Novel oxidative stress biomarker in sepsis: dynamic thiol-disulfide homeostasis

Betül Kozanhan; Ayşe İlksen Eğilmez; Busra Tok Cekmecelioglu; Mahmut Sami Tutar; Gulay Eren; Deniz Bilgi Özel; Çiğdem Damla Deniz; Salim Neşelioğlu; Ozcan Erel

doi:10.17826/cumj.637127

EN TR

Novel oxidative stress biomarker in sepsis: dynamic thiol-disulfide homeostasis

Abstract

Purpose: The aim of this study was to investigate the relationship between serum dynamic thiol-disulfide homeostasis (TDH) and sepsis, in adult patients.
Materials and Methods: In this observational, prospective, case-control study patients (n=44) diagnosed with sepsis compared with ages and gender-matched healthy controls (n=44). Patients were divided into two subgroups (survivors and non-survivors) dependent variable being remaining alive on the 28th day after ICU admission at the follow-up period. TDH parameters measured using a novel automatic and spectrophotometric method and compared statistically.
Results: In patients with sepsis, native thiol, total thiol, and disulfide levels were lower than the control group, and this difference was statistically significant. TDH parameters between surviving and non-surviving patients were similar at the sepsis diagnosis. However, significant differences found in native and total thiol levels at follow-up via repeated measurement analyses on days 3 and 7 in surviving and non-surviving sub-groups.
Conclusion: This study showed that impairment in dynamic TDH in adults with sepsis may be related to negative outcomes.

Keywords

Dynamic thiol-disulfide homeostasis,Sepsis

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Yoğun Bakım

Bölüm

Araştırma Makalesi

Yazarlar

Betül Kozanhan ^*
0000-0002-5097-9291
Türkiye

Ayşe İlksen Eğilmez Bu kişi benim
0000-0001-9072-0850

Busra Tok Cekmecelioglu Bu kişi benim
0000-0002-4049-6392

Mahmut Sami Tutar
0000-0002-5709-6504

Gulay Eren
0000-0002-5365-3641

Deniz Bilgi Özel Bu kişi benim
0000-0003-3594-5816

Çiğdem Damla Deniz
0000-0002-6052-4645

Salim Neşelioğlu
0000-0002-0974-5717

Ozcan Erel
0000-0002-2996-3236

Yayımlanma Tarihi

31 Mart 2020

Gönderilme Tarihi

23 Ekim 2019

Kabul Tarihi

3 Aralık 2019

Yayımlandığı Sayı

Yıl 2020 Cilt: 45 Sayı: 1

DOI

https://doi.org/10.17826/cumj.637127

IZ

https://izlik.org/JA46DU32MD

MLA

Kozanhan, Betül, vd. “Novel oxidative stress biomarker in sepsis: dynamic thiol-disulfide homeostasis”. Cukurova Medical Journal, c. 45, sy 1, Mart 2020, ss. 63-70, doi:10.17826/cumj.637127.