USE OF PLANT-DERIVED MATERIALS FOR THE INHIBITION OF QOURUM SENSING MECHANISMS

Öz

The gene regulation system of microorganisms through a cell density-dependent is controlled by a mechanism called Quorum Sensing. Quorum Sensing (QS) mechanism is a population physiology to control many characteristics regulated phenotypes like exopolysaccharide production, biofilm formation and virulence factor. In recent years, there is an increasing number of researches on the involvement of QS mechanism in the spoilage of food products and food safety. The strategy of inactivation of the QS is called Quorum Quenching (QQ). Studies have shown that QQ mechanism which plays a significant role in the inhibition of microbial growth might provide an alternative strategy to chemical preservatives for improving food safety. Plant-derived materials are promising potential sources of QS inhibitor as they can contain natural antimicrobial substances that inhibit the growth of microorganisms. In this review, the inhibition strategies of quorum sensing mechanism (QQ) by using plant-derived materials are focussed on.

Anahtar Kelimeler

• Quorum Sensing
• Quorum Quenching
• plant-drived material
• antimicrobial

ÇOĞUNLUK ALGILAMA MEKANİZMASININ İNHİBİSYONUNDA BİTKİSEL MATERYALLERİN KULLANIMI

Öz

Mikroorganizmaların hücre yoğunluğuna bağlı gen düzenleme sistemi çoğunluk algılama (Quorum Sensing) olarak adlandırılan mekanizma tarafından kontrol edilmektedir. Çoğunluk algılama mekanizması (QS) ekzopolisakkarit üretimi, biyofilm oluşumu ve virülans faktörü gibi popülasyon fizyolojisini düzenleyen fenotipleri kontrol eden mekanizmadır. Son yıllarda gıdaların bozulması ve gıda güvenliği alanlarında QS mekanizmasının rolü üzerine araştırmalar artmıştır. Çoğunluk algılama mekanizmasının inaktivasyonu stratejisine, çoğunluk algılama mekanizmasının inhibisyonu (Quorum Quenching-QQ) adı verilmektedir. Yapılan çalışmalar, QQ mekanizmasının mikrobiyel gelişimin inhibisyonunda önemli bir rol oynadığını ve kimyasal koruyucu yerine gıda güvenliğini arttırmak için alternatif bir strateji olabileceğini göstermiştir. Bitkisel materyaller, mikroorganizmaların gelişimini inhibe edici doğal antimikrobiyel bileşikler içerdikleri için potansiyel QS inhibitörü kaynaklarıdır. Bu derlemede, bitkisel materyaller kullanılarak çoğunluk algılama mekanizmasının inhibisyonu (QQ) stratejilerine odaklanılmıştır.

Anahtar Kelimeler

• Çoğunluk algılama mekanizması
• çoğunluk algılama mekanizmasının inhibisyonu
• bitkisel kaynaklı materyal
• antimikrobiyel

Kaynakça

1. Abisado, R.G., Benomar, S., Klaus, J.R., Dandekar, A.A., Chandler, J.R. (2018). Bacterial Quorum Sensing and microbial community interactions. MBio, 9(3), e02331-17.
2. Ahmed, S. A., Rudden, M., Smyth, T.J., Dooley, J. S., Marchant, R., Banat, I.M. (2019). Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors. Applied Microbiology and Biotechnology, 103(8), 3521-3535.
3. Almasoud, A., Hettiarachchy, N., Rayaprolu, S., Babu, D., Kwon, Y.M., Mauromoustakos, A. (2016). Inhibitory effects of lactic and malic organic acids on autoinducer type 2 (AI-2) Quorum sensing of Escherichia coli O157: H7 and Salmonella Typhimurium. LWT-Food Science and Technology, 66, 560-564.
4. Alvarez, M.V., Ortega-Ramirez, L.A., Gutierrez-Pacheco, M.M., Bernal-Mercado, A.T., Rodriguez-Garcia, I., Gonzalez-Aguilar, G.A., Ponce, A., Moreira, M. R., Roura, S. I., Ayala-Zavala, J.F. (2014). Oregano essential oil-pectin edible films as anti-quorum sensing and food antimicrobial agents. Frontiers in Microbiology, 5, 699.
5. Borges, A., Serra, S., Cristina Abreu, A., Saavedra, M. J., Salgado, A., Simões, M. (2014). Evaluation of the effects of selected phytochemicals on quorum sensing inhibition and in vitro cytotoxicity. Biofouling, 30(2), 183-195.
6. Borges, A., Sousa, P., Gaspar, A., Vilar, S., Borges, F., Simões, M. (2017). Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes. Biofouling, 33(2), 156-168.
7. Brackman, G., Celen, S., Hillaert, U., Van Calenbergh, S., Cos, P., Maes, L., Nelis, H. J., Coenye, T. (2011). Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp. PLoS One, 6(1), e16084.
8. Brackman, G., Defoirdt, T., Miyamoto, C., Bossier, P., Van Calenbergh, S., Nelis, H., Coenye, T. (2008). Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR. BMC Microbiology, 8(1), 149.

9. Chbib, C. (2020). Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram- negative bacteria. Bioorganic & Medicinal Chemistry, 115282. doi:10.1016/j.bmc.2019.115282.
10. Chen, F., Gao, Y., Chen, X., Yu, Z., Li, X. (2013). Quorum quenching enzymes and their application in degrading signal molecules to block Quorum Sensing-dependent infection. International Journal of Molecular Sciences, 14(9), 17477-17500.
11. Christiaen, S.E., Matthijs, N., Zhang, X.H., Nelis, H.J., Bossier, P., Coenye, T. (2014). Bacteria that inhibit quorum sensing decrease biofilm formation and virulence in Pseudomonas aeruginosa PAO1. Pathogens and Disease, 70(3), 271-279.
12. Dong, Y.H., Wang, L.H., Zhang, L.H. (2007). Quorum-quenching microbial infections: mechanisms and implications. Philosophical Transactions of the Royal Society of London B: Biological Sciences, 362(1483), 1201-1211.
13. Duanis-Assaf, D., Steinberg, D., Chai, Y., Shemesh, M. (2016). The LuxS based quorum sensing governs lactose induced biofilm formation by Bacillus subtilis. Frontiers in Microbiology, 6, 1517.
14. Erhabor, C.R., Erhabor, J.O., McGaw, L.J. (2019). The potential of South African medicinal plants against microbial biofilm and quorum sensing of foodborne pathogens: A review. South African Journal of Botany, 126, 214-231.
15. Galie, S., García-Gutiérrez, C., Miguélez, E. M., Villar, C. J., Lombó, F. (2018). Biofilms in the food industry: health aspects and control methods. Frontiers in Microbiology, 9, 898.
16. Galloway, W.R., Hodgkinson, J.T., Bowden, S.D., Welch, M., Spring, D.R. (2011). Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways. Chemical Reviews, 111(1), 28-67.
17. Gopu, V., Chandran, S., Shetty, P.H. (2018). Significance and application of Quorum Sensing in Food Microbiology. In: Quorum Sensing and its Biotechnological Applications, Kalia, V.C. (ed.), Springer, Singapore, pp. 193-219.
18. Gori, K., Moslehi-Jenabian, S., Purrotti, M., Jespersen, L. (2011). Autoinducer-2 activity produced by bacteria found in smear of surface ripened cheeses. International Dairy Journal, 21(1), 48-53.
19. Gutiérrez-Barranquero, J.A., Reen, F.J., McCarthy, R.R., O’Gara, F. (2015). Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens. Applied Microbiology and Biotechnology, 99(7), 3303-3316.
20. Husain, F.M., Ahmad, I., Al-thubiani Abdullah S., Abulreesh, H.H., AlHazza, I.M., Aqil, F. (2017). Leaf extracts of Mangifera indica L. inhibit Quorum Sensing – Regulated Production of virulence factors and biofilm in test bacteria. Frontiers in Microbiology, 8, 1-12.
21. Johansen, P., Jespersen, L. (2017). Impact of quorum sensing on the quality of fermented foods. Current Opinion in Food Science, 13, 16-25.
22. Jung, S. A., Hawver, L. A., Ng, W. L. (2016). Parallel quorum sensing signaling path- ways in Vibrio cholerae. Current Genetics, 62(2), 255–260.
23. Kalia, V.C. (ed.). (2018). Biotechnological applications of Quorum Sensing inhibitors. Springer, Singapore, 473 p.
24. Khan, D.M., Manzoor, M.A., Rao, I. V., Moosabba, M.S. (2019). Evaluation of biofilm formation, cell surface hydrophobicity and gelatinase activity in Acinetobacter baumannii strains isolated from patients of diabetic and non-diabetic foot ulcer infections. Biocatalysis and Agricultural Biotechnology, 18, 101007.
25. Kiran, G.S., Hassan, S., Sajayan, A., Selvin, J. (2017). Quorum quenching compounds from natural sources. In: Bioresources and Bioprocess in Biotechnology, Sugathan, S. (chief ed.), Springer, Singapore, pp. 351-364.
26. Li, T., Cui, F., Bai, F., Zhao, G., Li, J. (2016). Involvement of acylated homoserine lactones (AHLs) of Aeromonas sobria in spoilage of refrigerated turbot (Scophthalmus maximus L.). Sensors, 16(7), 1083.
27. Li, T., Wang, D., Liu, N., Ma, Y., Ding, T., Mei, Y., Li, J. (2018). Inhibition of quorum sensing-controlled virulence factors and biofilm formation in Pseudomonas fluorescens by cinnamaldehyde. International Journal of Food Microbiology, 269, 98–106.
28. Liu, J., Fu, K., Wu, C., Qin, K., Li, F., Zhou, L. (2018). “In-Group” communication in marine Vibrio: A review of N-Acyl homoserine lactones-driven Quorum Sensing. Frontiers in Cellular and Infection Microbiology, 8, 139.
29. Liu, M., Wang, H., Griffiths, M.W. (2007). Regulation of alkaline metallo-protease promoter by N-acyl homoserine lactone quorum sensing in Pseudomonas fluorescens. Journal of Applied Microbiology,103:2174–2184.
30. Luciardi, M.C., Blázquez, M.A., Alberto, M.R., Cartagena, E., Arena, M. E. (2019). Grapefruit essential oils inhibit quorum sensing of Pseudomonas aeruginosa. Food Science and Technology International, 1082013219883465.
31. Luciardi, M.C., Blázquez, M. A., Cartagena, E., Bardón, A., Arena, M. E. (2016). Mandarin essential oils inhibit quorum sensing and virulence factors of Pseudomonas aeruginosa. LWT-Food Science and Technology, 68, 373-380.
32. Lv, X., Cui, T., Du, H., Sun, M., Bai, F., Li, J., Zhang, D. (2020). Lactobacillus plantarum CY 1-1: A novel quorum quenching bacteria and anti-biofilm agent against Aeromonas sobria. LWT- Food Science and Technology, 110439.
33. Machado, I., Silva, L. R., Giaouris, E.D., Melo, L. F., Simões, M. (2020). Quorum sensing in food spoilage and natural-based strategies for its inhibition. Food Research International, 108754. doi:10.1016/j.foodres.2019.108754.
34. Majik, M.S., Gawas, U. B., Mandrekar, V.K. (2020). Next generation quorum sensing inhibitors: Accounts on structure activity relationship studies and biological activities. Bioorganic & Medicinal Chemistry, 28(21), 115728.
35. Melian, C., Segli, F., Gonzalez, R., Vignolo, G., Castellano, P. (2019). Lactocin AL 705 as quorum sensing inhibitor to control Listeria monocytogenes biofilm formation. Journal of Applied Microbiology, 127(3), 911-920.
36. Miller, C., Gilmore, J. (2020). Detection of Quorum-Sensing molecules for pathogenic molecules using cell-based and cell-free biosensors. Antibiotics, 9(5), 259.
37. Mohan, C.C., Harini, K., Sudharsan, K., Krishnan, K.R., Sukumar, M. (2019). Quorum quenching effect and kinetics of active compound from S. aromaticum and C. cassia fused packaging films in shelf life of chicken meat. LWT-Food Science and Technology, 105, 87-102.
38. Myszka, K., Schmidt, M.T., Majcher, M., Juzwa, W., Olkowicz, M., Czaczyk, K. (2016). Inhibition of quorum sensing-related biofilm of Pseudomonas fluorescens KM121 by Thymus vulgare essential oil and its major bioactive compounds. International Biodeterioration & Biodegradation, 114, 252-259.
39. O’Connor, G., Knecht, L. D., Salgado, N., Strobel, S., Pasini, P., Daunert, S. (2015). Whole-cell biosensors as tools for the detection of quorum-sensing molecules: uses in diagnostics and the investigation of the quorum-sensing mechanism. In: Bioluminescence: Fundamentals and Applications in Biotechnology, Thouand, G. (chief ed.), Volume 3, Springer, Cham, pp. 181-200.
40. Papenfort, K., Bassler, B.L. (2016). Quorum sensing signal- response systems in Gram-negative bacteria, Nature Reviews Microbiology, 14 (9), 576–588.
41. Park, H., Shin, H., Lee, K., Holzapfel, W. (2016). Autoinducer-2 properties of kimchi are associated with lactic acid bacteria involved in its fermentation. International Journal of Food Microbiology, 225, 38-42.
42. Passos da Silva, D., Schofield, M., Parsek, M., Tseng, B. (2017). An update on the sociomicrobiology of quorum sensing in Gram-negative biofilm development. Pathogens, 6(4), 51.
43. Peng, P., Baldry, M., Gless, B. H., Bojer, M. S., Gonora, C. E., Baig, S., Andersen, P. S., Olsen, C. A., Ingmer, H. (2019). Effect of co-inhabiting coagulase negative staphylococci on S. aureus agr quorum sensing, host factor binding, and biofilm formation. Frontiers in Microbiology, 10, 2212.
44. Quecan, B. X. V., Rivera, M. L. C., Hassimotto, N. M. A., Almeida, F. A. D., Pinto, U. M. (2019). Effect of quercetin rich onion extracts on bacterial quorum sensing. Frontiers in Microbiology, 10, 867.
45. Rasmussen, T.B., Givskov, M. (2006). Quorum-sensing inhibitors as anti-pathogenic drugs. International Journal of Medical Microbiology, 296(2-3), 149-161.
46. Rutherford, S.T., Bassler, B.L. (2012). Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harbor perspectives in Medicine, 2(11), a012427.
47. Singh, A., Gaur, M., Misra, R. (2018). Understanding the connect of quorum sensing and CRISPR-Cas system: potential role in biotechnological applications. In: Quorum Sensing and its Biotechnological Applications, Sugathan S. (chief ed.), Springer, Singapore, pp. 231-247.
48. Skandamis, P.N., Nychas, G.J.E. (2012). Quorum sensing in the context of food microbiology. Applied and Environmental Microbiology, 78(16), 5473-5482.
49. Snoussi, M., Noumi, E., Punchappady-Devasya, R., Trabelsi, N., Kanekar, S., Nazzaro, F., Fratianni, F., Flamini, G., Feo, V. D., Al-Sieni, A. (2018). Antioxidant properties and anti-quorum sensing potential of Carum copticum essential oil and phenolics against Chromobacterium violaceum. Journal of Food Science and Technology, 55(8), 2824-2832.
50. Stephens, K., Bentley, W. E. (2020). Synthetic biology for manipulating Quorum Sensing in microbial consortia. Trends in Microbiology, 28(8): 633-643.
51. Ta, C., Arnason, J. (2016). Mini review of phytochemicals and plant taxa with activity as microbial biofilm and quorum sensing inhibitors. Molecules, 21(1), 29.
52. Tabbouche, S. A., Gürgen, A., Yildiz, S., Kiliç, A. O., Sökmen, M. (2017). Antimicrobial and antiquorum sensing activity of some wild mushrooms collected from Turkey. Journal of Science and Technology MSU, 5(2), 453-457.
53. Tommonaro, G. (ed.) (2019). Quorum Sensing: Molecular mechanism and biotechnological application. Academic Press, Cambridge, United Kingdom, 309 p.
54. Truchado, P., Larrosa, M., Castro-Ibáñez, I., Allende, A. (2015). Plant food extracts and phytochemicals: their role as quorum sensing inhibitors. Trends in Food Science & Technology, 43(2), 189-204.
55. Truchado, P., Tomás-Barberán, F. A., Larrosa, M., Allende, A. (2012). Food phytochemicals act as quorum sensing inhibitors reducing production and/or degrading autoinducers of Yersinia enterocolitica and Erwinia carotovora. Food Control, 24(1-2), 78-85.
56. Whiteley, M., Diggle, S. P., Greenberg, E. P. (2017). Bacterial quorum sensing: The progress and promise of an emerging research area. Nature, 551(7680), 313.
57. Yuan, L., F. A. Sadiq, T. Liu, Y. Li, J. Gu, H. Yang, He, G. (2018). Spoilage potential of psychrotrophic bacteria isolated from raw milk and the thermo-stability of their enzymes. Journal of Zhejiang University-SCIENCE B, 19(8), 630-642.
58. Zhang, J., Feng, T., Wang, J., Wang, Y., Zhang, X. H. (2019). The mechanisms and applications of Quorum sensing (QS) and Quorum quenching (QQ). Journal of Ocean University of China, 18(6), 1427-1442.
59. Zhang, Y., Kong, J., Xie, Y., Guo, Y., Cheng, Y., Qian, H., Yao, W. (2018). Essential oil components inhibit biofilm formation in Erwinia carotovora and Pseudomonas fluorescens via anti-quorum sensing activity. LWT, 92, 133-139.
60. Zhou, J.W., Chen, T.T., Tan, X.J., Sheng, J. Y., Jia, A.Q. (2018). Can the quorum sensing inhibitor resveratrol function as an aminoglycoside antibiotic accelerant against Pseudomonas aeruginosa?. International Journal of Antimicrobial Agents, 52(1), 35-41.
61. Zhu, J., Huang, X., Zhang, F., Feng, L., Li, J. (2015). Inhibition of quorum sensing, biofilm, and spoilage potential in Shewanella baltica by green tea polyphenols. Journal of Microbiology, 53(12), 829-836.