Metabolik Sendromlu Hastalarda Oksidatif Durumun İncelenmesi

Year 2022, Volume: 1 Issue: 1, 8 - 14, 30.12.2022

Ilgın Öztürk , Orhan Değer , Ertuğrul Yiğit

Abstract

Metabolik sendrom (MS) obezite, dislipidemi, hipertansiyon ve insülin direnci gibi kardiyovasküler hastalıklar için risk faktörlerini içeren kriterlerin bir araya gelmesi olarak tanımlanmıştır. MS prevalansı obezite ve sedanter yaşama bağlı olarak tüm dünyada olduğu gibi Türkiye'de de giderek artmaktadır. Bu çalışmada MS’de lipid profilini tespit etmek amacıyla Trabzon il merkezinde toplam 2017 kişi tarandı ve MS tespit edilen 355 (231 kadın ve 124 erkek) kişi çalışmaya dahil edildi. National Cholesterol Education Program (NCEP) 2001 ATP III raporunda yer alan beş MS tanı kriterinden en az üçüne sahip olan hastalara MS tanısı konuldu. Kontrol grubu aynı örneklem grubu içindeki 100 (64 kadın, 36 erkek) kişiden oluşturuldu. MS tespit edilen 355 kişiden, 224'ü üç kritere, 11'i dört kritere, 20'si beş kritere sahip olmak üzere üç gruba ayrıldı. Hastalardan alınan serum örneklerinde rutin biyokimya laboratuvarında yüksek yoğunluklu lipoprotein (HDL-K), düşük yoğunluklu lipoprotein (LDL-K), C reaaktif protein (CRP), lipoprotein a [Lp(a)], apolipoprotein A-I (apo A-I), apolipoprotein B100 (apo B-100), insulin, total kolesterol (TK), trigliserid (TG) ölçüldü. Ayrıca serum örneklerinde okside LDL (oksLDL), peroksid kapasitesi ve total antioksidan kapasitesi (TAK) ticari kitler kullanılarak ölçüldü. OksLDL ve peroksid kapasitesi hasta gruplarında kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksek bulunurken, TAK ise istatistiksel olarak anlamlı derecede düşük bulundu. Bunun yanı sıra hasta gruplarında kontrol grubuna kıyasla apo B-100, Lp(a), CRP, insülin, TK, glukoz, TG, bel çevresi, sistolik ve diyastolik kan basıncı istatistiksel olarak anlamlı derecede yüksek bulunurken, apo A-I ve HDL-K seviyeleri istatistiksel olarak anlamlı derecede düşük bulundu. MS’de oksidatif stres dolayısıyla lipid oksidasyonunun arttığı, buna karşılık antioksidan sistemin zayıfladığı sonucuna varıldı.

Keywords

İnflamasyon, Metabolik sendrom, Oksidatif stres

Supporting Institution

KARADENİZ TEKNİK ÜNİVERSİTESİ BİLİMSEL ARAŞTIRMA PROJELERİ KOORDİNASYON BİRİMİ

Project Number

2003.114.003.5

Investigation of Oxidative Status in Patients with Metabolic Syndrome

Abstract

Metabolic syndrome has been defined as a combination of criteria including risk factors for cardiovascular diseases such as obesity (especially abdominal obesity), dyslipidemia, hypertension and insulin resistance. The prevalence of metabolic syndrome is increasing in Turkey as well as in the whole world due to obesity and sedentary life. In this study, a total of 2017 people were screened in Trabzon city center in order to determine the lipid profile of metabolic syndrome. A total of 355 people aged 20-59 years with metabolic syndrome were included in the study. The diagnosis of metabolic syndrome was made by the presence of at least three of the five metabolic syndrome diagnostic criteria according to the NCEP 2001 ATP III report. A total of 100 people, 64 women and 36 men, were included in the control group. Of the 355 people with metabolic syndrome, 224 met three criteria, 11 had four criteria and 20 had five criteria. In this study, oxidized LDL (oxLDL) antibody, peroxide capacity, which is one of the lipid oxidation tests, was found to be significantly higher in all three subgroups compared to the control group. Total antioxidant capacity was found to be significantly lower. In addition, apo B-100, Lypoprotein (a) [Lp(a)], C reactive protein (CRP), insulin, total cholesterol, glucose, triglyceride, waist circumference, systolic and diastolic blood pressure in the metabolic syndrome patient group compared to the control group while apo A-I and HDL-C were found to be significantly lower. It was concluded that lipid oxidation increased due to oxidative stress in patients with metabolic syndrome, while the antioxidant system was weakened.

Keywords

Inflammation, Metabolic syndrome, Oxidative stress

Project Number

2003.114.003.5

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