Research Article

The potential of Barbarea species in the management of obesity, hyperlipidemia, and diabetes

Volume: 9 Number: 1 June 20, 2026
TR EN

The potential of Barbarea species in the management of obesity, hyperlipidemia, and diabetes

Abstract

Barbarea species belonging to the Brassicaceae family contain glucosinolates, flavonoids, phenolic acids, saponosides, fatty acids, and other bioactive compounds. These compounds are reported to exhibit antioxidant, antimicrobial, antimutagenic, antiproliferative, and herbicidal effects, as well as beneficial effects on metabolic diseases. In particular, organosulfur and polyphenolic compounds have been reported to exhibit inhibitory effects on enzymes such as cyclooxygenase, lipoxygenase, nitric oxide synthase, pancreatic lipase, lipoprotein lipase, and glucosidase. In this study, the inhibitory activities of methanol extracts, chloroform, ethyl acetate, and remaining aqueous subfractions obtained from the aerial parts of B. auriculata var. paludosa Coode& Cullen and B. plantaginea DC on pancreatic lipase, cholesterol esterase, and α-glucosidase enzymes were investigated for the first time. When the results obtained in the study are evaluated, the ethyl acetate subfraction of B. plantaginea exhibited the strongest pancreatic lipase and cholesterol esterase inhibitory activities, with IC₅₀ values of 111.687 ± 1.291 µg/mL and 10.718 ± 0.308 µg/mL, respectively. For α-glucosidase inhibition, the methanol extract of B. auriculata subsp. paludosa demonstrated the highest activity with an IC₅₀ value of 135.207 ± 0.136 µg/mL. it is seen that the ethyl acetate subfraction of both species has stronger cholesterol esterase inhibitory effects, moderate lipase and glucosidase inhibitory effects.

Keywords

Barbarea, Glucosidase, Lipase, Cholesterol esterase

Supporting Institution

Office of Scientific Research Projects of Karadeniz Technical University

Project Number

TLÖ-2023-10992

Ethical Statement

There is no conflict of interest.

Thanks

The study was supported by Office of Scientific Research Projects of Karadeniz Technical University (Project number: TLÖ-2023-10992).

References

  1. Agerbirk, N., & Olsen, C. E. (2015). Glucosinolate hydrolysis products in the crucifer Barbarea vulgaris include a thiazolidine-2-one from a specific phenolic isomer as well as oxazolidine-2-thiones. Phytochemistry, 115, 143-151.
  2. Akkemik, Ü., & Yılmaz, H. (2016). A new species record for the flora of Turkey: Barbaraea bracteosa Guss. Journal of the Faculty of Forestry Istanbul University, 66(2), 636-640.
  3. Aktar, N., Qureshi, N. K., & Ferdous, H. S. (2017). Obesity: A review of pathogenesis and management strategies in adult. Delta Medical College Journal, 5(1), 35-48.
  4. Al-Shehbaz, I. A., Mutlu, B., & Dönmez, A. A. (2007). The Brassicaceae (Cruciferae) of Turkey, updated. Turkish Journal of Botany, 31(4), 327-336.
  5. Andersson, A. A., Merker, A., Nilsson, P., Sørensen, H., & Åman, P. (1999). Chemical composition of the potential new oilseed crops Barbarea vulgaris, Barbarea verna and Lepidium campestre. Journal of the Science of Food and Agriculture, 79(2), 179-186.
  6. Seyedan, A., Alshawsh, M. A., Alshagga, M. A., Koosha, S., & Mohamed, Z. (2015). Medicinal plants and their inhibitory activities against pancreatic lipase: A review. Evidence-Based Complementary and Alternative Medicine, 2015(1), 973143.
  7. Badem, M., Sener, S. O., Kanbolat, S., Korkmaz, N., Yildirmiş, S., Ozgen, U., ... & Çalış, İ. (2021). Evaluation of biological activities of Barbarea integrifolia and isolation of a new glucosinolate derivated compound. Zeitschrift für Naturforschung C, 76(9-10), 375-382.
  8. Badem, M., Sener, S. O., Korkmaz, N., Kanbolat, S., Yildirmiş, S., Ozgen, U., ... & Kandemir, A. (2020). Phenolic content and enzyme inhibition activities of Barbarea auriculata var. paludosa, B. integrifolia and B. plantaginea (Brassicaceae).
  9. Badenes-Perez, F. R., Gershenzon, J., & Heckel, D. G. (2014). Insect attraction versus plant defense: Young leaves high in glucosinolates stimulate oviposition by a specialist herbivore despite poor larval survival due to high saponin content. PLoS ONE, 9(4), e95766.
  10. Bağcı, Y. (2012). Barbarea. In A. Güner, S. Aslan, T. Ekim, M. Vural, & M. T. Babaç (Eds.), Türkiye bitkileri listesi (Damarlı bitkiler) (p. 1290). Nezahat Gökyiğit Botanik Bahçesi ve Flora Araştırmaları Derneği Yayını.
APA
Badem, M., Kanbolat, Ş., Kandemir, A., Öztürk, A. A., & Topçu, H. (2026). The potential of Barbarea species in the management of obesity, hyperlipidemia, and diabetes. Journal of Apitherapy and Nature, 9(1), 144-151. https://doi.org/10.35206/jan.1908389
AMA
1.Badem M, Kanbolat Ş, Kandemir A, Öztürk AA, Topçu H. The potential of Barbarea species in the management of obesity, hyperlipidemia, and diabetes. J.Apit.Nat. 2026;9(1):144-151. doi:10.35206/jan.1908389
Chicago
Badem, Merve, Şeyda Kanbolat, Ali Kandemir, Ayşe Aleyna Öztürk, and Hayrunnisa Topçu. 2026. “The Potential of Barbarea Species in the Management of Obesity, Hyperlipidemia, and Diabetes”. Journal of Apitherapy and Nature 9 (1): 144-51. https://doi.org/10.35206/jan.1908389.
EndNote
Badem M, Kanbolat Ş, Kandemir A, Öztürk AA, Topçu H (June 1, 2026) The potential of Barbarea species in the management of obesity, hyperlipidemia, and diabetes. Journal of Apitherapy and Nature 9 1 144–151.
IEEE
[1]M. Badem, Ş. Kanbolat, A. Kandemir, A. A. Öztürk, and H. Topçu, “The potential of Barbarea species in the management of obesity, hyperlipidemia, and diabetes”, J.Apit.Nat., vol. 9, no. 1, pp. 144–151, June 2026, doi: 10.35206/jan.1908389.
ISNAD
Badem, Merve - Kanbolat, Şeyda - Kandemir, Ali - Öztürk, Ayşe Aleyna - Topçu, Hayrunnisa. “The Potential of Barbarea Species in the Management of Obesity, Hyperlipidemia, and Diabetes”. Journal of Apitherapy and Nature 9/1 (June 1, 2026): 144-151. https://doi.org/10.35206/jan.1908389.
JAMA
1.Badem M, Kanbolat Ş, Kandemir A, Öztürk AA, Topçu H. The potential of Barbarea species in the management of obesity, hyperlipidemia, and diabetes. J.Apit.Nat. 2026;9:144–151.
MLA
Badem, Merve, et al. “The Potential of Barbarea Species in the Management of Obesity, Hyperlipidemia, and Diabetes”. Journal of Apitherapy and Nature, vol. 9, no. 1, June 2026, pp. 144-51, doi:10.35206/jan.1908389.
Vancouver
1.Merve Badem, Şeyda Kanbolat, Ali Kandemir, Ayşe Aleyna Öztürk, Hayrunnisa Topçu. The potential of Barbarea species in the management of obesity, hyperlipidemia, and diabetes. J.Apit.Nat. 2026 Jun. 1;9(1):144-51. doi:10.35206/jan.1908389