Prevalence of Vitamin D Deficiency in Healthy Adults

Öz

Objectives: Vitamin D is a well-known hormone and important for many metabolic pathways and different health outcomes. The physiology of vitamin D is very complex. Multiple factors like ethnicity, age, sex, diseases, and medication influence vitamin D concentrations. In this study, our aim was to determine the prevalence of vitamin D deficiency among adults in  Turkey. Material-methods: The 25(OH) vitD₃ test results of 2007 patients admitted to Selçuk University Medicine Faculty hospital between the years of 2015 and 2016 were analyzed, retrospectively. Patients using any vitamin D consisting drug, having chronic disease and inflammatory disorders were excluded. Vitamin D levels were measured by a chromatographic method (LC/MS/MS) with API3200 which is the gold standard to measure 25(OH)D₃. Results: Our results show that the prevalence of vitamin D deficiency is about 67.9%  in our society. The mean value of vitamin D was 16,87 ng/mL and females had significantly lower 25(OH)D₃ levels compared to males (p<0.001).The 25(OH)D₃ levels were higher in summer and in fall than in winter and spring. (p<0.001) Conclusıons: The results indicate that vitamin D deficiency is prevalent in this study population despite high levels of sunshine and UV radiation throughout the year. Preventive treatments should be planned.

Amaç: D vitamini, birçok metabolik yolakta rol alan ve bazı hastalıklarla ilişkili olan bir hormondur. Vitamin D fizyolojisi çok karmaşıktır.  Etnik köken, yaş, cinsiyet, hastalıklar ve ilaç kullanımı vitamin D konsantrasyonunu etkilemektedir. Bu çalışmada amacımız Türkiye’de sağlıklı erişkinlerde vitamin D eksikliği sıklığını belirlemekti. Yöntem: 2015-2016 yılları arasında Selçuk Üniversitesi Tıp Fakültesi Hastanesi'ne başvuran 2007 hastanın 25(OH)D₃ test sonuçları retrospektif olarak incelendi. Vitamin D içeren ilaç kullanan, kronik hastalık veya enflamatuar hastalıkları olan hastalar çalışma dışı bırakılmıştır. D vitamini seviyeleri, 25(OH)D₃ ölçmek için altın standart olan kromatografik yöntemle (LC / MS / MS) API3200 cihazı ile ölçülmüştür. Sonuçlar: Bulgularımız, çalışma popülasyonumuzda D vitamini eksikliği prevalansının yaklaşık %67,9 olduğunu göstermektedir. D vitamini ortalama değeri 16,87 ng/mL idi ve kadınlarda 25(OH)D3 seviyeleri, erkeklere göre anlamlı derecede düşüktü (p <0,001). Yaz ve sonbahar mevsiminde 25 (OH) D3 seviyeleri, kış ve ilkbahar mevsimine göre daha yüksekti.(p <0.001) Tartışma: Sonuçlarımız yıl boyunca yüksek düzeyde güneş ve UV ışığına rağmen, D vitamini eksikliğinin popülasyonumuzda yaygın olduğunu göstermektedir. Önleyici tedaviler planlanmalıdır.

Anahtar Kelimeler

• Vitamin D deficiency,LC/MS/MS,prevalence

Kaynakça

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