Çeşitli Tıbbi Suaeda Türlerinin Fitokimyasalları ve Antifungal Özellikleri

Öz

Halofitik bitki Suaeda türü, Irak'ın Anbar bölgesinde bulunur. Bu bitki uzun zamandır bakteriyel ve fungal ağız enfeksiyonlarının tedavisinde kullanılmaktadır. Su, etanol ve aseton özleri kullanılarak yapılan çalışmada, S. aegyptiaca, S. altissima, S. carnosissma ve S. fruticosa'nın fungal izolatlara (Candida albicans, C. dubliensis, C. krusei ve C. tropicalis) karşı fitokimyasal bileşenleri ve antifungal özellikleri belirlenmeye çalışılmıştır. Suaeda türü örneklerinin fitokimyasal bileşenleri kimyasal analizlerle belirlenmiş ve özleri üzerinde agar difüzyon analizleri yapılmıştır. Suaeda türü özlerinin antifungal özellikleri, minimum inhibitör konsantrasyon (MİK) ve minimum fungisit konsantrasyon (MFC) yöntemleri kullanılarak tahmin edilmiştir. Aseton S. altissima extract en yüksek alkaloid, tanen, riboflavin, karbonhidrat ve fosfor seviyelerine (sırasıyla 1.218, 02.501, 0.019, 09.733 ve 00.534 mg/g) sahipken, aseton S. aegyptiaca extract en yüksek polifenol ve flavonoid seviyelerine (sırasıyla 66.16 ve 40.25 mg/g) sahipti. Yaygın bir antibiyotik olan nistatin, aktif bitki özütlerinin antifungal özellikleriyle karşılaştırıldı. 29 mm'lik bir inhibisyon bölgesi ile S. aegyptiaca aseton extract, mevcut araştırmadaki örneklerin değerlendirilen tüm mantar suşlarına karşı etkili olmasına rağmen, Candida krusei'ye karşı en etkili olanıydı. Örneklerin MİK ve MFC'sini belirlemek için mikroseyreltme yöntemi kullanıldı. S. aegyptiaca extract için MİK ve MFC değerleri sırasıyla 2,5 ve 5,0 mg/mL olarak bulundu.

Anahtar Kelimeler

• Suaeda spp.
• Candida spp.
• ağızda pamukçuk
• tıbbi bitkiler
• ekstrakt
• engelleyici
• aktif bileşenler

The Phytochemicals and Antifungal Properties of Several Medicinal Suaeda spp. Halophytes

Öz

The halophytic genus Suaeda is traditionally used in Iraq to treat oral bacterial and fungal infections. This study evaluated the phytochemical composition and antifungal efficacy of aqueous, ethanolic, and acetonic extracts from four species: S. aegyptiaca, S. altissima, S. carnosissima, and S. fruticosa against Candida albicans, C. dubliniensis, C. krusei, and C. tropicalis fungi. Phytochemical profiles were determined via chemical analysis, while antifungal activity was assessed using agar well diffusion and broth microdilution methods to determine the Minimum Inhibitory Concentrations (MIC) and Minimum Fungicidal Concentrations (MFC). Results showed that the acetone extract of S. altissima contained the highest concentrations of alkaloids, tannins, riboflavin, carbohydrates, and phosphorous (1.218, 2.501, 0.019, 9.733, and 0.534 mg/g, respectively). Conversely, the acetone extract of S. aegyptiaca yielded the highest polyphenol (66.16 mg/g) and flavonoid (40.25 mg/g) content. Compared to the reference antifungal Nystatin, all extracts demonstrated efficacy against the tested fungal strains. Notably, the S. aegyptiaca acetone extract exhibited the strongest activity against C. krusei (29 mm inhibition zone), with MIC and MFC values of 2.5 mg/mL and 5.0 mg/mL, respectively.

Anahtar Kelimeler

• Suaeda spp.
• Candida spp.
• Mycoses
• medicinal plants
• extract
• inhibitory
• active components

Etik Beyan

Ethics committee approval is not required for this study

Kaynakça

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