Yıl 2020, Cilt 13 , Sayı 3, Sayfalar 535 - 540 2020-09-18

Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia
İmmun trombositopenili çocuklarda kronikleşmeyi etkileyen klinik ve laboratuvar faktörler

Yılmaz AY [1] , Hakan SARBAY [2]


Abstract
Purpose: Immune thrombocytopenia (ITP) is one of the most common hematologic disorders in childhood.
Approximately 20-25% of patients with newly diagnosed ITP become chronic. We aimed to investigate the risk
factors that may affect chronicity of ITP.
Materials and methods: A total of 75 pediatric patients with ITP who were admitted to the Pediatric Hematology
Department of Pamukkale University Faculty of Medicine Hospital between January 2013 and July 2018 were
included in the study. 17 of the 75 cases were excluded, because 13 of those had lack of data in the system
and 4 of those were persistent ITP. The patients’ characteristics such as clinical features, laboratory results,
treatment requirements and type of treatment were retrospectively evaluated using the hospital's information
system.
Results: 46 (79.3%) of the 58 patients with ITP were acute and 12 (20.7%) of those were chronic. The mean age
of the patients with acute ITP was 4±3.84 years, while the mean age of the patient with chronic ITP was 9.6±4.6
years. Statistical analysis revealed that children with a diagnosis age greater than 10 years had a significantly
higher rate of chronicity. The dominant season in acute cases was spring with 34.8%, while in chronic cases it
was summer with 50%. Acute cases were significantly higher in the spring season. 26 of 46 patients with acute
ITP (56.5%) and 3 of 12 patients with chronic ITP (25%) were treated with IVIG firstly.
Conclusion: We determined that in newly diagnosed patients with ITP who are older 10 years of age and no
history of infection may have high risk of chronicity, while the patients diagnosed in the spring and administered
IVIG may have less chronicity. 

Purpose: Immune thrombocytopenia (ITP) is one of the most common hematologic disorders in childhood. Approximately 20-25% of patients with newly diagnosed ITP become chronic. We aimed to investigate the risk factors that may affect chronicity of ITP. Materials and Methods: A total of 75 pediatric patients with ITP who were admitted to the Pediatric Hematology Department of Pamukkale University Faculty of Medicine Hospital between January 2013 and July 2018 were included in the study. The patients’ characteristics such as clinical features, laboratory results, treatment requirements and type of treatment were retrospectively evaluated using the hospital's information system. Results: 46 (79,3%) of the 58 patients with ITP were acute and 12 (20,7%) of those were chronic. The mean age of the patients with acute ITP were 4 ± 3,84 years, while the mean age of the patient with chronic ITP were 9,6 ± 4,6 years. Statistical analysis revealed that children with a diagnosis age greater than 10 years had a significantly higher rate of chronicity. The dominant season in acute cases was spring with 34,8%, while in chronic cases it was summer with 50%. Acute cases were significantly higher in the spring season. 26 of 46 patients with acute ITP (56,5%) and 3 of 12 patients with chronic ITP (25%) were treated with IVIG firstly. Conclusion: We determined that in newly diagnosed patients with ITP who are older 10 years of age and no history of infection may have high risk of chronicity, while the patients diagnosed in the spring and administered IVIG may have less chronicity.
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Birincil Dil en
Konular Pediatri
Yayınlanma Tarihi Eylül 2020
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-5525-5647
Yazar: Yılmaz AY (Sorumlu Yazar)
Kurum: PAU. Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları
Ülke: Turkey


Orcid: 0000-0002-6332-2213
Yazar: Hakan SARBAY
Kurum: ISTANBUL YENI YUZYIL UNIVERSITY
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 18 Eylül 2020

Bibtex @araştırma makalesi { patd695982, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {13}, pages = {535 - 540}, doi = {10.31362/patd.695982}, title = {Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia}, key = {cite}, author = {Ay, Yılmaz and Sarbay, Hakan} }
APA Ay, Y , Sarbay, H . (2020). Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia . Pamukkale Tıp Dergisi , 13 (3) , 535-540 . DOI: 10.31362/patd.695982
MLA Ay, Y , Sarbay, H . "Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia" . Pamukkale Tıp Dergisi 13 (2020 ): 535-540 <https://dergipark.org.tr/tr/pub/patd/issue/55097/695982>
Chicago Ay, Y , Sarbay, H . "Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia". Pamukkale Tıp Dergisi 13 (2020 ): 535-540
RIS TY - JOUR T1 - Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia AU - Yılmaz Ay , Hakan Sarbay Y1 - 2020 PY - 2020 N1 - doi: 10.31362/patd.695982 DO - 10.31362/patd.695982 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 535 EP - 540 VL - 13 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.695982 UR - https://doi.org/10.31362/patd.695982 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia %A Yılmaz Ay , Hakan Sarbay %T Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia %D 2020 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 13 %N 3 %R doi: 10.31362/patd.695982 %U 10.31362/patd.695982
ISNAD Ay, Yılmaz , Sarbay, Hakan . "Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia". Pamukkale Tıp Dergisi 13 / 3 (Eylül 2020): 535-540 . https://doi.org/10.31362/patd.695982
AMA Ay Y , Sarbay H . Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia. Pamukkale Tıp Dergisi. 2020; 13(3): 535-540.
Vancouver Ay Y , Sarbay H . Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia. Pamukkale Tıp Dergisi. 2020; 13(3): 535-540.