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INVESTIGATION OF CHANGES IN SOME BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS FROM PULP AND SEED TISSUES OF ZIZIPHUS JUJUBA DURING IN VITRO DIGESTION

Yıl 2023, Cilt: 48 Sayı: 3, 602 - 613, 16.06.2023

Eda Şensu , Ayhan Duran , Beraat Özçelik , Aysun Yücetepe

https://doi.org/10.15237/gida.GD23033
Cited By: 1

Öz

In this study, changes in angiotensin-I converting enzyme (ACE) inhibitory, α-amylase inhibitory and antioxidant activities, total phenolic content (TPC), total monomeric anthocyanin content (TMAC) of ultrasonic phenolic extracts from pulp and seed of Ziziphus jujuba were investigated during in vitro digestion. Bioaccessible fractions of phenolics in seed and pulp extracts were calculated as 23.24±4.46% and 9.43±0.24%, respectively. Moreover, bioaccessibility for TMAC in seed extracts (147.83±9.20%) was higher than pulp (15.76±3.89%) (P<0.05). A decrease in the antioxidant activity of the extracts occurred after in vitro digestion (P<0.05). The ACE inhibitory activity of undigested extracts from seed (86.04±0.00%) was higher than that of the undigested pulp extract (42.74±8.57%) (P<0.05). The α-amylase inhibitory activity of seed and pulp extracts was determined as 49.18±0.35% and 36.07±5.83%, respectively. The results of the study showed that ACE inhibitory activity and α-amylase inhibitory activity of the polyphenolics from pulp increased after in vitro digestion.

Anahtar Kelimeler

Ziziphus jujuba antioxidant activity ACE inhibitory activity α-amylase inhibitory activity anthocyanin.

Destekleyen Kurum

Aksaray University Scientific Research Projects Agency (BAP)

Proje Numarası

2020-032 and 2018-045

Teşekkür

This study was funded and supported by Aksaray University Scientific Research Projects Agency (BAP) (project number: 2020-032 and project number: 2018-045). All authors thank Aksaray University Scientific Research Projects Agency.

Kaynakça

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ZIZIPHUS JUJUBE (HÜNNAP) İÇ VE ÇEKİRDEK DOKULARINDAN FENOLİKLERİN IN VITRO SİNDİRİM SIRASINDA BAZI BİYOAKTİF ÖZELLİKLERİNDEKİ DEĞİŞİMİN ARAŞTIRILMASI

Yıl 2023, Cilt: 48 Sayı: 3, 602 - 613, 16.06.2023

Eda Şensu , Ayhan Duran , Beraat Özçelik , Aysun Yücetepe

https://doi.org/10.15237/gida.GD23033
Cited By: 1

Öz

sindirim sırasında anjiyotensin-I dönüştürücü enzim (ADE) inhibisyon, α-amilaz inhibisyon ve antioksidan aktivitesi ile toplam fenolik madde (TFM) ve toplam monomerik antosiyanin miktarı (TMAM) üzerindeki değişiklikler incelenmiştir. In vitro sindirim sonrasında, çekirdek ve iç ekstraktlarındaki biyoerişilebilir fenolik fraksiyonlar sırasıyla %23.24±4.46 ve %9.43±0.24 olarak hesaplanmıştır. Ayrıca, çekirdek ekstraktlarında toplam monomerik antosiyaninlerin biyoerişilebilirliği (147.83±9.20%) iç ekstraktların toplam monomerik antosiyaninlerinin biyoerişilebilirliğinden (15.76±3.89%) daha yüksek bulunmuştur (P<0.05). In vitro sindirim sonrasında ekstraktların antioksidan aktivitesinde azalma meydana gelmiştir (P<0.05). Çekirdek ekstraktlarının sindirim öncesi ADE inhibisyon aktivitesi (%86.04±0.00), sindirim öncesi iç ekstraktın ADE inhibisyon aktivitesinden (%42.74±8.57) daha yüksektir (P<0.05). Çekirdek ve iç ekstraktların α-amilaz inhibisyon aktivitesi sırasıyla %49.18±0.35 ve %36.07±5.83 olarak belirlenmiştir. Çalışmanın sonuçlarına göre iç fraksiyonundan elde edilen ekstraktların ADE inhibisyon ve α-amilaz inhibisyon aktivitesi in vitro sindirimden sonra artmıştır.

Anahtar Kelimeler

Ziziphus jujuba antioksidan aktivite ACE inhibisyon aktivite α-amilaz inhibisyon aktivite antosiyanin.

Proje Numarası

2020-032 and 2018-045

Kaynakça

  • Al-Azzawie, H. F., Alhamdani, M. S. S. (2006). Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sciences, 78(12), 1371-1377.
  • Adefegha, S. A., Oyeleye, S. I., Oboh, G. (2015). Distribution of phenolic contents, antidiabetic potentials, antihypertensive properties, and antioxidative effects of soursop (Annona muricata L.) fruit parts in vitro. Biochemistry Research International, 2015.
  • Ahn, C. B., Jeon, Y. J., Kim, Y. T., Je, J. Y. (2012). Angiotensin I converting enzyme (ACE) inhibitory peptides from salmon byproduct protein hydrolysate by Alcalase hydrolysis. Process Biochemistry, 47(12), 2240-2245.
  • Angerhofer, C. K., Maes, D., Giacomoni, P. U. (2009). The use of natural compounds and botanicals in the development of anti-aging skin care products. In Skin Aging Handbook (pp. 205-263). William Andrew Publishing. https://doi.org/10.1016/B978-0-8155-1584-5.50014-4
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  • AOAC international 2006. AOAC International Guidelines for Laboratories Performing Microbiological and Chemical Analyses of Food and Pharmaceuticals: An Aid to Interpretation of ISO/IEC 17025: 2005.
  • Apak, R., Güçlü, K., Özyürek, M., Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of Agricultural and Food Chemistry, 52(26), 7970-7981. https://doi.org/10.1021/jf048741x
  • Benammar, C., Baghdad, C., Belarbi, M., Subramaniam, S., Hichami, A., Khan, N. A. (2014). Antidiabetic and antioxidant activities of Zizyphus lotus L aqueous extracts in Wistar rats. Journal of Nutrition Food Sciences, 8(004), 1-6.
  • Castañeda-Ovando, A., de Lourdes Pacheco-Hernández, M., Páez-Hernández, M. E., Rodríguez, J. A., Galán-Vidal, C. A. (2009). Chemical studies of anthocyanins: A review. Food Chemistry, 113(4), 859-871. https://doi.org/ 10.1016/j.foodchem.2008.09.001
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  • Daskaya-Dikmen, C., Yucetepe, A., Karbancioglu-Guler, F., Daskaya, H., Ozcelik, B. (2017). Angiotensin-I-converting enzyme (ACE)-inhibitory peptides from plants. Nutrients, 9(4), 316. https://doi.org/10.3390/nu9040316
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  • Hoshyar, R., Mohaghegh, Z., Torabi, N., Abolghasemi, A. (2015). Antitumor activity of aqueous extract of Ziziphus jujube fruit in breast cancer: an in vitro and in vivo study. Asian Pacific Journal of Reproduction, 4(2), 116-122. https://doi.org/10.1016/S2305-0500(15)30007-5
  • Imamoglu, H. (2016). Total antioxidant capacity, phenolic compounds and sugar content of Turkey Ziziphus jujubes. Acta Scientiarum Polonorum Hortorum Cultus, 15(5), 93-108.
  • Jiang, J. G., Huang, X. J., Chen, J., Lin, Q. S. (2007). Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube. Natural Product Research, 21(4), 310-320. https://doi.org/10.1080/14786410701192827
  • Koh, J., Xu, Z., Wicker, L. (2020). Blueberry pectin and increased anthocyanins stability under in vitro digestion. Food Chemistry, 302, 125343. https://doi.org/10.1016/j.foodchem.2019.125343
  • Koley, T. K., Kaur, C., Nagal, S., Walia, S., Jaggi, S. (2016). Antioxidant activity and phenolic content in genotypes of Indian jujube (Zizyphus mauritiana Lamk.). Arabian Journal of Chemistry, 9, S1044-S1052.
  • Kumar, S., Ganachari, M. S., Nagoor, V. S. (2004). Anti-inflammatory activity of Ziziphus jujuba Lam leaves extract in rats. Journal of Natural Remedies, 183-185.
  • Kumar, S., Prahalathan, P., Raja, B. (2011). Antihypertensive and antioxidant potential of vanillic acid, a phenolic compound in L-NAME-induced hypertensive rats: a dose-dependence study. Redox Report, 16(5), 208-215. https://doi.org/10.1179/1351000211Y.0000000009
  • Kumaran, A., Karunakaran, R. J. (2006). Anti-oxidant activity of polyphenols from Phyllanthus debilis Klein ex Willd. Journal of Natural Remedies, 141-146.
  • Li, J. W., Ding, S. D., Ding, X. L. (2005). Comparison of antioxidant capacities of extracts from five cultivars of Chinese jujube. Process Biochemistry, 40(11), 3607-3613.
  • Li, J., Liu, Y., Fan, L., Ai, L., Shan, L. (2011). Antioxidant activities of polysaccharides from the fruiting bodies of Zizyphus Jujuba cv. Jinsixiaozao. Carbohydrate Polymers, 84(1), 390-394. https://doi.org/10.1016/j.carbpol.2010.11.051
  • Liu, Z., Dang, J., Wang, Q., Yu, M., Jiang, L., Mei, L., ... Tao, Y. (2013). Optimization of polysaccharides from Lycium ruthenicum fruit using RSM and its anti-oxidant activity. International Journal of Biological Macromolecules, 61, 127-134. https://doi.org/10.1016/j.ijbiomac.2013.06.042
  • Liu, X. X., Liu, H. M., Yan, Y. Y., Fan, L. Y., Yang, J. N., Wang, X. D., Qin, G. Y. (2020). Structural characterization and antioxidant activity of polysaccharides extracted from jujube using subcritical water. LWT, 117, 108645. https://doi.org/10.1016/j.lwt.2019.108645
  • López-Fernández-Sobrino, R., Soliz-Rueda, J. R., Margalef, M., Arola-Arnal, A., Suárez, M., Bravo, F. I., Muguerza, B. (2021). ACE Inhibitory and antihypertensive activities of wine lees and relationship among bioactivity and phenolic profile. Nutrients, 13(2), 679. https://doi.org/ 10.3390/nu13020679
  • Ma, Y., Yang, Y., Gao, J., Feng, J., Shang, Y., Wei, Z. (2020). Phenolics and antioxidant activity of bamboo leaves soup as affected by in vitro digestion. Food and Chemical Toxicology, 135, 110941. https://doi.org/10.1016/ j.fct.2019.110941
  • Marmouzi, I., Kharbach, M., El Jemli, M., Bouyahya, A., Cherrah, Y., Bouklouze, A., ... Faouzi, M. E. A. (2019). Antidiabetic, dermatoprotective, antioxidant and chemical functionalities in Zizyphus lotus leaves and fruits. Industrial Crops and Products, 132, 134-139. https://doi.org/10.1016/j.indcrop.2019.02.007
  • McDougall, G. J., Fyffe, S., Dobson, P., Stewart, D. (2005). Anthocyanins from red wine–their stability under simulated gastrointestinal digestion. Phytochemistry, 66(21), 2540-2548. https://doi.org/10.1016/j.phytochem.2005.09.003
  • Minekus, M., Alminger, M., Alvito, P., Ballance, S., Bohn, T. O. R. S. T. E. N., Bourlieu, C., ... Brodkorb, A. (2014). A standardised static in vitro digestion method suitable for food–an international consensus. Food Function, 5(6), 1113-1124. https://doi.org/10.1039/C3FO60702J
  • Mohebbati, R., Rahimi, M., Bavarsad, K., Shafei, M. N. (2017). Long-term administration of Ziziphus jujuba extract attenuates cardiovascular responses in hypertensive rats induced by angiotensinii. Ancient Science of Life, 37(2), 68. https://doi.org/10.4103/asl.ASL_122_17
  • Mourya, P., Shukla, A., Rai, G., Lodhi, S. (2017). Hypoglycemic and hypolipidemic effects of ethanolic and aqueous extracts from Ziziphus oenoplia (L) Mill on alloxan-induced diabetic rats. Beni-Suef University Journal of Basic and Applied Sciences, 6(1), 1-9. https://doi.org/10.1016/ j.bjbas.2016.12.002
  • Naik, S. R., Bhagat, S., Shah, P. D., Tare, A. A., Ingawale, D., Wadekar, R. R. (2013). Evaluation of anti-allergic and anti-anaphylactic activity of ethanolic extract of Zizyphus jujuba fruits in rodents. Revista Brasileira de Farmacognosia, 23(5), 811-818. https://doi.org/10.1590/S0102-695X2013000500014
  • Ng, Z. X., See, A. N. (2019). Effect of in vitro digestion on the total polyphenol and flavonoid, antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of selected functional plant‐based foods. Journal of Food Processing and Preservation, 43(4), e13903. https://doi.org/10.1111/jfpp.13903
  • Nho, J. W., Hwang, I. G., Kim, H. Y., Lee, Y. R., Woo, K. S., Hwang, B. Y., ... Jeong, H. S. (2010). Free radical scavenging, angiotensin I-converting enzyme (ACE) inhibitory, and in vitro anticancer activities of ramie (Boehmeria nivea) leaves extracts. Food Science and Biotechnology, 19, 383-390. https://doi.org/10.1007/s10068-010-0054-6
  • Pérez-Vicente, A., Gil-Izquierdo, A., García-Viguera, C. (2002). In vitro gastrointestinal digestion study of pomegranate juice phenolic compounds, anthocyanins, and vitamin C. Journal of Agricultural and Food Chemistry, 50(8), 2308-2312. https://doi.org/10.1021/jf0113833
  • Puangkam, K., Muanghorm, W., Konsue, N. (2017). Stability of bioactive compounds and antioxidant activity of Thai cruciferous vegetables during in vitro digestion. Current Research in Nutrition and Food Science Journal, 5(2), 100-108. http://dx.doi.org/10.12944/CRNFSJ.5.2.06
  • Rawat, P., Singh, P. K., Kumar, V. (2016). Anti-hypertensive medicinal plants and their mode of action. Journal of Herbal Medicine, 6(3), 107-118. https://doi.org/10.1016/j.hermed.2016.06.001
  • Quesada, C., Bartolomé, B., Nieto, O., Gómez-Cordovés, C., Hernández, T., Estrella, I. (1996). Phenolic inhibitors of α-amylase and trypsin enzymes by extracts from pears, lentils, and cocoa. Journal of Food Protection, 59(2), 185-192. https://doi.org/10.4315/0362-028X-59.2.185
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  • Shi, Q., Zhang, Z., Su, J., Zhou, J., Li, X. (2018). Comparative analysis of pigments, phenolics, and antioxidant activity of Chinese jujube (Ziziphus jujuba Mill.) during fruit development. Molecules, 23(8), 1917. https://doi.org/10.3390/ molecules23081917
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  • Wu, C. S., Gao, Q. H., Guo, X. D., Yu, J. G., Wang, M. (2012). Effect of ripening stage on physicochemical properties and antioxidant profiles of a promising table fruit ‘pear-jujube’(Zizyphus jujuba Mill.). Scientia Horticulturae, 148, 177-184. https://doi.org/10.1016/ j.scienta.2012.09.026
  • Zaidan, U. H., Zen, N. I. M., Amran, N. A., Shamsi, S., Abd Gani, S. S. (2019). Biochemical evaluation of phenolic compounds and steviol glycoside from Stevia rebaudiana extracts associated with in vitro antidiabetic potential. Biocatalysis and Agricultural Biotechnology, 18, 101049. https://doi.org/10.1016/j.bcab.2019.101049
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Toplam 64 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Gıda Mühendisliği
Bölüm Makaleler
Yazarlar

Eda Şensu 0000-0002-6240-8381

Ayhan Duran 0000-0002-4042-0988

Beraat Özçelik 0000-0002-1810-8154

Aysun Yücetepe 0000-0002-3800-4774

Proje Numarası 2020-032 and 2018-045
Erken Görünüm Tarihi 4 Nisan 2023
Yayımlanma Tarihi 16 Haziran 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 48 Sayı: 3

Kaynak Göster

APA Şensu, E., Duran, A., Özçelik, B., Yücetepe, A. (2023). INVESTIGATION OF CHANGES IN SOME BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS FROM PULP AND SEED TISSUES OF ZIZIPHUS JUJUBA DURING IN VITRO DIGESTION. Gıda, 48(3), 602-613. https://doi.org/10.15237/gida.GD23033
AMA Şensu E, Duran A, Özçelik B, Yücetepe A. INVESTIGATION OF CHANGES IN SOME BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS FROM PULP AND SEED TISSUES OF ZIZIPHUS JUJUBA DURING IN VITRO DIGESTION. GIDA. Haziran 2023;48(3):602-613. doi:10.15237/gida.GD23033
Chicago Şensu, Eda, Ayhan Duran, Beraat Özçelik, ve Aysun Yücetepe. “INVESTIGATION OF CHANGES IN SOME BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS FROM PULP AND SEED TISSUES OF ZIZIPHUS JUJUBA DURING IN VITRO DIGESTION”. Gıda 48, sy. 3 (Haziran 2023): 602-13. https://doi.org/10.15237/gida.GD23033.
EndNote Şensu E, Duran A, Özçelik B, Yücetepe A (01 Haziran 2023) INVESTIGATION OF CHANGES IN SOME BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS FROM PULP AND SEED TISSUES OF ZIZIPHUS JUJUBA DURING IN VITRO DIGESTION. Gıda 48 3 602–613.
IEEE E. Şensu, A. Duran, B. Özçelik, ve A. Yücetepe, “INVESTIGATION OF CHANGES IN SOME BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS FROM PULP AND SEED TISSUES OF ZIZIPHUS JUJUBA DURING IN VITRO DIGESTION”, GIDA, c. 48, sy. 3, ss. 602–613, 2023, doi: 10.15237/gida.GD23033.
ISNAD Şensu, Eda vd. “INVESTIGATION OF CHANGES IN SOME BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS FROM PULP AND SEED TISSUES OF ZIZIPHUS JUJUBA DURING IN VITRO DIGESTION”. Gıda 48/3 (Haziran 2023), 602-613. https://doi.org/10.15237/gida.GD23033.
JAMA Şensu E, Duran A, Özçelik B, Yücetepe A. INVESTIGATION OF CHANGES IN SOME BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS FROM PULP AND SEED TISSUES OF ZIZIPHUS JUJUBA DURING IN VITRO DIGESTION. GIDA. 2023;48:602–613.
MLA Şensu, Eda vd. “INVESTIGATION OF CHANGES IN SOME BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS FROM PULP AND SEED TISSUES OF ZIZIPHUS JUJUBA DURING IN VITRO DIGESTION”. Gıda, c. 48, sy. 3, 2023, ss. 602-13, doi:10.15237/gida.GD23033.
Vancouver Şensu E, Duran A, Özçelik B, Yücetepe A. INVESTIGATION OF CHANGES IN SOME BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS FROM PULP AND SEED TISSUES OF ZIZIPHUS JUJUBA DURING IN VITRO DIGESTION. GIDA. 2023;48(3):602-13.

Cited By

AN INVESTIGATION OF THE ACE INHIBITORY ACTIVITY, ANTIOXIDANT CAPACITY, AND PHYTOCHEMICAL CONSTITUENTS OF POLAR AND NON-POLAR EXTRACTS OF ZIZIPHUS JUJUBA FRUIT: STATISTICAL SCREENING THE MAIN COMPONENTS RESPONSIBLE FOR BIOACTIVITY
GIDA / THE JOURNAL OF FOOD
https://doi.org/10.15237/gida.GD24028
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