Expression of Glut-1 in benign, borderline and malignnat tumors of the ovary, its relationship with prognostic parameters

Yıl 2008, Cilt 39, Sayı 1, 21 - 25, 01.02.2008

Müberra Seğmen YILMAZ Dilek YAVUZER Nimet KARADAY Aylin Ege GÜL Gözde KIR

Öz

Objective: Aberrant expression of Glut 1 in epithelial malignancies and its relationship with neoplatic progression is well known. Glut 1 exists on the cell surface. In this retrospective study we evaluated the Glut 1 expression, in benign,borderline malign serous and mucinous ovarian tumours, as a prognostic parameter. Materials and Methods: We studied totally 92 cases; consisted of 38 malign(34 serous and 4 mucinous),15 borderline (9 borderline serous and 6 borderline mucinous), 34 benign(19 benign serous cystadenoma and 15 benign mucinous cystadenoma) and 5 cases diagnosed as endosalpingiosis of ovary. Sections from paraffin blocks of the cases had been immunohistochemically stained with Glut 1-Ab-l (Rabbit PAB RB-078-A Neomarkers) antibody. Results: The benign and endosalpingiosis group showed non-staining with the antibody however %86,7 of borderlines and %97,4 of malign ones revealed positive membranous staining (p

Anahtar Kelimeler

Glucose Transporter Type 1, Ovarian Neoplasms, Carcinoma, Neoplasms, Cystic, Mucinous, and Serous, Cystadenoma, Mucinous, Cystadenoma, Serous

Overin bening, ''borderline'' ve malign epitelyal tümörlerinde Glut-1 ekspresyonu ve prognostik parametrelerle ilişkisi

Öz

Amaç: Hücre yüzeyinde yer alan Glut I 'in epitelyal malignitelerde aberan ekspresyonu ve neoplastik progresyonla ilişkisi bilinmektedir. Bu retrospektif çalışmada; benign, borderline, malign s er öz ve müsinöz over tümörlerindeki Glut 1 ekspresyonu, borderline ve malign tümörlerde prognostik parametre olarak anlamlılığı araştırılmıştır. Materyal ve Metod: 38'i malign(34'ü seröz karsinom, 4'ü müsinöz karsinom), 15'i borderline(9'u borderline seröz tümör, 6[sı borderline müsinöz tümör), 34'ü benign(19'u benign serözkist veya benign seröz kistadenom,15'i benign müsinöz kistadenom) over tümörü ve 5 'i överde endosalpingiozis tanısı almış olan toplam 92 olgunun parafin bloklarından elde edilen kesitlere Glutl-Ab-1 (Rabbit PAB RB-078-A Neomarkers) antikoru ile immünohistokimyasal boyama prosedürü uygulandı. Bulgular: Glut-1 ile benign olgularda ve endosalpingiozis olgularında hiç boyanma olmazken borderline olguların %86,7'sinde malign olguların ise %97,4'ünde pozitif membranöz boyanma saptanmıştır (p

Anahtar Kelimeler

Glukoz taşıyıcı tip 1, Yumurtalık neoplazmları, Karsinom, Neoplazmlar, kistik, müsinöz ve seröz, Kistadenom, müsinöz, Kistadenom, seröz

Kaynakça

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