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EFFECTS OF EXTRACTION METHODS AND EXTRACTION VARIABLES ON BIOACTIVE COMPOUNDS OF PROPOLIS

Yıl 2023, , 1123 - 1131, 15.12.2023
https://doi.org/10.15237/gida.GD23074

Öz

Propolis is a bee product that has been used in traditional medicine since ancient times due to its bioactive components, and has been and will be the subject of many studies today because of its rich content. The interest in natural antioxidant and antimicrobial substances is increasing with the awareness of the consumer. The effort of science to make something effective and most efficient has led to many studies on the extraction of bioactive components. Studies investigating the extraction of bioactive components from propolis, using many methods from traditional methods to modern techniques, were examined in this study, and the effectiveness of this methods agains each others were emphasized. There are lots of studies in the literature investigating different solvent types, extraction times and temperatures. Since there are many variables affecting the extraction process, studies on optimization of extraction variables in propolis extraction are needed.

Kaynakça

  • Aboulghazi, A., Bakour, M., Fadil, M., Lyoussi, B. (2022). Simultaneous Optimization of Extraction Yield, Phenolic Compounds and Antioxidant Activity of Moroccan Propolis Extracts: Improvement of Ultrasound-Assisted Technique Using Response Surface Methodology. Processes, 10(2). https://doi.org/10.3390/pr10020297
  • Ahangari, Z., Naseri, M., Vatandoost, F. (2018). Propolis: Chemical composition and its applications in endodontics. Iranian Endodontic Journal, 13(3), 285–292. https://doi.org/10.22037/iej.v13i3.20994
  • Al-Hariri, M. (2011). Propolis and its direct and indirect hypoglycemic effect. Journal of Family and Community Medicine, 18(3), 152–154. https://doi.org/10.4103/2230-8229.90015
  • AlDreini, S., Fatfat, Z., Abou Ibrahim, N., Fatfat, M., Gali-Muhtasib, H., Khalife, H. (2023). Thymoquinone enhances the antioxidant and anticancer activity of Lebanese propolis. World Journal of Clinical Oncology, 14(5), 203–214. https://doi.org/10.5306/wjco.v14.i5.203
  • Anjum, S. I., Ullah, A., Khan, K. A., Attaullah, M., Khan, H., Ali, H., Dash, C. K. (2019). Composition and functional properties of propolis (bee glue): A review. Saudi Journal of Biological Sciences, 26(7), 1695–1703. https://doi.org/10.1016/j.sjbs.2018.08.013
  • Bakkaloglu, Z., Arici, M., Karasu, S. (2021). Optimization of ultrasound-assisted extraction of turkish propolis and characterization of phenolic profile, antioxidant and antimicrobial activity. Food Science and Technology (Brazil), 41(3), 687–695. https://doi.org/10.1590/fst.14520
  • Bankova, V., Trusheva, B., Popova, M. (2021). Propolis extraction methods : a review. Journal of Apicultural Research, 0(0), 1–10. https://doi.org/ 10.1080/00218839.2021.1901426
  • Basyirah, N., Zin, M., Azemin, A., Muslim, M., Rodi, M., Mohd, S. (2018). Chemical Composition and Antioxidant Activity of Stingless Bee Propolis from Different Extraction Methods. International Journal of Engineering & Technology, (July 2019), 90–95. Tarihinde adresinden erişildi www.sciencepubco.com/ index.php/IJET Bayram, N. E., Gercek, Y. C. (2020). Appropriate Maceration Duration for. (October).
  • Bobiş, O., Berretta, A. A., Vilas-Boas, M., De Jong, D. (2023). Editorial: Therapeutic potential of propolis—from in vitro studies to clinical trials. Frontiers in Pharmacology, 14(May), 2022–2024. https://doi.org/10.3389/fphar.2023.1192045
  • Carlos, J., Ruiz, R., Aracely, N., Pacheco, L., Guadalupe, E. (2023). Phenolic Content and Bioactivity as Geographical Classifiers of.
  • Chong, F. C., Chua, L. S. (2020). Effects of Solvent and pH on Stingless Bee Propolis in Ultrasound-Assisted Extraction. AgriEngineering, 2(2), 308–316. https://doi.org/10.3390/ agriengineering2020020
  • Contieri, L. S., Souza, L. M. De, Sanches, V. L., Chaves, J., Pizani, R. S., Laíse, C., Sim, R. L. (2022). Recent progress on the recovery of bioactive compounds obtained from propolis as a natural resource : Processes, and applications. 298(June). https://doi.org/10.1016/j.seppur.2022.121640
  • D.Wagh, V. (2013). Propolis: A wonder bees product and its pharmacological potentials. Advances in Pharmacological Sciences.
  • De Groot, A. C. (2013). Propolis: A review of properties, applications, chemical composition, contact allergy, and other adverse effects. Dermatitis, 24(6), 263–282. https://doi.org/ 10.1097/DER.0000000000000011
  • do Nascimento Araújo, C., Mayworm, M. A. S., Yatsuda, R., Negri, G., Salatino, M. L. F., Salatino, A., Campos, G. B. (2020). Chemical composition and antimycoplasma activity of a brown propolis from southern Brazil. Journal of Food Science and Technology, 57(11), 4228–4235. https://doi.org/ 10.1007/s13197-020-04461-y
  • El-Guendouz, S., Lyoussi, B., Miguel, M. G. (2019). Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields. Chemistry and Biodiversity, 16(7). https://doi.org/10.1002/ cbdv.201900094
  • Farooq, S., Farooq, S., Rather, S. A., Ganaie, T. A. (2023). Supercritical CO2 extraction of natural products. Içinde Extraction of Natural Products from Agro-Industrial Wastes (ss. 79–90). https://doi.org/ 10.1016/B978-0-12-823349-8.00011-3
  • Hamzah, N., Leo, C. P. (2015). Microwave-Assisted extraction of trigona propolis: The effects of processing parameters. International Journal of Food Engineering, 11(6), 861–870. https://doi.org/10.1515/ijfe-2015-0106
  • Heidari, G., Najafpour, G. D., Mohammadi, M., Moghadamnia, A. A. (2019). Microwave ultrasound assisted extraction: Determination of quercetin for antibacterial and antioxidant activities of Iranian propolis. International Journal of Engineering, Transactions B: Applications, 32(8), 1057–1064. https://doi.org/10.5829/ ije.2019.32.08b.01
  • Huang, S., Zhang, C. P., Wang, K., Li, G. Q., Hu, F. L. (2014). Recent advances in the chemical composition of propolis. Molecules, 19(12), 19610–19632. https://doi.org/10.3390/ molecules191219610
  • Karagecili, H., Yılmaz, M. A., Ertürk, A., Kiziltas, H., Güven, L., Alwasel, S. H., Gulcin, İ. (2023). Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects. Molecules, 28(4), 1739. https://doi.org/10.3390/molecules28041739
  • Kasiotis, K. M., Anastasiadou, P., Papadopoulos, A., Machera, K. (2017). Revisiting Greek propolis: Chromatographic analysis and antioxidant activity study. PLoS ONE, 12(1), 1–27. https://doi.org/10.1371/journal.pone.0170077
  • Kasote, D., Bankova, V., Viljoen, A. M. (2022). Propolis: chemical diversity and challenges in quality control. Phytochemistry Reviews, 21(6), 1887–1911. https://doi.org/10.1007/s11101-022-09816-1
  • Kuropatnicki, A. K., Szliszka, E., Krol, W. (2013). Historical aspects of propolis research in modern times. Evidence-based Complementary and Alternative Medicine, 2013. https://doi.org/10.1155/ 2013/964149
  • Margeretha, I., Fatma Suniarti, D., Herda, E., Mas’ud, Z. A. (2012). Optimization and comparative study of different extraction methods of biologically active components of Indonesian propolis Trigona spp. /Journal of Natural Products, 5, 233–242. Tarihinde adresinden erişildi www.JournalofNaturalProducts.Com
  • Mele, E. (2023). Electrospinning of honey and propolis for wound care. Biotechnology and Bioengineering, 120(5), 1229–1240. https://doi.org/10.1002/bit.28341
  • Mokhtar, S. U. (2019). Comparison of total phenolic and flavonoids contents in Malaysian propolis extract with two different extraction solvents. International Journal of Engineering Technology and Sciences, 6(2), 1–11. https://doi.org/10.15282/ijets.v6i2.2577
  • Monroy, Y. M., Rodrigues, R. A. F., Rodrigues, M. V. N., Sant’Ana, A. S., Silva, B. S., Cabral, F. A. (2017). Brazilian green propolis extracts obtained by conventional processes and by processes at high pressure with supercritical carbon dioxide, ethanol and water. Journal of Supercritical Fluids, 130(August), 189–197. https://doi.org/10.1016/ j.supflu.2017.08.006
  • Oroian, M., Dranca, F., Ursachi, F. (2020). Comparative evaluation of maceration, microwave and ultrasonic-assisted extraction of phenolic compounds from propolis. Journal of Food Science and Technology, 57(1), 70–78. https://doi.org/10.1007/s13197-019-04031-x
  • Osés, S. M., Marcos, P., Azofra, P., de Pablo, A., Fernández-Muíño, M. Á., Sancho, M. T. (2020). Phenolic Profile, Antioxidant Capacities and Enzymatic Inhibitory Activities of Propolis from Different Geographical Areas: Needs for Analytical Harmonization. Antioxidants (Basel, Switzerland), 9(1). https://doi.org/10.3390/ antiox9010075
  • Pina, R., Silva, D., Aparecida, B., Machado, S., De, G., Barreto, A., Umsza-guez, M. A. (2017). cytotoxic properties of various Brazilian propolis extracts. PLoS ONE, 12(3), 1–18.
  • Pratami, D. K., Eksadita, N. U. R. E., Sahlan, M., Im, A. M. U. N. (2023). Comparison of Total Phenolic Content and Antioxidant Activity of Indonesian Propolis Extracted with Various Solvents ( Perbandingan Kandungan Fenolik Total dan Aktivitas Antioksidan Propolis Indonesia yang Diekstraksi dengan Berbagai Pelarut ). 21(1), 121–129.
  • Przybyłek, I., Karpiński, T. M. (2019). Antibacterial properties of propolis. Molecules, 24(11), 11–13. https://doi.org/10.3390/ molecules24112047
  • Ribeiro, V. P., Mejia, J. A. A., Rodrigues, D. M., Alves, G. R., de Freitas Pinheiro, A. M., Tanimoto, M. H., Ambrósio, S. R. (2023). Brazilian Brown Propolis: an Overview About Its Chemical Composition, Botanical Sources, Quality Control, and Pharmacological Properties. Revista Brasileira de Farmacognosia, 33(2), 288–299. https://doi.org/10.1007/s43450-023-00374-x
  • Rivera-Yañez, N., Rivera-Yañez, C. R., Pozo-Molina, G., Méndez-Catalá, C. F., Méndez-Cruz, A. R., Nieto-Yañez, O. (2021). Biomedical properties of propolis on diverse chronic diseases and its potential applications and health benefits. Nutrients, 13(1), 1–31. https://doi.org/10.3390/ nu13010078
  • Rocha, V. M., Portela, R. D., dos Anjos, J. P., de Souza, C. O., Umsza-Guez, M. A. (2023). Stingless bee propolis: composition, biological activities and its applications in the food industry. Food Production, Processing and Nutrition, 5(1). https://doi.org/10.1186/s43014-023-00146-z
  • Sforcin, J. M. (2016). Biological Properties and Therapeutic Applications of Propolis. Phytotherapy Research, 30(6), 894–905. https://doi.org/ 10.1002/ptr.5605
  • Simões-Ambrosio, L. M. C., Gregório, L. E., Sousa, J. P. B., Figueiredo-Rinhel, A. S. G., Azzolini, A. E. C. S., Bastos, J. K., Lucisano-Valim, Y. M. (2010). The role of seasonality on the inhibitory effect of Brazilian green propolis on the oxidative metabolism of neutrophils. Fitoterapia, 81(8), 1102–1108. https://doi.org/ 10.1016/j.fitote.2010.07.008
  • Šturm, L., Ulrih, N. P. (2020). Advances in the Propolis Chemical Composition between 2013 and 2018: A Review. eFood, 1(1), 24–37. https://doi.org/10.2991/efood.k.191029.001
  • Sun, J., Mu, Y., Shi, J., Zhao, Y., Xu, B. (2022). Super/subcritical fluid extraction combined with ultrasound-assisted ethanol extraction in propolis development. Journal of Apicultural Research, 61(2), 255–263. https://doi.org/10.1080/ 00218839.2020.1772529
  • Šuran, J., Cepanec, I., Mašek, T., Starčević, K., Gajger, I. T., Vranješ, M., Vlainić, J. (2021). Nonaqueous polyethylene glycol as a safer alternative to ethanolic propolis extracts with comparable antioxidant and antimicrobial activity. Antioxidants, 10(6). https://doi.org/10.3390/ antiox10060978
  • Teixeira, T. D., Aparecida, B., Machado, S., Barreto, G. D. A., Pereira, J., Leal, I. L., Andr, M. (2023). Extraction of Antioxidant Compounds from Brazilian Green.
  • Tilahun, A., Basa, B., Belay, W., Teshale, A. (2016). Review on Medicinal Value of Honeybee Products: Apitherapy. Advances in Biological Research, 10(4), 236–247. https://doi.org/ 10.5829/idosi.abr.2016.10.4.10529
  • Trusheva, B., Petkov, H., Popova, M., Dimitrova, L., Zaharieva, M., Tsvetkova, I., Bankova, V. (2019). “Green” approach to propolis extraction: natural deep eutectic solvents. Comptes Rendus de L’Academie Bulgare des Sciences, 72(7), 897–905. https://doi.org/10.7546/CRABS.2019.07.06
  • Tzani, A., Pitterou, I., Divani, F., Tsiaka, T., Sotiroudis, G., Zoumpoulakis, P., Detsi, A. (2022). Green Extraction of Greek Propolis Using Natural Deep Eutectic Solvents (NADES) and Incorporation of the NADES-Extracts in Cosmetic Formulation. Sustainable Chemistry, 4(1), 8–25. https://doi.org/10.3390/suschem4010002
  • Widelski, J., Okińczyc, P., Suśniak, K., Malm, A., Bozhadze, A., Jokhadze, M., Korona-Głowniak, I. (2023). Correlation between Chemical Profile of Georgian Propolis Extracts and Their Activity against Helicobacter pylori. Molecules, 28(3), 1–14. https://doi.org/10.3390/molecules28031374
  • Wyan, L. O., Charland, J. M., Mojica, E.-R. E. (2021). Comparative Study of the Extraction Methods for the Instrumental Analysis of Bee Propolis. Louisiana State University of Alexandria undergraduate journal of teaching research, 1(January 2021), 51–62.
  • Xi, J., Shouqin, Z. (2007). Antioxidant activity of ethanolic extracts of propolis by high hydrostatic pressure extraction. International Journal of Food Science and Technology, 42(11), 1350–1356. https://doi.org/10.1111/j.1365-2621.2006.01339.x
  • Zainal, W. N. H. W., Azian, N. A. A. M., Albar, S. S., Rusli, A. S. (2022). Effects of extraction method, solvent and time on the bioactive compounds and antioxidant activity of Tetrigona apicalis Malaysian propolis. Journal of Apicultural Research, 61(2), 264–270. https://doi.org/ 10.1080/00218839.2021.1930958

PROPOLİSİN BİYOAKTİF BİLEŞENLERİ ÜZERİNE EKSTRAKSİYON YÖNTEMLERİNİN VE EKSTRAKSİYON DEĞİŞKENLERİNİN ETKİLERİ

Yıl 2023, , 1123 - 1131, 15.12.2023
https://doi.org/10.15237/gida.GD23074

Öz

Propolis içeriğinde bulundurduğu biyoaktif bileşenler sayesinde antik çağlardan beri geleneksel tıpta kullanılan, günümüzde ise zengin içeriği sayesinde çok sayıda çalışmaya konu olmuş ve olacak bir arı ürünüdür. Doğal antioksidan ve antimikrobiyal maddelere olan ilgi tüketicinin bilinçlenmesi ile artmaktadır. Bilimin bir şeyi etkili ve en verimli yapma çabası biyoaktif bileşenlerin ekstraksiyonunu konu alan birçok çalışmaya yol açmıştır. Propolisten biyoaktif bileşenlerin ekstraksiyonunu inceleyen, geleneksel metotlardan modern tekniklere kadar birçok yöntemin kullanıldığı araştırmalar bu çalışmada incelenmiş olup, yöntemlerin birbirine karşı etkinliği vurgulanmıştır. Farklı çözücü tiplerinin, farklı ekstraksiyon süresi ve sıcaklıklarının araştırdığı çalışmalar literatürde mevcuttur. Ekstraksiyon işlemine etki eden birçok değişkenin mevcut olması nedeniyle propolis ekstraksiyonunda ekstraksiyon değişkenlerinin optimizasyonu konu alan çalışmalara ihtiyaç duyulmaktadır.

Kaynakça

  • Aboulghazi, A., Bakour, M., Fadil, M., Lyoussi, B. (2022). Simultaneous Optimization of Extraction Yield, Phenolic Compounds and Antioxidant Activity of Moroccan Propolis Extracts: Improvement of Ultrasound-Assisted Technique Using Response Surface Methodology. Processes, 10(2). https://doi.org/10.3390/pr10020297
  • Ahangari, Z., Naseri, M., Vatandoost, F. (2018). Propolis: Chemical composition and its applications in endodontics. Iranian Endodontic Journal, 13(3), 285–292. https://doi.org/10.22037/iej.v13i3.20994
  • Al-Hariri, M. (2011). Propolis and its direct and indirect hypoglycemic effect. Journal of Family and Community Medicine, 18(3), 152–154. https://doi.org/10.4103/2230-8229.90015
  • AlDreini, S., Fatfat, Z., Abou Ibrahim, N., Fatfat, M., Gali-Muhtasib, H., Khalife, H. (2023). Thymoquinone enhances the antioxidant and anticancer activity of Lebanese propolis. World Journal of Clinical Oncology, 14(5), 203–214. https://doi.org/10.5306/wjco.v14.i5.203
  • Anjum, S. I., Ullah, A., Khan, K. A., Attaullah, M., Khan, H., Ali, H., Dash, C. K. (2019). Composition and functional properties of propolis (bee glue): A review. Saudi Journal of Biological Sciences, 26(7), 1695–1703. https://doi.org/10.1016/j.sjbs.2018.08.013
  • Bakkaloglu, Z., Arici, M., Karasu, S. (2021). Optimization of ultrasound-assisted extraction of turkish propolis and characterization of phenolic profile, antioxidant and antimicrobial activity. Food Science and Technology (Brazil), 41(3), 687–695. https://doi.org/10.1590/fst.14520
  • Bankova, V., Trusheva, B., Popova, M. (2021). Propolis extraction methods : a review. Journal of Apicultural Research, 0(0), 1–10. https://doi.org/ 10.1080/00218839.2021.1901426
  • Basyirah, N., Zin, M., Azemin, A., Muslim, M., Rodi, M., Mohd, S. (2018). Chemical Composition and Antioxidant Activity of Stingless Bee Propolis from Different Extraction Methods. International Journal of Engineering & Technology, (July 2019), 90–95. Tarihinde adresinden erişildi www.sciencepubco.com/ index.php/IJET Bayram, N. E., Gercek, Y. C. (2020). Appropriate Maceration Duration for. (October).
  • Bobiş, O., Berretta, A. A., Vilas-Boas, M., De Jong, D. (2023). Editorial: Therapeutic potential of propolis—from in vitro studies to clinical trials. Frontiers in Pharmacology, 14(May), 2022–2024. https://doi.org/10.3389/fphar.2023.1192045
  • Carlos, J., Ruiz, R., Aracely, N., Pacheco, L., Guadalupe, E. (2023). Phenolic Content and Bioactivity as Geographical Classifiers of.
  • Chong, F. C., Chua, L. S. (2020). Effects of Solvent and pH on Stingless Bee Propolis in Ultrasound-Assisted Extraction. AgriEngineering, 2(2), 308–316. https://doi.org/10.3390/ agriengineering2020020
  • Contieri, L. S., Souza, L. M. De, Sanches, V. L., Chaves, J., Pizani, R. S., Laíse, C., Sim, R. L. (2022). Recent progress on the recovery of bioactive compounds obtained from propolis as a natural resource : Processes, and applications. 298(June). https://doi.org/10.1016/j.seppur.2022.121640
  • D.Wagh, V. (2013). Propolis: A wonder bees product and its pharmacological potentials. Advances in Pharmacological Sciences.
  • De Groot, A. C. (2013). Propolis: A review of properties, applications, chemical composition, contact allergy, and other adverse effects. Dermatitis, 24(6), 263–282. https://doi.org/ 10.1097/DER.0000000000000011
  • do Nascimento Araújo, C., Mayworm, M. A. S., Yatsuda, R., Negri, G., Salatino, M. L. F., Salatino, A., Campos, G. B. (2020). Chemical composition and antimycoplasma activity of a brown propolis from southern Brazil. Journal of Food Science and Technology, 57(11), 4228–4235. https://doi.org/ 10.1007/s13197-020-04461-y
  • El-Guendouz, S., Lyoussi, B., Miguel, M. G. (2019). Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields. Chemistry and Biodiversity, 16(7). https://doi.org/10.1002/ cbdv.201900094
  • Farooq, S., Farooq, S., Rather, S. A., Ganaie, T. A. (2023). Supercritical CO2 extraction of natural products. Içinde Extraction of Natural Products from Agro-Industrial Wastes (ss. 79–90). https://doi.org/ 10.1016/B978-0-12-823349-8.00011-3
  • Hamzah, N., Leo, C. P. (2015). Microwave-Assisted extraction of trigona propolis: The effects of processing parameters. International Journal of Food Engineering, 11(6), 861–870. https://doi.org/10.1515/ijfe-2015-0106
  • Heidari, G., Najafpour, G. D., Mohammadi, M., Moghadamnia, A. A. (2019). Microwave ultrasound assisted extraction: Determination of quercetin for antibacterial and antioxidant activities of Iranian propolis. International Journal of Engineering, Transactions B: Applications, 32(8), 1057–1064. https://doi.org/10.5829/ ije.2019.32.08b.01
  • Huang, S., Zhang, C. P., Wang, K., Li, G. Q., Hu, F. L. (2014). Recent advances in the chemical composition of propolis. Molecules, 19(12), 19610–19632. https://doi.org/10.3390/ molecules191219610
  • Karagecili, H., Yılmaz, M. A., Ertürk, A., Kiziltas, H., Güven, L., Alwasel, S. H., Gulcin, İ. (2023). Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects. Molecules, 28(4), 1739. https://doi.org/10.3390/molecules28041739
  • Kasiotis, K. M., Anastasiadou, P., Papadopoulos, A., Machera, K. (2017). Revisiting Greek propolis: Chromatographic analysis and antioxidant activity study. PLoS ONE, 12(1), 1–27. https://doi.org/10.1371/journal.pone.0170077
  • Kasote, D., Bankova, V., Viljoen, A. M. (2022). Propolis: chemical diversity and challenges in quality control. Phytochemistry Reviews, 21(6), 1887–1911. https://doi.org/10.1007/s11101-022-09816-1
  • Kuropatnicki, A. K., Szliszka, E., Krol, W. (2013). Historical aspects of propolis research in modern times. Evidence-based Complementary and Alternative Medicine, 2013. https://doi.org/10.1155/ 2013/964149
  • Margeretha, I., Fatma Suniarti, D., Herda, E., Mas’ud, Z. A. (2012). Optimization and comparative study of different extraction methods of biologically active components of Indonesian propolis Trigona spp. /Journal of Natural Products, 5, 233–242. Tarihinde adresinden erişildi www.JournalofNaturalProducts.Com
  • Mele, E. (2023). Electrospinning of honey and propolis for wound care. Biotechnology and Bioengineering, 120(5), 1229–1240. https://doi.org/10.1002/bit.28341
  • Mokhtar, S. U. (2019). Comparison of total phenolic and flavonoids contents in Malaysian propolis extract with two different extraction solvents. International Journal of Engineering Technology and Sciences, 6(2), 1–11. https://doi.org/10.15282/ijets.v6i2.2577
  • Monroy, Y. M., Rodrigues, R. A. F., Rodrigues, M. V. N., Sant’Ana, A. S., Silva, B. S., Cabral, F. A. (2017). Brazilian green propolis extracts obtained by conventional processes and by processes at high pressure with supercritical carbon dioxide, ethanol and water. Journal of Supercritical Fluids, 130(August), 189–197. https://doi.org/10.1016/ j.supflu.2017.08.006
  • Oroian, M., Dranca, F., Ursachi, F. (2020). Comparative evaluation of maceration, microwave and ultrasonic-assisted extraction of phenolic compounds from propolis. Journal of Food Science and Technology, 57(1), 70–78. https://doi.org/10.1007/s13197-019-04031-x
  • Osés, S. M., Marcos, P., Azofra, P., de Pablo, A., Fernández-Muíño, M. Á., Sancho, M. T. (2020). Phenolic Profile, Antioxidant Capacities and Enzymatic Inhibitory Activities of Propolis from Different Geographical Areas: Needs for Analytical Harmonization. Antioxidants (Basel, Switzerland), 9(1). https://doi.org/10.3390/ antiox9010075
  • Pina, R., Silva, D., Aparecida, B., Machado, S., De, G., Barreto, A., Umsza-guez, M. A. (2017). cytotoxic properties of various Brazilian propolis extracts. PLoS ONE, 12(3), 1–18.
  • Pratami, D. K., Eksadita, N. U. R. E., Sahlan, M., Im, A. M. U. N. (2023). Comparison of Total Phenolic Content and Antioxidant Activity of Indonesian Propolis Extracted with Various Solvents ( Perbandingan Kandungan Fenolik Total dan Aktivitas Antioksidan Propolis Indonesia yang Diekstraksi dengan Berbagai Pelarut ). 21(1), 121–129.
  • Przybyłek, I., Karpiński, T. M. (2019). Antibacterial properties of propolis. Molecules, 24(11), 11–13. https://doi.org/10.3390/ molecules24112047
  • Ribeiro, V. P., Mejia, J. A. A., Rodrigues, D. M., Alves, G. R., de Freitas Pinheiro, A. M., Tanimoto, M. H., Ambrósio, S. R. (2023). Brazilian Brown Propolis: an Overview About Its Chemical Composition, Botanical Sources, Quality Control, and Pharmacological Properties. Revista Brasileira de Farmacognosia, 33(2), 288–299. https://doi.org/10.1007/s43450-023-00374-x
  • Rivera-Yañez, N., Rivera-Yañez, C. R., Pozo-Molina, G., Méndez-Catalá, C. F., Méndez-Cruz, A. R., Nieto-Yañez, O. (2021). Biomedical properties of propolis on diverse chronic diseases and its potential applications and health benefits. Nutrients, 13(1), 1–31. https://doi.org/10.3390/ nu13010078
  • Rocha, V. M., Portela, R. D., dos Anjos, J. P., de Souza, C. O., Umsza-Guez, M. A. (2023). Stingless bee propolis: composition, biological activities and its applications in the food industry. Food Production, Processing and Nutrition, 5(1). https://doi.org/10.1186/s43014-023-00146-z
  • Sforcin, J. M. (2016). Biological Properties and Therapeutic Applications of Propolis. Phytotherapy Research, 30(6), 894–905. https://doi.org/ 10.1002/ptr.5605
  • Simões-Ambrosio, L. M. C., Gregório, L. E., Sousa, J. P. B., Figueiredo-Rinhel, A. S. G., Azzolini, A. E. C. S., Bastos, J. K., Lucisano-Valim, Y. M. (2010). The role of seasonality on the inhibitory effect of Brazilian green propolis on the oxidative metabolism of neutrophils. Fitoterapia, 81(8), 1102–1108. https://doi.org/ 10.1016/j.fitote.2010.07.008
  • Šturm, L., Ulrih, N. P. (2020). Advances in the Propolis Chemical Composition between 2013 and 2018: A Review. eFood, 1(1), 24–37. https://doi.org/10.2991/efood.k.191029.001
  • Sun, J., Mu, Y., Shi, J., Zhao, Y., Xu, B. (2022). Super/subcritical fluid extraction combined with ultrasound-assisted ethanol extraction in propolis development. Journal of Apicultural Research, 61(2), 255–263. https://doi.org/10.1080/ 00218839.2020.1772529
  • Šuran, J., Cepanec, I., Mašek, T., Starčević, K., Gajger, I. T., Vranješ, M., Vlainić, J. (2021). Nonaqueous polyethylene glycol as a safer alternative to ethanolic propolis extracts with comparable antioxidant and antimicrobial activity. Antioxidants, 10(6). https://doi.org/10.3390/ antiox10060978
  • Teixeira, T. D., Aparecida, B., Machado, S., Barreto, G. D. A., Pereira, J., Leal, I. L., Andr, M. (2023). Extraction of Antioxidant Compounds from Brazilian Green.
  • Tilahun, A., Basa, B., Belay, W., Teshale, A. (2016). Review on Medicinal Value of Honeybee Products: Apitherapy. Advances in Biological Research, 10(4), 236–247. https://doi.org/ 10.5829/idosi.abr.2016.10.4.10529
  • Trusheva, B., Petkov, H., Popova, M., Dimitrova, L., Zaharieva, M., Tsvetkova, I., Bankova, V. (2019). “Green” approach to propolis extraction: natural deep eutectic solvents. Comptes Rendus de L’Academie Bulgare des Sciences, 72(7), 897–905. https://doi.org/10.7546/CRABS.2019.07.06
  • Tzani, A., Pitterou, I., Divani, F., Tsiaka, T., Sotiroudis, G., Zoumpoulakis, P., Detsi, A. (2022). Green Extraction of Greek Propolis Using Natural Deep Eutectic Solvents (NADES) and Incorporation of the NADES-Extracts in Cosmetic Formulation. Sustainable Chemistry, 4(1), 8–25. https://doi.org/10.3390/suschem4010002
  • Widelski, J., Okińczyc, P., Suśniak, K., Malm, A., Bozhadze, A., Jokhadze, M., Korona-Głowniak, I. (2023). Correlation between Chemical Profile of Georgian Propolis Extracts and Their Activity against Helicobacter pylori. Molecules, 28(3), 1–14. https://doi.org/10.3390/molecules28031374
  • Wyan, L. O., Charland, J. M., Mojica, E.-R. E. (2021). Comparative Study of the Extraction Methods for the Instrumental Analysis of Bee Propolis. Louisiana State University of Alexandria undergraduate journal of teaching research, 1(January 2021), 51–62.
  • Xi, J., Shouqin, Z. (2007). Antioxidant activity of ethanolic extracts of propolis by high hydrostatic pressure extraction. International Journal of Food Science and Technology, 42(11), 1350–1356. https://doi.org/10.1111/j.1365-2621.2006.01339.x
  • Zainal, W. N. H. W., Azian, N. A. A. M., Albar, S. S., Rusli, A. S. (2022). Effects of extraction method, solvent and time on the bioactive compounds and antioxidant activity of Tetrigona apicalis Malaysian propolis. Journal of Apicultural Research, 61(2), 264–270. https://doi.org/ 10.1080/00218839.2021.1930958
Toplam 49 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Gıda Kimyası ve Gıda Sensör Bilimi, Gıda Teknolojileri
Bölüm Makaleler
Yazarlar

Harun Reşit Özdal 0009-0005-5844-7221

Emine Nakilcioğlu 0000-0003-4334-2900

Semih Ötleş 0000-0003-4571-8764

Erken Görünüm Tarihi 12 Ekim 2023
Yayımlanma Tarihi 15 Aralık 2023
Yayımlandığı Sayı Yıl 2023

Kaynak Göster

APA Özdal, H. R., Nakilcioğlu, E., & Ötleş, S. (2023). PROPOLİSİN BİYOAKTİF BİLEŞENLERİ ÜZERİNE EKSTRAKSİYON YÖNTEMLERİNİN VE EKSTRAKSİYON DEĞİŞKENLERİNİN ETKİLERİ. Gıda, 48(6), 1123-1131. https://doi.org/10.15237/gida.GD23074
AMA Özdal HR, Nakilcioğlu E, Ötleş S. PROPOLİSİN BİYOAKTİF BİLEŞENLERİ ÜZERİNE EKSTRAKSİYON YÖNTEMLERİNİN VE EKSTRAKSİYON DEĞİŞKENLERİNİN ETKİLERİ. GIDA. Aralık 2023;48(6):1123-1131. doi:10.15237/gida.GD23074
Chicago Özdal, Harun Reşit, Emine Nakilcioğlu, ve Semih Ötleş. “PROPOLİSİN BİYOAKTİF BİLEŞENLERİ ÜZERİNE EKSTRAKSİYON YÖNTEMLERİNİN VE EKSTRAKSİYON DEĞİŞKENLERİNİN ETKİLERİ”. Gıda 48, sy. 6 (Aralık 2023): 1123-31. https://doi.org/10.15237/gida.GD23074.
EndNote Özdal HR, Nakilcioğlu E, Ötleş S (01 Aralık 2023) PROPOLİSİN BİYOAKTİF BİLEŞENLERİ ÜZERİNE EKSTRAKSİYON YÖNTEMLERİNİN VE EKSTRAKSİYON DEĞİŞKENLERİNİN ETKİLERİ. Gıda 48 6 1123–1131.
IEEE H. R. Özdal, E. Nakilcioğlu, ve S. Ötleş, “PROPOLİSİN BİYOAKTİF BİLEŞENLERİ ÜZERİNE EKSTRAKSİYON YÖNTEMLERİNİN VE EKSTRAKSİYON DEĞİŞKENLERİNİN ETKİLERİ”, GIDA, c. 48, sy. 6, ss. 1123–1131, 2023, doi: 10.15237/gida.GD23074.
ISNAD Özdal, Harun Reşit vd. “PROPOLİSİN BİYOAKTİF BİLEŞENLERİ ÜZERİNE EKSTRAKSİYON YÖNTEMLERİNİN VE EKSTRAKSİYON DEĞİŞKENLERİNİN ETKİLERİ”. Gıda 48/6 (Aralık 2023), 1123-1131. https://doi.org/10.15237/gida.GD23074.
JAMA Özdal HR, Nakilcioğlu E, Ötleş S. PROPOLİSİN BİYOAKTİF BİLEŞENLERİ ÜZERİNE EKSTRAKSİYON YÖNTEMLERİNİN VE EKSTRAKSİYON DEĞİŞKENLERİNİN ETKİLERİ. GIDA. 2023;48:1123–1131.
MLA Özdal, Harun Reşit vd. “PROPOLİSİN BİYOAKTİF BİLEŞENLERİ ÜZERİNE EKSTRAKSİYON YÖNTEMLERİNİN VE EKSTRAKSİYON DEĞİŞKENLERİNİN ETKİLERİ”. Gıda, c. 48, sy. 6, 2023, ss. 1123-31, doi:10.15237/gida.GD23074.
Vancouver Özdal HR, Nakilcioğlu E, Ötleş S. PROPOLİSİN BİYOAKTİF BİLEŞENLERİ ÜZERİNE EKSTRAKSİYON YÖNTEMLERİNİN VE EKSTRAKSİYON DEĞİŞKENLERİNİN ETKİLERİ. GIDA. 2023;48(6):1123-31.

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