Yıl 2021, Cilt 14 , Sayı 3, Sayfalar 612 - 619 2021-07-01

Yüksek sol atriyal hacim indeksi ve diyastolik disfonksiyonunda sol atriyum fonksiyonel parametrelerindeki değişiklikler
The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction

Mehmet Furkan ÖZEN [1] , Sara ÇETİN ŞANLIALP [2] , Hande ŞENOL [3] , Asuman KAFTAN [4]


Amaç: Önceki çalışmalar, sol ventrikül diyastolik disfonksiyon (DD) ile sol atriyal hacim indeksi (LAVi) arasındaki ilişkiyi göstermiştir. Bununla birlikte, sol atriyumun (LA) fonksiyonel parametrelerinin LAVi ve DD ile ilişkisi hakkında sınırlı sayıda çalışma bildirilmiştir. Bu nedenle, biz bu çalışmada yüksek LAVi ve DD'deki LA'nin fonksiyonel parametrelerindeki değişiklikleri incelemeyi amaçladık.
Gereç ve yöntem: 81 sağlıklı kişiye (LAVi <30 ml/m2) ve diyastolik disfonksiyonu olan 81 hastaya (LAVi>30 ml/m²) transtorasik ekokardiyografi yapıldı. Maksimum, minimum ve preatriyal hacimler alan-uzunluk yöntemi kullanılarak ölçüldü. LA'nin fonksiyonel parametreleri ve miyokardiyal performans indeksi (MPI), sol ventrikül kitle indeksi, rölatif duvar kalınlığı, maks LAVi / A', LA sferisite indeksi, toplam atriyal iletim süresi (PA-TDI) gibi diğer parametreler hesaplandı ve DD transmitral giriş, pulmoner ven girişi, pulse dalga (PW) Doppler ve doku Doppler (TDI) kullanılarak belirlendi.
Bulgular: Başlangıçta; maks LAVi, min LAVi, preA LAVi, maks LAVi/A ', LA sferisite indeksi, LA total boşalma hacmi (EV) indeksi, LA aktif EV indeksi, LA pasif EV indeksi, PA-TDI, sol ventriküler rölatif duvar kalınlığı, sol ventriküler kitle indeksi ve MPI, DD ve yüksek LAVi'li hastalarda anlamlı olarak daha yüksekti (p<0,05). Yaş farkı Ancova test analizi ile kaldırıldığında gruplar benzer toplam LAEF değerine sahipti. Korelasyon analizinde DD ve yüksek LAVi’si olan hastalarda LA genişleme indeksi yaşla birlikte azaldı (r=-0,408, p<0,001).

Sonuç: Maks LAVi, min LAVi, preA LAVi, maks LAVi/A ', LA sferisite indeksi, LA toplam EV indeksi, LA aktif EV indeksi, LA pasif EV indeksi, PA-TDI, rölatif duvar kalınlığı, sol ventriküler kitle indeksi ve MPI yaşa bakılmaksızın DD ve yüksek LAVi’si olan hastalarda daha yüksekti. Bu çalışmada sağlıklı kişilerde LA genişleme indeksi ve toplam LAEF, 57 yaşına kadar anlamlı değişiklikler göstermemekle birlikte her ikisi de DD'li ve yüksek LAVi'li hastalarda, özellikle ileri yaşlarda uzamış sol ventrikül yüksek dolum basıncına uzun süre maruz kalması nedeniyle azalabilir.

Purpose: Previous studies have shown the relationship between left ventricular diastolic dysfunction (DD) and left atrial volume index (LAVi). However, limited studies have been reported have been reported on the relationship of functional parameters of left atrium (LA) with LAVi and DD. Therefore, we aimed to examine the changes of functional parameters of LA in high LAVi and DD in this study.
Materials and methods: Transthoracic echocardiography was performed in 81 healty subjects (LAVi<30 ml/m2) and 81 patients with DD (LAVi>30 ml/m²). Maximum, minimum and preatrial volumes were measured using area-length method. The functional parameters of LA and other parameters including miyocardial performance index (MPI), left ventricular mass index, relative wall thickness, max LAVi/A’, LA sphericity index, the total atrial conduction time (PA-TDI) were calculated and DD was determined by using transmitral and pulmoner ven inflow, pulsed wave Doppler and tissue Doppler.
Results: Initially; max LAVi, min LAVi, preA LAVi, max LAVi/A’, LA sphericity index, LA total emptying volume (EV) index, LA active EV index, LA passive EV index, PA-TDI, left ventricular relative wall thickness, left ventricular mass index and MPI were significantly higher in patients with DD and high LAVi (p<0.05). The groups had similar total LA emptying fraction (LAEF) when age difference was removed with Ancova test analysis. LA expansion index decreased with age in patients with DD and high LAVi in correlation analysis (r=-0.408, p<0.001).
Conclusion: Max LAVi, min LAVi, preA LAVi, max LAVi/A’, LA sphericity index, LA total EV index, LA active EV index, LA passive EV index, PA-TDI, relative wall thickness, left ventricular mass index and MPI were higher in DD and high LAVi regardless of age. Although LA expansion index and total LAEF did not show significant alterations until 57 years in healthy subjects in this study, both of them may decrease in patients with DD and high LAVi, especially in advanced ages, due to prolonged exposure to high filling pressure of left ventricle.

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Birincil Dil en
Konular Kalp ve Kalp Damar Sistemi
Yayınlanma Tarihi Temmuz 2021
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-2108-4720
Yazar: Mehmet Furkan ÖZEN (Sorumlu Yazar)
Kurum: Anamur Devlet Hastanesi
Ülke: Turkey


Orcid: 0000-0001-9328-9197
Yazar: Sara ÇETİN ŞANLIALP
Kurum: DENİZLİ SERVERGAZİ DEVLET HASTANESİ
Ülke: Turkey


Orcid: 0000-0001-6395-7924
Yazar: Hande ŞENOL
Kurum: PAMUKKALE ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0002-5073-7348
Yazar: Asuman KAFTAN
Kurum: PAMUKKALE ÜNİVERSİTESİ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Temmuz 2021

Bibtex @araştırma makalesi { patd818185, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2021}, volume = {14}, pages = {612 - 619}, doi = {10.31362/patd.818185}, title = {The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction}, key = {cite}, author = {Özen, Mehmet Furkan and Çetin Şanlıalp, Sara and Şenol, Hande and Kaftan, Asuman} }
APA Özen, M , Çetin Şanlıalp, S , Şenol, H , Kaftan, A . (2021). The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction . Pamukkale Tıp Dergisi , 14 (3) , 612-619 . DOI: 10.31362/patd.818185
MLA Özen, M , Çetin Şanlıalp, S , Şenol, H , Kaftan, A . "The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction" . Pamukkale Tıp Dergisi 14 (2021 ): 612-619 <https://dergipark.org.tr/tr/pub/patd/issue/61233/818185>
Chicago Özen, M , Çetin Şanlıalp, S , Şenol, H , Kaftan, A . "The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction". Pamukkale Tıp Dergisi 14 (2021 ): 612-619
RIS TY - JOUR T1 - The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction AU - Mehmet Furkan Özen , Sara Çetin Şanlıalp , Hande Şenol , Asuman Kaftan Y1 - 2021 PY - 2021 N1 - doi: 10.31362/patd.818185 DO - 10.31362/patd.818185 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 612 EP - 619 VL - 14 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.818185 UR - https://doi.org/10.31362/patd.818185 Y2 - 2021 ER -
EndNote %0 Pamukkale Tıp Dergisi The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction %A Mehmet Furkan Özen , Sara Çetin Şanlıalp , Hande Şenol , Asuman Kaftan %T The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction %D 2021 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 14 %N 3 %R doi: 10.31362/patd.818185 %U 10.31362/patd.818185
ISNAD Özen, Mehmet Furkan , Çetin Şanlıalp, Sara , Şenol, Hande , Kaftan, Asuman . "The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction". Pamukkale Tıp Dergisi 14 / 3 (Temmuz 2021): 612-619 . https://doi.org/10.31362/patd.818185
AMA Özen M , Çetin Şanlıalp S , Şenol H , Kaftan A . The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction. Pam Tıp Derg. 2021; 14(3): 612-619.
Vancouver Özen M , Çetin Şanlıalp S , Şenol H , Kaftan A . The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction. Pamukkale Tıp Dergisi. 2021; 14(3): 612-619.
IEEE M. Özen , S. Çetin Şanlıalp , H. Şenol ve A. Kaftan , "The alterations of left atrial functional parameters in high left atrial volume index and diastolic dysfunction", Pamukkale Tıp Dergisi, c. 14, sayı. 3, ss. 612-619, Tem. 2021, doi:10.31362/patd.818185