Prevalence of Vitamin D Deficiency in Healthy Adults

Yıl 2019, Cilt: 13 Sayı: 3, 335 - 341, 20.09.2019

Esra Paydaş Hataysal Beyza Saraçlıgil Sedat Abuşoğlu Ali Ünlü Hüsamettin Vatansev

https://doi.org/10.21763/tjfmpc.451729

Cited By: 1

Öz

Objectives: Vitamin D is a
well-known hormone and important for many metabolic pathways and different
health outcomes. The physiology of vitamin D is very complex. Multiple factors
like ethnicity, age, sex, diseases, and medication influence vitamin D
concentrations. In this study, our aim was to determine the prevalence
of vitamin D deficiency among adults in 
Turkey.
Material-methods: The 25(OH) vitD₃
test results of 2007 patients admitted to Selçuk University Medicine Faculty hospital
between the years of 2015 and 2016 were analyzed, retrospectively. Patients
using any vitamin D consisting drug, having chronic disease and inflammatory
disorders were excluded. Vitamin D levels were measured by a
chromatographic method (LC/MS/MS) with API3200 which is the gold standard to
measure 25(OH)D₃. Results: Our
results show that the prevalence of vitamin D deficiency is
about 67.9%  in our society. The mean
value of vitamin D was 16,87 ng/mL and females had significantly lower 25(OH)D₃
levels compared to males (p<0.001).The 25(OH)D₃ levels were
higher in summer and in fall than in winter and spring. (p<0.001) Conclusıons: The results indicate that
vitamin D deficiency is prevalent in this study population despite high
levels of sunshine and UV radiation throughout the year. Preventive treatments should be
planned.

Amaç: D vitamini,
birçok metabolik yolakta rol alan ve bazı hastalıklarla ilişkili olan bir
hormondur. Vitamin D fizyolojisi çok karmaşıktır.  Etnik köken, yaş, cinsiyet, hastalıklar ve
ilaç kullanımı vitamin D konsantrasyonunu etkilemektedir. Bu çalışmada amacımız
Türkiye’de sağlıklı erişkinlerde vitamin D eksikliği sıklığını belirlemekti. Yöntem: 2015-2016
yılları arasında Selçuk Üniversitesi Tıp Fakültesi Hastanesi'ne başvuran 2007
hastanın 25(OH)D₃ test sonuçları retrospektif olarak incelendi. Vitamin
D içeren ilaç kullanan, kronik hastalık veya enflamatuar hastalıkları olan
hastalar çalışma dışı bırakılmıştır. D vitamini seviyeleri, 25(OH)D₃
ölçmek için altın standart olan kromatografik yöntemle (LC / MS / MS) API3200
cihazı ile ölçülmüştür. Sonuçlar: Bulgularımız,
çalışma popülasyonumuzda D vitamini eksikliği prevalansının yaklaşık %67,9
olduğunu göstermektedir. D vitamini ortalama değeri 16,87 ng/mL idi ve
kadınlarda 25(OH)D3 seviyeleri, erkeklere göre anlamlı derecede düşüktü (p
<0,001). Yaz ve sonbahar mevsiminde 25 (OH) D3 seviyeleri, kış ve ilkbahar
mevsimine göre daha yüksekti.(p <0.001) Tartışma: Sonuçlarımız
yıl boyunca yüksek düzeyde güneş ve UV ışığına rağmen, D vitamini eksikliğinin
popülasyonumuzda yaygın olduğunu göstermektedir. Önleyici tedaviler
planlanmalıdır.

Anahtar Kelimeler

Vitamin D deficiency, LC/MS/MS, prevalence

Kaynakça

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