Kedi ve Köpeklerde Yaşla İlişkili Kognitif Disfonksiyon: Güncel Durum ve Gelişmeler

Yıl 2025, Cilt: 5 Sayı: 3, 77 - 89, 29.12.2025

Umut Coşkun , Alper Sungur , Cansu Balıkçı , Ayşe İdil Kizilkanat , İlayda Tendar , Pelin Dinç , Halil Emre Cengiz Songül Erdoğan , Hasan Erdoğan , Kerem Ural

https://doi.org/10.71255/maunsbd.1662318

Öz

Veteriner hekimliği alanındaki ilerlemeler ve evcil hayvanların aile üyeleri olarak giderek daha fazla kabul görmesiyle birlikte, köpeklerin ve kedilerin yaşam süreleri önemli ölçüde artmıştır. Bunun sonucunda, yaşa bağlı hastalıklar daha yaygın hale gelmiştir. Kognitif Disfonksiyon Sendromu (KDS), özellikle yaşlı ve geriatrik hayvanları etkileyen, insanlardaki Alzheimer hastalığına benzer nörodejeneratif bir durumdur. Klinik belirtiler geniş bir çeşitlilik gösterirken genellikle azalmış aktivite, dikkat eksikliği, anksiyete, idrar kaçırma, amaçsız dolaşma, uyku-uyanıklık döngüsü bozuklukları, mekânsal dezoryantasyon, hafıza kaybı ve davranış değişikliklerini içermektedir. Etkilenen hayvanların beyinlerinde, beta-amiloid plakları sıklıkla, hem ekstraselüler yaşlı plaklar hem de kan damarlarının etrafında gözlemlenmektedir. Kaydedilen ilerlemelere rağmen, KDS' nin tanı ve tedavisi hala zorluklar içermektedir. Bu derlemede, KDS' ye ilişkin güncel gelişmeler sunulmaktadır.

Anahtar Kelimeler

Geriatri , Kognitif disfonksiyon sendromu , Neurodejeneratif hastalıklar , Veteriner nöroloji

Age-Related Cognitive Dysfunction in Cats and Dogs: Current Status and Developments

Öz

With the continuous progress in veterinary medicine and the increasing acknowledgment of pets as family members, the life expectancy of dogs and cats has notably risen. As a result, age-associated disorders have become more prevalent. Cognitive Dysfunction Syndrome (KDS) is a neurodegenerative condition primarily affecting senior and geriatric animals, resembling Alzheimer's disease in humans. The clinical manifestations vary widely and often include decreased activity, impaired attention, anxiety, urinary incontinence, aimless wandering, sleep-wake cycle disturbances, spatial disorientation, memory impairment, and behavioral changes. In affected animals, beta-amyloid plaques are frequently observed in the brain, both as extracellular senile plaques and around blood vessels. Despite advances in understanding, diagnosing and treating KDS remains challenging. In this review, current developments related to KDS are presented.

Anahtar Kelimeler

Geriatrics , Cognitive Dysfunction Syndrome , Neurodegenerative Diseases , Veterinary Neurology

Kaynakça

• Bartus, R. T., Dean, R. L., III, Beer, B., & Lippa, A. S. (1982). The cholinergic hypothesis of geriatric memory dysfunction. Science, 217(4558), 408–414.
• Bécuwe-Bonnet, V., Bélanger, M. C., Frank, D., Parent, J., & Hélie, P. (2012). Gastrointestinal disorders in dogs with excessive licking of surfaces. Journal of Veterinary Behavior: Clinical Applications and Research, 7(4), 195–204. Bowen, J., & Heath, S. (2005). Behaviour problems in small animals: Practical advice for the veterinary team. Elsevier Saunders.
• Camps, T., Amat, M., Mariotti, V. M., Le Brech, S., & Manteca, X. (2012). Pain-related aggression in dogs: 12 clinical cases. Journal of Veterinary Behavior, 7(2), 99–102.
• Černá, P., Gardiner, H., Sordo, L., Tørnqvist-Johnsen, C., & Gunn-Moore, D. A. (2020). Potential causes of increased vocalisation in elderly cats with cognitive dysfunction syndrome as assessed by their owners. Animals, 10(6), 1092. Schake, C. (n.d.). Sundowner syndrome in dogs. Positively. Retrieved December 28, 2019, from https://positively.com/contributors/sundowner-syndrome-in-dogs/
• Chambers, J. K., Tokuda, T., Uchida, K., Ishii, R., Tatebe, H., Takahashi, E., Tomiyama, T., Une, Y., & Nakayama, H. (2015). The domestic cat as a natural animal model of Alzheimer's disease. Acta Neuropathologica Communications, 3, 78.
• Cummings, B. J., Satou, T., Head, E., Milgram, N. W., Cole, G. M., Savage, M. J., Podlisny, M. B., Selkoe, D. J., Siman, R., Greenberg, B. D., & Cotman, C. W. (1996). Diffuse plaques contain C-terminal Aβ42 and not Aβ40: Evidence from cats and dogs. Neurobiology of Aging, 17(4), 653–659.
• Denenberg, S., & Landsberg, G. M. (2016). Excessive vocalization and waking at nights. In L. P. Tilley & F. W. K. Smith (Eds.), Blackwell’s Five-Minute Veterinary Consult: Canine and Feline (6th ed., pp. 470–471). Wiley & Sons.
• Farmer-Dougan, V., Quick, A., Harper, K., Schmidt, K., & Campbell, D. (2014). Behavior of hearing or vision impaired and normal hearing and vision dogs (Canis lupus familiaris): Not the same, but not that different. Journal of Veterinary Behavior: Clinical Applications and Research, 9, 316–323.
• Frank, D. (2014). Recognizing behavioral signs of pain and disease: A guide for practitioners. The Veterinary Clinics of North America: Small Animal Practice, 44(3), 507–524.
• Glabe, C. G. (2006). Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiology of Aging, 27(4), 570–575.
• Gould, E. (1999). Serotonin and hippocampal neurogenesis. Neuropsychopharmacology, 21(2 Suppl), 46S–51S. Gunn-Moore, D., Moffat, K., Christie, L. A., & Head, E. (2007). Cognitive dysfunction and the neurobiology of ageing in cats. The Journal of Small Animal Practice, 48(10), 546–553.
• Katina, S., Farbakova, J., Madari, A., Novak, M., & Zilka, N. (2016). Risk factors for canine cognitive dysfunction syndrome in Slovakia. Acta Veterinaria Scandinavica, 58, 17.
• Kumar, V., Abbas, A. K., & Fausto, N. (2014). Robbins ve Cotran hastalığın patolojik temeli, profesyonel baskı e-kitabı. Elsevier Sağlık Bilimleri. Landsberg, G. (2005). Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 29(3), 471–479.
• Landsberg, G. M., & Denenberg, S. (2009). Chapter 12. In D. Horwitz & D. Mills (Eds.), BSAVA manual of canine and feline behavioural medicine (pp. 127–135). British Small Animal Veterinary Association. Landsberg, G. M., Denenberg, S., & Araujo, J. A. (2010). Cognitive dysfunction in cats: A syndrome we used to dismiss as 'old age'. Journal of Feline Medicine and Surgery, 12(11), 837–848.
• Landsberg, G. M., Hunthausen, W., & Ackerman, L. A. (2013). The effect of aging on behavior in senior pets. In Behavior problems of the dog and cat (3rd ed., pp. 211–235). Saunders.
• Landsberg, G. M., Nichol, J., & Araujo, J. A. (2012). Cognitive dysfunction syndrome: A disease of canine and feline brain aging. The Veterinary Clinics of North America: Small Animal Practice, 42(4), 749–vii.
• Landsberg, G., & Araujo, J. A. (2005). Behavior problems in geriatric pets. The Veterinary Clinics of North America: Small Animal Practice, 35(3), 675–698.
• Luescher, A. U. (2003). Diagnosis and management of compulsive disorders in dogs and cats. The Veterinary Clinics of North America: Small Animal Practice, 33(2), 253–vi.
• Madari, A., Farbakova, J., Katina, S., Smolek, T., Novak, P., Weissova, T., Novak, M., & Zilka, N. (2015). Assessment of severity and progression of canine cognitive dysfunction syndrome using the CAnine DEmentia Scale (CADES). Applied Animal Behaviour Science, 171, 138–145.
• Manteca, X. (2011). Nutrition and behavior in senior dogs. Topics in Companion Animal Medicine, 26(1), 33–36.
• Matteau, E., Landreville, P., Laplante, L., & Laplante, C. (2003). Disruptive vocalizations: A means to communicate in dementia? American Journal of Alzheimer's Disease and Other Dementias, 18(3), 147–153.
• Meleo, K. A., & Peterson, M. E. (2014). Treatment of insulinoma in the dog, cat, and ferret. In Bonagura, J. D., & Twedt, D. C. (Eds.), Current veterinary therapy XV (Web Chapter 23, pp. e130–e134). Saunders Elsevier.
• Milgram, N. W., Head, E., Zicker, S. C., Ikeda-Douglas, C. J., Murphey, H., Muggenburg, B., Siwak, C., Tapp, D., & Cotman, C. W. (2005). Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: A two-year longitudinal study. Neurobiology of Aging, 26(1), 77–90.
• Neilson, J. C. (2004). Feline house soiling: Elimination and marking behaviors. Clinical Techniques in Small Animal Practice, 19(4), 216–224.
• Ohl, F., Arndt, S. S., & van der Staay, F. J. (2008). Pathological anxiety in animals. The Veterinary Journal, 175(1), 18–26.
• Overall, K. L. (2020). Mental illness in animals: Diagnostic considerations using selected mental disorders. In Mental health and well-being in animals (pp. 167–181). CABI.
• Pan, Y., Landsberg, G., Mougeot, I., Kelly, S., Xu, H., Bhatnagar, S., Gardner, C. L., & Milgram, N. W. (2018). Efficacy of a therapeutic diet on dogs with signs of cognitive dysfunction syndrome (KDS): A prospective double-blinded placebo-controlled clinical study. Frontiers in Nutrition, 5, 127.
• Pryor, P. A., Hart, B. L., Bain, M. J., & Cliff, K. D. (2001). Causes of urine marking in cats and effects of environmental management on frequency of marking. Journal of the American Veterinary Medical Association, 219(12), 1709–1713.
• Reinberg, A., & Ashkenazi, I. (2003). Concepts in human biological rhythms. Dialogues in Clinical Neuroscience, 5(4), 327–342.
• Rofina, J. E., van Ederen, A. M., Toussaint, M. J. M., Secrève, M., van der Spek, A., van der Meer, I., Van Eerdenburg, F. J. C. M., & Gruys, E. (2006). Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer’s disease. Brain Research, 1069(1), 216–226.
• Sordo, L., & Gunn-Moore, D. A. (2021). Cognitive dysfunction in cats: Update on neuropathological and behavioural changes plus clinical management. The Veterinary Record, 188(1), e3.
• Sordo, L., Breheny, C., Halls, V., Cotter, A., Tørnqvist-Johnsen, C., Caney, S. M. A., & Gunn-Moore, D. A. (2020). Prevalence of disease and age-related behavioural changes in cats: Past and present. Veterinary Sciences, 7(3), 85.
• Tisdall, P. L., Hunt, G. B., Youmans, K. R., & Malik, R. (2000). Neurological dysfunction in dogs following attenuation of congenital extrahepatic portosystemic shunts. The Journal of Small Animal Practice, 41(12), 539–546.
• van Berkel, A. A., IJff, D. M., & Verkuyl, J. M. (2018). Cognitive benefits of the ketogenic diet in patients with epilepsy: A systematic overview. Epilepsy & Behavior: E&B, 87, 69-77.
• Volicer, L., Harper, D. G., Manning, B. C., Goldstein, R., & Satlin, A. (2001). Sundowning and circadian rhythms in Alzheimer's disease. The American Journal of Psychiatry, 158(5), 704–711.
• Zhang, J. H., Sampogna, S., Morales, F. R., & Chase, M. H. (2005). Age-related changes in cholinergic neurons in the laterodorsal and the pedunculo-pontine tegmental nuclei of cats: A combined light and electron microscopic study. Brain Research, 1052(1), 47–55.