Nitrate Metabolism and Physical Activity: A Systematic Review

Öz

Nitrate is a natural compound that stands out as a nutritional ergogenic supplement in sports nutrition. Dietary inorganic nitrate (notably from beetroot and leafy green vegetables) has been reported to convert to nitric oxide, thereby enhancing vasodilation, improving muscle oxygenation, and supporting energy metabolism. In this review, literature searches were conducted in PubMed, ScienceDirect, SpringerLink, Taylor & Francis, EBSCOhost, and Google Scholar for the period January 2020–January 2025, using the keywords “nitrate”, “nitric oxide”, “exercise performance”, “ergogenic aid”, “aerobic performance”, “anaerobic exercise”, “resistance training”, and “cognitive performance” Based on predefined inclusion and exclusion criteria, 15 studies were selected and reported thematically. The findings indicate that nitrate-based nutritional ergogenic support exerts positive effects particularly on aerobic performance by enhancing endurance, reducing oxygen consumption, and increasing exercise tolerance. The effects on anaerobic performance are more heterogeneous; some studies have reported increased power output in repeated sprint and resistance exercises, while others found no significant changes. Additionally, nitrate appears to offer potential benefits for cognitive function, oxidative stress regulation, and high-altitude adaptation, although further evidence is needed. Overall, nitrate metabolism demonstrates considerable potential for enhancing sports performance; nevertheless, there remains a need for future randomized, controlled, and long-term investigations that systematically account for individual variability in responses, as well as factors such as dosage, duration of administration, and training status.

Anahtar Kelimeler

• Nitrate
• Nitric oxide
• Exercise performance

Nitrat Metabolizması ve Fiziksel Aktivite: Sistematik İnceleme

Öz

Nitrat, sporcu beslenmesinde besinsel ergojenik destek olarak öne çıkan doğal bir bileşendir. Diyetle alınan inorganik nitratın (özellikle pancar ve yeşil yapraklı sebzelerden) nitrik okside dönüşerek vazodilatasyonu artırdığı, kas oksijenlenmesini iyileştirdiği ve enerji metabolizmasını desteklediği rapor edilmiştir. Bu derlemede, Ocak 2020 – Ocak 2025 arasında PubMed, ScienceDirect, SpringerLink, Taylor & Francis, EBSCOhost ve Google Scholar veri tabanları taranmış; “nitrate”, “nitric oxide”, “exercise performance”, “ergogenic aid”, “aerobic performance”, “anaerobic exercise”, “resistance training” ve “cognitive performance” anahtar kelimeleriyle ulaşılan çalışmalar incelenmiştir. Dahil etme ve hariç tutma kriterlerine göre seçilen 15 makale tematik olarak rapor edilmiştir. Bulgular, nitrat besinsel ergojenik desteğinin özellikle aerobik performansta dayanıklılığı artırma, oksijen tüketimini azaltma ve egzersiz toleransını yükseltme yönünde olumlu etkiler sağladığını göstermektedir. Anaerobik performans üzerindeki etkiler ise heterojendir; bazı çalışmalarda tekrarlı sprint ve direnç egzersizlerinde güç artışı görülürken, bazılarında anlamlı değişim rapor edilmemiştir. Ayrıca nitratın bilişsel işlev, oksidatif stres regülasyonu ve yüksek irtifa adaptasyonunda potansiyel katkılar sunduğu ancak daha fazla kanıta ihtiyaç duyulduğu belirtilmiştir. Genel olarak, nitrat metabolizması spor performansını destekleme açısından umut vericidir; ancak bireysel yanıt farklılıkları, dozaj, kullanım süresi ve antrenman düzeyi gibi faktörler göz önünde bulundurularak gelecekte randomize kontrollü ve uzun süreli çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Nitrat
• Nitrik oksit
• Egzersiz performansı

Kaynakça

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