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Estrogen and progesteron immunreactivity in hyperplastic and atypical hyperplastic endometrium

Year 2003, Volume: 34 Issue: 3, 9 - 11, 01.04.2003

Gözde Kır Handan Çetiner Ayşe Gürbüz

Abstract

Objective: In our study; we aimed to evaluate estrogen and progesteron receptor expression in hyperplastic and atypical hyperplastic endometrium. Materials and Methods: ER and PR receptor staining was performed immunohistochemically in paraffin embedded specimens from seventeen patients who had simple or complex nonatypical and ten patients with atypical complex hyperplasia Results: Estrogen positivity was significantly lower in atypical hyperplastic endometrial glands and stroma than nonatypical hyperplastic type (p=0.01 ve p

Keywords

Endometrial Hyperplasia Estrogens Receptors Estrogen Receptors Progesterone Immunohistochemistry

References

  • 1. Nakopoulou L.D, Tsionou MCH, Mastrominas M. Value of immunohistochemical demonstration of several epithelial markers in hyperplastic and neoplastic endometrium.Gynecol Oncol 1990; 37: 346-53
  • 2. Mazur TM and Kurman RJ. Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach. New York 1995,Springer-Verlag: 173
  • 3. Kurman RJ, Norris HJ. Evaluation of criteria for distinguishing atypical endometrial hyperplasia from well differentiated carcinoma. Cancer 1982; 49: 2547-59
  • 4. Carcangiu ML, Chambers JT, Vaynick 1M, Pirro M, Schwartz PE. Immunhistochemical evaluation of estrogen and progesterone receptor content in 183patients with endometrial carcinoma. Parti: clinical and histologic correlations. Am J Clin Pathol 1990; 94: 247-54
  • 5. Huang SJ, Cheng KJ, Yao SF. Immunohistoc hemical estrogen receptor assessment in hyperplastic, neoplastic, and physiologic endometria. Path Res Pract 1991; 187: 487-95
  • 6. Papadimitriou CS, Athanaiadou S, Stylianidou A, Bai MK, Demoliatis J, Stephanou DG. Immunhistochemical detection of estrogen receptors on paraffin sections of normal, hyperplastic and carcinomatous endometrium. Oncol 1992; 49:196- 202
  • 7. Brustein S, Fruchter R, Greene GL, Pertschuk LP. Immunohistochemical assay of progesterone receptors in paraffin-embedded specimens of endometrial carcinoma and hyperplasia: a preliminary evaluation. Mod Pathol 1989 ; 2: 449- 55
  • 8. Bergeron C, FerenezyA, Toft DO, Shyamala G. Immunocytochemical study of progesterone receptors in hyperplastic and neoplastic endometrial tissues. Cancer Res. 1988; 48: 6132-6
  • 9. Teleman S, Hilgarth M; Fredunberg N, Bettendorf H, Mihailovci MS. An immunohistochemical study of the steroid hormone receptors in endometrial hyperplasia. Rev Med Soc Med Nat Iasi. 1999; 103: 138-41
  • 10. Snijders MP, de Goeij AF, Knoudstaal AB, de Haan J, Bosman FT. Oestrogen and progesterone receptor immunocytochemistry in human hyperplastic and neoplastic endometrium. J Pathol 1992; 166; 171-7.

Atipisiz ve atipli endometrial hiperplazilerde, östrogen ve progesteron reseptür immun reaktivitesi

Year 2003, Volume: 34 Issue: 3, 9 - 11, 01.04.2003

Gözde Kır Handan Çetiner Ayşe Gürbüz

Abstract

Amaç:Atipisiz ve atipili endometrial hiperplazilerdeki östrojen ve ve progesteron reseptör ekspresyonunun değerlendirilmesi. Materyal ve Metod: Onyediadet atipisiz basit veya kompleks hiperplazi ve 10 adet atipili kompleks hiperplazi içeren parafin blokda immunhistokimyasal yöntemle östrojen ve progesteron reseptörleri çalışıldı. Bulgular: Atipili hiperplazilerde gland epiteli ve stromal hücrelerin östrojen pozitivitesi, atipisiz hiperlazilere göre önemli derecede düşük bulundu (p=0.01 ve p

Keywords

Endometriyum hiperplazisi Östrojenler Reseptörler östrojen Reseptörler progesteron İmmünohistokimya

References

  • 1. Nakopoulou L.D, Tsionou MCH, Mastrominas M. Value of immunohistochemical demonstration of several epithelial markers in hyperplastic and neoplastic endometrium.Gynecol Oncol 1990; 37: 346-53
  • 2. Mazur TM and Kurman RJ. Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach. New York 1995,Springer-Verlag: 173
  • 3. Kurman RJ, Norris HJ. Evaluation of criteria for distinguishing atypical endometrial hyperplasia from well differentiated carcinoma. Cancer 1982; 49: 2547-59
  • 4. Carcangiu ML, Chambers JT, Vaynick 1M, Pirro M, Schwartz PE. Immunhistochemical evaluation of estrogen and progesterone receptor content in 183patients with endometrial carcinoma. Parti: clinical and histologic correlations. Am J Clin Pathol 1990; 94: 247-54
  • 5. Huang SJ, Cheng KJ, Yao SF. Immunohistoc hemical estrogen receptor assessment in hyperplastic, neoplastic, and physiologic endometria. Path Res Pract 1991; 187: 487-95
  • 6. Papadimitriou CS, Athanaiadou S, Stylianidou A, Bai MK, Demoliatis J, Stephanou DG. Immunhistochemical detection of estrogen receptors on paraffin sections of normal, hyperplastic and carcinomatous endometrium. Oncol 1992; 49:196- 202
  • 7. Brustein S, Fruchter R, Greene GL, Pertschuk LP. Immunohistochemical assay of progesterone receptors in paraffin-embedded specimens of endometrial carcinoma and hyperplasia: a preliminary evaluation. Mod Pathol 1989 ; 2: 449- 55
  • 8. Bergeron C, FerenezyA, Toft DO, Shyamala G. Immunocytochemical study of progesterone receptors in hyperplastic and neoplastic endometrial tissues. Cancer Res. 1988; 48: 6132-6
  • 9. Teleman S, Hilgarth M; Fredunberg N, Bettendorf H, Mihailovci MS. An immunohistochemical study of the steroid hormone receptors in endometrial hyperplasia. Rev Med Soc Med Nat Iasi. 1999; 103: 138-41
  • 10. Snijders MP, de Goeij AF, Knoudstaal AB, de Haan J, Bosman FT. Oestrogen and progesterone receptor immunocytochemistry in human hyperplastic and neoplastic endometrium. J Pathol 1992; 166; 171-7.
There are 10 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Gözde Kır This is me

Handan Çetiner This is me

Ayşe Gürbüz This is me

Publication Date April 1, 2003
Published in Issue Year 2003 Volume: 34 Issue: 3

Cite

APA Kır, G., Çetiner, H., & Gürbüz, A. (2003). Atipisiz ve atipli endometrial hiperplazilerde, östrogen ve progesteron reseptür immun reaktivitesi. Zeynep Kamil Tıp Bülteni, 34(3), 9-11. https://doi.org/10.16948/zktb.78687
AMA Kır G, Çetiner H, Gürbüz A. Atipisiz ve atipli endometrial hiperplazilerde, östrogen ve progesteron reseptür immun reaktivitesi. Zeynep Kamil Tıp Bülteni. April 2003;34(3):9-11. doi:10.16948/zktb.78687
Chicago Kır, Gözde, Handan Çetiner, and Ayşe Gürbüz. “Atipisiz Ve Atipli Endometrial Hiperplazilerde, östrogen Ve Progesteron reseptür Immun Reaktivitesi”. Zeynep Kamil Tıp Bülteni 34, no. 3 (April 2003): 9-11. https://doi.org/10.16948/zktb.78687.
EndNote Kır G, Çetiner H, Gürbüz A (April 1, 2003) Atipisiz ve atipli endometrial hiperplazilerde, östrogen ve progesteron reseptür immun reaktivitesi. Zeynep Kamil Tıp Bülteni 34 3 9–11.
IEEE G. Kır, H. Çetiner, and A. Gürbüz, “Atipisiz ve atipli endometrial hiperplazilerde, östrogen ve progesteron reseptür immun reaktivitesi”, Zeynep Kamil Tıp Bülteni, vol. 34, no. 3, pp. 9–11, 2003, doi: 10.16948/zktb.78687.
ISNAD Kır, Gözde et al. “Atipisiz Ve Atipli Endometrial Hiperplazilerde, östrogen Ve Progesteron reseptür Immun Reaktivitesi”. Zeynep Kamil Tıp Bülteni 34/3 (April 2003), 9-11. https://doi.org/10.16948/zktb.78687.
JAMA Kır G, Çetiner H, Gürbüz A. Atipisiz ve atipli endometrial hiperplazilerde, östrogen ve progesteron reseptür immun reaktivitesi. Zeynep Kamil Tıp Bülteni. 2003;34:9–11.
MLA Kır, Gözde et al. “Atipisiz Ve Atipli Endometrial Hiperplazilerde, östrogen Ve Progesteron reseptür Immun Reaktivitesi”. Zeynep Kamil Tıp Bülteni, vol. 34, no. 3, 2003, pp. 9-11, doi:10.16948/zktb.78687.
Vancouver Kır G, Çetiner H, Gürbüz A. Atipisiz ve atipli endometrial hiperplazilerde, östrogen ve progesteron reseptür immun reaktivitesi. Zeynep Kamil Tıp Bülteni. 2003;34(3):9-11.