The Effect of Regular Walking and Intermittent Fasting on Insulin Resistance and Blood Lipid Profile: A Clinical Study

Öz

The aim of this study was to investigate the effects of regular walking and intermittent fasting on insulin resistance and blood lipid profile. Thirty-eight adults (22 males, 16 females) aged ≥18 years who practiced intermittent fasting for at least 24 days and regularly practiced walking exercise for 30 minutes 5 days a week were included in the study. Waist circumference, body weight, blood lipid profile, insulin resistance and other biochemical parameters were measured before and after intermittent fasting. Paired t-test was used to analyze the data. A significant decrease in waist circumference (pretest: 97.28±12.42; posttest: 92.31±12.15, p<0.001) and body weight (pretest: 81.22±14.30; posttest: 78.88±13.37, p=0.001) was observed after intermittent fasting. Significant improvements were also observed in HbA1C, HDL and insulin levels (p<0.05). However, no significant changes were observed in fasting glucose, ALT, AST, B12, cholesterol, LDL, triglyceride and TSH levels (p>0.05). In gender comparison, the increase in HDL levels and the decrease in waist circumference and body weight after fasting were more significant in men than in women. This study shows that intermittent fasting and regular walking exercise have positive effects on BMI, waist circumference, body weight, insulin sensitivity and blood lipid profile in overweight adults. Intermittent fasting can be considered a potential strategy for the treatment of obesity and related metabolic disorders. However, larger and long-term studies are needed to generalize the results.

Anahtar Kelimeler

• Blood lipid profile
• intermittent fasting
• insulin resistance
• regular walking

Düzenli Yürüyüş Yapma ve Aralıklı Orucun İnsülin Direnci ve Kan Lipid Profili Üzerindeki Etkisi: Klinik Bir Çalışma

Öz

Bu çalışmanın amacı, düzenli yürüyüş yapma ve aralıklı orucun insülin direnci ve kan lipid profili üzerindeki etkilerini araştırmaktır. Çalışmaya en az 24 gün aralıklı oruç tutan ve düzenli olarak haftada 5 gün 30 dakika yürüyüş egzersizi yapan 18 yaş üstü 38 yetişkin (22 erkek, 16 kadın) dahil edildi. Bel çevresi, vücut ağırlığı, kan lipid profili, insülin direnci ve diğer biyokimyasal parametreler aralıklı oruçtan önce ve sonra ölçüldü. Verileri analiz etmek için eşleştirilmiş t-testi kullanılmıştır. Aralıklı oruç sonrasında bel çevresinde (ön test: 97,28±12,42; son test: 92,31±12,15, p<0,001) ve vücut ağırlığında (ön test: 81,22±14,30; son test: 78,88±13,37, p=0,001) anlamlı bir azalma gözlendi. HbA1C, HDL ve insülin seviyelerinde de anlamlı iyileşmeler gözlenmiştir (p<0,05). Ancak açlık glukozu, ALT, AST, B12, kolesterol, LDL, trigliserit ve TSH düzeylerinde anlamlı bir değişiklik gözlenmedi (p>0,05). Cinsiyet karşılaştırmasında, açlık sonrası HDL düzeylerindeki artış ile bel çevresi ve vücut ağırlığındaki azalma erkeklerde kadınlara göre daha anlamlı bulunmuştur. Bu çalışma, aralıklı orucun ve düzenli yürüyüş egzersizi yapmanın fazla kilolu yetişkinlerde VKİ, bel çevresi, vücut ağırlığı, insülin duyarlılığı ve kan lipit profili üzerinde olumlu etkileri olduğunu göstermektedir. Aralıklı oruç, obezite ve ilgili metabolik bozuklukların tedavisinde potansiyel bir strateji olarak düşünülebilir. Ancak sonuçların genellenebilmesi için daha büyük ve uzun süreli çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Aralıklı oruç
• düzenli yürüyüş
• insülin direnci
• kan lipid profili

Kaynakça

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