Overin bening, ''borderline'' ve malign epitelyal tümörlerinde Glut-1 ekspresyonu ve prognostik parametrelerle ilişkisi

Müberra Seğmen Yılmaz; Dilek Yavuzer; Nimet Karaday; Aylin Ege Gül; Gözde Kır

Research Article

Expression of Glut-1 in benign, borderline and malignnat tumors of the ovary, its relationship with prognostic parameters

Year 2008, Volume: 39 Issue: 1, 21 - 25, 01.02.2008

Müberra Seğmen Yılmaz Dilek Yavuzer Nimet Karaday Aylin Ege Gül Gözde Kır

Abstract

Objective: Aberrant expression of Glut 1 in epithelial malignancies and its relationship with neoplatic progression is well known. Glut 1 exists on the cell surface. In this retrospective study we evaluated the Glut 1 expression, in benign,borderline malign serous and mucinous ovarian tumours, as a prognostic parameter. Materials and Methods: We studied totally 92 cases; consisted of 38 malign(34 serous and 4 mucinous),15 borderline (9 borderline serous and 6 borderline mucinous), 34 benign(19 benign serous cystadenoma and 15 benign mucinous cystadenoma) and 5 cases diagnosed as endosalpingiosis of ovary. Sections from paraffin blocks of the cases had been immunohistochemically stained with Glut 1-Ab-l (Rabbit PAB RB-078-A Neomarkers) antibody. Results: The benign and endosalpingiosis group showed non-staining with the antibody however %86,7 of borderlines and %97,4 of malign ones revealed positive membranous staining (p

Keywords

Glucose Transporter Type 1, Ovarian Neoplasms, Carcinoma, Neoplasms, Cystic, Mucinous, and Serous, Cystadenoma, Mucinous, Cystadenoma, Serous

References

1. Kalır T, Wang BY, Goldfischer M, et al: İmmünohistochemical staining of Glut I in benign, borderline and malignant ovarian epithelia. Cancer 2002; 94:1078-1082
2. Wang BY, Kalir T, Sabo E, et al: immünohistochemical staining of Glut 1 in benign, hyperplastic, and malignant endometrial epithelia
Cancer 2000; 88: 2774-2781
3. Alo PL, Visca P, Botti C, et al: İmmünohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue. Am J Clin Pathol 2001; 116: 129-134. 4. Kawamura T, Kusakabe T, Sugino T, et ah Expression of glucose transporter 1 in human gastric carcinoma. Cancer 2001; 92: 634-641
5. Kim YW, Park YK, Yoon TY, et al: Expression of the Glut 1 glucose transporter in gallbladder carcinomas. Hepatogastroenterology 2002; 49: 907-911
6. Cantuaria G, Fagotti A, Ferrandina G, et at: Glut 1 expression in ovarian carcinoma. Cancer 2001; 92:1144-1150
7. Cantuaria G, Magalhaes A, Penalver M, et ah Expression of Glut 1 glucose transporter in borderline and malignant epithelial tumours of the ovary. Gynecol Oncol 2000; 79: 33-7
8. Furudoi A, Tanaka S, Horuma K, etal: Clinical significance of human erythrocyte glucose transporter 1 expression at the deepest invasive site of advanced colorectal carcinoma. Oncology 2001;60:162-169
9. Iserovich P, Wang D, Ma L, et ah Changes in glucose transport and water permeability resulting from the T31OIpathogenic mutation in Glut 1 are consistent with two transport channels Per monomer. J Biol Chem 2002; 277: 30991-30997
10. MenschLS, WellerL, Simmons-Arnold L, et ah Glut 1 antibody staining in thin- layer specimens of benign and malignant body cavity effusions. Acta Cytol 2002; 46: 813-818
11. Nguyen XC, Lee WW,Chung JH, at ah FDG uptake, glucose transporter type 1, and Ki-67 expressions in non-small-cell lung cancer: Correlations and prognosticvalues
Eur J Radiol. 2007 May;62(2):214- 9.Epub2007Janl8
12. Wincewicz A,Sulkowska M, Koda M, at ah Significant coexpression of GLUT-1, Bcl-xL, and Box in colorectalc oncer. Ann N YAcadSci. 2007 Jan;1095:53-61
13. Kundel M, Moergel M, Stockinger M,at ah Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oralcavity. OralOncol.200 7Jan3

Overin bening, ''borderline'' ve malign epitelyal tümörlerinde Glut-1 ekspresyonu ve prognostik parametrelerle ilişkisi

Year 2008, Volume: 39 Issue: 1, 21 - 25, 01.02.2008

Müberra Seğmen Yılmaz Dilek Yavuzer Nimet Karaday Aylin Ege Gül Gözde Kır

Abstract

Amaç: Hücre yüzeyinde yer alan Glut I 'in epitelyal malignitelerde aberan ekspresyonu ve neoplastik progresyonla ilişkisi bilinmektedir. Bu retrospektif çalışmada; benign, borderline, malign s er öz ve müsinöz over tümörlerindeki Glut 1 ekspresyonu, borderline ve malign tümörlerde prognostik parametre olarak anlamlılığı araştırılmıştır. Materyal ve Metod: 38'i malign(34'ü seröz karsinom, 4'ü müsinöz karsinom), 15'i borderline(9'u borderline seröz tümör, 6[sı borderline müsinöz tümör), 34'ü benign(19'u benign serözkist veya benign seröz kistadenom,15'i benign müsinöz kistadenom) over tümörü ve 5 'i överde endosalpingiozis tanısı almış olan toplam 92 olgunun parafin bloklarından elde edilen kesitlere Glutl-Ab-1 (Rabbit PAB RB-078-A Neomarkers) antikoru ile immünohistokimyasal boyama prosedürü uygulandı. Bulgular: Glut-1 ile benign olgularda ve endosalpingiozis olgularında hiç boyanma olmazken borderline olguların %86,7'sinde malign olguların ise %97,4'ünde pozitif membranöz boyanma saptanmıştır (p

Keywords

Glukoz taşıyıcı tip 1, Yumurtalık neoplazmları, Karsinom, Neoplazmlar, kistik, müsinöz ve seröz, Kistadenom, müsinöz, Kistadenom, seröz

References

1. Kalır T, Wang BY, Goldfischer M, et al: İmmünohistochemical staining of Glut I in benign, borderline and malignant ovarian epithelia. Cancer 2002; 94:1078-1082
2. Wang BY, Kalir T, Sabo E, et al: immünohistochemical staining of Glut 1 in benign, hyperplastic, and malignant endometrial epithelia
Cancer 2000; 88: 2774-2781
3. Alo PL, Visca P, Botti C, et al: İmmünohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue. Am J Clin Pathol 2001; 116: 129-134. 4. Kawamura T, Kusakabe T, Sugino T, et ah Expression of glucose transporter 1 in human gastric carcinoma. Cancer 2001; 92: 634-641
5. Kim YW, Park YK, Yoon TY, et al: Expression of the Glut 1 glucose transporter in gallbladder carcinomas. Hepatogastroenterology 2002; 49: 907-911
6. Cantuaria G, Fagotti A, Ferrandina G, et at: Glut 1 expression in ovarian carcinoma. Cancer 2001; 92:1144-1150
7. Cantuaria G, Magalhaes A, Penalver M, et ah Expression of Glut 1 glucose transporter in borderline and malignant epithelial tumours of the ovary. Gynecol Oncol 2000; 79: 33-7
8. Furudoi A, Tanaka S, Horuma K, etal: Clinical significance of human erythrocyte glucose transporter 1 expression at the deepest invasive site of advanced colorectal carcinoma. Oncology 2001;60:162-169
9. Iserovich P, Wang D, Ma L, et ah Changes in glucose transport and water permeability resulting from the T31OIpathogenic mutation in Glut 1 are consistent with two transport channels Per monomer. J Biol Chem 2002; 277: 30991-30997
10. MenschLS, WellerL, Simmons-Arnold L, et ah Glut 1 antibody staining in thin- layer specimens of benign and malignant body cavity effusions. Acta Cytol 2002; 46: 813-818
11. Nguyen XC, Lee WW,Chung JH, at ah FDG uptake, glucose transporter type 1, and Ki-67 expressions in non-small-cell lung cancer: Correlations and prognosticvalues
Eur J Radiol. 2007 May;62(2):214- 9.Epub2007Janl8
12. Wincewicz A,Sulkowska M, Koda M, at ah Significant coexpression of GLUT-1, Bcl-xL, and Box in colorectalc oncer. Ann N YAcadSci. 2007 Jan;1095:53-61
13. Kundel M, Moergel M, Stockinger M,at ah Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oralcavity. OralOncol.200 7Jan3

There are 14 citations in total.

Details

Primary Language	Turkish
Subjects	Health Care Administration
Journal Section	Articles
Authors	Müberra Seğmen Yılmaz This is me Dilek Yavuzer This is me Nimet Karaday This is me Aylin Ege Gül This is me Gözde Kır This is me
Publication Date	February 1, 2008
Published in Issue	Year 2008 Volume: 39 Issue: 1

Cite

APA	Yılmaz, M. S., Yavuzer, D., Karaday, N., Gül, A. E., et al. (2008). Overin bening, ’’borderline’’ ve malign epitelyal tümörlerinde Glut-1 ekspresyonu ve prognostik parametrelerle ilişkisi. Zeynep Kamil Tıp Bülteni, 39(1), 21-25.
AMA	Yılmaz MS, Yavuzer D, Karaday N, Gül AE, Kır G. Overin bening, ’’borderline’’ ve malign epitelyal tümörlerinde Glut-1 ekspresyonu ve prognostik parametrelerle ilişkisi. Zeynep Kamil Tıp Bülteni. February 2008;39(1):21-25.
Chicago	Yılmaz, Müberra Seğmen, Dilek Yavuzer, Nimet Karaday, Aylin Ege Gül, and Gözde Kır. “Overin Bening, ’’borderline’’ Ve Malign Epitelyal tümörlerinde Glut-1 Ekspresyonu Ve Prognostik Parametrelerle ilişkisi”. Zeynep Kamil Tıp Bülteni 39, no. 1 (February 2008): 21-25.
EndNote	Yılmaz MS, Yavuzer D, Karaday N, Gül AE, Kır G (February 1, 2008) Overin bening, ’’borderline’’ ve malign epitelyal tümörlerinde Glut-1 ekspresyonu ve prognostik parametrelerle ilişkisi. Zeynep Kamil Tıp Bülteni 39 1 21–25.
IEEE	M. S. Yılmaz, D. Yavuzer, N. Karaday, A. E. Gül, and G. Kır, “Overin bening, ’’borderline’’ ve malign epitelyal tümörlerinde Glut-1 ekspresyonu ve prognostik parametrelerle ilişkisi”, Zeynep Kamil Tıp Bülteni, vol. 39, no. 1, pp. 21–25, 2008.
ISNAD	Yılmaz, Müberra Seğmen et al. “Overin Bening, ’’borderline’’ Ve Malign Epitelyal tümörlerinde Glut-1 Ekspresyonu Ve Prognostik Parametrelerle ilişkisi”. Zeynep Kamil Tıp Bülteni 39/1 (February 2008), 21-25.
JAMA	Yılmaz MS, Yavuzer D, Karaday N, Gül AE, Kır G. Overin bening, ’’borderline’’ ve malign epitelyal tümörlerinde Glut-1 ekspresyonu ve prognostik parametrelerle ilişkisi. Zeynep Kamil Tıp Bülteni. 2008;39:21–25.
MLA	Yılmaz, Müberra Seğmen et al. “Overin Bening, ’’borderline’’ Ve Malign Epitelyal tümörlerinde Glut-1 Ekspresyonu Ve Prognostik Parametrelerle ilişkisi”. Zeynep Kamil Tıp Bülteni, vol. 39, no. 1, 2008, pp. 21-25.
Vancouver	Yılmaz MS, Yavuzer D, Karaday N, Gül AE, Kır G. Overin bening, ’’borderline’’ ve malign epitelyal tümörlerinde Glut-1 ekspresyonu ve prognostik parametrelerle ilişkisi. Zeynep Kamil Tıp Bülteni. 2008;39(1):21-5.