Araştırma Makalesi
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Evaluation of plasma atherogenic index in patients with coronary slow flow phenomenon

Yıl 2022, Cilt 15, Sayı 3, 491 - 498, 01.07.2022
https://doi.org/10.31362/patd.1091410

Öz

Purpose: Coronary slow flow phenomenon (CSFP) is considered a precursor of coronary artery disease (CAD) and associated with diffuse atherosclerosis, although its pathophysiology is still unclear. The atherogenic index of plasma (AIP) is associated with high cardiovascular risk. In this study, it is aimed to investigate the relationship between AIP and CSFP.
Material and method: Hospital records and coronary angiography (CAG) images of 214 patients with normal coronary arteries (NCA) and CSFP patients who underwent CAG between January 2019 and November 2021 have been retrospectively reviewed.
Results: The patients were divided into two groups, CSFP (n=107) and NCA (n=107). The mean age was 59.3 years and 50.9% were male. Other demographic characteristics were similar between the two groups, except for gender distribution, age, frequency of HT, and smoking history. There was no difference in laboratory findings except glomerular filtration rate (GFR), serum creatinine level, LDL-C, HDL-C, non-HDL-C, and triglyceride levels. The AIP value was found high and statistically significant in patients with CSFP (p<0.001). In the backward logistic regression analysis, age, smoking, GFR, and AIP were determined as independent predictors for CSFP. In ROC curve analysis, the cut-off value of AIP was found 0.068 in predicting CSFP [sensitivity 72%, specificity 42%, area under the curve (AUC)=0.630; p=0.045].
Conclusion: AIP, a rapid, inexpensive, and applicable index in daily clinical practice for the evaluation of atherogenic dyslipidemia, was found an independent predictor together with the traditional risk factors of age, smoking, LDL-C level, and GFR in patients with CSFP.

Kaynakça

  • 1. Wang X, Nie SP. The coronary slow flow phenomenon: characteristics, mechanisms and implications. Cardiovasc Diagn Ther. 2011;1(1):37-43. https://doi.org/10.3978/j.issn.2223-3652.2011.10.01
  • 2. Tambe AA, Demany MA, Zimmerman HA, Mascarenhas E. Angina pectoris and slow flow velocity of dye in coronary arteries--a new angiographic finding. Am Heart J. 1972;84(1):66-71. https://doi.org/10.1016/0002-8703(72)90307-9
  • 3. Wang X, Geng LL, Nie SP. Coronary slow flow phenomenon: a local or systemic disease? Med Hypotheses. 2010;75(3):334-7. https://doi.org/10.1016/j.mehy.2010.03.016
  • 4. Canpolat U, Cetin EH, Cetin S, et al. Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflammation. Clin Appl Thromb Hemost. 2016;22(5):476-82. https://doi.org/10.1177/1076029615594002
  • 5. Cin VG, Pekdemir H, Camsar A et al. Diffuse intimal thickening of coronary arteries in slow coronary flow. Jpn Heart J. 2003;44(6):907-19. https://doi.org/10.1536/jhj.44.907
  • 6. Pekdemir H, Cin VG, Cicek D, et al. Slow coronary flow may be a sign of diffuse atherosclerosis. Contribution of FFR and IVUS. Acta Cardiol. 2004;59(2):127-33. https://doi.org/10.2143/AC.59.2.2005166
  • 7. Lee BK, Lim HS, Fearon WF, et al. Invasive evaluation of patients with angina in the absence of obstructive coronary artery disease. Circulation. 2015;131(12):1054-60. https://doi.org/10.1161/CIRCULATIONAHA.114.012636
  • 8. Ivanova EA, Myasoedova VA, Melnichenko AA, Grechko AV, Orekhov AN. Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases. Oxid Med Cell Longev. 2017;2017:1273042. https://doi.org/10.1155/2017/1273042
  • 9. Dobiasova M, Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clin Biochem. 2001;34(7):583-8. https://doi.org/ 10.1016/s0009-9120(01)00263-6
  • 10. Bolego C, Poli A, Cignarella A, Catapano AL, Paoletti R. Novel statins: pharmacological and clinical results. Cardiovasc Drugs Ther. 2002;16(3):251-7. https://doi.org/10.1023/a:1020656607497
  • 11. Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, et al. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease. Med J Islam Repub Iran. 2015;29:240. https://www.ncbi.nlm.nih.gov/pubmed/26793631
  • 12. Cosentino F, Grant PJ, Aboyans V, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020;41(2):255-323. https://doi.org/10.1093/eurheartj/ehz486
  • 13. Gibson CM, Cannon CP, Daley WL, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation. 1996;93(5):879-88. https://doi.org/10.1161/01.cir.93.5.879
  • 14. Conversion factors of Conventional units to SI units. Kidney International Supplements. 2013;Volume 3(Issue 3):Page ix. https://doi.org/10.1016/S2157-1716(16)30001-6.
  • 15. Chalikias G, Tziakas D. Slow Coronary Flow: Pathophysiology, Clinical Implications, and Therapeutic Management. Angiology. 2021;72(9):808-18. https://doi.org/ 10.1177/00033197211004390
  • 16. Dai YX, Li CG, Huang ZY, et al. [Clinical and angiographic characteristics of patients with slow coronary flow]. Zhonghua Xin Xue Guan Bing Za Zhi. 2011;39(7):642-6. https://www.ncbi.nlm.nih.gov/pubmed/22088246
  • 17. Fineschi M, Gori T. Coronary slow-flow phenomenon or syndrome Y: a microvascular angina awaiting recognition. J Am Coll Cardiol. 2010;56(3):239-40; author reply 40. https://doi.org/10.1016/j.jacc.2009.09.082
  • 18. Yilmaz H, Demir I, Uyar Z. Clinical and coronary angiographic characteristics of patients with coronary slow flow. Acta Cardiol. 2008;63(5):579-84. https://doi.org/10.2143/AC.63.5.2033224
  • 19. Stahel P, Xiao C, Hegele RA, Lewis GF. The Atherogenic Dyslipidemia Complex and Novel Approaches to Cardiovascular Disease Prevention in Diabetes. Can J Cardiol. 2018;34(5):595-604. https://doi.org/10.1016/j.cjca.2017.12.007
  • 20. Onat A, Can G, Kaya H, Hergenc G. "Atherogenic index of plasma" (log10 triglyceride/high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes, and vascular events. J Clin Lipidol. 2010;4(2):89-98. https://doi.org/10.1016/j.jacl.2010.02.005
  • 21. Dobiasova M. [AIP--atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice]. Vnitr Lek. 2006;52(1):64-71. https://www.ncbi.nlm.nih.gov/pubmed/16526201
  • 22. Cai G, Shi G, Xue S, Lu W. The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population. Medicine (Baltimore). 2017;96(37):e8058. https://doi.org/10.1097/MD.0000000000008058
  • 23. Wu TT, Gao Y, Zheng YY, Ma YT, Xie X. Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women. Lipids Health Dis. 2018;17(1):197. https://doi.org/10.1186/s12944-018-0828-z
  • 24. Won KB, Jang MH, Park EJ, et al. Atherogenic index of plasma and the risk of advanced subclinical coronary artery disease beyond traditional risk factors: An observational cohort study. Clin Cardiol. 2020;43(12):1398-404. https://doi.org/10.1002/clc.23450
  • 25. Nam JS, Kim MK, Nam JY, et al. Association between atherogenic index of plasma and coronary artery calcification progression in Korean adults. Lipids Health Dis. 2020;19(1):157. https://doi.org/10.1186/s12944-020-01317-4
  • 26. Wang L, Chen F, Xiaoqi C, Yujun C, Zijie L. Atherogenic Index of Plasma Is an Independent Risk Factor for Coronary Artery Disease and a Higher SYNTAX Score. Angiology. 2021;72(2):181-6. https://doi.org/10.1177/0003319720949804
  • 27. Cai G, Liu W, Lv S, et al. Gender-specific associations between atherogenic index of plasma and the presence and severity of acute coronary syndrome in very young adults: a hospital-based observational study. Lipids Health Dis. 2019;18(1):99. https://doi.org/10.1186/s12944-019-1043-2
  • 28. Zheng Y, Li C, Yang J, et al. Atherogenic index of plasma for non-diabetic, coronary artery disease patients after percutaneous coronary intervention: a prospective study of the long-term outcomes in China. Cardiovasc Diabetol. 2022;21(1):29. https://doi.org/10.1186/s12933-022-01459-y

Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi

Yıl 2022, Cilt 15, Sayı 3, 491 - 498, 01.07.2022
https://doi.org/10.31362/patd.1091410

Öz

Öz Amaç: Koroner yavaş akım fenomeni (KYAF), patofizyolojisi halen net olmasa da koroner arter hastalığı (KAH) öncüsü ve diffüz ateroskleroz ile ilişkili olarak kabul edilmektedir. Plazma aterojenik indeksi (PAİ) yüksek kardiyovasküler risk ile ilişkilidir. Bu çalışmada KYAF ile PAİ arasındaki ilişkinin araştırılması amaçlanmıştır. Gereç ve yöntem: Retrospektif olarak Ocak 2019 ile Kasım 2021 tarihleri arasında koroner anjiyografi (KAG) uygulanan ve KYAF saptanan hastalar ile normal koroner arterleri (NKA) olan toplam 214 hastanın hastane kayıtları ve KAG görüntüleri incelenmiştir. Bulgular: Hastalar KYAF (n=107) ve NKA (n=107) olmak üzere iki gruba ayrıldı. Yaş ortalaması 59.3 olup %50.9’u erkekti. İki grup arasında cinsiyet dağılımı, yaş, HT sıklığı ve sigara öyküsü dışında diğer demografik özellikler benzerdi. Glomerüler filtrasyon hızı (GFH), serum kreatinin düzeyi, LDL-K, HDL-K, non HDL-K ve trigliserid düzeyleri dışında laboratuvar bulguları arasında fark yoktu. PAİ değeri, KYAF olan hastalarda yüksek ve istatiksel olarak anlamlı bulundu (p<0.001). Backward lojistik regresyon analizinde yaş, sigara kullanımı, GFH ve PAİ, KYAF için bağımsız prediktör olarak saptanmıştır. ROC eğrisi analizinde KYAF’yi öngörmede PAİ cut-off değeri 0.068 olarak saptanmıştır [sensitivite %72, spesifite %42, eğri altında kalan alan (AUC)= 0.630; p=0.045]. Sonuç: Aterojenik dislipideminin değerlendirilmesinde hızlı, ucuz, günlük klinik pratikte uygulanabilir bir indeks olan PAİ, KYAF olan hastalarda geleneksel risk faktörleri olan yaş, sigara kullanımı, LDL-K düzeyi ve GFH ile birlikte bağımsız prediktör olarak bulunmuştur.

Kaynakça

  • 1. Wang X, Nie SP. The coronary slow flow phenomenon: characteristics, mechanisms and implications. Cardiovasc Diagn Ther. 2011;1(1):37-43. https://doi.org/10.3978/j.issn.2223-3652.2011.10.01
  • 2. Tambe AA, Demany MA, Zimmerman HA, Mascarenhas E. Angina pectoris and slow flow velocity of dye in coronary arteries--a new angiographic finding. Am Heart J. 1972;84(1):66-71. https://doi.org/10.1016/0002-8703(72)90307-9
  • 3. Wang X, Geng LL, Nie SP. Coronary slow flow phenomenon: a local or systemic disease? Med Hypotheses. 2010;75(3):334-7. https://doi.org/10.1016/j.mehy.2010.03.016
  • 4. Canpolat U, Cetin EH, Cetin S, et al. Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflammation. Clin Appl Thromb Hemost. 2016;22(5):476-82. https://doi.org/10.1177/1076029615594002
  • 5. Cin VG, Pekdemir H, Camsar A et al. Diffuse intimal thickening of coronary arteries in slow coronary flow. Jpn Heart J. 2003;44(6):907-19. https://doi.org/10.1536/jhj.44.907
  • 6. Pekdemir H, Cin VG, Cicek D, et al. Slow coronary flow may be a sign of diffuse atherosclerosis. Contribution of FFR and IVUS. Acta Cardiol. 2004;59(2):127-33. https://doi.org/10.2143/AC.59.2.2005166
  • 7. Lee BK, Lim HS, Fearon WF, et al. Invasive evaluation of patients with angina in the absence of obstructive coronary artery disease. Circulation. 2015;131(12):1054-60. https://doi.org/10.1161/CIRCULATIONAHA.114.012636
  • 8. Ivanova EA, Myasoedova VA, Melnichenko AA, Grechko AV, Orekhov AN. Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases. Oxid Med Cell Longev. 2017;2017:1273042. https://doi.org/10.1155/2017/1273042
  • 9. Dobiasova M, Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clin Biochem. 2001;34(7):583-8. https://doi.org/ 10.1016/s0009-9120(01)00263-6
  • 10. Bolego C, Poli A, Cignarella A, Catapano AL, Paoletti R. Novel statins: pharmacological and clinical results. Cardiovasc Drugs Ther. 2002;16(3):251-7. https://doi.org/10.1023/a:1020656607497
  • 11. Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, et al. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease. Med J Islam Repub Iran. 2015;29:240. https://www.ncbi.nlm.nih.gov/pubmed/26793631
  • 12. Cosentino F, Grant PJ, Aboyans V, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020;41(2):255-323. https://doi.org/10.1093/eurheartj/ehz486
  • 13. Gibson CM, Cannon CP, Daley WL, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation. 1996;93(5):879-88. https://doi.org/10.1161/01.cir.93.5.879
  • 14. Conversion factors of Conventional units to SI units. Kidney International Supplements. 2013;Volume 3(Issue 3):Page ix. https://doi.org/10.1016/S2157-1716(16)30001-6.
  • 15. Chalikias G, Tziakas D. Slow Coronary Flow: Pathophysiology, Clinical Implications, and Therapeutic Management. Angiology. 2021;72(9):808-18. https://doi.org/ 10.1177/00033197211004390
  • 16. Dai YX, Li CG, Huang ZY, et al. [Clinical and angiographic characteristics of patients with slow coronary flow]. Zhonghua Xin Xue Guan Bing Za Zhi. 2011;39(7):642-6. https://www.ncbi.nlm.nih.gov/pubmed/22088246
  • 17. Fineschi M, Gori T. Coronary slow-flow phenomenon or syndrome Y: a microvascular angina awaiting recognition. J Am Coll Cardiol. 2010;56(3):239-40; author reply 40. https://doi.org/10.1016/j.jacc.2009.09.082
  • 18. Yilmaz H, Demir I, Uyar Z. Clinical and coronary angiographic characteristics of patients with coronary slow flow. Acta Cardiol. 2008;63(5):579-84. https://doi.org/10.2143/AC.63.5.2033224
  • 19. Stahel P, Xiao C, Hegele RA, Lewis GF. The Atherogenic Dyslipidemia Complex and Novel Approaches to Cardiovascular Disease Prevention in Diabetes. Can J Cardiol. 2018;34(5):595-604. https://doi.org/10.1016/j.cjca.2017.12.007
  • 20. Onat A, Can G, Kaya H, Hergenc G. "Atherogenic index of plasma" (log10 triglyceride/high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes, and vascular events. J Clin Lipidol. 2010;4(2):89-98. https://doi.org/10.1016/j.jacl.2010.02.005
  • 21. Dobiasova M. [AIP--atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice]. Vnitr Lek. 2006;52(1):64-71. https://www.ncbi.nlm.nih.gov/pubmed/16526201
  • 22. Cai G, Shi G, Xue S, Lu W. The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population. Medicine (Baltimore). 2017;96(37):e8058. https://doi.org/10.1097/MD.0000000000008058
  • 23. Wu TT, Gao Y, Zheng YY, Ma YT, Xie X. Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women. Lipids Health Dis. 2018;17(1):197. https://doi.org/10.1186/s12944-018-0828-z
  • 24. Won KB, Jang MH, Park EJ, et al. Atherogenic index of plasma and the risk of advanced subclinical coronary artery disease beyond traditional risk factors: An observational cohort study. Clin Cardiol. 2020;43(12):1398-404. https://doi.org/10.1002/clc.23450
  • 25. Nam JS, Kim MK, Nam JY, et al. Association between atherogenic index of plasma and coronary artery calcification progression in Korean adults. Lipids Health Dis. 2020;19(1):157. https://doi.org/10.1186/s12944-020-01317-4
  • 26. Wang L, Chen F, Xiaoqi C, Yujun C, Zijie L. Atherogenic Index of Plasma Is an Independent Risk Factor for Coronary Artery Disease and a Higher SYNTAX Score. Angiology. 2021;72(2):181-6. https://doi.org/10.1177/0003319720949804
  • 27. Cai G, Liu W, Lv S, et al. Gender-specific associations between atherogenic index of plasma and the presence and severity of acute coronary syndrome in very young adults: a hospital-based observational study. Lipids Health Dis. 2019;18(1):99. https://doi.org/10.1186/s12944-019-1043-2
  • 28. Zheng Y, Li C, Yang J, et al. Atherogenic index of plasma for non-diabetic, coronary artery disease patients after percutaneous coronary intervention: a prospective study of the long-term outcomes in China. Cardiovasc Diabetol. 2022;21(1):29. https://doi.org/10.1186/s12933-022-01459-y

Ayrıntılar

Birincil Dil Türkçe
Konular Kalp ve Kalp Damar Sistemi
Yayınlanma Tarihi Temmuz 2022
Bölüm Araştırma Makalesi
Yazarlar

Mehmet Koray ADALI> (Sorumlu Yazar)
PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALI
0000-0002-0054-6252
Türkiye


İpek BÜBER>
PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALI
0000-0003-2457-313X
Türkiye


Anıl TÜRKÖZ>
PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALI
0000-0003-0697-4837
Türkiye


Ayşen TİL>
Burdur İl Halk Sağlığı Müdürlüğü
0000-0002-2283-1847
Türkiye

Yayımlanma Tarihi 1 Temmuz 2022
Kabul Tarihi 25 Mart 2022
Yayınlandığı Sayı Yıl 2022, Cilt 15, Sayı 3

Kaynak Göster

Bibtex @araştırma makalesi { patd1091410, journal = {Pamukkale Tıp Dergisi}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2022}, volume = {15}, number = {3}, pages = {491 - 498}, doi = {10.31362/patd.1091410}, title = {Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi}, key = {cite}, author = {Adalı, Mehmet Koray and Büber, İpek and Türköz, Anıl and Til, Ayşen} }
APA Adalı, M. K. , Büber, İ. , Türköz, A. & Til, A. (2022). Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi . Pamukkale Tıp Dergisi , 15 (3) , 491-498 . DOI: 10.31362/patd.1091410
MLA Adalı, M. K. , Büber, İ. , Türköz, A. , Til, A. "Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi" . Pamukkale Tıp Dergisi 15 (2022 ): 491-498 <https://dergipark.org.tr/tr/pub/patd/issue/68347/1091410>
Chicago Adalı, M. K. , Büber, İ. , Türköz, A. , Til, A. "Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi". Pamukkale Tıp Dergisi 15 (2022 ): 491-498
RIS TY - JOUR T1 - Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi AU - Mehmet Koray Adalı , İpek Büber , Anıl Türköz , Ayşen Til Y1 - 2022 PY - 2022 N1 - doi: 10.31362/patd.1091410 DO - 10.31362/patd.1091410 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 491 EP - 498 VL - 15 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.1091410 UR - https://doi.org/10.31362/patd.1091410 Y2 - 2022 ER -
EndNote %0 Pamukkale Tıp Dergisi Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi %A Mehmet Koray Adalı , İpek Büber , Anıl Türköz , Ayşen Til %T Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi %D 2022 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 15 %N 3 %R doi: 10.31362/patd.1091410 %U 10.31362/patd.1091410
ISNAD Adalı, Mehmet Koray , Büber, İpek , Türköz, Anıl , Til, Ayşen . "Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi". Pamukkale Tıp Dergisi 15 / 3 (Temmuz 2022): 491-498 . https://doi.org/10.31362/patd.1091410
AMA Adalı M. K. , Büber İ. , Türköz A. , Til A. Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi. Pam Tıp Derg. 2022; 15(3): 491-498.
Vancouver Adalı M. K. , Büber İ. , Türköz A. , Til A. Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi. Pamukkale Tıp Dergisi. 2022; 15(3): 491-498.
IEEE M. K. Adalı , İ. Büber , A. Türköz ve A. Til , "Koroner yavaş akım fenomeni olan hastalarda plazma aterojenik indeksinin incelenmesi", Pamukkale Tıp Dergisi, c. 15, sayı. 3, ss. 491-498, Tem. 2022, doi:10.31362/patd.1091410
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