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AFLATOXIN ENTERING OUR LIVES WITH FEED AND FOOD AND PREVENTION METHODS

Yıl 2021, Cilt: 12 Sayı: 2, 105 - 117, 11.09.2021

Fadime Tonbak Pelin Demir

https://doi.org/10.38137/vftd.966325

Öz

Aflatoxins are fungal metabolites found in feeds and foods. Among mycotoxins, the aflatoxin group has received much attention due to its serious effects on human and animal health. When ruminants eat feed containing Aflatoxin B1 (AFB1), this toxin is metabolized and passed into milk as Aflatoxin M1 (AFM1). In recent years, AFB1 and AFM1 have been frequently mentioned in the correlation between toxin exposure and cancer cell proliferation and invasion. Recently, some epidemiological studies have been conducted to evaluate the effects of aflatoxin on cancer cells. This review summarizes of some data reported in the literature on the activation states of AFB1 and AFM1 and their correlation with cancer development.

Anahtar Kelimeler

AFB1 AFM1 Aflatoxin Cancer Milk

Kaynakça

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  • Anfossi, L., Baggiani, C., Giovannoli, C., Biagioli, F., D’Arco, G., Giraudi, G. (2013). Optimization of a lateral flow immunoassay for the ultrasensitive detection of aflatoxin M1 in milk. Anal. Chim. Acta, 772, 75-80.
  • Assaf, J.C., Atoui, A., El Khoury, A., Chokr, A., & Louka, N.A. (2017). Comparative study of procedures for binding of aflatoxin M1 to Lactobacillus rhamnosus GG. Brazilian J. Microbiol., 49, 120-127.
  • Assaf, J.C., El Khoury, A., Atoui, A., Louka, N., Chokr, A. (2018). A novel technique for aflatoxin M1 detoxification using chitin or treated shrimp shells: In vitro effect of physical and kinetic parameters on the binding stability. Appl. Microbiol. Biotechnol. 102, 6687-6697.
  • Assaf, J.C., EL Khoury, A., Chokr, A., Louka, N., & Atoui, A. (2019b). A novel method for elimination of aflatoxin M1 in milk using Lactobacillus rhamnosus GG biofilm. Dairy Technol., 70, 1-9.
  • Assaf, J.C., Nahle, S., Chokr, A., Louka, N., Atoui, A., & Khoury, A. (2019a). Assorted methods for decontamination of aflatoxin M1 in milk using microbial adsorbents. Review Toxins (Basel) , May 29, 11 (6), 304.
  • Atasever, M.A., Adıgüzel, G., Atasever, M., & Özturan, K. (2010b). Determination of Aflatoxin M1 Levels in Some Cheese Types Consumed in Erzurum-Turkey. Kafkas Univ Vet Fak Derg., 16 (Suppl-A): S87-S91, 2010. DOI:10.9775/kvfd.2009.1639.
  • Atasever, M.A., Adiguzel, G., Atasever, M., Özlü, H., & Ozturan, K. (2010a), Occurrence of aflatoxin M1 in UHT milk in Erzurum-Turkey. Kafkas Univ Vet Fak Derg., 16, 119-122.
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YEM VE GIDALARLA HAYATIMIZA GİREN AFLATOKSİNLERİ ÖNLEME YÖNTEMLERİ

Yıl 2021, Cilt: 12 Sayı: 2, 105 - 117, 11.09.2021

Fadime Tonbak Pelin Demir

https://doi.org/10.38137/vftd.966325

Öz

Aflatoksinler, yemlerde ve gıdalarda bulunan mantar metabolitleridir. Mikotoksinler arasında, aflatoksin grubu insan ve hayvan sağlığı üzerine ciddi etkileri nedeniyle çok dikkat çekmiştir. Geviş getiren hayvanlar Aflatoksin B1 (AFB1) içeren yemleri yediğinde, bu toksin metabolize olur ve Aflatoksin M1 (AFM1) olarak süte geçer. Son yıllarda, toksin maruziyeti ile kanser hücresi proliferasyonu ve invazyonu arasındaki korelasyonda AFB1 ve AFM1’den sıkça söz edilmektedir. Son zamanlarda kanser hücreleri üzerindeki aflatoksin etkilerini değerlendirmeyi amaçlayan bazı epidemiyolojik çalışmalar yapılmıştır. Bu derlemede, AFB1 ve AFM1’in aktivasyon durumları ve literatürde kanser gelişimiyle ilgili korelasyon hakkında rapor edilmiş olan bazı veriler özetlenmektedir.

Anahtar Kelimeler

AFB1 AFM1 Kanser Süt

Kaynakça

  • Ajani, J., Chakravarthy, D.V.S., Tanuja, P., Vali Pasha, K. (2014). Aflatoxins. Indian J. Adv. Chem. Sci., 3, 49-60.
  • Akdemir, Ç., & Altıntaş, A. (2004) Ankara’da işlenen sütlerde aflatoksin-M1 varlığının ve düzeylerinin HPLC ile araştırılması. Ankara Üniv Vet Fak Derg, 51, 175-179.
  • Anfossi, L., Baggiani, C., Giovannoli, C., Biagioli, F., D’Arco, G., Giraudi, G. (2013). Optimization of a lateral flow immunoassay for the ultrasensitive detection of aflatoxin M1 in milk. Anal. Chim. Acta, 772, 75-80.
  • Assaf, J.C., Atoui, A., El Khoury, A., Chokr, A., & Louka, N.A. (2017). Comparative study of procedures for binding of aflatoxin M1 to Lactobacillus rhamnosus GG. Brazilian J. Microbiol., 49, 120-127.
  • Assaf, J.C., El Khoury, A., Atoui, A., Louka, N., Chokr, A. (2018). A novel technique for aflatoxin M1 detoxification using chitin or treated shrimp shells: In vitro effect of physical and kinetic parameters on the binding stability. Appl. Microbiol. Biotechnol. 102, 6687-6697.
  • Assaf, J.C., EL Khoury, A., Chokr, A., Louka, N., & Atoui, A. (2019b). A novel method for elimination of aflatoxin M1 in milk using Lactobacillus rhamnosus GG biofilm. Dairy Technol., 70, 1-9.
  • Assaf, J.C., Nahle, S., Chokr, A., Louka, N., Atoui, A., & Khoury, A. (2019a). Assorted methods for decontamination of aflatoxin M1 in milk using microbial adsorbents. Review Toxins (Basel) , May 29, 11 (6), 304.
  • Atasever, M.A., Adıgüzel, G., Atasever, M., & Özturan, K. (2010b). Determination of Aflatoxin M1 Levels in Some Cheese Types Consumed in Erzurum-Turkey. Kafkas Univ Vet Fak Derg., 16 (Suppl-A): S87-S91, 2010. DOI:10.9775/kvfd.2009.1639.
  • Atasever, M.A., Adiguzel, G., Atasever, M., Özlü, H., & Ozturan, K. (2010a), Occurrence of aflatoxin M1 in UHT milk in Erzurum-Turkey. Kafkas Univ Vet Fak Derg., 16, 119-122.
  • Atasever, M.A., Atasever, M., Özturan, K. (2011). Afl atoxin M1 levels in retail yoghurt and ayran in Erzurum in Turkey Ataturk University. Turk. J. Vet. Anim. Sci., 35 (1), 59-62.
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  • Chen, G., Gong, Y.Y., Martin, E., Kimanya, M.E., Shirima, C.P., Routledge, M.N. (2018). Comparison of urinary aflatoxin M1 and aflatoxin albumin adducts as biomarkers for assessing aflatoxin exposure in Tanzanian children. Comparative Study Journal Biomarkers Mar, 23 (2), 131-136.
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  • Markov, K., Mihaljevi´c, B., Domijan, A.M., Pleadin, J., Delaš, F., & Frece, J. (2015). Inactivation of aflatoxigenic fungi and the reduction of aflatoxin B1 invitro and in situ using gamma irradiation. Food Control, 54, 79-85.
  • Mohammed, S., Munissi, J.E., Nyandoro, S. (2016). Aflatoxin M1 in raw milk and aflatoxin B1 in feed from household cows in Singida, Tanzania. Food Addit. Contam., 9, 85-90.
  • Mokhles, M., Abd El Wahhab, M.A., Tawfik, M., Ezzat, W., Gamil, K., Ibrahim, M. (2007). Detection of aflatoxin among hepatocellular carcinoma patients in Egypt. Pak. J. Biol. Sci., 10, 1422-1429.
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  • Palou, L., Crisosto, C.H., Smilanick, J.L., Adaskaveg, J.E., & Zoffoli, J.P. (2002). Effects of continuous 0.3 ppm ozone exposure on decay development and physiological responses of peaches and table grapes in cold storage. Postharvest Biol. Technol., 24, 39-48.
  • Polat, F. (2013). Hatay ili süt ineği işletmelerinde kullanılan yemlerin aflatoksin düzeylerinin belirlenmesi ve bu yemlerin kan parametreleri ile sütteki aflatoksin düzeyleri üzerine etkisi. Hatay, Turkey, Thesis of PhD, AU, diss.
  • Prüss-Ustün, A., Wolf, J., Corvalán, C.F., Neville, T., Bos, R., & Neira, M. (2016). Diseases due to unhealthy environments: an updated estimate of the global burden of disease attributable to environmental determinants of health. J. Public Health, 39 (3), 464-475.
  • Radoni´c, J.R., Tanackov, S.D.K., Mihajlovi´c, I.J., Zorica, S., Miloradov, M.B.V., Škrinjar, M.M., Turk, M.M. (2016). Occurrence of aflatoxin M1 in human milk samples in Vojvodina, Serbia: Estimation of average daily intake by babies. J. Environ. Sci. Health Part B, 52, 59-63.
  • Rapisarda, V., Loreto, C., Malaguarnera, M., Ardiri, A., Proiti, M., Rigano, G., Frazzetto, E., Ruggeri, M.I., Malaguarnera, G., Bertino, N., & ve ark. (2016). Hepatocellular carcinoma and the risk of occupational exposure. World J. Hepatol., 8, 573-590.
  • Rastogi, S., Dwivedi, P.D., Khanna, S.K., & ve ark. (2004). Detection of aflatoxin M1 contamination in milk and infant milk products from Indian markets by ELISA. Food Control, 15, 287-290.
  • Saad-Hussein, A., Beshir, S., Moubarz, G., Elserougy, S., & Ibrahim, M.I. (2013). Effect of occupational exposure to aflatoxins on some liver tumor markers in textile workers. Am. J. Ind. Med., 56, 818-824.
  • Saltzmann, J., Xu, Y., Gong, Y.Y., Lindahl, J., Kersten, S., Dänicke, S., Routledge, M.N. (2020). Preliminary Study on the Relationship Between Aflatoxin-Bovine Serum Albumin Adducts in Blood and Aflatoxin M1 Levels in Milk of Dairy Cows. Mycotoxin Res. May, 36 (2), 207-211.
  • Scholl, P.F., & Groopman, J.D. (2008). Long-term stability of human aflatoxin B1 albumin adducts assessed by isotope dilution mass spectrometry and high performance liquid chromatography-fluorescence. Cancer Epidemiol. Biomark. Prev., 17, 1436-1439.
  • Sheijooni-Fumani, N., Hassan, J., & Yousefi, S.R. (2011). Determination of aflatoxin B1 in cereals by homogeneous liquid-liquid extraction coupled to high performance liquid chromatography-fluorescence detection. J.Sep. Sci., 34, 1333-1337.
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  • Sulaiman, S.H., Jamaluddin, R., & Sabran, M.R. (2018). Association Between Urinary Aflatoxin (AFM₁) and Dietary Intake Among Adults in Hulu Langat District, Selangor, Malaysia. Nutrients, Apr 7, 10 (4), 460.
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  • Wang, D., Zhang, Z.W., Li, P.W., Zhang, Q., & Zhang, W. (2016). Time resolved fluorescent immuno chromatographyof aflatoxin B1 in soybean sauce: A rapid and sensitive quantitative Analysis. Sensors, 1094-1102.
  • Weidenbörner, M. (2001). Encyclopedia of food mycotoxins. Sprinter-Verlog, Berlin.
  • Williams, J.H., Phillips, T.D., Jolly, P.E., Stiles, J.K., Jolly, C.M., & Aggarwal, D. (2018). Human aflatoxicosis in developing countries: A review of toxicology, exposure, potential health consequences, and interventions. Am. J. Clin. Nutr,. 80, 1106-1122.
  • Yu, M.W., Lien, J.P., Chiu, Y.H., Santella, R.M., Liaw, Y.F., & Chen, C.J. (1997). Effect of aflatoxin metabolism and DNA adduct formation on hepatocellular carcinoma among chronic hepatitis B carriers in Taiwan. J. Hepatol., 27, 320-330.
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  • Zhao, M., Wang, P., Guo, Y., Wang, L., Luo, F., Qiu, B., & ve ark. (2018). Detection of aflatoxin B1 in food samples based on target-responsive aptamer-crosslinked hydrogel using a hand held pH meter as readout. Talanta 176, 34-39.
Toplam 83 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Veteriner Bilimleri
Bölüm Derleme
Yazarlar

Fadime Tonbak 0000-0001-7308-512X

Pelin Demir 0000-0002-0824-1672

Yayımlanma Tarihi 11 Eylül 2021
Kabul Tarihi 30 Ağustos 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 12 Sayı: 2

Kaynak Göster

APA Tonbak, F., & Demir, P. (2021). YEM VE GIDALARLA HAYATIMIZA GİREN AFLATOKSİNLERİ ÖNLEME YÖNTEMLERİ. Veteriner Farmakoloji Ve Toksikoloji Derneği Bülteni, 12(2), 105-117. https://doi.org/10.38137/vftd.966325
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