Arı sütünün diyabet, tümör oluşumu ve metabolik sendrom üzerine etkisi

Öz

Arı sütü kozmetik ve ticari tıbbi ürünlerin üretiminde ve fonksiyonel besin olarak kullanımaktadır. Kraliçe arının yaşamı boyunca ve larvaların ise 3 gün kullandığı arı sütü insan sağlığını geliştirici etkilere sahiptir. Esansiyel amino asitlerden zengin olan arı sütü, çeşitli fenolik bileşikleri, yağ asitlerini, proteinleri, peptidleri, karbohitratları, vitaminleri ve mineralleri yapısında barındırmaktadır. Bu derleme arı sütünün hipoglisemik, hipotansif, hipokolestrolemik, antitümör, antidiyabetik etkisi ve metabolik sendrom gelişimine etkisini açıklayacaktır. 

Anahtar Kelimeler

• Arı Sütü,Antidiyabetik Etki,Antitumör Aktivite,Metbolik Sendrom

The effect of royal jelly on diabetes, tumor formation and metabolic syndrome

Abstract

Royal jelly has been used in manufacturing of cosmetics and commercial medical products and as a founctional food. Royal jelly which used during the lifetime of queen bee and three days by larval and has health promotion effects on humans. Royal jelly which is rich from essential amino acids, consist of many kind of phenolic coumpounds, fatty acids, proteins, carbohydrates, vitamins and minerals. This review explains the hypoglisemic, hypothensive, hypocholestrolemic, antitumor, antidiabetic effects of royal jelly and its effect on devolepment of metabolic syndrome.

Keywords

• Royal Jelly,Antidiabetic Effect,Antitumor Activity,Metabolic Syndrome

Kaynakça

1. Referans1-Ramadan MF, Al-Ghamdi A. Bioactive compounds and health-promoting properties of royal jelly: A review. J Funct Foods. 2012; 4(1):39-52.
2. Referans2-Fratini, F, Cilia G, Mancini S, Felicioli A: Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiol Res. Novembet 2016; 192:130-141.
3. Referans3-Sabatini, AG, Marcazzan, GL, Caboni, MF, Bogdanov S, de Almeida-Muradian, LB. Quality and standardisation of royal jelly. JAAS. 2009; 1(1):1-6.
4. Referans4-Schmidt, JO. Bee Products, Chemical Composition and Application, (Ed.)Mizrahi A, Lensky Y, Bee Products Properties, Applications, and Apitherapy, New York and London, Plenum Press;1997.
5. Referans5-Albert S, Bhattacharya D, Klaudiny J, Schmitzova J, Simuth J. The family of major royal jelly proteins and its evolution. J Mol Evol. Febuary 1999; 49:290-297.
6. Referans6-Cornara L, Biagi M, Xiao J, Burlando B. Therapeutic Properties of Bioactive Compounds from Different Honeybee Products. Front Pharmacol. 2017; 8(412):1-20.
7. Referans7-Akyol E, Baran Y. Arı Sütünün Yapısı, insanlar ve arılar için önemi. U Arı Drg. 2015; 15(1):16-21.
8. Referans8-Xue XF, Zhou JH, Wu LM, Fu LH, Zhao J. HPLC determination of adenosine in royal jelly. Food Chem. 2009; 115(2):715-719.

9. Referans9-Stocker A, Schramel P, Kettrup A, Bengsch E. Trace and mineral elements in royal jelly and homeostaic effects. J Trace Elem Med Biol. 2005; 19(2-3):183-189.
10. Referans10-Khoshpey B, Djazayeri S, Amiri F, et al. Effect of Royal Jelly Intake on Serum Glucose, Apolipoprotein A-I (ApoA-I), Apolipoprotein B (ApoB) and ApoB/ApoA-I Ratios in Patients with Type 2 Diabetes: A Randomized, Double-Blind Clinical Trial Study. Can J Diabetes. 2016; 40(4):324-8.
11. Referans11-Yoneshiro T, Kaede R, Nagaya K, et al. Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. Obes Res Clin Pract. 2017; Jan 11.
12. Referans12-Gawish AM, ElFiky S, Therase M, AbdElraaof A, Khalil W, Mohamed KA. Sperm abnormality toxicity due to cyclosporine A and the ameliorative effect of royal jelly in male rats. JOBAZ. 2016; 76:60-73.
13. Referans13-Mishima S, Suzuki KM, Isohama Y, et al. Royal jelly has estrogenic effects in vitro and in vivo. J Ethnopharmacol.2005; 101(1-3):215–220.
14. Referans14-Estiyaghi M, Deldar H, Pirsaraei ZA, Shohreh B. Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro and embryonic development following in vitro fertilization. Theriogenology. 2016; 86(9):2210-2221.
15. Referans15-Pourmoradian S, Mahdavi R, Mobasseri M, Effects of royal jelly suplementation on body weight and dietary intake in type 2 diabetic females. Health Promot Perspect. 2012; 2(2):231-235.
16. Referans16-Pourmoradian S, Mahdavi R, Mobasseri M, Faramarzi E, Mobasseri M. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial. Chin J Integr Med. 2014; 20(5):347-352.
17. Referans17-Münstedt K, Bargello M, Hauenschild A. Royal jelly reduces the serum glucose levels in healthy subjects. J Med Food. 2009; 12(5):1170-1172.
18. Referans18-Zamami Y, Takatori S, Goda M, et al. Royal jelly ameliorates insulin resistance in fructose-drinking rats. Biol Pharm Bull. 2008; 31(11):2103-2107.
19. Referans19-Mobasseri M, Ghiyasvand S, Ostadrahimi A, Ghojazadeh M, Noshad H, Pourmoradian S. Effect of fresh royal jelly ingestion on glycemic response in patients with type 2 diabetes. Iran Red Crescent Med J. 2015; 17(9):1-5.e20074.
20. Referans20-Siavash M, Shokri S, Haghighi S, Mohammadi M, Shahtalebi MA, Farajzadehgan Z. The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series. J Res Med Sci. 2011; 16(7):904-909.
21. Referans21-Kashima Y, Kanematsu S, Asai S, et al. Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly. PloS One. 2014; 9(8):1-13.
22. Referans22-Fan P, Han B, Feng M, et al. Functional and Proteomic Investigations Reveal Major Royal Jelly Protein 1 Associated with Anti-hypertension Activity in Mouse Vascular Smooth Muscle Cells. Sci Rep. 2016; 6(30230):1-13.
23. Referans23-Takikawa M, Kumagai A, Hirata H, et al. 10-Hydroxy-2-decenoic acid, a unique medium-chain fatty acid, activates 5'-AMP-activated protein kinase in L6 myotubes and mice. Mol Nutr Food Res. 2013; 57(10):1794-1802.
24. Referans24-Xu D, Mei X, Xu S. [The research of 10-hydroxy-2-decenoic acid on experiment hyperlipoidemic rat]. Zhong Yao Cai. 2002; 25(5):346-347.
25. Referans25-Kamakura M, Moriyama T, Sakaki T. Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly. J Pharm Pharmacol. 2006; 58(12):1683-1689.
26. Referans26-Guo H, Saiga A, Sato M, et al. Royal jelly supplementation improves lipoprotein metabolism in humans. J Nutr Sci Vitaminol (Tokyo). 2007; 53(4):345-348.
27. Referans27-Matsui T, Yukiyoshi A, Doi S, Sugimoto H, Yamada H, Matsumoto K. Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR. J Nutr Biochem. 2002; 13(2):80–86.
28. Referans28-Takaki-Do S, Hashimoto K, Yamamura M, Kamei C. Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats. Acta Med Okayama. 2009; 63(1):57-64.
29. Referans29-Samaranayaka AGP, Li-Chan ECY. Food-derived peptidic antioxidants: A review of their production, assessment, and potential applications. J Funct Foods. May 2011; 3:229-254.
30. Referans30-Nagai, T, Inoue, R. Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food Chem. 2004; 84:181-186.
31. Referans31-Gomez-Caravaca AM, Gomez-Romero M, Arraez-Roman D, Segura-Carretero A, Fernandez-Gutierrez A. Advances in the analysis of phenolic compounds in products derived from bees. J Pharm Biomed Anal. 2006; 41(4):1220-1234.
32. Referans32-Buratti S, Benedetti S, Cosio MS. Evaluation of the antioxidant power of honey, propolis and royal jelly by amperometric flow injection analysis. Talanta. 2007; 71(3):1387-1392.
33. Referans33-Liu JR, Yang YC, Shi LS, Peng CC. Antioxidant properties of royal jelly associated with larval age and time of harvest. J Agric Food Chem. 2008; 56(23):11447-11452.
34. Referans34-Jamnik P, Goranovic D, Raspor P. Antioxidative action of royal jelly in the yeast cell. Exp Gerontol. 2007; 42(7):594-600.
35. Referans35-Silici S, Ekmekcioglu O, Eraslan G, Demirtas A. Antioxidative effect of royal jelly in cisplatin-induced testes damage. Urology. 2009; 74(3):545-551.
36. Referans36-Teixeira RR, de Souza AV, Peixoto LG, Machado HL, Caixeta DC, Vilela DD, Baptista NB, Franci CR, Espindola FS. Royal jelly decreases corticosterone levels and improves the brain antioxidant system in restraint and cold stressed rats. Neurosci Lett. August 2017; 655:179-185.
37. Referans37-Rahman Mohamed AA, Galal AAA, Elewa YHA. Comparative protective effects of royal jelly and cod liver oil against neurotoxic impact of tartrazine on male rat pups brain. Acta Histochemica. July 2015; 117:649-658.
38. Referans38-Abdel-Hafez SMN, Rifaai RA, Abdelzaher WH. Possible protective effect of royal jelly against cyclophosphamide induced prostatic damage in male albino rats; a biochemical, histological and immuno-histo-chemical study. Biomed Pharmacother. June 2017; 90:15-23.
39. Referans39-Orsolic N, Terzic S, Sver L, Basic I. Honey-bee products in prevention and/or therapy of murine transplantable tumours. J Sci Food Agric. February 2005; 85:363-370.
40. Referans40-Bincoletto C, Eberlin S, Figueiredo C AV, Luengo MB, Queiroz MLS. Effects produced by Royal Jelly on haematopoiesis: relation with host resistance against Ehrlich ascites tumour challenge. Int Immunopharmacol. 2005; 5(4):679–688.
41. Referans41-Shirzad M, Kordyazdi R, Shahinfard N, Nikokar M. Does Royal jelly affect tumor cells? HerbMed Pharmacol. 2013; 2(2):45-48.
42. Referans42-Tamura T, Fujii A, Kuboyama N. Antitumor effects of royal jelly (RJ). Nihon Yakurigaku Zasshi. 2000; 89(2):73-80.