CD45 pozitif ve CD45 negatif neoplastik plazma hücreleri saptanan multiple miyelom olgusu

Yıl 2021, Cilt: 14 Sayı: 2, 360 - 365, 25.08.2021

Oya Gezer , Cemil Gülüm , Onur Bobuşoğlu , Anıl Tombak , Mehmet Burak Çimen , Lülüfer Tamer

https://doi.org/10.26559/mersinsbd.864232

Öz

Multiple Miyelom (MM) kemik iliğindeki plazma hücrelerinin üretimini etkileyen bir kanser türüdür. B hücrelerinin farklılaşması sonucu oluşan, immunglobulin (antikor) üreten plazma hücreleri miyelom hücresine dönüşünce, antikor yerine monoklonal protein (M-protein) üretirler. Miyeloma hücreleri genellikle CD45 ekspresyonu göstermezler. Bu makalede akım sitometrik immünfenotipleme çalışmasında CD45(+) ve CD45(-) hücreleri birlikte taşıyan bir multiple miyelom vakası sunulmaktadır.

Anahtar Kelimeler

CD45(+), CD45(-), Multiple Miyelom, akım sitometri

Destekleyen Kurum

Yoktur

Proje Numarası

Yoktur

A case of multiple myeloma with CD45 positive and CD45 negative neoplastic plasma cells

Öz

Multiple Myeloma (MM) is a type of cancer that affects the plasma cells proliferation in the bone marrow. When plasma cells that produce immunoglobulin (antibody), which are formed as a result of differentiation of B cells, turn into myeloma cells, they produce monoclonal protein (M-protein) instead of antibody. Myeloma cells are usually detected as CD45(-). In this article, we present a case of multiple myeloma carrying CD45(+) and CD45(-) cells together in a flow cytometric immunophenotyping study.

Anahtar Kelimeler

CD45(+), CD45(-), multiple myeloma, flow cytometry

Proje Numarası

Yoktur

Kaynakça

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