Tip 2 Diyabetes Mellitus’ lu Hastalarda 25 Hidroksivitamin D Düzeyi ile HbA1c ve Vücut Kitle İndeksi Arasındaki İlişkisinin Değerlendirilmesi

Ahmet Keskin

Araştırma Makalesi

Evaluation of Serum 25-hydroxyvitamin D levels in the Patients With Type2 Diabetes Mellitus and Its Relationship with HbA1c and Body Mass Index

Yıl 2012, Cilt: 12 Sayı: 3, 124 - 125, 01.03.2012

Ahmet Keskin

Öz

Aim: Aim of this study was to evaluate the relationship between 25-hydroxyvitamin D (25(OH)D) values and
HbA1c and body mass index (BMI).
Method: 25(OH)D, BMI and HbA1c values were evaluated
in a diabetic population. Their relationship was evaluated
with spearman corelation analysis.
Results: Vitamin D hypovitaminosis was found in %78 of
patients. There was not found a significant corelation between vitamin D and HbA1c, BMI values.
Discussion: Large randomized controlled studies are needed to evaluate the relationship between DM and vitamin D.

Anahtar Kelimeler

Evaluation, Serum 25-hydroxyvitamin D, Patients

Kaynakça

1. Mizuno CS, Chittiboyina AG, Kurtz TW, Pershadsingh HA, Avery MA.Type 2 diabetes and oral antihyperglycemic drugs. Curr Med Chem. 2008;15(1):61-74
2. Facchini FS, Hua N, Abbasi F, Reaven GM.. Insulin resistance as a predictor of age-related diseases. J Clin Endocrinol Metab. 2001;86:3574–3578.
3. Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria The DECODE study group. European Diabetes Epidemiology Group. Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe. Lancet. 1999;354:617–621.
4. Satman İ. The update criteria and the reasons of them in diagnosis and follow up of diabetes mellitus. Türkiye Klinikleri Journal of Internal Medical Sciences 2007;3:1.15.
5. Tümer G, Çolak R. Tip 2 diabetes mellitusda tıbbi beslenme tedavisi. J. Exp. Clin. Med., 2012; 29:S12-S15
6. Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E: Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus. Diabetes Res Clin Pract 27:181–188, 1995
7. Scragg R, Sowers M, Bell C: Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 27:2813–2818, 2004
8. Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ (1995) Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia 38:1239–1245
9. Chiu KC, Chu A, Go VL, Saad MF (2004) Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 79:820–825
10.Mathieu C, Gysemans C, Giulietti A, Bouillo R. Vitamin D and diabetes. Diabetologia (2005) 48: 1247–1257
11.Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96: 1911-30.
12.Pilz S, van den Hurk K, Nijpels G, Stehouwer CDA. Vitamin D status, incident diabetes and prospective changes in glucose metabolism in older subjects: The Hoorn study. Nutrition, Metabolism & Cardiovascular Diseases (2012) , 1-7
13.Zhao G, Ford ES, Li C. Associations of serum concentrations of 25-hydroxyvitamin 1. D and parathyroid hormone with surrogate markers of insulin resistance among U.S. adults without physician-diagnosed diabetes: NHANES, 2003–2006. Diabetes Care 2010; 33: 344–347.
14. Vilarrasa N, Vendrell J, Maravall J et al. Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population? Endocrine 2010; 38: 235–242.