Ketogenic Diet and Cancer

Öz

The ketogenic diet is a diet implemented with high fat consumption and adequate protein by reducing glucose and increasing ketone bodies. Ketogenic diet; It is recommended as an effective intervention on diseases such as diabetes, obesity, cardiovascular diseases and cancer. The ketogenic diet is a diet with high fat and low protein by reducing glucose and increasing ketone bodies. Ketogenic diet; It is recommended as an effective intervention on diseases such as diabetes, obesity, cardiovascular diseases and cancer. In experimental models and clinical studies, the ketogenic diet has an antitumor effect by reducing energy sources to cells and preventing tumor growth. Cancer cells use the Warburg effect on ketogenic diet metabolism. Aerobically dominant glucose utilization may be a possible pathway to be targeted during cancer therapy. Research emphasizes that the integration of the ketogenic diet with the traditional treatment protocol will show positive results on the antitumor effect of chemotherapy. This review provides evidence for understanding the mechanism of action of the ketogenic diet on cancer treatment and its therapeutic use.

Anahtar Kelimeler

• cancer
• ketogenic diet
• antitumor
• warburg effect.

Ketojenik Diyet ve Kanser

Öz

Ketojenik diyet, glikozu azaltıp keton cisimlerini arttırarak yüksek yağ kullanımı ve yeterli miktarda protein ile uygulanan bir diyettir. Ketojenik diyet; diyabet, obezite, kardiyovasküler rahatsızlıklar ve kanser gibi hastalıklar üzerinde etkili bir müdahale olarak önerilmektedir. Deneysel modellerde ve klinik çalışmalarda ketojenik diyet, hücrelere giden enerji kaynaklarını azaltıp tümör büyümesini engelleyerek, antitümör etki göstermektedir. Kanser hücreleri ketojenik diyet metabolizması üzerinde Warburg etkisini kullanmaktadır. Aerobik olarak baskın glikoz kullanımı, kanser tedavisi sırasında hedef alınması gereken muhtemel bir yol olabilir. Araştırmalar ketojenik diyetin, uygulanan geleneksel tedavi protokolü ile bütünleşmesinin kemoterapinin antitümör etkisi üzerinde olumlu sonuçlar göstereceğini vurgulamaktadır. Bu derleme, ketojenik diyetin kanser tedavisi üzerindeki etki mekanizmasını anlamak ve terapötik olarak kullanımına ilişkin kanıtlar sunmaktadır.

Anahtar Kelimeler

• kanser
• ketojenik diyet
• antitümör
• warburg etkisi

Kaynakça

1. Batch JT, Lamsal SP, Adkins M, Sultan S, Ramirez MN (2020). Advantages and disadvantages of the ketogenic diet: a review article. Cureus. 12 (8), e9639.
2. Bolla AM, Caretto A, Laurenzi A, Scavini M, & Piemonti L. (2019). Low-carb and ketogenic diets in type 1 and type 2 diabetes. Nutrients, 11(5), 962.
3. Cohen CW, Fontaine KR, Arend RC, Alvarez RD, Leath III CA, Huh WK et al. (2018). A ketogenic diet reduces central obesity and serum insulin in women with ovarian or endometrial cancer. The Journal of Nutrition, 148(8), 1253-1260.
4. Dąbek A, Wojtala M, Pirola L, Balcerczyk A. (2020). Modulation of cellular biochemistry, epigenetics and metabolomics by ketone bodies. Implications of the ketogenic diet in the physiology of the organism and pathological states. Nutrients, 12(3), 788.
5. Dhillon KK, Gupta S. (2023). Biochemistry, Ketogenesis. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29630231.
6. Ding J, Xu X, Wu X, Huang Z, Kong G, Liu J et al. (2019). Bone loss and biomechanical reduction of appendicular and axial bones under ketogenic diet in rats. Experimental and Therapeutic Medicine, 17(4), 2503-2510.
7. Dowis K, Banga S (2021). The potential health benefits of the ketogenic diet: a narrative review. Nutrients, 13(5), 1654.
8. Ferraris C, Meroni E, Casiraghi MC, Tagliabue A, De Giorgis V, Erba D. (2021). One month of classic therapeutic ketogenic diet decreases short chain fatty acids production in epileptic patients. Frontiers in Nutrition, 8, 613100.

9. Font-Burgada J, Sun B, Karin M. (2016). Obesity and cancer: the oil that feeds the flame. Cell Metabolism, 23(1), 48-62.
10. Gluschnaider U, Hertz R, Ohayon S, Smeir E, Smets M, Pikarsky E et al. (2014). Long-chain fatty acid analogues suppress breast tumorigenesis and progression. Cancer Research, 74(23), 6991-7002.
11. Golemis EA, Scheet P, Beck TN, Scolnick EM, Hunter DJ, Hawk E et al. (2018). Molecular mechanisms of the preventable causes of cancer in the United States. Genes & Development, 32(13-14), 868-902.
12. Gunter MJ, Xie X, Xue X, Kabat GC, Rohan TE, Wassertheil-Smoller S et al. (2015). Breast cancer risk in metabolically healthy but overweight postmenopausal women. Cancer Research, 75(2), 270-274.
13. Hernández MAG, Canfora EE, Jocken JWE, Blaak EE. (2019). The short-chain fatty acid acetate in body weight control and insulin sensitivity. Nutrients, 11, 1943.
14. Hernandez F. (2021). Glycolysis and gluconeogenesis: A teaching view. Journal of Biological Chemistry, 296.
15. Kasumi E, Sato N. (2019). A ketogenic diet improves the prognosis in a mouse model of peritoneal dissemination without tumor regression. Journal of Clinical Biochemistry and Nutrition, 64(3), 201-208.
16. Klement RJ. (2019). The emerging role of ketogenic diets in cancer treatment. Current Opinion in Clinical Nutrition & Metabolic Care, 22(2), 129-134.
17. Klement RJ, Weigel MM, Sweeney RA. (2021). A ketogenic diet consumed during radiotherapy improves several aspects of quality of life and metabolic health in women with breast cancer. Clinical Nutrition, 40(6), 4267-4274.
18. Luong TV, Abild CB, Bangshaab M, Gormsen LC, Søndergaard E (2022). Ketogenic diet and cardiac substrate metabolism. Nutrients, 14(7).
19. Masood W, Annamaraju P, Suheb MZK, Uppaluri KR. (2023). Ketogenic diet. In StatPearls StatPearls Publishing O'Neill B, Raggi P (2020). The ketogenic diet: Pros and cons. Atherosclerosis, 292,119-126.
20. Poff AM, Ari C, Seyfried TN, D’Agostino DP (2013). The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PloS One, 8(6), e65522.
21. Shah VN, Mohan V. (2015). Diabetes in India: what is different? Current Opinion in Endocrinology, Diabetes and Obesity, 22(4), 283-289.
22. Shilpa J, Mohan V. (2018). Ketogenic diets: Boon or bane? Indian Journal of Medical Research, 148(3), 251-253. Sims D, Liman AK, Leung V, Hwang A, Means J, Liman AD (2023). What we have learned about combining a ketogenic diet and chemoimmunotherapy: A case report and review of literature. Federal Practitioner, 40(Suppl 3), S98.
23. Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P et al. (2014). Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Cancer & Metabolism, 2, 1-19.
24. Talib WH, Mahmod AI, Kamal A, Rashid HM, Alashqar AMD, Khater S et al. (2021). Ketogenic diet in cancer prevention and therapy: Molecular targets and therapeutic opportunities. Current Issues in Molecular Biology, 43(2), 558-589.
25. Tan D, Zhao J, Liu XJ, Yang WR, Yuan F. (2022). Significance of calorie-restricted ketogenic diet for lung cancer with brain metastases and hepatoma with pulmonary metastases: report of two cases. New Advances in Brain & Critical Care, 3(1), 41-46. Toadere TM, Ţichindeleanu A, Bondor DA, Topor I, Trella ŞE, Nenu I. (2024). Bridging the divide: unveiling mutual immunological pathways of cancer and pregnancy. Inflammation Research, 73(5), 793-807.
26. Tobias DK, Chen M, Manson JE, Ludwig DS, Willett W, Hu FB. (2015). Effect of low-fat diet interventions versus other diet interventions on long-term weight change in adults: a systematic review and meta-analysis. Lancet Diabetes Endocrinology, 3(12), 968-979.
27. Tony David K, Divyanjali P, Sai Krishna G. (2017). Ketogenic diet in the management of diabetes. Indo American Journal of Pharmaceutical Research, 7, 8109-15.
28. Tran Q, Lee H, Kim C, Kong G, Gon, N, Kwon SH, Park J et al. (2020). Revisiting the Warburg effect: Diet‐based strategies for cancer prevention. BioMed Research International, 2020(1), 8105735.
29. Wallis J. (2018). The ketogenic diet for cancer patients: A Narrative Review. doi.org/10.17615/ 6c1s-8j47. Weber DD, Aminazdeh-Gohari S, Kofler B. (2018). Ketogenic diet in cancer therapy. Aging (Albany NY), 10(2), 164.
30. Yang YF, Mattamel PB, Joseph T, Huang J, Chen Q, Akinwunmi BO et al. (2021). Efficacy of low-carbohydrate ketogenic diet as an adjuvant cancer therapy: A systematic review and meta-analysis of randomized controlled trials. Nutrients, 13(5), 1388.
31. Zhao H, Jin H, Xian J, Zhang Z, Shi J, Bai X. (2022). Effect of ketogenic diets on body composition and metabolic parameters of cancer patients: a systematic review and meta-analysis. Nutrients, 14(19), 4192.