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Prognostic factors in vulvar cancer patients: a single center experience

Yıl 2021, Cilt 14, Sayı 4, 900 - 907, 01.10.2021
https://doi.org/10.31362/patd.978808

Öz

Purpose: Many prognostic factors have been investigated in vulvar cancer patients. In our study, we aimed to
compare clinical and pathological prognostic factors and investigate the factors that affect the recurrence and
survival in patients with recurrent and non-recurrent squamous cell vulvar cancer.
Materials and methods: This retrospective study was conducted in Tepecik Research Hospital, Izmir, Turkey
between 1999-2020. The descriptive features, prognostic factors and survival in recurrent patients were
evaluated.
Results: Tumor invasion depth, surgical margin positivity, lymphovascular space invasion (LVSI), are
statistically significant for recurrence (p=0.03, p=0.00, p=0.04). Variables such as age, tumor size, surgical
margin distance (mm), tumor localization, presence of metastatic lymph node, operation type (surgery with
lymph node dissection) and adjuvant therapy were not found to be statistically significant in terms of recurrent
patients with vulvar cancer. There was correlation between recurrence, LVSI, surgical margin positivity, stage
and survival in Kaplan Meier survival analysis.
Conclusion: As in other studies, many prognostic factors like tumor invasion depth, surgical margin positivity,
LVSI are risk factors for recurrence in our study. Stage, LVSI, recurrence, surgical margin positivity were
significant factors for survival as well.

Kaynakça

  • 1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019; 69: 7–34.
  • 2. de Hullu JA, van der Zee AG. Surgery and radiotherapy in vulvar cancer. Crit Rev Oncol Hematol 2006;60(1):38–58.
  • 3. Zweizig S, Korets S, Cain J. Key concepts in management of vulvar cancer. Best Practice Res Clin Obstet Gynaecol 2014;28:959-966.
  • 4. Tan A, Bieber AK, Stein JA, Pomeranz MK. Diagnosis and management of vulvar cancer: A review. J Am Acad Dermatol. 2019;81(6):1387-1396.
  • 5. Baiocchi G, Silva Cestari FM, Rocha RM et al. Prognostic value of the number and laterality of metastatic inguinal lymph nodes in vulvar cancer: revisiting the FIGO staging system. Eur J Surg Oncol 2013;39(7):780–5.
  • 6. Te Grootenhuis NC, van der Zee AG, van Doorn HC et al. Sentinel nodes in vulvar cancer: long-term follow-up of the GROningen International Study on Sentinel nodes in Vulvar cancer (GROINSSV). Gynecol Oncol 2016;140(1):8-14.
  • 7. Heaps JM, Fu YS, Montz FJ, Hacker NF, Berek JS. Surgical-Pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynaecologic Oncol 1990;38:309-14.
  • 8. Iversen T, Aalders JG, Christensen A. Squamous cell carcinoma of the vulva: a review of 424 patients, 1956–1974. Gynecol Oncol1980; 9:271–279.
  • 9. Gadducci A, Tana R, Barsotti C, Guerrieri ME, Genazzani AR. Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva. Crit Rev Oncol Hematol 2012; 83(1):71-83.
  • 10. Viswanathan AN, Pinto AP, Schultz D, Berkowitz R, Crum CP. Relationship of margin status and radiation dose to recurrence in post-operative vulvar carcinoma. Gynecol Oncol 2013;130(3):545-9.
  • 11. Woelber L, Mahner S, Voelker K et al. Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer. Anticancer Res.2009;29: 545-52.
  • 12. Zach D, Avall-Lundqvist, Falconer H, Hellman K, Johansson H, Flöter Radestad A. Patterns of Recurrence and Survival in Vulvar Cancer: A Nationwide population based study. 2021;161(3):748-754.
  • 13. Perez CA, Grigsby PW, Chao C et al. Irradiation in carcinoma of the vulva: factors affecting outcome. Int J Radiat Oncol Biol Phys. 1998: 42:335–344.
  • 14. Imoto S, Inamine M, Kudaka W et al. Prognostic Factors in patients with vulvar cancer treated with primary surgery: a single-center experience. 2016;5:125.
  • 15. Woelber L, Mahner S, Voelker K et al. Clinicopathological Prognostic Factors and Patterns of Recurrence in Vulvar Cancer. Anticancer Research 2009;29:545-552.
  • 16. Stankevica J, Macuks R, Baidekalna I, Donina S. Midline Involvement as a Risk Factor for Vulvar Cancer Recurrence. Asian Pacific J Cancer Prev, 2012;13(10):5237-5240.

Vulvar Kanserli Hastalarda Prognostik Faktörler: Tek Merkez Deneyimi

Yıl 2021, Cilt 14, Sayı 4, 900 - 907, 01.10.2021
https://doi.org/10.31362/patd.978808

Öz

Amaç: Vulvar kanserli hastalarda birçok prognostik faktör araştırılmıştır. Çalışmamızda nüks ve nüks olmayan skuamöz hücreli vulvar kanserli hastalarda klinik ve patolojik prognostik faktörleri karşılaştırmayı, nüks ve sağkalımı etkileyen faktörleri araştırmayı amaçladık. Gereç-Yöntem: Bu prospektif çalışma 1999-2020 yılları arasında İzmir, Tepecik Araştırma Hastanesi’nde yapıldı. Tekrarlayan hastalarda tanımlayıcı özellikler, prognostik faktörler ve sağkalım değerlendirildi. Bulgular: Tümör invazyon derinliği, cerrahi sınır pozitifliği, lenfovasküler boşluk invazyonu (LVSI) nüks açısından istatiksel olarak anlamlıdır(p=0,03, p=0,00, p=0,04). Yaş, tümör boyutu, cerrahi sınır mesafesi (mm), tümör lokalizasyonu, metastatik lenf nodu varlığı, operasyon tipi (lenf nodu diseksiyonlu cerrahi) ve adjuvan tedavi gibi değişkenler nüks vulvar kanseri hastaları açısından istatiksel olarak anlamlı bulunmadı. Kaplan Meier sağkalım analizinde nüks, lenfovasküler boşluk invazyonu, cerrahi sınır pozitifliği, evre ve sağkalım arasında korelasyon vardı. Sonuç: Diğer çalışmalarda olduğu gibi bizim çalışmamızda da tümör invazyon derinliği,cerrahi sınır pozitifliği, lenfovasküler boşluk invazyonu gibi birçok prognostik faktör nüks için risk faktörüdür. Evre, lenfovasküler boşluk invazyonu, nüks, cerrahi sınır pozitifliği de sağkalım için önemli faktörlerdendir.

Kaynakça

  • 1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019; 69: 7–34.
  • 2. de Hullu JA, van der Zee AG. Surgery and radiotherapy in vulvar cancer. Crit Rev Oncol Hematol 2006;60(1):38–58.
  • 3. Zweizig S, Korets S, Cain J. Key concepts in management of vulvar cancer. Best Practice Res Clin Obstet Gynaecol 2014;28:959-966.
  • 4. Tan A, Bieber AK, Stein JA, Pomeranz MK. Diagnosis and management of vulvar cancer: A review. J Am Acad Dermatol. 2019;81(6):1387-1396.
  • 5. Baiocchi G, Silva Cestari FM, Rocha RM et al. Prognostic value of the number and laterality of metastatic inguinal lymph nodes in vulvar cancer: revisiting the FIGO staging system. Eur J Surg Oncol 2013;39(7):780–5.
  • 6. Te Grootenhuis NC, van der Zee AG, van Doorn HC et al. Sentinel nodes in vulvar cancer: long-term follow-up of the GROningen International Study on Sentinel nodes in Vulvar cancer (GROINSSV). Gynecol Oncol 2016;140(1):8-14.
  • 7. Heaps JM, Fu YS, Montz FJ, Hacker NF, Berek JS. Surgical-Pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynaecologic Oncol 1990;38:309-14.
  • 8. Iversen T, Aalders JG, Christensen A. Squamous cell carcinoma of the vulva: a review of 424 patients, 1956–1974. Gynecol Oncol1980; 9:271–279.
  • 9. Gadducci A, Tana R, Barsotti C, Guerrieri ME, Genazzani AR. Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva. Crit Rev Oncol Hematol 2012; 83(1):71-83.
  • 10. Viswanathan AN, Pinto AP, Schultz D, Berkowitz R, Crum CP. Relationship of margin status and radiation dose to recurrence in post-operative vulvar carcinoma. Gynecol Oncol 2013;130(3):545-9.
  • 11. Woelber L, Mahner S, Voelker K et al. Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer. Anticancer Res.2009;29: 545-52.
  • 12. Zach D, Avall-Lundqvist, Falconer H, Hellman K, Johansson H, Flöter Radestad A. Patterns of Recurrence and Survival in Vulvar Cancer: A Nationwide population based study. 2021;161(3):748-754.
  • 13. Perez CA, Grigsby PW, Chao C et al. Irradiation in carcinoma of the vulva: factors affecting outcome. Int J Radiat Oncol Biol Phys. 1998: 42:335–344.
  • 14. Imoto S, Inamine M, Kudaka W et al. Prognostic Factors in patients with vulvar cancer treated with primary surgery: a single-center experience. 2016;5:125.
  • 15. Woelber L, Mahner S, Voelker K et al. Clinicopathological Prognostic Factors and Patterns of Recurrence in Vulvar Cancer. Anticancer Research 2009;29:545-552.
  • 16. Stankevica J, Macuks R, Baidekalna I, Donina S. Midline Involvement as a Risk Factor for Vulvar Cancer Recurrence. Asian Pacific J Cancer Prev, 2012;13(10):5237-5240.

Ayrıntılar

Birincil Dil İngilizce
Konular Kadın Hastalıkları ve Doğum
Yayınlanma Tarihi Ekim 2021
Bölüm Araştırma Makalesi
Yazarlar

Gülşah SELVİ DEMİRTAŞ (Sorumlu Yazar)
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR TEPECİK SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
0000-0002-1634-8365
Türkiye


Fatih DİNÇER
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR TEPECİK SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
0000-0003-0796-6257
Türkiye


Gökşen GÖRGÜLÜ Bu kişi benim
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR TEPECİK SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
0000-0003-2837-8497
Türkiye


Muzaffer SANCI
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR TEPECİK SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
0000-0001-6209-0003
Türkiye


Sevil SAYHAN
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR TEPECİK SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
0000-0003-4783-5550
Türkiye

Yayımlanma Tarihi 1 Ekim 2021
Yayınlandığı Sayı Yıl 2021, Cilt 14, Sayı 4

Kaynak Göster

Bibtex @araştırma makalesi { patd978808, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2021}, volume = {14}, pages = {900 - 907}, doi = {10.31362/patd.978808}, title = {Prognostic factors in vulvar cancer patients: a single center experience}, key = {cite}, author = {Selvi Demirtaş, Gülşah and Dinçer, Fatih and Görgülü, Gökşen and Sancı, Muzaffer and Sayhan, Sevil} }
APA Selvi Demirtaş, G. , Dinçer, F. , Görgülü, G. , Sancı, M. & Sayhan, S. (2021). Prognostic factors in vulvar cancer patients: a single center experience . Pamukkale Tıp Dergisi , 14 (4) , 900-907 . DOI: 10.31362/patd.978808
MLA Selvi Demirtaş, G. , Dinçer, F. , Görgülü, G. , Sancı, M. , Sayhan, S. "Prognostic factors in vulvar cancer patients: a single center experience" . Pamukkale Tıp Dergisi 14 (2021 ): 900-907 <https://dergipark.org.tr/tr/pub/patd/issue/63191/978808>
Chicago Selvi Demirtaş, G. , Dinçer, F. , Görgülü, G. , Sancı, M. , Sayhan, S. "Prognostic factors in vulvar cancer patients: a single center experience". Pamukkale Tıp Dergisi 14 (2021 ): 900-907
RIS TY - JOUR T1 - Prognostic factors in vulvar cancer patients: a single center experience AU - Gülşah Selvi Demirtaş , Fatih Dinçer , Gökşen Görgülü , Muzaffer Sancı , Sevil Sayhan Y1 - 2021 PY - 2021 N1 - doi: 10.31362/patd.978808 DO - 10.31362/patd.978808 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 900 EP - 907 VL - 14 IS - 4 SN - -1308-0865 M3 - doi: 10.31362/patd.978808 UR - https://doi.org/10.31362/patd.978808 Y2 - 2021 ER -
EndNote %0 Pamukkale Tıp Dergisi Prognostic factors in vulvar cancer patients: a single center experience %A Gülşah Selvi Demirtaş , Fatih Dinçer , Gökşen Görgülü , Muzaffer Sancı , Sevil Sayhan %T Prognostic factors in vulvar cancer patients: a single center experience %D 2021 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 14 %N 4 %R doi: 10.31362/patd.978808 %U 10.31362/patd.978808
ISNAD Selvi Demirtaş, Gülşah , Dinçer, Fatih , Görgülü, Gökşen , Sancı, Muzaffer , Sayhan, Sevil . "Prognostic factors in vulvar cancer patients: a single center experience". Pamukkale Tıp Dergisi 14 / 4 (Ekim 2021): 900-907 . https://doi.org/10.31362/patd.978808
AMA Selvi Demirtaş G. , Dinçer F. , Görgülü G. , Sancı M. , Sayhan S. Prognostic factors in vulvar cancer patients: a single center experience. Pam Tıp Derg. 2021; 14(4): 900-907.
Vancouver Selvi Demirtaş G. , Dinçer F. , Görgülü G. , Sancı M. , Sayhan S. Prognostic factors in vulvar cancer patients: a single center experience. Pamukkale Tıp Dergisi. 2021; 14(4): 900-907.
IEEE G. Selvi Demirtaş , F. Dinçer , G. Görgülü , M. Sancı ve S. Sayhan , "Prognostic factors in vulvar cancer patients: a single center experience", Pamukkale Tıp Dergisi, c. 14, sayı. 4, ss. 900-907, Eki. 2021, doi:10.31362/patd.978808