Obesity and Gastrointestinal Regulation of Food Intake

Year 2024, , 37 - 42, 30.03.2024

Öznur Demirtaş , Ayşegül Sümer

https://doi.org/10.59518/farabimedj.1328565

Abstract

The aim in this review is to explain the role of the gastrointestinal system in obesity and related complications by focusing on the biological mechanisms between obesity and the gastrointestinal system, based on the latest evidence in the literature. A systematic search of the literatures in the PubMed and ScienceDirect databases was conducted. Factors such as inflammation, mechanical space-occupying effect, microbiota, and adipocyte peptides are involved the development of obesity-related gastrointestinal system comorbidities. However, obesity occurs when the connection between the gastrointestinal tract and the brain changes. Signaling dysfunction disrupts the brain-gut axis, leading to increased frequency of food intake and excessive fat accumulation. Obesity increases the risk of developing gastrointestinal system disorders. However, the gastrointestinal tract and its pathophysiology play a key role the regulation of food intake and subsequent progression to obesity.

Keywords

Brain-gut axis, Food intake, Gastrointestinal system, Obesity

Obezite ve Gıda Alımının Gastrointestinal Düzenlenmesi

Abstract

Bu derlemedeki amaç, obezite ve gastrointestinal sistem arasındaki biyolojik mekanizmalara odaklanarak literatürdeki en son kanıtlara dayanarak gastrointestinal sistemin obezite ve ilişkili komplikasyonlardaki rolünü açıklamaktır. PubMed ve ScienceDirect veri tabanlarındaki literatürlerin sistematik bir taraması yapılmıştır. Obezite ile ilişkili gastrointestinal sistem komorbiditelerin gelişmesinde inflamasyon, mekanik olarak yer kaplayan etki, mikrobiyota, adiposit peptitler gibi faktörler yer almaktadır. Bununla birlikte gastrointestinal sistem ve beyin arasındaki bağlantı değiştiğinde obezite ortaya çıkmaktadır. Sinyal verme disfonksiyonu, beyin-bağırsak eksenini bozarak, artan gıda alım sıklığına ve aşırı yağ birikimine yol açmaktadır. Obezite, gastrointestinal sistem bozukluklarını geliştirme riskini artırmaktadır. Bununla birlikte gastrointestinal sistem ve patofizyolojisi, gıda alımının düzenlenmesinde ve ardından obeziteye doğru ilerlemede anahtar rol oynamaktadır.

Keywords

Beyin-bağırsak ekseni, Gastrointestinal sistem, Gıda alımı, Obezite

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