Yıl 2020, Cilt 13 , Sayı 2, Sayfalar 403 - 413 2020-05-14

Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses

Derya KILIÇ [1] , Hakan YETİMALAR [2] , Mehmet KÖSEOĞLU [3] , Gülcan SAĞLAM [4]


Purpose: Human epididymis protein 4 (HE4) is a novel biomarker for ovarian cancers. The aim of this study is to assess the usefulness and efficacy of HE4, in comparison with CA-125 in the differential diagnosis of malignant and benign gynecological diseases in women with adnexal masses. Materials and Methods: 85 patients diagnosed with adnexial mass who were operated at a tertiary referral center between the years of 2012 and 2013 were included in the study. Demographic data, physical examination, results of the laboratory tests, imaging, and pathology were recorded from all subjects. Blood samples were collected before surgery for the evaluation of HE4 and CA-125 levels. Patients were divided into 4 groups according to their histopathologic diagnosis: benign (n:58), malignant (n:17), borderline (n:5) and metastatic (n:5) and serum CA-125 and HE4 levels were compared considering menopausal status. Results: Using 35 U/mL as the cut-off value, CA-125 had a sensitivity of 82.4%, spesificity of 67.2%, a negative predictive value of 92.9%, and a positive predictive value of %42.4%. For the same sensitivity level, specificity was 87.9%, negative predictive value was 94.4%, and the positive predictive value was 66.7% for HE4. Receiver operator characteristic (ROC) area under the curve was higher in both the premenopausal and postmenopausal group for the HE4 curve. Accordingly, sensitivity at set specificity of 90% was 82.4%, and 70.6% for 95% of specificity and 41.1% for 98%. Same sensitivity values for CA-125 were 47.1%, 35.3% and 23.5%, respectively. Conclusion: According to our study, especially in the premenopausal period, HE4 shows higher sensitivity and specificity values than CA-125.
adnexal mass, ovarian cancer, CA-125, HE4
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Birincil Dil en
Konular Kadın Hastalıkları ve Doğum
Yayımlanma Tarihi Mayıs 2020
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0001-8003-9586
Yazar: Derya KILIÇ (Sorumlu Yazar)
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0000-0000-0000
Yazar: Hakan YETİMALAR
Kurum: Izmir Gozde Hospital
Ülke: Turkey


Orcid: 0000-0001-0000-0000
Yazar: Mehmet KÖSEOĞLU
Kurum: Izmir Katip Celebi University Ataturk Training and Research Hospital
Ülke: Turkey


Orcid: 0000-0000-0000-0000
Yazar: Gülcan SAĞLAM
Kurum: ISTINYE UNIVERSITY, FACULTY OF MEDICINE
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 14 Mayıs 2020

Bibtex @araştırma makalesi { patd712419, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {13}, pages = {403 - 413}, doi = {10.31362/patd.712419}, title = {Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses}, key = {cite}, author = {KILIÇ, Derya and YETİMALAR, Hakan and SAĞLAM, Gülcan} }
APA KILIÇ, D , YETİMALAR, H , KÖSEOĞLU, M , SAĞLAM, G . (2020). Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses. Pamukkale Tıp Dergisi , 13 (2) , 403-413 . DOI: 10.31362/patd.712419
MLA KILIÇ, D , YETİMALAR, H , KÖSEOĞLU, M , SAĞLAM, G . "Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses". Pamukkale Tıp Dergisi 13 (2020 ): 403-413 <https://dergipark.org.tr/tr/pub/patd/issue/54327/712419>
Chicago KILIÇ, D , YETİMALAR, H , KÖSEOĞLU, M , SAĞLAM, G . "Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses". Pamukkale Tıp Dergisi 13 (2020 ): 403-413
RIS TY - JOUR T1 - Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses AU - Derya KILIÇ , Hakan YETİMALAR , Mehmet KÖSEOĞLU , Gülcan SAĞLAM Y1 - 2020 PY - 2020 N1 - doi: 10.31362/patd.712419 DO - 10.31362/patd.712419 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 403 EP - 413 VL - 13 IS - 2 SN - -1308-0865 M3 - doi: 10.31362/patd.712419 UR - https://doi.org/10.31362/patd.712419 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses %A Derya KILIÇ , Hakan YETİMALAR , Mehmet KÖSEOĞLU , Gülcan SAĞLAM %T Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses %D 2020 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 13 %N 2 %R doi: 10.31362/patd.712419 %U 10.31362/patd.712419
ISNAD KILIÇ, Derya , YETİMALAR, Hakan , KÖSEOĞLU, Mehmet , SAĞLAM, Gülcan . "Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses". Pamukkale Tıp Dergisi 13 / 2 (Mayıs 2020): 403-413 . https://doi.org/10.31362/patd.712419
AMA KILIÇ D , YETİMALAR H , KÖSEOĞLU M , SAĞLAM G . Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses. Pamukkale Tıp Dergisi. 2020; 13(2): 403-413.
Vancouver KILIÇ D , YETİMALAR H , KÖSEOĞLU M , SAĞLAM G . Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses. Pamukkale Tıp Dergisi. 2020; 13(2): 413-403.