INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS

Belma Nural Yaman; Benay Çolak; Doç. Dr. Ahmet Çabuk

doi:10.31796/ogummf.1205232

TR EN

BİYOMEDİKAL UYGULAMALARDA KULLANILAN MİKROBİYAL BİYOPOLİMERLERE BAKIŞ

Öz

Mikrobiyal biyopolimerler, mikroorganizma, bitki vb. dahil canlı organizmaların ürünleri olarak tanımlanır. Biyolojik olarak parçalanabilir, biyouyumlu, toksik olmayan veya düşük toksik, anti enflamatuar ve antimikrobiyal aktivite gibi özelliklere sahip olabilirler. Polisakkarit, lipid ve protein olarak gruplandırılmışlardır. Mikrobiyal biyopolimerler, biyomedikal uygulamalar, doku mühendisliği, gıda endüstrisi, yara onarım sistemi, ilaç dağılımını içeren değişken sektörlerdeki biyomalzemeler olarak önemli bir kaynaktır. Bu nedenle, tıbbi implantların şeklinden dolayı bu alanlar için seçim kriterleri hayati önem taşımaktadır. Medikal uygulamalarda güvenli ve uzun süreli implant için bu kriterler pasif ve inert seçilmelidir. Bu derlemede, biyopolimer türevli mikroorganizmalar, özellikle aljinat, kitin, kitosan, levan, polihidroksalkanoatlar, hyaluronik asit ele alınmış ve mikrobiyal biyopolimerlerin biyomedikal araştırma alanındaki potansiyeline ışık tutmuştur. Biyomedikal uygulamalar için bu polimerlerin ekonomik faktörleri, biyosentezi ve özellikleri incelenmiştir. Mikrobiyal biyopolimerlerin olağanüstü derecede değişken olma ve uyarılmış özelliklere sahip olma yetenekleri, onları biyomedikal araştırmalardaki sorunları çözmek için avantajlı kılar. Mikrobiyal biyopolimerler, doku mühendisliği, tıbbi cihazların geliştirilmesi, ilaç dağılımı, kanser tedavisi ve yara iyileşmesi dahil olmak üzere bir dizi tıbbi uygulamada sürdürülebilir süreçleri düzenlemek için kullanılabilir. Bu nedenle bu biyopolimerlerin tarihçesi, özellikleri, ekstraksiyon yöntemleri ve uygulama alanları yaklaşımı üzerinde durulmuştur.

Anahtar Kelimeler

biyomedikal uygulamalar , biyopolimer , mikroorganizma

INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS

Abstract

Microbial biopolymers are products of living organisms include microorganism, plant etc. They could be biodegradable, biocompatible, non or low toxic and show anti-inflammatory and antimicrobial activity. They have been grouped in polysaccharide, lipid and protein. Microbial biopolymers are important source as biomaterials in variable sectors consist of biomedical applications, tissue engineering, food industry, wound repair system, and also drug delivery. Therefore, the selection criteria are vital for these areas because these materials use for shaping of medical implants. These criteria should be elected passive and inert for safe and long-term implant in medical applications. In this review, biopolymers derivatives from microorganisms are handled especially alginate, chitin, chitosan, levan, polyhydroxalkanoates, hyaluronic acid and this review has highlighted the potential of microbial biopolymers in the field of biomedical research. For biomedical applications, the economic factors, biosynthesis, and characteristics of these polymers have been examined. The ability of microbial biopolymers to be extraordinarily variable and to have induced features makes them advantageous for solving issues in biomedical research. Microbial biopolymers can be used to arrange sustainable processes in a range of medical applications, including tissue engineering, the development of medical devices, drug delivery, cancer therapy, and wound healing. Therefore, these biopolymers historical past, properties and extraction methods and application approach were emphasized.

Keywords

biomedical application , biopolymer , microorganisms

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Biyomedikal Mühendisliği (Diğer)

Bölüm

Derleme

Yazarlar

Belma Nural Yaman ^*
0000-0003-2576-1300
Türkiye

Benay Çolak
0000-0003-2116-5966
Türkiye

Doç. Dr. Ahmet Çabuk
0000-0002-4619-6948
Türkiye

Erken Görünüm Tarihi

22 Aralık 2023

Yayımlanma Tarihi

22 Aralık 2023

Gönderilme Tarihi

21 Kasım 2022

Kabul Tarihi

25 Ocak 2023

Yayımlandığı Sayı

Yıl 1970 Cilt: 31 Sayı: 4

DOI

https://doi.org/10.31796/ogummf.1205232

IZ

https://izlik.org/JA34ZX69ZW

APA

Nural Yaman, B., Çolak, B., & Çabuk, D. D. A. (2023). INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi, 31(4), 975-987. https://doi.org/10.31796/ogummf.1205232

AMA

1.Nural Yaman B, Çolak B, Çabuk DDA. INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS. ESOGÜ Müh Mim Fak Derg. 2023;31(4):975-987. doi:10.31796/ogummf.1205232

Chicago

Nural Yaman, Belma, Benay Çolak, ve Doç. Dr. Ahmet Çabuk. 2023. “INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS”. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi 31 (4): 975-87. https://doi.org/10.31796/ogummf.1205232.

EndNote

Nural Yaman B, Çolak B, Çabuk DDA (01 Aralık 2023) INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi 31 4 975–987.

IEEE

[1]B. Nural Yaman, B. Çolak, ve D. D. A. Çabuk, “INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS”, ESOGÜ Müh Mim Fak Derg, c. 31, sy 4, ss. 975–987, Ara. 2023, doi: 10.31796/ogummf.1205232.

ISNAD

Nural Yaman, Belma - Çolak, Benay - Çabuk, Doç. Dr. Ahmet. “INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS”. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi 31/4 (01 Aralık 2023): 975-987. https://doi.org/10.31796/ogummf.1205232.

JAMA

1.Nural Yaman B, Çolak B, Çabuk DDA. INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS. ESOGÜ Müh Mim Fak Derg. 2023;31:975–987.

MLA

Nural Yaman, Belma, vd. “INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS”. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi, c. 31, sy 4, Aralık 2023, ss. 975-87, doi:10.31796/ogummf.1205232.

Vancouver

1.Belma Nural Yaman, Benay Çolak, Doç. Dr. Ahmet Çabuk. INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS. ESOGÜ Müh Mim Fak Derg. 01 Aralık 2023;31(4):975-87. doi:10.31796/ogummf.1205232

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INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS

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