Yıl 2021, Cilt 14 , Sayı 3, Sayfalar 706 - 716 2021-07-01

Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases
Olası ve kesin COVID-19 vakalarının sosyodemografik, klinik, radyolojik ve laboratuvar bulgularının retrospektif olarak karşılaştırılması

Erhan UGURLU [1] , Nazlı ÇETİN [2] , Furkan UFUK [3] , Nilüfer YİĞİT [4] , Hüseyin Gökhan YAVAŞ [5] , Seçim KOLAK [6] , Ahmet ÇALIŞKAN [7] , Neşe DURSUNOĞLU [8] , Sevin BAŞER ÖNCEL [9] , Göksel ALTINIŞIK ERGUR [10] , Sibel PEKCAN [11]


Purpose: We aimed to determine the number of possible and precise cases among the patients hospitalized in our clinic and to examine the differences between the sociodemographic, clinical, chest CT and laboratory findings of these two groups. Materials and methods: The data of all patients hospitalized at the department of pulmonology service between March 13 as the date of the first case and May 5 with probable and definitive COVID-19 were evaluated retrospectively. Patient ward files and hospital data management system were examined. Chest CT findings of the patients were interpreted by two radiologists separately according to the CO-RADS classification blinded to clinical and PCR test results of the patients and then consensus was achieved with joint evaluation. Results: A total of 99 patients, 38 RT-PCR positive, 61 RT-PCR negative, were included in the study. Neutrophil-to-lymphocyte ratio(NLR) values and lymphocyte count were lower at a statistically significant level in positive patients(respectively p=0.038, p=0.041). Similarly, CRP values were observed to be lower at a statistically significant level in positive patients(p=0.029). When the patients with RT-PCR(+) and RT-PCR(-) but with positive chest CT findings according to CO-RADS staging were compared, the values of WBC, LDH and CRP level was observed to be high were statistically significant in the group with RT-PCR(-) but positive chest CT findings. Conclusion: In the presence of clinical findings, without waiting for RT-PCR positivity, the probability of COVID-19 disease will increase if there are elevated WBC, CRP and LDH findings with CT findings(stage 4-5 according to CO-RADS).
Amaç: Kliniğimizde takip edilen kesin COVID-19 vakalar ile olası COVID-19 vakalar arasındaki sosyodemografik, klinik, BT ve laboratuvar bulgularının farklarını incelemeyi amaçladık. Gereç ve yöntem: İlk vaka tarihi olan 13 Mart 2020 ile 5 Mayıs 2020 arasında, olası ve kesin COVID-19 tanısıyla Göğüs Hastalıkları servisinde yatan tüm hastaların verileri retrospektif olarak incelendi. Hastaların toraks BT bulguları, hastaların klinik ve PCR test sonuçlarına körleştirilen iki farklı radyolog tarafından CO-RADS sınıflamasına göre ayrı ayrı yorumlandı ve daha sonra ortak değerlendirme ile konsensüs sağlandı. Klinik, laboratuvar ve görüntüleme bulguları ile çoklu regresyon modellemesi yapıldı. Bulgular: Çalışmaya 38 RT-PCR pozitif, 62 RT-PCR negatif olmak üzere toplam 99 hasta dahil edildi. Nötrofil/lenfosit oranı (NLR) ve lenfosit sayısı, RT-PCR pozitif hastalarda istatistiksel olarak anlamlı düzeyde daha düşüktü (sırasıyla p = 0.038, p = 0.041). Benzer şekilde, pozitif hastalarda CRP değerlerinin istatistiksel olarak anlamlı düzeyde düşük olduğu gözlendi (p = 0.029). RT-PCR (+) ile RT-PCR (-) ancak toraks BT ‘si CO-RADS evrelemesine göre pozitif olan hastaların karşılaştırmalarında, RT-PCR (-) ancak toraks BT pozitif olan grupta anlamlı şekilde WBC, LDH ve CRP değerlerinin daha yüksek olduğu görüldü (sırasıyla p=0.001, p=0.033, p=0.004). Öksürük, WBC, LDH, CRP değerleri ve toraks BT skoru kullanılarak geliştirilen modelde en yüksek AUC değeri elde edilmiş, RT-PCR pozitifliğini ayırt etmede başarılı olabileceği görüldü (AUC=0.725, 95% CI: 0.619-0.830) Sonuç: Klinik bulgular varlığında RT-PCR pozitifliğini beklemeden COVID-19 uyumlu BT bulguları (CO-RADS'ye göre evre 4-5) ile yüksek WBC, CRP VE LDH varsa COVID-19 olasılığı artacaktır.
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Birincil Dil en
Konular Enfeksiyon Hastalıkları
Yayınlanma Tarihi Temmuz 2021
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0001-5402-6925
Yazar: Erhan UGURLU
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-9077-0580
Yazar: Nazlı ÇETİN (Sorumlu Yazar)
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-8614-5387
Yazar: Furkan UFUK
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-5871-6461
Yazar: Nilüfer YİĞİT
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0003-4220-3482
Yazar: Hüseyin Gökhan YAVAŞ
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-5406-3459
Yazar: Seçim KOLAK
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-1156-3787
Yazar: Ahmet ÇALIŞKAN
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-6323-3456
Yazar: Neşe DURSUNOĞLU
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-5538-7754
Yazar: Sevin BAŞER ÖNCEL
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0001-6869-1301
Yazar: Göksel ALTINIŞIK ERGUR
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0001-5321-0034
Yazar: Sibel PEKCAN
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Destekleyen Kurum None
Tarihler

Yayımlanma Tarihi : 1 Temmuz 2021

Bibtex @araştırma makalesi { patd900915, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2021}, volume = {14}, pages = {706 - 716}, doi = {10.31362/patd.900915}, title = {Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases}, key = {cite}, author = {Ugurlu, Erhan and Çetin, Nazlı and Ufuk, Furkan and Yiğit, Nilüfer and Yavaş, Hüseyin Gökhan and Kolak, Seçim and Çalışkan, Ahmet and Dursunoğlu, Neşe and Başer Öncel, Sevin and Altınışık Ergur, Göksel and Pekcan, Sibel} }
APA Ugurlu, E , Çetin, N , Ufuk, F , Yiğit, N , Yavaş, H , Kolak, S , Çalışkan, A , Dursunoğlu, N , Başer Öncel, S , Altınışık Ergur, G , Pekcan, S . (2021). Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases . Pamukkale Tıp Dergisi , 14 (3) , 706-716 . DOI: 10.31362/patd.900915
MLA Ugurlu, E , Çetin, N , Ufuk, F , Yiğit, N , Yavaş, H , Kolak, S , Çalışkan, A , Dursunoğlu, N , Başer Öncel, S , Altınışık Ergur, G , Pekcan, S . "Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases" . Pamukkale Tıp Dergisi 14 (2021 ): 706-716 <https://dergipark.org.tr/tr/pub/patd/issue/61233/900915>
Chicago Ugurlu, E , Çetin, N , Ufuk, F , Yiğit, N , Yavaş, H , Kolak, S , Çalışkan, A , Dursunoğlu, N , Başer Öncel, S , Altınışık Ergur, G , Pekcan, S . "Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases". Pamukkale Tıp Dergisi 14 (2021 ): 706-716
RIS TY - JOUR T1 - Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases AU - Erhan Ugurlu , Nazlı Çetin , Furkan Ufuk , Nilüfer Yiğit , Hüseyin Gökhan Yavaş , Seçim Kolak , Ahmet Çalışkan , Neşe Dursunoğlu , Sevin Başer Öncel , Göksel Altınışık Ergur , Sibel Pekcan Y1 - 2021 PY - 2021 N1 - doi: 10.31362/patd.900915 DO - 10.31362/patd.900915 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 706 EP - 716 VL - 14 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.900915 UR - https://doi.org/10.31362/patd.900915 Y2 - 2021 ER -
EndNote %0 Pamukkale Tıp Dergisi Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases %A Erhan Ugurlu , Nazlı Çetin , Furkan Ufuk , Nilüfer Yiğit , Hüseyin Gökhan Yavaş , Seçim Kolak , Ahmet Çalışkan , Neşe Dursunoğlu , Sevin Başer Öncel , Göksel Altınışık Ergur , Sibel Pekcan %T Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases %D 2021 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 14 %N 3 %R doi: 10.31362/patd.900915 %U 10.31362/patd.900915
ISNAD Ugurlu, Erhan , Çetin, Nazlı , Ufuk, Furkan , Yiğit, Nilüfer , Yavaş, Hüseyin Gökhan , Kolak, Seçim , Çalışkan, Ahmet , Dursunoğlu, Neşe , Başer Öncel, Sevin , Altınışık Ergur, Göksel , Pekcan, Sibel . "Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases". Pamukkale Tıp Dergisi 14 / 3 (Temmuz 2021): 706-716 . https://doi.org/10.31362/patd.900915
AMA Ugurlu E , Çetin N , Ufuk F , Yiğit N , Yavaş H , Kolak S , Çalışkan A , Dursunoğlu N , Başer Öncel S , Altınışık Ergur G , Pekcan S . Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases. Pam Tıp Derg. 2021; 14(3): 706-716.
Vancouver Ugurlu E , Çetin N , Ufuk F , Yiğit N , Yavaş H , Kolak S , Çalışkan A , Dursunoğlu N , Başer Öncel S , Altınışık Ergur G , Pekcan S . Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases. Pamukkale Tıp Dergisi. 2021; 14(3): 706-716.
IEEE E. Ugurlu , N. Çetin , F. Ufuk , N. Yiğit , H. Yavaş , S. Kolak , A. Çalışkan , N. Dursunoğlu , S. Başer Öncel , G. Altınışık Ergur ve S. Pekcan , "Retrospective comparison of the sociodemographic, clinical, radiological and laboratory findings of probable and definitive COVID-19 cases", Pamukkale Tıp Dergisi, c. 14, sayı. 3, ss. 706-716, Tem. 2021, doi:10.31362/patd.900915