Yıl 2019, Cilt 12 , Sayı 3, Sayfalar 1381 - 1391 2019-12-31

Türkiye'de yetişen Heliotropium dolosum, H. lasiocarpum ve H. hirsutissimum’un Antioksidan ve Antikolinestaraz Aktiviteleri
Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey

Songül KARAKAYA [1] , Mehmet KOCA [2] , Ceyda Sibel KILIÇ [3]


Alzheimer hastalığı (AD), bilimi AD'nin profilaksisinde kullanılabilecek bitkileri veya biyolojik bileşikleri bulmaya teşvik etmektedir. Heliotropium cinsi Türkiye'de 16 taksonla temsil edilir ve bu türler pirolizidin alkaloitleri içermektedir ve bazılarının antioksidan ve antikolinesteraz aktivitelere sahip olduğu bilinmektedir. Bu çalışmada, H. dolosum, H. lasiocarpum ve H. hirsutissimum'un toprak üstü kısımlarının liyofilize sulu ekstrelerinin antikolinesteraz ve antioksidan kapasiteleri incelenmiştir. Örneklerin fenolik içerikleri ve antioksidan aktivitesi Folin-Ciocalteu, kalitatif / kantitatif DPPH ve TBA ile belirlenmiştir. Antikolinesteraz aktivitesi Ellman metodu ile değerlendirilmiştir. En yüksek toplam fenolik içerik H. lasiocarpum ekstresinde (738.39 mg/g), ancak en düşük toplam fenolik içerik H. dolosum ekstresinde (122.731 mg/g) tespit edilmiştir. Her örnek DPPH testi ile antioksidan aktivite göstermiş ve en yüksek aktivite H. lasiocarpum'da (69.99 μg/mL) görülmüştür. Ayrıca, H. lasiocarpum ekstresi, sırasıyla asetilkolinesteraz (%5.90) ve butirilkolinesteraz (%24.04) enzimlerine karşı önemli ölçüde inhibisyon göstermiştir. Bu sonuçlar, bu Heliotropium türlerinin, antioksidan ve antikolinesteraz aktivitesine sahip farmasötik ürünler için etkili olabileceğini göstermektedir.

Alzheimer's disease (AD) has encouraged science to find plants or biologic compounds which can be utilized for prophylaxis of AD. Heliotropium genus is presented by 16 taxa in Turkey and they contain pyrrolizidine alkaloids, and certain are known to have antioxidant and anticholinesterase activities. The paper displays the anticholinesterase and antioxidant capacities of the aerial parts lyophilized aqueous extracts of H. dolosum, H. lasiocarpum and H. hirsutissimum. Phenolic contents and antioxidant activity of examples were determined by Folin-Ciocalteu's, qualitative/quantitative DPPH and TBA. Anticholinesterase activity was assessed by Ellman’s method. The total phenolic content of H. lasiocarpum extract was found the highest (738.39 mg/g), however the total phenolic content of H. dolosum extract was found the lowest (122.731 mg/g). Every example indicated that antioxidant activity with DPPH test and H. lasiocarpum presented the highest activities (69.99 μg/mL). Furthermore, the H. lasiocarpum extract indicated considerable inhibition towards acetylcholinesterase (5.90%) and butyrylcholinesyterase (24.04%) enzymes. These findings suggest that these Heliotropium species can be effective for pharmaceutic products that achieve anticholinesterase and antioxidant activities.

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Birincil Dil en
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Orcid: 0000-0002-3268-721X
Yazar: Songül KARAKAYA (Sorumlu Yazar)
Ülke: Turkey


Orcid: 0000-0002-1517-5925
Yazar: Mehmet KOCA

Orcid: 0000-0003-2905-7628
Yazar: Ceyda Sibel KILIÇ

Tarihler

Yayımlanma Tarihi : 31 Aralık 2019

Bibtex @araştırma makalesi { erzifbed530721, journal = {Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi}, issn = {1307-9085}, eissn = {2149-4584}, address = {}, publisher = {Erzincan Üniversitesi}, year = {2019}, volume = {12}, pages = {1381 - 1391}, doi = {10.18185/erzifbed.530721}, title = {Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey}, key = {cite}, author = {KARAKAYA, Songül and KOCA, Mehmet and KILIÇ, Ceyda Sibel} }
APA KARAKAYA, S , KOCA, M , KILIÇ, C . (2019). Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi , 12 (3) , 1381-1391 . DOI: 10.18185/erzifbed.530721
MLA KARAKAYA, S , KOCA, M , KILIÇ, C . "Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey". Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 12 (2019 ): 1381-1391 <https://dergipark.org.tr/tr/pub/erzifbed/issue/51325/530721>
Chicago KARAKAYA, S , KOCA, M , KILIÇ, C . "Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey". Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 12 (2019 ): 1381-1391
RIS TY - JOUR T1 - Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey AU - Songül KARAKAYA , Mehmet KOCA , Ceyda Sibel KILIÇ Y1 - 2019 PY - 2019 N1 - doi: 10.18185/erzifbed.530721 DO - 10.18185/erzifbed.530721 T2 - Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi JF - Journal JO - JOR SP - 1381 EP - 1391 VL - 12 IS - 3 SN - 1307-9085-2149-4584 M3 - doi: 10.18185/erzifbed.530721 UR - https://doi.org/10.18185/erzifbed.530721 Y2 - 2019 ER -
EndNote %0 Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey %A Songül KARAKAYA , Mehmet KOCA , Ceyda Sibel KILIÇ %T Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey %D 2019 %J Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi %P 1307-9085-2149-4584 %V 12 %N 3 %R doi: 10.18185/erzifbed.530721 %U 10.18185/erzifbed.530721
ISNAD KARAKAYA, Songül , KOCA, Mehmet , KILIÇ, Ceyda Sibel . "Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey". Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 12 / 3 (Aralık 2020): 1381-1391 . https://doi.org/10.18185/erzifbed.530721
AMA KARAKAYA S , KOCA M , KILIÇ C . Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2019; 12(3): 1381-1391.
Vancouver KARAKAYA S , KOCA M , KILIÇ C . Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2019; 12(3): 1391-1381.