Yıl 2020, Cilt 13 , Sayı 3, Sayfalar 529 - 533 2020-09-18

Is screening for Cushing's syndrome before bariatric surgery necessary?
Bariatrik cerrahi öncesi Cushing sendromu için tarama testi gerekli midir?

Mehmet Sercan ERTÜRK [1] , Mehmet CELİK [2] , Mehmet Nuri KOŞAR [3]


Purpose: Recent studies have shown a higher prevalence of Cushing's syndrome in obese patients with type 2 diabetes, but its prevalence in overweight and obese populations is not clear. The aim of this study was to evaluate the need for screening tests for Cushing's syndrome in morbidly obese individuals before bariatric surgery.

Materials and methods: Between January 2015 and December 2019, 300 patients with Body Mass Index (BMI) ≥35 kg/m2 that admitted to our endocrine outpatient clinic for evaluation before bariatric surgery were included in this study. Overnight low dose 1 mg dexamethasone suppression test was applied to all patients. Next day 8 am serum cortisol concentration less than 1.8 μg/dL was defined as normal suppression.

Results: Three hundred patients undergoing bariatric surgery were screened for Cushing's syndrome. The mean±standard deviation age of the patients was 39.4±11.7 years and 236 (77.3%) were women. The mean BMI of the patients was 45.9±5.5 kg/m2 before bariatric surgery. Forty-seven (15.7%) patients in type 2 diabetes mellitus, 28 (9.3%) patients with hypertension and 3 (1%) patients who had achived euthyroidism after levothyroxine treatment. The mean one year BMI after bariatric surgery was 28±4.6 kg/m2. Serum cortisol concentration was <1.8 μg/dL after 1 mg overnight dexamethasone suppression test in all patients.

Conclusion: The results of the evaluated data  revealed that the routine screening of morbidly obese individuals for Cushing's syndrome before bariatric surgery is not necessary.

Amaç: Son çalışmalar diyabeti bulunan obez hastalarda Cushing sendromu prevalansının daha yüksek olduğunu göstermiştir, ancak aşırı kilolu ve obez popülasyonlardaki prevalansı net değildir. Bu çalışmanın amacı, bariatrik cerrahi öncesi morbid obez bireylerde Cushing sendromu için tarama testlerine duyulan ihtiyacı değerlendirmektir.

Gereç ve yöntem: Ocak 2015-Aralık 2019 tarihleri ​​arasında bariatrik cerrahi öncesi değerlendirme için endokrin polikliniğimize başvuran Vücut Kitle İndeksi (VKİ) ≥ 35 kg/m2 olan 300 hasta çalışmaya dahil edildi. Tüm hastalara gece 23:00’de  düşük doz 1 mg deksametazon supresyon testi uygulandı. Ertesi gün sabah serum kortizol konsantrasyonu 1,8 μg/dL'den az olması normal supresyon olarak tanımlandı.

Bulgular: Bariatrik cerrahi geçiren 300 hasta Cushing sendromu açısından tarandı. Hastaların yaşı 39,4±11,7 yıl ve %77,3'ü kadındı. Bariatrik cerrahi öncesi hastaların ortalama VKİ'si 45,9±5,5 kg/m2 idi. Tip 2 diyabetli 47 (%15,7) hasta, hipertansif olan 28 (%9,3) hasta ve hipotiroidi tedavisi sonrası ötiroidi ile takip edilen 3 (%1) hasta olduğu saptandı. Bariatrik cerrahi sonrası ortalama 1 yıllık VKİ 28±4,6 kg/m2 idi. Tüm hastalarda 1 gecelik 1 mg deksametazon supresyon testinden sonra serum kortizol konsantrasyonu <1,8 μg/dL idi.

Sonuç: Çalışmamızda değerlendirilen verilerin sonuçları, morbid obez bireylerin bariatrik cerrahi öncesi Cushing sendromu için rutin olarak taranmasının gerekli olmadığını göstermiştir.

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Birincil Dil en
Konular Endokrinoloji ve Metabolizma
Yayınlanma Tarihi Eylül 2020
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-0411-553X
Yazar: Mehmet Sercan ERTÜRK (Sorumlu Yazar)
Kurum: Department of Endocrinology and Metabolic Diseases, University of Health Sciences, Antalya Training and Research Hospital
Ülke: Turkey


Orcid: 0000-0001-7364-370X
Yazar: Mehmet CELİK
Kurum: Department of Endocrinology and Metabolic Diseases, Trakya University Faculty of Medicine
Ülke: Turkey


Orcid: 0000-0002-8824-6632
Yazar: Mehmet Nuri KOŞAR
Kurum: Department of General Surgery, University of Health Sciences, Antalya Training and Research Hospital
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 18 Eylül 2020

Bibtex @araştırma makalesi { patd694115, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {13}, pages = {529 - 533}, doi = {10.31362/patd.694115}, title = {Is screening for Cushing's syndrome before bariatric surgery necessary?}, key = {cite}, author = {Ertürk, Mehmet Sercan and Celi̇k, Mehmet and Koşar, Mehmet Nuri} }
APA Ertürk, M , Celi̇k, M , Koşar, M . (2020). Is screening for Cushing's syndrome before bariatric surgery necessary? . Pamukkale Tıp Dergisi , 13 (3) , 529-533 . DOI: 10.31362/patd.694115
MLA Ertürk, M , Celi̇k, M , Koşar, M . "Is screening for Cushing's syndrome before bariatric surgery necessary?" . Pamukkale Tıp Dergisi 13 (2020 ): 529-533 <https://dergipark.org.tr/tr/pub/patd/issue/55097/694115>
Chicago Ertürk, M , Celi̇k, M , Koşar, M . "Is screening for Cushing's syndrome before bariatric surgery necessary?". Pamukkale Tıp Dergisi 13 (2020 ): 529-533
RIS TY - JOUR T1 - Is screening for Cushing's syndrome before bariatric surgery necessary? AU - Mehmet Sercan Ertürk , Mehmet Celi̇k , Mehmet Nuri Koşar Y1 - 2020 PY - 2020 N1 - doi: 10.31362/patd.694115 DO - 10.31362/patd.694115 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 529 EP - 533 VL - 13 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.694115 UR - https://doi.org/10.31362/patd.694115 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Is screening for Cushing's syndrome before bariatric surgery necessary? %A Mehmet Sercan Ertürk , Mehmet Celi̇k , Mehmet Nuri Koşar %T Is screening for Cushing's syndrome before bariatric surgery necessary? %D 2020 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 13 %N 3 %R doi: 10.31362/patd.694115 %U 10.31362/patd.694115
ISNAD Ertürk, Mehmet Sercan , Celi̇k, Mehmet , Koşar, Mehmet Nuri . "Is screening for Cushing's syndrome before bariatric surgery necessary?". Pamukkale Tıp Dergisi 13 / 3 (Eylül 2020): 529-533 . https://doi.org/10.31362/patd.694115
AMA Ertürk M , Celi̇k M , Koşar M . Is screening for Cushing's syndrome before bariatric surgery necessary?. Pamukkale Tıp Dergisi. 2020; 13(3): 529-533.
Vancouver Ertürk M , Celi̇k M , Koşar M . Is screening for Cushing's syndrome before bariatric surgery necessary?. Pamukkale Tıp Dergisi. 2020; 13(3): 529-533.