1000 IU C1 esterase inhibitor 1-6 hours before minor surgery. Case 1 did not develop an attack during the procedure and within postoperative one month. In case 2 with incomplete lupus erythematosus, angioedema occurred in the lips one hour after the procedure. One more dose of C1 esterase inhibitor was administered to the patient and angioedema was delayed within half an hour. In this study, it was aimed to emphasize the importance of prophylactic treatment to prevent attack development during the procedure in patients with hereditary angioedema.

Anahtar Kelimeler

• Hereditary angioedema,prophylaxis,C1 esterase inhibitor

İKİ OLGU İLE HEREDİTER ANJİYOÖDEMLİ HASTALARA PREOPERATİF YAKLAŞIMIN GÖZDEN GEÇİRİLMESİ

Öz

Küçük veya büyük cerrahi işlem planlanan herediter anjiyoödem olguları için preoperatif dönemde proflaktik tedavinin önemi, perioperatif ve postoperatif dönemde karşılaşılabilecek sorunlar konusuna dikkat çekilmesi amaçlanmıştır. Herediter anjiyoödem tanısı ile takibi süren 2 olguya minör cerrahi işlemden 1-6 saat önce 1000 IU C1 esteraz inhibitörü uygulandı. Olgu 1'de işlem sırasında ve sonraki bir ayda atak gelişmedi. İnkomplet lupus eritematozusu olan olgu 2’de ise işlemden bir saat sonra dudakta anjiyoödem ortaya çıktı. Hastaya bir doz daha C1 esteraz inhibitörü verildi ve anjiyoödem yarım saat içinde geriledi. Bu çalışmada herediter anjiyoödemli hastalarda işlem sırasında atak gelişimine engel olmak için proflaktik tedavinin önemine dikkat çekilmesi amaçlanmıştır.

Anahtar Kelimeler

• proflaksi,Herediter anjiyoödem,C1 esteraz inhibitörü

Kaynakça

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