INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS

Belma Nural Yaman; Benay Çolak; Doç. Dr. Ahmet Çabuk

doi:10.31796/ogummf.1205232

TR EN

BİYOMEDİKAL UYGULAMALARDA KULLANILAN MİKROBİYAL BİYOPOLİMERLERE BAKIŞ

Öz

Mikrobiyal biyopolimerler, mikroorganizma, bitki vb. dahil canlı organizmaların ürünleri olarak tanımlanır. Biyolojik olarak parçalanabilir, biyouyumlu, toksik olmayan veya düşük toksik, anti enflamatuar ve antimikrobiyal aktivite gibi özelliklere sahip olabilirler. Polisakkarit, lipid ve protein olarak gruplandırılmışlardır. Mikrobiyal biyopolimerler, biyomedikal uygulamalar, doku mühendisliği, gıda endüstrisi, yara onarım sistemi, ilaç dağılımını içeren değişken sektörlerdeki biyomalzemeler olarak önemli bir kaynaktır. Bu nedenle, tıbbi implantların şeklinden dolayı bu alanlar için seçim kriterleri hayati önem taşımaktadır. Medikal uygulamalarda güvenli ve uzun süreli implant için bu kriterler pasif ve inert seçilmelidir. Bu derlemede, biyopolimer türevli mikroorganizmalar, özellikle aljinat, kitin, kitosan, levan, polihidroksalkanoatlar, hyaluronik asit ele alınmış ve mikrobiyal biyopolimerlerin biyomedikal araştırma alanındaki potansiyeline ışık tutmuştur. Biyomedikal uygulamalar için bu polimerlerin ekonomik faktörleri, biyosentezi ve özellikleri incelenmiştir. Mikrobiyal biyopolimerlerin olağanüstü derecede değişken olma ve uyarılmış özelliklere sahip olma yetenekleri, onları biyomedikal araştırmalardaki sorunları çözmek için avantajlı kılar. Mikrobiyal biyopolimerler, doku mühendisliği, tıbbi cihazların geliştirilmesi, ilaç dağılımı, kanser tedavisi ve yara iyileşmesi dahil olmak üzere bir dizi tıbbi uygulamada sürdürülebilir süreçleri düzenlemek için kullanılabilir. Bu nedenle bu biyopolimerlerin tarihçesi, özellikleri, ekstraksiyon yöntemleri ve uygulama alanları yaklaşımı üzerinde durulmuştur.

Anahtar Kelimeler

biyomedikal uygulamalar , biyopolimer , mikroorganizma

INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS

Abstract

Microbial biopolymers are products of living organisms include microorganism, plant etc. They could be biodegradable, biocompatible, non or low toxic and show anti-inflammatory and antimicrobial activity. They have been grouped in polysaccharide, lipid and protein. Microbial biopolymers are important source as biomaterials in variable sectors consist of biomedical applications, tissue engineering, food industry, wound repair system, and also drug delivery. Therefore, the selection criteria are vital for these areas because these materials use for shaping of medical implants. These criteria should be elected passive and inert for safe and long-term implant in medical applications. In this review, biopolymers derivatives from microorganisms are handled especially alginate, chitin, chitosan, levan, polyhydroxalkanoates, hyaluronic acid and this review has highlighted the potential of microbial biopolymers in the field of biomedical research. For biomedical applications, the economic factors, biosynthesis, and characteristics of these polymers have been examined. The ability of microbial biopolymers to be extraordinarily variable and to have induced features makes them advantageous for solving issues in biomedical research. Microbial biopolymers can be used to arrange sustainable processes in a range of medical applications, including tissue engineering, the development of medical devices, drug delivery, cancer therapy, and wound healing. Therefore, these biopolymers historical past, properties and extraction methods and application approach were emphasized.

Keywords

biomedical application , biopolymer , microorganisms

Kaynakça

Abdallah, M. M., Fernández, N., Matias, A. A., & Bronze, M. do R. (2020). Hyaluronic acid and Chondroitin sulfate from marine and terrestrial sources: Extraction and purification methods. In Carbohydrate Polymers (Vol. 243). https://doi.org/10.1016/j.carbpol.2020.116441
Ahmad Raus, R., Wan Nawawi, W. M. F., & Nasaruddin, R. R. (2021). Alginate and alginate composites for biomedical applications. In Asian Journal of Pharmaceutical Sciences (Vol. 16, Issue 3). https://doi.org/10.1016/j.ajps.2020.10.001
Anderson, A. J., & Dawes, E. A. (1990). Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiological Reviews, 54(4). https://doi.org/10.1128/mr.54.4.450-472.1990
Anitha, A., Sowmya, S., Kumar, P. T. S., Deepthi, S., Chennazhi, K. P., Ehrlich, H., Tsurkan, M., & Jayakumar, R. (2014). Chitin and chitosan in selected biomedical applications. In Progress in Polymer Science (Vol. 39, Issue 9). https://doi.org/10.1016/j.progpolymsci.2014.02.008
Aranaz, I., Alcántara, A. R., Civera, M. C., Arias, C., Elorza, B., Caballero, A. H., & Acosta, N. (2021). Chitosan: An overview of its properties and applications. In Polymers (Vol. 13, Issue 19). https://doi.org/10.3390/polym13193256
Arbia, W., Arbia, L., Adour, L., & Amrane, A. (2013). Chitin extraction from crustacean shells using biological methods -A review. Food Technology and Biotechnology, 51(1).
A.R.C. (2020). Biopolymers Market–Forecast (2022–2027).https://www.industryarc.com/Report/11739/biopolymersmarket.html this site was avaliable on 23. 12.2022
Balakrishna Pillai, A., Jaya Kumar, A., & Kumarapillai, H. (2020). Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) in Bacillus aryabhattai and cytotoxicity evaluation of PHBV/poly(ethylene glycol) blends. 3 Biotech, 10(2). https://doi.org/10.1007/s13205-019-2017-9
Barr, T. (2020). The Past and Future of the Seaweed Derived Impression Material Alginate.
Braunegg, G., Lefebvre, G., & Genser, K. F. (1998). Polyhydroxyalkanoates, biopolyesters from renewable resources: Physiological and engineering aspects. In Journal of Biotechnology (Vol. 65, Issues 2–3). https://doi.org/10.1016/S0168-1656(98)00126-6

Baranwal, J., Barse, B., Fais, A., Delogu, G. L., & Kumar, A. (2022). Biopolymer: A Sustainable Material for Food and Medical Applications. Polymers, 14(5), 983. https://doi.org/10.3390/polym14050983
Çakmak, H., Çelik, P. A., Çınar, S., Hoşgün, E. Z., Mutlu, M. B., & Çabuk, A. (2020). Levan Production Potentials from Different Hypersaline Environments in Turkey. Journal of Microbiology, Biotechnology and Food Sciences, 10(1). https://doi.org/10.15414/jmbfs.2020.10.1.61-64
Çankaya, N. (2017). Biyopolimerler ve Montmorillonit Kil Nanokompozitleri. Politeknik Dergisi, 20(3).
Chen, G. Q., & Wu, Q. (2005). The application of polyhydroxyalkanoates as tissue engineering materials. In Biomaterials (Vol. 26, Issue 33). https://doi.org/10.1016/j.biomaterials.2005.04.036
Chen, Y., Guo, Z., Wang, X., & Qiu, C. (2008). Sample preparation. In Journal of Chromatography A (Vol. 1184, Issues 1–2). https://doi.org/10.1016/j.chroma.2007.10.026
Chesterman, J., Zhang, Z., Ortiz, O., Goyal, R., & Kohn, J. (2020). Biodegradable polymers. In Principles of Tissue Engineering. https://doi.org/10.1016/B978-0-12-818422-6.00019-8
Crini, G., & Lichtfouse, E. (2019). Sustainable Agriculture Reviews 35. In Sustainable Agriculture Reviews (Vol. 35, Issue Chitin and Chitosan: History, Fundamentals and Innovations).
Dash, M., Chiellini, F., Ottenbrite, R. M., & Chiellini, E. (2011). Chitosan - A versatile semi-synthetic polymer in biomedical applications. In Progress in Polymer Science (Oxford) (Vol. 36, Issue 8). https://doi.org/10.1016/j.progpolymsci.2011.02.001
de Lima Batista, A. C., de Souza Neto, F. E., & de Souza Paiva, W. (2018). Review of fungal chitosan: past, present and perspectives in Brazil. In Polimeros (Vol. 28, Issue 3). https://doi.org/10.1590/0104-1428.08316
Dovedytis, M., Liu, Z. J., & Bartlett, S. (2020). Hyaluronic acid and its biomedical applications: A review. In Engineered Regeneration (Vol. 1). https://doi.org/10.1016/j.engreg.2020.10.001
Dunlop, W. F., & Robards, A. W. (1973). Ultrastructural study of poly β hydroxybutyrate granules from Bacillus cereus. Journal of Bacteriology, 114(3). https://doi.org/10.1128/jb.114.3.1271-1280.1973
Durner, R., Witholt, B., & Egli, T. (2000). Accumulation of poly[(R)-3-hydroxyalkanoates] in Pseudomonas oleovorans during growth with octanoate in continuous culture at different dilution rates. Applied and Environmental Microbiology, 66(8). https://doi.org/10.1128/AEM.66.8.3408-3414.2000
el Knidri, H., Belaabed, R., Addaou, A., Laajeb, A., & Lahsini, A. (2018). Extraction, chemical modification and characterization of chitin and chitosan. In International Journal of Biological Macromolecules (Vol. 120). https://doi.org/10.1016/j.ijbiomac.2018.08.139
Falcone, S. J., Palmeri, D., & Berg, R. A. (2006). Biomedical applications of hyaluronic acid. ACS Symposium Series, 934. https://doi.org/10.1021/bk-2006-0934.ch008
Gedikli, S., Çelik, P. A., Demirbilek, M., Mutlu, M. B., Denkbaş, E. B., & Çabuk, A. (2019). Experimental Exploration of Thermostable Poly (β-Hydroxybutyrates) by Geobacillus kaustophilus Using Box-Behnken Design. Journal of Polymers and the Environment, 27(2). https://doi.org/10.1007/s10924-018-1335-z
Ghosh, S., Lahiri, D., Nag, M., Dey, A., Sarkar, T., Pathak, S. K., Edinur, H. A., Pati, S., & Ray, R. R. (2021). Bacterial biopolymer: Its role in pathogenesis to effective biomaterials. In Polymers (Vol. 13, Issue 8). https://doi.org/10.3390/polym13081242
Gomes, T. D., Caridade, S. G., Sousa, M. P., Azevedo, S., Kandur, M. Y., Öner, E. T., Alves, N. M., & Mano, J. F. (2018). Adhesive free-standing multilayer films containing sulfated levan for biomedical applications. Acta Biomaterialia, 69. https://doi.org/10.1016/j.actbio.2018.01.027
González-Garcinuño, Á., Tabernero, A., Domínguez, Á., Galán, M. A., & Martin del Valle, E. M. (2018). Levan and levansucrases: Polymer, enzyme, micro-organisms and biomedical applications. Biocatalysis and Biotransformation, 36(3). https://doi.org/10.1080/10242422.2017.1314467
Gouda, M. K., Swellam, A. E., & Omar, S. H. (2001). Production of PHB by a Bacillus megaterium strain using sugarcane molasses and corn steep liquor as sole carbon and nitrogen sources. Microbiological Research, 156(3). https://doi.org/10.1078/0944-5013-00104
Güngör, G., Gedikli, S., Toptaş, Y., Akgün, D. E., Demirbilek, M., Yazıhan, N., Aytar Çelik, P., Denkbaş, E. B., & Çabuk, A. (2019). Bacterial hyaluronic acid production through an alternative extraction method and its characterization. Journal of Chemical Technology and Biotechnology, 94(6). https://doi.org/10.1002/jctb.5957
Güngörmedi, G., Demirbilek, M., Mutlu, M. B., Denkbaş, E. B., & Çabuk, A. (2014). Polyhydroxybutyrate and hydroxyvalerate production by Bacillus megaterium strain A1 isolated from hydrocarbon-contaminated soil. Journal of Applied Polymer Science, 131(15). https://doi.org/10.1002/app.40530
Haddar, A., Hamed, M., Bouallegue, A., Bastos, R., Coelho, E., & Coimbra, M. A. (2021). Structural elucidation and interfacial properties of a levan isolated from Bacillus mojavensis. Food Chemistry, 343. https://doi.org/10.1016/j.foodchem.2020.128456
Hinchliffe, J. D., Madappura, A. P., Syed Mohamed, S. M. D., & Roy, I. (2021). Biomedical applications of bacteria-derived polymers. In Polymers (Vol. 13, Issue 7). https://doi.org/10.3390/polym13071081
Jose, A. A., Hazeena, S. H., Lakshmi, N. M., B, A. K., Madhavan, A., Sirohi, R., Tarafdar, A., Sindhu, R., Awasthi, M. K., Pandey, A., & Binod, P. (2022). Bacterial biopolymers: From production to applications in biomedicine. Sustainable Chemistry and Pharmacy, 25, 100582. https://doi.org/10.1016/j.scp.2021.100582
Koller, M., Atlić, A., Dias, M., Reiterer, A., & Braunegg, G. (2010). Microbial PHA Production from Waste Raw Materials. https://doi.org/10.1007/978-3-642-03287-5_5
Kuzgun, N. K., & İnanlı, A. G. (2013). Kitosan üretimi ve özellikleri ile kitosanın kullanım alanları. Türk Bilimsel Derlemeler Dergisi 6, 6(2).
Lee, K. Y., & Mooney, D. J. (2012). Alginate: Properties and biomedical applications. In Progress in Polymer Science (Oxford) (Vol. 37, Issue 1). https://doi.org/10.1016/j.progpolymsci.2011.06.003
Liu, L., Liu, Y., Li, J., Du, G., & Chen, J. (2011). Microbial production of hyaluronic acid: current state, challenges, and perspectives. In Microbial Cell Factories (Vol. 10). https://doi.org/10.1186/1475-2859-10-99
Madison, L. L., & Huisman, G. W. (1999). Metabolic Engineering of Poly(3-Hydroxyalkanoates): From DNA to Plastic. Microbiology and Molecular Biology Reviews, 63(1). https://doi.org/10.1128/mmbr.63.1.21-53.1999
Masaeli, E., Morshed, M., Nasr-Esfahani, M. H., Sadri, S., Hilderink, J., van Apeldoorn, A., van Blitterswijk, C. A., & Moroni, L. (2013). Fabrication, Characterization and Cellular Compatibility of Poly (Hydroxy Alkanoate) Composite Nanofibrous Scaffolds for Nerve Tissue Engineering. PLoS ONE, 8(2). https://doi.org/10.1371/journal.pone.0057157
Miu, D. M., Eremia, M. C., & Moscovici, M. (2022). Polyhydroxyalkanoates (PHAs) as Biomaterials in Tissue Engineering: Production, Isolation, Characterization. In Materials (Vol. 15, Issue 4). https://doi.org/10.3390/ma15041410
Mohan, S., Oluwafemi, O. S., Kalarikkal, N., Thomas, S., & Songca, S. P. (2016). Biopolymers – Application in Nanoscience and Nanotechnology. In Recent Advances in Biopolymers. https://doi.org/10.5772/62225
Moradali, M. F., & Rehm, B. H. A. (2020). Bacterial biopolymers: from pathogenesis to advanced materials. In Nature Reviews Microbiology (Vol. 18, Issue 4). https://doi.org/10.1038/s41579-019-0313-3
Morin-Crini, N., Lichtfouse, E., Torri, G., & Crini, G. (2019). Applications of chitosan in food, pharmaceuticals, medicine, cosmetics, agriculture, textiles, pulp and paper, biotechnology, and environmental chemistry. In Environmental Chemistry Letters (Vol. 17, Issue 4). https://doi.org/10.1007/s10311-019-00904-x
Muhammadi, Shabina, Afzal, M., & Hameed, S. (2015). Bacterial polyhydroxyalkanoates-eco-friendly next generation plastic: Production, biocompatibility, biodegradation, physical properties and applications. Green Chemistry Letters and Reviews, 8(3–4). https://doi.org/10.1080/17518253.2015.1109715
Murado, M. A., Montemayor, M. I., Cabo, M. L., Vázquez, J. A., & González, M. P. (2012). Optimization of extraction and purification process of hyaluronic acid from fish eyeball. Food and Bioproducts Processing, 90(3). https://doi.org/10.1016/j.fbp.2011.11.002
Odian, G. (2004). Principles of Polymerization. In Principles of Polymerization. https://doi.org/10.1002/047147875x
Öner, E. T., Hernández, L., & Combie, J. (2016). Review of Levan polysaccharide: From a century of past experiences to future prospects. In Biotechnology Advances (Vol. 34, Issue 5). https://doi.org/10.1016/j.biotechadv.2016.05.002
Othman, S. H. (2014). Bio-nanocomposite Materials for Food Packaging Applications: Types of Biopolymer and Nano-sized Filler. Agriculture and Agricultural Science Procedia, 2. https://doi.org/10.1016/j.aaspro.2014.11.042
Pawar, S. N., & Edgar, K. J. (2012). Alginate derivatization: A review of chemistry, properties and applications. In Biomaterials (Vol. 33, Issue 11). https://doi.org/10.1016/j.biomaterials.2012.01.007
Penkhrue, W., Jendrossek, D., Khanongnuch, C., Pathomareeid, W., Aizawa, T., Behrens, R. L., & Lumyongid, S. (2020). Response surface method for polyhydroxybutyrate (PHB) bioplastic accumulation in Bacillus drentensis BP17 using pineapple peel. PLoS ONE, 15(3). https://doi.org/10.1371/journal.pone.0230443
Pereira, R., Mendes, A., & Bártolo, P. (2013). Alginate/Aloe vera hydrogel films for biomedical applications. Procedia CIRP, 5. https://doi.org/10.1016/j.procir.2013.01.042
Poirier, Y. (2002). Polyhydroxyalknoate synthesis in plants as a tool for biotechnology and basic studies of lipid metabolism. In Progress in Lipid Research (Vol. 41, Issue 2). https://doi.org/10.1016/S0163-7827(01)00018-2
Puscaselu, R. G., Lobiuc, A., Dimian, M., & Covasa, M. (2020). Alginate: From food industry to biomedical applications and management of metabolic disorders. In Polymers (Vol. 12, Issue 10). https://doi.org/10.3390/polym12102417
Quillaguamán, J., Guzmán, H., Van-Thuoc, D., & Hatti-Kaul, R. (2010). Synthesis and production of polyhydroxyalkanoates by halophiles: Current potential and future prospects. In Applied Microbiology and Biotechnology (Vol. 85, Issue 6). https://doi.org/10.1007/s00253-009-2397-6
Ramsay, B. A., Saracovan, I., Ramsay, J. A., & Marchessault, R. H. (1991). Continuous production of long-side-chain poly-β-hydroxyalkanoates by Pseudomonas oleovorans. Applied and Environmental Microbiology, 57(3). https://doi.org/10.1128/aem.57.3.625-629.1991
Rebelo, R., Fernandes, M., & Fangueiro, R. (2017).
Biopolymers in Medical Implants: A Brief Review. Procedia Engineering, 200, 236–243. https://doi.org/10.1016/j.proeng.2017.07.034
Rinaudo, M. (2006). Chitin and chitosan: Properties and applications. In Progress in Polymer Science (Oxford) (Vol. 31, Issue 7). https://doi.org/10.1016/j.progpolymsci.2006.06.001
Ruiz, G. A. M., & Corrales, H. F. Z. (2017). Chitosan, Chitosan Derivatives and their Biomedical Applications. In Biological Activities and Application of Marine Polysaccharides. https://doi.org/10.5772/66527
Sahoo, D. R., & Biswal, T. (2021). Alginate and its application to tissue engineering. In SN Applied Sciences (Vol. 3, Issue 1). https://doi.org/10.1007/s42452-020-04096-w
Salehizadeh, H., & van Loosdrecht, M. C. M. (2004). Production of polyhydroxyalkanoates by mixed culture: Recent trends and biotechnological importance. Biotechnology Advances, 22(3). https://doi.org/10.1016/j.biotechadv.2003.09.003
Salernitano, E., & Migliaresi, C. (2018). Composite Materials for Biomedical Applications: A Review: https://doi.org/10.1177/228080000300100102
Saranraj, P., & Naidu, M. A. (2013). Hyaluronic Acid Production and its Applications-A Review. In International Journal of Pharmaceutical & Biological Archives (Vol. 4, Issue 5).
Selyanin, M. A., Boykov, P. Ya., Khabarov, V. N., & Polyak, F. (2015). The History of Hyaluronic Acid Discovery, Foundational Research and Initial Use. In Hyaluronic Acid. https://doi.org/10.1002/9781118695920.ch1
Slater, S., Gallaher, T., & Dennis, D. (1992). Production of poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) in a recombinant Escherichia coli strain. Applied and Environmental Microbiology, 58(4). https://doi.org/10.1128/aem.58.4.1089-1094.1992
Srikanth, R., Reddy, C. H. S. S. S., Siddartha, G., Ramaiah, M. J., & Uppuluri, K. B. (2015). Review on production, characterization and applications of microbial levan. In Carbohydrate Polymers (Vol. 120). https://doi.org/10.1016/j.carbpol.2014.12.003
Steinbüchel, A., & Schlegel, H. G. (1991). Physiology and molecular genetics of poly (β‐hydroxyalkanoic acid) synthesis in Alcaligenes eutrophus. In Molecular Microbiology (Vol. 5, Issue 3). https://doi.org/10.1111/j.1365-2958.1991.tb00725.x
Szekalska, M., Puciłowska, A., Szymańska, E., Ciosek, P., & Winnicka, K. (2016). Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications. In International Journal of Polymer Science (Vol. 2016). https://doi.org/10.1155/2016/7697031
Taidi, B., Anderson, A. J., Dawes, E. A., & Byrom, D. (1994). Effect of carbon source and concentration on the molecular mass of poly(3-hydroxybutyrate) produced by Methylobacterium extorquens and Alcaligenes eutrophus. Applied Microbiology and Biotechnology, 40(6). https://doi.org/10.1007/BF00173975
Taran, M., Etemadi, S., & Safaei, M. (2017). Microbial levan biopolymer production and its use for the synthesis of an antibacterial iron (II,III) oxide–levan nanocomposite. Journal of Applied Polymer Science, 134(12). https://doi.org/10.1002/app.44613
Tobin, K. M., & O’Connor, K. E. (2005). Polyhydroxyalkanoate accumulating diversity of Pseudomonas species utilising aromatic hydrocarbons. FEMS Microbiology Letters, 253(1). https://doi.org/10.1016/j.femsle.2005.09.025
Tohme, S., Hacıosmanoğlu, G. G., Eroğlu, M. S., Kasavi, C., Genç, S., Can, Z. S., & Toksoy Oner, E. (2018). Halomonas smyrnensis as a cell factory for co-production of PHB and levan. International Journal of Biological Macromolecules, 118. https://doi.org/10.1016/j.ijbiomac.2018.06.197
Wani, S., Shaikh, S., & Sayyed z, R. (2016). Microbial Biopolymers in Biomedical Field. MOJ Cell Science & Report, 3(3). https://doi.org/10.15406/mojcsr.2016.03.00055
Williams, S. F., Martin, D. P., Horowitz, D. M., & Peoples, O. P. (1999). PHA applications: Addressing the price performance issue I. Tissue engineering. International Journal of Biological Macromolecules, 25(1–3). https://doi.org/10.1016/S0141-8130(99)00022-7
Yasin, A., Ren, Y., Li, J., Sheng, Y., Cao, C., & Zhang, K. (2022). Advances in Hyaluronic Acid for Biomedical Applications. Frontiers in Bioengineering and Biotechnology, 10, 910290. https://doi.org/10.3389/fbioe.2022.910290
Zhang, Z., Ortiz, O., Goyal, R., & Kohn, J. (2014). Biodegradable Polymers. In Handbook of Polymer Applications in Medicine and Medical Devices. https://doi.org/10.1016/B978-0-323-22805-3.00013-X

Ayrıntılar

Birincil Dil

İngilizce

Konular

Biyomedikal Mühendisliği (Diğer)

Bölüm

Derleme

Yazarlar

Belma Nural Yaman ^*
0000-0003-2576-1300
Türkiye

Benay Çolak
0000-0003-2116-5966
Türkiye

Doç. Dr. Ahmet Çabuk
0000-0002-4619-6948
Türkiye

Erken Görünüm Tarihi

22 Aralık 2023

Yayımlanma Tarihi

22 Aralık 2023

Gönderilme Tarihi

21 Kasım 2022

Kabul Tarihi

25 Ocak 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 31 Sayı: 4

DOI

https://doi.org/10.31796/ogummf.1205232

IZ

https://izlik.org/JA34ZX69ZW

APA

Nural Yaman, B., Çolak, B., & Çabuk, D. D. A. (2023). INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi, 31(4), 975-987. https://doi.org/10.31796/ogummf.1205232

AMA

1.Nural Yaman B, Çolak B, Çabuk DDA. INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS. ESOGÜ Müh Mim Fak Derg. 2023;31(4):975-987. doi:10.31796/ogummf.1205232

Chicago

Nural Yaman, Belma, Benay Çolak, ve Doç. Dr. Ahmet Çabuk. 2023. “INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS”. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi 31 (4): 975-87. https://doi.org/10.31796/ogummf.1205232.

EndNote

Nural Yaman B, Çolak B, Çabuk DDA (01 Aralık 2023) INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi 31 4 975–987.

IEEE

[1]B. Nural Yaman, B. Çolak, ve D. D. A. Çabuk, “INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS”, ESOGÜ Müh Mim Fak Derg, c. 31, sy 4, ss. 975–987, Ara. 2023, doi: 10.31796/ogummf.1205232.

ISNAD

Nural Yaman, Belma - Çolak, Benay - Çabuk, Doç. Dr. Ahmet. “INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS”. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi 31/4 (01 Aralık 2023): 975-987. https://doi.org/10.31796/ogummf.1205232.

JAMA

1.Nural Yaman B, Çolak B, Çabuk DDA. INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS. ESOGÜ Müh Mim Fak Derg. 2023;31:975–987.

MLA

Nural Yaman, Belma, vd. “INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS”. Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi, c. 31, sy 4, Aralık 2023, ss. 975-87, doi:10.31796/ogummf.1205232.

Vancouver

1.Belma Nural Yaman, Benay Çolak, Doç. Dr. Ahmet Çabuk. INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS. ESOGÜ Müh Mim Fak Derg. 01 Aralık 2023;31(4):975-87. doi:10.31796/ogummf.1205232

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INSIGHT TO THE MICROBIAL BIOPOLYMERS USED IN BIOMEDICAL APPLICATIONS

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