Squalene and Health Effects

Abstract

Squalene is a terpenoid and main hydrocarbon of olive oil and found at levels as high as 0.7 % in olive oil. Its main sources are olive oil, palm oil, shark liver oil, wheat germ and rice bran. In human body squalene is synthesized by the liver and skin and it is transported in the blood by the small and very small density lipoproteins. In addition to sythesize in human body, it is consumed as an inseparable part of human diet. Besides squalene is a natural antioxidant, it contributes to olive oil stability and flavor by preventing otooxidation reactions. It also has a protective activity against breast cancer, cardiovasculer diseases, tumor formation and it decreases cholesterol level and increases the patient’s responce to vaccine. Squalene is used as a moisturizing or softening agent in cosmetic preparations in natural or hydrogene form (squalene).

Keywords

• Olive oil,Squalene,Hydrocarbon,Health

Skualen ve Sağlık Üzerine Etkisi

Öz

Zeytinyağının temel hidrokarbonu olan skualen, terpenoid hidrokarbon olup zeytinyağında %0.7 gibi yüksek seviyelerde bulunmaktadır. Zeytinyağının yanı sıra doğada özellikle palm yağı, köpek balığı karaciğeri yağı, buğday tohumu ve pirinç kepeğinde yaygın olarak bulunmaktadır. İnsanlarda skualen karaciğerde ve deride sentezlenir ve kanda çok düşük yoğunluklu lipoproteinler (VLDL) ve düşük yoğunluklu lipoproteinlerle (LDL) taşınır. Ayrıca hücre içinde sentezlenmelerinin yanı sıra insan diyetinin ayrılmaz bir parçası olarak da tüketilmektedir. Skualen doğal antioksidan olmanın yanında otooksidasyon reaksiyonlarını engelleyerek yağların stabilitesi ve aroması ile lezzet özelliklerine katkıda bulunur. Bunun yanı sıra aşılarda ağrıyı hafifletici, göğüs kanserini önleyici etki, kardiyovasküler-koruma, tümör-koruma ve serum kolesterol seviyesini düşürme özelliklerine sahiptir. Skualen doğal veya hidrojene formunda (skualen) kozmetik preparatlarda nemlendirici veya yumuşatıcı bir madde olarak kullanılmaktadır.

Anahtar Kelimeler

• Zeytinyağı,Skualen,Hidrokarbon,Sağlık

Kaynakça

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